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AR103399A1 - Derivados de (r)-2-metil-piperazina como moduladores del receptor cxcr3 - Google Patents

Derivados de (r)-2-metil-piperazina como moduladores del receptor cxcr3

Info

Publication number
AR103399A1
AR103399A1 ARP160100068A ARP160100068A AR103399A1 AR 103399 A1 AR103399 A1 AR 103399A1 AR P160100068 A ARP160100068 A AR P160100068A AR P160100068 A ARP160100068 A AR P160100068A AR 103399 A1 AR103399 A1 AR 103399A1
Authority
AR
Argentina
Prior art keywords
cxcr3
piperazine
derivatives
methyl
receiver modulators
Prior art date
Application number
ARP160100068A
Other languages
English (en)
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of AR103399A1 publication Critical patent/AR103399A1/es

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
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  • Pain & Pain Management (AREA)
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  • Hospice & Palliative Care (AREA)
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  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
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Abstract

Reivindicación 1: Un compuesto de fórmula (1) en donde R¹ representa alquilo C₁₋₄, alcoxi C₁₋₂-alquilo C₁₋₂, hidroxi-alquilo C₁₋₄ o -C(O)NH₂; y R² representa cicloalquilo C₃₋₆, alcoxi C₁₋₄, cicloalcoxi C₃₋₆ o fluoroalquilo C₁₋₂; o una sal del mismo.
ARP160100068A 2015-01-15 2016-01-12 Derivados de (r)-2-metil-piperazina como moduladores del receptor cxcr3 AR103399A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP2015050691 2015-01-15

Publications (1)

Publication Number Publication Date
AR103399A1 true AR103399A1 (es) 2017-05-10

Family

ID=55129889

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP160100068A AR103399A1 (es) 2015-01-15 2016-01-12 Derivados de (r)-2-metil-piperazina como moduladores del receptor cxcr3

Country Status (16)

Country Link
US (1) US10047080B2 (es)
EP (1) EP3256469B1 (es)
JP (1) JP6595003B2 (es)
KR (1) KR102568469B1 (es)
CN (1) CN107207491B (es)
AR (1) AR103399A1 (es)
AU (1) AU2016207990B2 (es)
BR (1) BR112017015116A2 (es)
CA (1) CA2972954C (es)
ES (1) ES2712727T3 (es)
MX (1) MX2017009292A (es)
PL (1) PL3256469T3 (es)
RU (1) RU2706232C2 (es)
TR (1) TR201901977T4 (es)
TW (1) TWI698434B (es)
WO (1) WO2016113346A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112016001238B1 (pt) 2013-07-22 2022-10-11 Idorsia Pharmaceuticals Ltd Derivados de 1-(piperazin-1-il)-2-([1,2,4]triazol-1-il)-etanona, seus usos e composição farmacêutica os compreendendo
AR099789A1 (es) 2014-03-24 2016-08-17 Actelion Pharmaceuticals Ltd Derivados de 8-(piperazin-1-il)-1,2,3,4-tetrahidro-isoquinolina
AR103399A1 (es) 2015-01-15 2017-05-10 Actelion Pharmaceuticals Ltd Derivados de (r)-2-metil-piperazina como moduladores del receptor cxcr3
MX2017009288A (es) * 2015-01-15 2017-10-11 Idorsia Pharmaceuticals Ltd Derivados de hidroxialquil-piperazina como moduladores del receptor cxcr3.
WO2018011265A1 (en) * 2016-07-13 2018-01-18 Idorsia Pharmaceuticals Ltd Hydroxyalkyl-piperazine derivatives as cxcr3 receptor modulators
CN110183388A (zh) * 2019-06-06 2019-08-30 常州合全药业有限公司 一种2-（1h-1,2,4-三氮唑-1-乙基）醋酸的合成方法

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