AR072359A1 - Encapsulacion de agentes biologicamente activos - Google Patents
Encapsulacion de agentes biologicamente activosInfo
- Publication number
- AR072359A1 AR072359A1 ARP090101617A ARP090101617A AR072359A1 AR 072359 A1 AR072359 A1 AR 072359A1 AR P090101617 A ARP090101617 A AR P090101617A AR P090101617 A ARP090101617 A AR P090101617A AR 072359 A1 AR072359 A1 AR 072359A1
- Authority
- AR
- Argentina
- Prior art keywords
- biologically active
- active agent
- encapsulation
- aqueous
- active agents
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5138—Organic macromolecular compounds; Dendrimers obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A61K9/0051—Ocular inserts, ocular implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
- A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5192—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Nanotechnology (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Ophthalmology & Optometry (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Composiciones que comprenden vehículos en forma de partículas que pueden obtenerse por dichos procedimientos y usos de dichas composiciones en un tratamiento. Reivindicacion 1: Un procedimiento para producir un vehículo en forma de partículas que comprende las etapas de: a) disolver polibutilcianoacrilato (PBCA) en un disolvente orgánico para formar una solucion polimérica; b) anadir una solucion acuosa que contiene un agente biologicamente activo a la solucion polimérica para formar una emulsion primaria de gotas de fase acuosa en una fase orgánica continua; c) mezclar la emulsion primaria con un medio acuoso para formar una emulsion secundaria; y d) permitir que la fase orgánica se evapore y por lo tanto obtener vehículos en forma de partículas que comprende una luz hueca que contiene el agente biologicamente activo en una fase acuosa. Reivindicacion 6: El procedimiento de una cualquiera de las reivindicaciones 1 a 4, en el que el vehículo en forma de partículas es una nanopartícula. Reivindicacion 7: El procedimiento de una cualquiera de las reivindicaciones 1 a 6, en el que el agente biologicamente activo es una proteína o péptido.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5077508P | 2008-05-06 | 2008-05-06 | |
US7417108P | 2008-06-20 | 2008-06-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR072359A1 true AR072359A1 (es) | 2010-08-25 |
Family
ID=40944671
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP090101619A AR072668A1 (es) | 2008-05-06 | 2009-05-05 | Encapsulacion de agentes biologicamente activos |
ARP090101616A AR071633A1 (es) | 2008-05-06 | 2009-05-05 | Encapsulacion de agentes biologicamente activos |
ARP090101617A AR072359A1 (es) | 2008-05-06 | 2009-05-05 | Encapsulacion de agentes biologicamente activos |
ARP090101618A AR071634A1 (es) | 2008-05-06 | 2009-05-05 | Nanoparticulas para encapsulacion de agentes biologicamente activos |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP090101619A AR072668A1 (es) | 2008-05-06 | 2009-05-05 | Encapsulacion de agentes biologicamente activos |
ARP090101616A AR071633A1 (es) | 2008-05-06 | 2009-05-05 | Encapsulacion de agentes biologicamente activos |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP090101618A AR071634A1 (es) | 2008-05-06 | 2009-05-05 | Nanoparticulas para encapsulacion de agentes biologicamente activos |
Country Status (11)
Country | Link |
---|---|
US (1) | US20110064821A1 (es) |
EP (2) | EP2271323A2 (es) |
JP (1) | JP2011522792A (es) |
KR (3) | KR20110015604A (es) |
AR (4) | AR072668A1 (es) |
CA (1) | CA2721241A1 (es) |
CL (4) | CL2009001080A1 (es) |
PE (4) | PE20091964A1 (es) |
TW (4) | TW201012490A (es) |
UY (4) | UY31807A (es) |
WO (1) | WO2009135853A2 (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20110064819A1 (en) * | 2008-05-06 | 2011-03-17 | Andrew Beaton | Encapsulation of biologically active agents |
US9504759B2 (en) | 2011-08-11 | 2016-11-29 | Bar-Ilan University | Surface modified proteinaceous spherical particles and uses thereof |
