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AR079764A1 - Aumento de la produccion de metionina mediante la sobreexpresion de succinato deshidrogenasa - Google Patents

Aumento de la produccion de metionina mediante la sobreexpresion de succinato deshidrogenasa

Info

Publication number
AR079764A1
AR079764A1 ARP100104976A ARP100104976A AR079764A1 AR 079764 A1 AR079764 A1 AR 079764A1 AR P100104976 A ARP100104976 A AR P100104976A AR P100104976 A ARP100104976 A AR P100104976A AR 079764 A1 AR079764 A1 AR 079764A1
Authority
AR
Argentina
Prior art keywords
production
succinate dehydrogenase
metionin
overexpression
increasing
Prior art date
Application number
ARP100104976A
Other languages
English (en)
Original Assignee
Metabolic Explorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Metabolic Explorer Sa filed Critical Metabolic Explorer Sa
Publication of AR079764A1 publication Critical patent/AR079764A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/12—Methionine; Cysteine; Cystine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/001—Oxidoreductases (1.) acting on the CH-CH group of donors (1.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y103/00—Oxidoreductases acting on the CH-CH group of donors (1.3)
    • C12Y103/05—Oxidoreductases acting on the CH-CH group of donors (1.3) with a quinone or related compound as acceptor (1.3.5)
    • C12Y103/05001—Succinate dehydrogenase (ubiquinone) (1.3.5.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/185—Escherichia
    • C12R2001/19—Escherichia coli
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/848—Escherichia
    • Y10S435/849—Escherichia coli

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Proceso para la mejora de la produccion de metionina mediante el cultivo de un microorganismo modificado para aumentar la expresion de genes implicados en la síntesis de succinato deshidrogenasa. Los microorganismos fueron modificados de tal modo que el rendimiento de metionina/fuente de carbono aumenta. También se reivindica el aislamiento de metionina del medio de fermentacion.
ARP100104976A 2009-12-30 2010-12-28 Aumento de la produccion de metionina mediante la sobreexpresion de succinato deshidrogenasa AR079764A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IB2009/056063 WO2011080542A1 (en) 2009-12-30 2009-12-30 Increasing methionine production by overexpressing succinate dehydrogenase

Publications (1)

Publication Number Publication Date
AR079764A1 true AR079764A1 (es) 2012-02-15

Family

ID=42791079

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP100104976A AR079764A1 (es) 2009-12-30 2010-12-28 Aumento de la produccion de metionina mediante la sobreexpresion de succinato deshidrogenasa

Country Status (11)

Country Link
US (1) US9267160B2 (es)
EP (1) EP2519643B1 (es)
JP (1) JP5819316B2 (es)
KR (1) KR101770123B1 (es)
CN (1) CN102712941A (es)
AR (1) AR079764A1 (es)
BR (1) BR112012016274B1 (es)
ES (1) ES2654659T3 (es)
MX (1) MX2012007718A (es)
PL (1) PL2519643T3 (es)
WO (1) WO2011080542A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6393898B2 (ja) * 2014-08-03 2018-09-26 国立大学法人 奈良先端科学技術大学院大学 酵母の培養方法
KR20170044740A (ko) 2014-09-01 2017-04-25 메타볼릭 익스플로러 메티오닌 유출이 개선된 발효에 의한 메티오닌 생산을 위한 방법 및 미생물
WO2017025766A1 (en) 2015-08-07 2017-02-16 Metabolic Explorer Protein thiocarboxylate-dependent l-methionine production by fermentation
ES2748226T3 (es) 2015-11-27 2020-03-16 Evonik Operations Gmbh Procedimiento de producción de L-metionina
EP3296404A1 (en) 2016-09-15 2018-03-21 Evonik Degussa GmbH Modified microorganism for production of methionine

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000157267A (ja) 1998-11-24 2000-06-13 Ajinomoto Co Inc 変異型ｍｅｔＪ遺伝子及びＬ−メチオニンの製造法
JP2003180348A (ja) 1999-07-02 2003-07-02 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
DE19959650A1 (de) * 1999-12-10 2001-06-13 Degussa Neue für die Gene sdhA, sdhB und sdhC codierende Nukleotidsequenzen
ATE393226T1 (de) * 2001-07-18 2008-05-15 Evonik Degussa Gmbh Verfahren zur herstellung von l-threonin durch enterobakteriaceae-stämmen mit verstärkter exprimierung des male-gens
MXPA05008857A (es) 2003-02-18 2006-03-09 Metabolic Explorer Sa Procedimiento de preparacion de microorganismos evolucionados que permite la creacion o la modificacion de vias metabolicas.
EP1656454A4 (en) 2003-07-08 2011-06-22 Novus Int Inc PROCESS FOR METHIONINAL RECOVERY
DE10359668A1 (de) 2003-12-18 2005-07-14 Basf Ag Verfahren zur Herstellung von Methionin
WO2005111202A1 (en) 2004-05-12 2005-11-24 Metabolic Explorer Recombinant enzyme with altered feedback sensitivity
DE602006018468D1 (de) * 2005-07-18 2011-01-05 Evonik Degussa Gmbh Verwendung von dimethyldisulfid für die methioninproduktion in mikroorganismen
WO2007017710A1 (en) 2005-08-11 2007-02-15 Metabolic Explorer Process for the preparation of aspartate and derived amino acids like lysine, threonine, isoleucine, methionine, homoserine, or valine employing a microorganism with enhanced isocitrate lyase and/or malate synthase expression
US20090191610A1 (en) 2005-08-18 2009-07-30 Evonik Degussa Gmbh Microorganisms With Increased Efficiency for Methionine Synthesis
JP2007185184A (ja) 2005-12-16 2007-07-26 Ajinomoto Co Inc Ｌ−アミノ酸生産菌及びｌ−アミノ酸の製造法
CN101351558B (zh) * 2006-01-04 2013-08-14 代谢探索者公司 使用硫酸盐通透酶表达增强的微生物制备甲硫氨酸及其前体高丝氨酸或琥珀酰高丝氨酸的方法
WO2009043372A1 (en) 2007-10-02 2009-04-09 Metabolic Explorer Increasing methionine yield
US20110229942A1 (en) 2007-12-13 2011-09-22 Glycos Biotechnologies, Incorporated Microbial Conversion of Oils and Fatty Acids to High-Value Chemicals
KR20110008065A (ko) 2008-04-30 2011-01-25 에보니크 데구사 게엠베하 이소시트레이트 데하이드로게나제 활성이 감소된 미생물을 사용한 메티오닌 생산 방법

Also Published As

Publication number Publication date
JP2013516167A (ja) 2013-05-13
BR112012016274A8 (pt) 2017-09-19
KR20120106999A (ko) 2012-09-27
JP5819316B2 (ja) 2015-11-24
MX2012007718A (es) 2012-07-25
EP2519643A1 (en) 2012-11-07
BR112012016274A2 (pt) 2015-10-06
KR101770123B1 (ko) 2017-08-23
US9267160B2 (en) 2016-02-23
WO2011080542A1 (en) 2011-07-07
US20120288903A1 (en) 2012-11-15
PL2519643T3 (pl) 2018-03-30
BR112012016274B1 (pt) 2019-08-20
CN102712941A (zh) 2012-10-03
EP2519643B1 (en) 2017-11-15
ES2654659T3 (es) 2018-02-14

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