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AR111425A2 - MODULADORES SELECTIVOS DE RECEPTORES DE ANDRÓGENOS (SARMs) Y COMPOSICIONES FARMACÉUTICAS QUE LOS COMPRENDEN - Google Patents

MODULADORES SELECTIVOS DE RECEPTORES DE ANDRÓGENOS (SARMs) Y COMPOSICIONES FARMACÉUTICAS QUE LOS COMPRENDEN

Info

Publication number
AR111425A2
AR111425A2 ARP180101066A ARP180101066A AR111425A2 AR 111425 A2 AR111425 A2 AR 111425A2 AR P180101066 A ARP180101066 A AR P180101066A AR P180101066 A ARP180101066 A AR P180101066A AR 111425 A2 AR111425 A2 AR 111425A2
Authority
AR
Argentina
Prior art keywords
pharmaceutical compositions
sarms
androgen receptors
selective modulators
methyl
Prior art date
Application number
ARP180101066A
Other languages
English (en)
Inventor
Lin Zhi
Original Assignee
Ligand Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ligand Pharm Inc filed Critical Ligand Pharm Inc
Publication of AR111425A2 publication Critical patent/AR111425A2/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D498/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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Abstract

En la presente se proveen compuestos de fórmula (1), donde: R¹ es CF₃, F ó Cl; R² es H o metil; y R³ es H o metil; o sales o ésteres farmacéuticamente aceptables de los mismos. Composiciones farmacéuticas que los comprenden y su uso en el tratamiento de enfermedades óseas y de diferentes tipos de cáncer.
ARP180101066A 2007-12-21 2018-04-25 MODULADORES SELECTIVOS DE RECEPTORES DE ANDRÓGENOS (SARMs) Y COMPOSICIONES FARMACÉUTICAS QUE LOS COMPRENDEN AR111425A2 (es)

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US873107P 2007-12-21 2007-12-21

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AR111425A2 true AR111425A2 (es) 2019-07-10

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ARP080105633A AR092284A1 (es) 2007-12-21 2008-12-19 MODULADORES SELECTIVOS DE RECEPTORES DE ANDROGENOS (SARMs) Y USOS DE LOS MISMOS
ARP180101066A AR111425A2 (es) 2007-12-21 2018-04-25 MODULADORES SELECTIVOS DE RECEPTORES DE ANDRÓGENOS (SARMs) Y COMPOSICIONES FARMACÉUTICAS QUE LOS COMPRENDEN

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ARP080105633A AR092284A1 (es) 2007-12-21 2008-12-19 MODULADORES SELECTIVOS DE RECEPTORES DE ANDROGENOS (SARMs) Y USOS DE LOS MISMOS

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US (7) US8354446B2 (es)
EP (2) EP2489656A1 (es)
JP (2) JP5539221B2 (es)
KR (1) KR101595238B1 (es)
CN (2) CN104188971B (es)
AR (2) AR092284A1 (es)
BR (1) BRPI0821090B8 (es)
CA (1) CA2709677C (es)
CL (1) CL2008003825A1 (es)
DK (1) DK2222636T3 (es)
ES (1) ES2413504T3 (es)
HR (1) HRP20130552T1 (es)
MX (1) MX2010006972A (es)
PL (1) PL2222636T3 (es)
PT (1) PT2222636E (es)
TW (1) TWI437003B (es)
WO (1) WO2009082437A2 (es)

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