US10112988B2 (en) | 2012-01-09 | 2018-10-30 | Icb International, Inc. | Methods of assessing amyloid-beta peptides in the central nervous system by blood-brain barrier permeable peptide compositions comprising a vab domain of a camelid single domain heavy chain antibody against an anti-amyloid-beta peptide |
US10112987B2 (en) * | 2012-01-09 | 2018-10-30 | Icb International, Inc. | Blood-brain barrier permeable peptide compositions comprising a vab domain of a camelid single domain heavy chain antibody against an amyloid-beta peptide |
EP3148516A1 (en) * | 2014-05-30 | 2017-04-05 | AbbVie Deutschland GmbH & Co. KG | Nanoencapsulation of antigen-binding molecules |
WO2015181346A1 (en) * | 2014-05-30 | 2015-12-03 | AbbVie Deutschland GmbH & Co. KG | Highly drug-loaded poly(alkyl 2-cyanoacrylate) nanocapsules |
CA2951905A1 (en) * | 2014-06-12 | 2015-12-17 | Orbis Biosciences, Inc. | Extended-release drug delivery compositions |
US10231937B2 (en) | 2014-06-24 | 2019-03-19 | The Trustees Of Princeton University | Process for encapsulating soluble biologics, therapeutics, and imaging agents |
WO2019055539A1 (en) | 2017-09-12 | 2019-03-21 | Prudhomme Robert K | CELLULOSIC POLYMER NANOPARTICLES AND METHODS OF FORMING THE SAME |
US11731099B2 (en) | 2018-07-20 | 2023-08-22 | The Trustees Of Princeton University | Method for controlling encapsulation efficiency and burst release of water soluble molecules from nanoparticles and microparticles produced by inverse flash nanoprecipitation |
US20220031630A1 (en) * | 2018-09-13 | 2022-02-03 | The Brigham And Women's Hospital, Inc. | Nanoparticle formulations and methods of their use |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
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US4833666A (en) | 1986-12-24 | 1989-05-23 | U.S. Philips Corporation | Disc-record player suitable for scanning disc of different types |
FR2649321A1 (fr) * | 1989-07-07 | 1991-01-11 | Inst Nat Sante Rech Med | Compositions a base de derives nucleotidiques, leurs procedes de preparation, et leurs utilisations notamment en tant que compositions pharmaceutiques |
FR2659554B1 (fr) * | 1990-03-16 | 1994-09-30 | Oreal | Composition pour le traitement cosmetique et/ou pharmaceutique des couches superieures de l'epiderme par application topique sur la peau et procede de preparation correspondant. |
WO1994017789A1 (en) * | 1993-02-15 | 1994-08-18 | Shield Research Limited | Polyalkylcyanoacrylate nanocapsules |
CA2171303C (en) * | 1993-09-09 | 2006-06-06 | Werner Weitschies | Active principles and gas containing microparticles |
DE19742706B4 (de) | 1997-09-26 | 2013-07-25 | Pieris Proteolab Ag | Lipocalinmuteine |
GB9809839D0 (en) | 1998-05-09 | 1998-07-08 | Glaxo Group Ltd | Antibody |
IL127127A0 (en) | 1998-11-18 | 1999-09-22 | Peptor Ltd | Small functional units of antibody heavy chain variable regions |
US6818418B1 (en) | 1998-12-10 | 2004-11-16 | Compound Therapeutics, Inc. | Protein scaffolds for antibody mimics and other binding proteins |
US7115396B2 (en) | 1998-12-10 | 2006-10-03 | Compound Therapeutics, Inc. | Protein scaffolds for antibody mimics and other binding proteins |
US20030152636A1 (en) * | 2000-02-23 | 2003-08-14 | Nanopharm Ag | Method of treating cancer |
ATE448301T1 (de) | 2000-09-08 | 2009-11-15 | Univ Zuerich | Sammlung von proteinen mit sich wiederholenden sequenzen (repeat proteins), die repetitive sequenzmodule enthalten |
JP2005514326A (ja) * | 2001-07-10 | 2005-05-19 | コリクサ コーポレイション | ミクロスフェア中に封入されたタンパク質およびアジュバントを送達するための組成物および方法 |
AR040778A1 (es) | 2002-08-06 | 2005-04-20 | Glaxo Group Ltd | Anticuerpos alterados o fragmentos funcionales que se unen a mag (glicoproteina asociada a mielina). |
EP1641818B1 (en) | 2003-07-04 | 2008-12-03 | Affibody AB | Polypeptides having binding affinity for her2 |
WO2005019255A1 (en) | 2003-08-25 | 2005-03-03 | Pieris Proteolab Ag | Muteins of tear lipocalin |
RU2402567C2 (ru) | 2003-12-05 | 2010-10-27 | Бристоль-Майерз Сквибб Компани | Ингибиторы рецепторов фактора роста эндотелия сосудов типа 2 |
ATE419842T1 (de) | 2004-09-14 | 2009-01-15 | Nanodel Technologies Gmbh | Abgabevehikel mit nanoteilchen |
GB0525662D0 (en) | 2005-12-16 | 2006-01-25 | Glaxo Group Ltd | Immunoglobulins |
KR101263294B1 (ko) | 2006-03-30 | 2013-06-04 | 글락소 그룹 리미티드 | 아밀로이드베타 펩티드에 대한 항체 |
EP1958957A1 (en) | 2007-02-16 | 2008-08-20 | NascaCell Technologies AG | Polypeptide comprising a knottin protein moiety |
GB0724331D0 (en) | 2007-12-13 | 2008-01-23 | Domantis Ltd | Compositions for pulmonary delivery |
JP2010528647A (ja) | 2007-06-06 | 2010-08-26 | ドマンティス リミテッド | ポリペプチド、抗体可変ドメインおよびアンタゴニスト |
-
2009
- 2009-05-05 KR KR1020107027425A patent/KR20110015604A/ko not_active Application Discontinuation
- 2009-05-05 WO PCT/EP2009/055436 patent/WO2009135853A2/en active Application Filing
- 2009-05-05 PE PE2009000608A patent/PE20091964A1/es not_active Application Discontinuation
- 2009-05-05 TW TW098114865A patent/TW201012490A/zh unknown
- 2009-05-05 KR KR1020107027240A patent/KR20110010758A/ko not_active Application Discontinuation
- 2009-05-05 EP EP09742071A patent/EP2271323A2/en not_active Withdrawn
- 2009-05-05 UY UY0001031807A patent/UY31807A/es unknown
- 2009-05-05 TW TW098114853A patent/TW201012489A/zh unknown
- 2009-05-05 PE PE2009000609A patent/PE20091965A1/es not_active Application Discontinuation
- 2009-05-05 AR ARP090101619A patent/AR072668A1/es not_active Application Discontinuation
- 2009-05-05 TW TW098114851A patent/TW201012488A/zh unknown
- 2009-05-05 EP EP11192165A patent/EP2441447A1/en not_active Withdrawn
- 2009-05-05 CL CL2009001080A patent/CL2009001080A1/es unknown
- 2009-05-05 UY UY0001031810A patent/UY31810A/es unknown
- 2009-05-05 PE PE2009000607A patent/PE20091829A1/es not_active Application Discontinuation
- 2009-05-05 US US12/991,556 patent/US20110064821A1/en not_active Abandoned
- 2009-05-05 UY UY0001031809A patent/UY31809A/es unknown
- 2009-05-05 JP JP2011507897A patent/JP2011522792A/ja active Pending
- 2009-05-05 CL CL2009001077A patent/CL2009001077A1/es unknown
- 2009-05-05 UY UY0001031808A patent/UY31808A/es unknown
- 2009-05-05 AR ARP090101616A patent/AR071633A1/es not_active Application Discontinuation
- 2009-05-05 KR KR1020107027449A patent/KR20110010760A/ko not_active Application Discontinuation
- 2009-05-05 CL CL2009001076A patent/CL2009001076A1/es unknown
- 2009-05-05 PE PE2009000606A patent/PE20091882A1/es not_active Application Discontinuation
- 2009-05-05 CA CA2721241A patent/CA2721241A1/en not_active Abandoned
- 2009-05-05 CL CL2009001081A patent/CL2009001081A1/es unknown
- 2009-05-05 AR ARP090101617A patent/AR072359A1/es not_active Application Discontinuation
- 2009-05-05 AR ARP090101618A patent/AR071634A1/es not_active Application Discontinuation
- 2009-05-05 TW TW098114867A patent/TW201006495A/zh unknown
Also Published As
Publication number | Publication date |
---|---|
JP2011522792A (ja) | 2011-08-04 |
US20110064821A1 (en) | 2011-03-17 |
PE20091965A1 (es) | 2010-01-09 |
PE20091882A1 (es) | 2009-12-24 |
KR20110010758A (ko) | 2011-02-07 |
CL2009001076A1 (es) | 2010-09-24 |
AR072668A1 (es) | 2010-09-15 |
AR071634A1 (es) | 2010-06-30 |
WO2009135853A3 (en) | 2011-05-12 |
CL2009001077A1 (es) | 2010-09-24 |
CA2721241A1 (en) | 2009-11-12 |
KR20110015604A (ko) | 2011-02-16 |
PE20091829A1 (es) | 2009-12-12 |
AR071633A1 (es) | 2010-06-30 |
EP2271323A2 (en) | 2011-01-12 |
UY31807A (es) | 2009-12-14 |
WO2009135853A2 (en) | 2009-11-12 |
UY31808A (es) | 2009-12-14 |
PE20091964A1 (es) | 2010-01-09 |
TW201006495A (en) | 2010-02-16 |
EP2441447A1 (en) | 2012-04-18 |
UY31809A (es) | 2009-12-14 |
TW201012490A (en) | 2010-04-01 |
KR20110010760A (ko) | 2011-02-07 |
CL2009001080A1 (es) | 2010-09-24 |
TW201012488A (en) | 2010-04-01 |
CL2009001081A1 (es) | 2010-09-24 |
UY31810A (es) | 2009-12-14 |
TW201012489A (en) | 2010-04-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |