AR049631A1 - Proceso de acoplamiento para la generacion de derivados reactivos de pirrol -2- carbonitrilo n- sustituidos con contenido de boro para producir biarilos - Google Patents
Proceso de acoplamiento para la generacion de derivados reactivos de pirrol -2- carbonitrilo n- sustituidos con contenido de boro para producir biarilosInfo
- Publication number
- AR049631A1 AR049631A1 ARP050101622A ARP050101622A AR049631A1 AR 049631 A1 AR049631 A1 AR 049631A1 AR P050101622 A ARP050101622 A AR P050101622A AR P050101622 A ARP050101622 A AR P050101622A AR 049631 A1 AR049631 A1 AR 049631A1
- Authority
- AR
- Argentina
- Prior art keywords
- substituted
- alkyl
- aminoalkyl
- alkoxy
- biarilos
- Prior art date
Links
- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical group [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 title abstract 2
- LELOWRISYMNNSU-UHFFFAOYSA-N Hydrocyanic acid Natural products N#C LELOWRISYMNNSU-UHFFFAOYSA-N 0.000 title 1
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 title 1
- 238000010168 coupling process Methods 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 20
- 125000004103 aminoalkyl group Chemical group 0.000 abstract 8
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 7
- 125000006716 (C1-C6) heteroalkyl group Chemical group 0.000 abstract 4
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 4
- BQMPGKPTOHKYHS-UHFFFAOYSA-N 1h-pyrrole-2-carbonitrile Chemical compound N#CC1=CC=CN1 BQMPGKPTOHKYHS-UHFFFAOYSA-N 0.000 abstract 4
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 4
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 4
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 150000002367 halogens Chemical class 0.000 abstract 4
- 125000001072 heteroaryl group Chemical group 0.000 abstract 4
- 241000689227 Cora <basidiomycete fungus> Species 0.000 abstract 2
- 241000347391 Umbrina cirrosa Species 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 150000002148 esters Chemical class 0.000 abstract 2
- 125000003107 substituted aryl group Chemical group 0.000 abstract 2
- 150000005247 2-cyanopyrroles Chemical class 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 229910052796 boron Inorganic materials 0.000 abstract 1
- 150000001639 boron compounds Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000000269 nucleophilic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Reivindicacion 1: Un método para la preparacion de ésteres boricos o ésteres borosos de 2-cianopirrol (i) de las formulas (1) o (2); (ii) compuestos de boro de las formulas (3) o (4); o (iii) las sales de las formulas (5), (6), (7) u (8); en las cuales: R1, R2 y R3 son, independientemente, alquilo C1-6, alquilo C1-6 sustituido, cicloalquilo C3-8, cicloalquilo C3-8 sustituido, heteroalquilo C1-6 o heteroalquilo C1-6 sustituido. R4, R5 y R6 son, independientemente, halogeno, alquilo C1-6 o alquilo C1-6 sustituido; R7 es seleccionado entre alquilo C1-6, alquilo C1-6 sustituido, arilo, arilo sustituido, heteroarilo, heteroarilo sustituido o CORA; Q es OH, NH2, CN, halogeno, alquilo C1-6, alquilo C1-6 sustituido, alquenilo C2-6, alquenilo C2-6 sustituido, alquinilo C2-6, alquinilo C2-6 sustituido, alcoxi C1-6, alcoxi C1-6 sustituido, aminoalquilo C1-6 o aminoalquilo C1-6 sustituido o CORB; a es 0 a 2; CC+ es un contracation, que comprende la reaccion de: (a) un agente de boro de la formula: (i) B(OR1)(OR2)(OR3), y R1, R2 y R3 son, independientemente, alquilo C1-6, alquilo C1-6 sustituido, cicloalquilo C3-8, cicloalquilo C3-8 sustituido, heteroalquilo C1-6 o heteroalquilo C1-6 sustituido o bien (ii) B(R4)(R5)(R6), en la cual R4, R5 y R6 son, independientemente, halogeno, alquilo C1-6 o alquilo C1-6 sustituido; (b) un 2-cianopirrol sustituido de la formula (9) en la cual R7 es alquilo C1-6, alquilo C1-6 sustituido, arilo, arilo sustituido, heteroarilo, heteroarilo sustituido o CORA; RA es H, alquilo C1-6, alquilo C1-6 sustituido, alcoxi C1-6, alcoxi C1-6 sustituido, aminoalquilo C1-6 o aminoalquilo C1-6 sustituido; Q es OH; NH2, CN, halogeno, alquilo C1-6, alquilo C1-6 sustituido, alquenilo C2-6, alquenilo C2-6 sustituido, alquinilo C2-6, alquinilo C2-6 sustituido, alcoxi C1-6, alcoxi C1-6 sustituido, aminoalquilo C1-6 o aminoalquilo C1-6 sustituido o CORB; a es 0 a 2; RB es H, alquilo C1-6, alquilo C1-6 sustituido, alcoxi C1-6, alcoxi C1-6 sustituido, aminoalquilo C1-6 o aminoalquilo C1-6 sustituido, y (c) una base fuerte no nucleofílica.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US56563604P | 2004-04-27 | 2004-04-27 | |
| US64765605P | 2005-01-27 | 2005-01-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR049631A1 true AR049631A1 (es) | 2006-08-23 |
Family
ID=34967855
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP050101622A AR049631A1 (es) | 2004-04-27 | 2005-04-25 | Proceso de acoplamiento para la generacion de derivados reactivos de pirrol -2- carbonitrilo n- sustituidos con contenido de boro para producir biarilos |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US7446211B2 (es) |
| AR (1) | AR049631A1 (es) |
| PA (1) | PA8631101A1 (es) |
| PE (1) | PE20060331A1 (es) |
| SV (1) | SV2005002092A (es) |
| TW (1) | TW200604137A (es) |
| WO (1) | WO2005105817A2 (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PA8631101A1 (es) | 2004-04-27 | 2006-09-08 | Wyeth Corp | Proceso de acoplamiento para la generacion de derivados reactivos de pirrol-2-carbonitrilo n-sustituidos con contenido de boro para producir biarilos |
| AU2005238520B2 (en) | 2004-04-27 | 2011-09-08 | Wyeth | Cyanopyrrole containing cyclic carbamate and thiocarbamate biaryls and methods for preparing the same |
| GT200500185A (es) * | 2004-08-09 | 2006-04-10 | Moduladores del receptor de progesterona que comprenden derivados de pirrol-oxindol y sus usos | |
| WO2006020712A1 (en) * | 2004-08-13 | 2006-02-23 | Wyeth | Tanaproget derivatives, metabolites, and uses thereof |
| BRPI0610437A2 (pt) | 2005-04-28 | 2012-10-23 | Wyeth Corp | composição farmacêutica, comprimido, embalagem farmacêutica, e, processo para a preparação de uma composição farmacêutica |
| JP2008539254A (ja) * | 2005-04-28 | 2008-11-13 | ワイス | タナプロゲットの精製形態 |
| MX2007013469A (es) | 2005-04-28 | 2008-01-22 | Wyeth Corp | Forma ii polimorfa de tanaproget. |
| CN101166533A (zh) | 2005-04-28 | 2008-04-23 | 惠氏公司 | 微粉化的tanaproget和含有它的组合物 |
| PE20070220A1 (es) | 2005-07-29 | 2007-03-19 | Wyeth Corp | Proceso para la sintesis de moduladores del receptor de progesterona |
| US20070213526A1 (en) * | 2006-03-07 | 2007-09-13 | Wyeth | Purification of progesterone receptor modulators |
| AU2008211047B2 (en) | 2007-01-29 | 2013-07-25 | Wako Pure Chemical Industries, Ltd. | Reagent for organic synthesis reaction containing organic triol borate salt |
| US20080319204A1 (en) * | 2007-06-25 | 2008-12-25 | Wyeth | Process for the synthesis of progesterone receptor modulators |
| BRPI0819571A2 (pt) * | 2007-12-20 | 2019-09-24 | Teva Womenss Health Inc | "método para contracepção de emergência, pacote farmacêutico para contracepção de emergência e composição farmacêutica" |
| KR20240131463A (ko) | 2020-05-05 | 2024-08-30 | 뉴베일런트, 아이엔씨. | 헤테로방향족 거대환식 에터 화학치료제 |
| KR102699528B1 (ko) | 2020-05-05 | 2024-08-30 | 뉴베일런트, 아이엔씨. | 헤테로방향족 거대환식 에터 화학치료제 |
| EP4408844A1 (en) | 2021-10-01 | 2024-08-07 | Nuvalent, Inc. | Solid forms, pharmaceutical compositions and preparation of heteroaromatic macrocyclic ether compounds |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5194628A (en) | 1988-03-18 | 1993-03-16 | Ciba-Geigy Corporation | Process for the preparation of substituted difluorobenzo-1,3-dioxoles |
| MX9206628A (es) * | 1991-11-22 | 1993-05-01 | Boehringer Ingelheim Pharma | Ester de prolinaboronato y metodo para su preparacion. |
| KR960704886A (ko) | 1993-09-10 | 1996-10-09 | 베르너 발데크 | 포토크롬 화합물, 그의 제조 방법과 제조 중간체 및 그의 용도 (Photochromic Compounds, Methods and Intermediates for Producing Them and Their Use) |
| CA2363628A1 (en) | 1999-02-22 | 2000-08-31 | James Allen Ponasik Jr. | Catalysts containing n-pyrrolyl substituted nitrogen donors |
| US6545108B1 (en) | 1999-02-22 | 2003-04-08 | Eastman Chemical Company | Catalysts containing N-pyrrolyl substituted nitrogen donors |
| US6407101B1 (en) * | 1999-05-04 | 2002-06-18 | American Home Products Corporation | Cyanopyrroles |
| US6509334B1 (en) | 1999-05-04 | 2003-01-21 | American Home Products Corporation | Cyclocarbamate derivatives as progesterone receptor modulators |
| US6391907B1 (en) | 1999-05-04 | 2002-05-21 | American Home Products Corporation | Indoline derivatives |
| US6444668B1 (en) | 1999-05-04 | 2002-09-03 | Wyeth | Combination regimens using progesterone receptor modulators |
| US7306643B2 (en) * | 2000-01-10 | 2007-12-11 | Sulzer Chemtech Ag | Method for introducing additives to liquid metal, ceramic/metallic powder |
| US20020065192A1 (en) | 2000-02-18 | 2002-05-30 | Mackenzie Peter Borden | Productivity catalysts and microstructure control |
| UA73119C2 (en) | 2000-04-19 | 2005-06-15 | American Home Products Corpoir | Derivatives of cyclic thiocarbamates, pharmaceutical composition including noted derivatives of cyclic thiocarbamates and active ingredients of medicines as modulators of progesterone receptors |
| US6350837B1 (en) | 2000-06-09 | 2002-02-26 | Eastman Chemical Company | Copolymerization of norbornene and functional norbornene monomers |
| EP1404723A2 (en) | 2000-11-06 | 2004-04-07 | Eastman Chemical Company | Olefin polymerization processes using supported catalysts |
| WO2002036641A2 (en) | 2000-11-06 | 2002-05-10 | Eastman Chemical Company | Improved productivity catalysts and microstructure control |
| US6387992B1 (en) | 2000-11-27 | 2002-05-14 | Ciba Specialty Chemicals Corporation | Substituted 5-heteroaryl-2-(2-hydroxyphenyl)-2h-benzotriazole UV absorbers, a process for preparation thereof and compositions stabilized therewith |
| MXPA03004655A (es) | 2000-11-27 | 2003-09-04 | Ciba Sc Holding Ag | Derivados 5-aril y 5-heteroaril-2-(2-hidroxifenil)-2h-benzotriazol substituidos como absorbentes de uv. |
| DE10111262A1 (de) | 2001-03-09 | 2002-09-12 | Studiengesellschaft Kohle Mbh | Verfahren zur Herstellung von Vinyl- Aryl- und Heteroarylessigsäuren und ihrer Devivate |
| JP2005194190A (ja) | 2001-10-05 | 2005-07-21 | Fumie Satou | １９−ノル−ビタミンｄ誘導体の製造法 |
| DE10152989A1 (de) | 2001-10-26 | 2003-05-08 | Bayer Ag | Komplexe N-heterocyslischer Carbene und ihre Verwendung |
| AU2003223930A1 (en) | 2002-06-14 | 2003-12-31 | Novo Nordisk A/S | Pharmaceutical use of boronic acids and esters thereof |
| PA8631101A1 (es) | 2004-04-27 | 2006-09-08 | Wyeth Corp | Proceso de acoplamiento para la generacion de derivados reactivos de pirrol-2-carbonitrilo n-sustituidos con contenido de boro para producir biarilos |
-
2005
- 2005-04-25 PA PA20058631101A patent/PA8631101A1/es unknown
- 2005-04-25 WO PCT/US2005/013992 patent/WO2005105817A2/en active Application Filing
- 2005-04-25 TW TW094113123A patent/TW200604137A/zh unknown
- 2005-04-25 PE PE2005000458A patent/PE20060331A1/es not_active Application Discontinuation
- 2005-04-25 US US11/113,794 patent/US7446211B2/en not_active Expired - Fee Related
- 2005-04-25 AR ARP050101622A patent/AR049631A1/es unknown
- 2005-04-25 SV SV2005002092A patent/SV2005002092A/es not_active Application Discontinuation
-
2008
- 2008-09-26 US US12/238,530 patent/US8129523B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20050272702A1 (en) | 2005-12-08 |
| WO2005105817A2 (en) | 2005-11-10 |
| SV2005002092A (es) | 2005-12-13 |
| US8129523B2 (en) | 2012-03-06 |
| US20090054663A1 (en) | 2009-02-26 |
| TW200604137A (en) | 2006-02-01 |
| PE20060331A1 (es) | 2006-05-16 |
| WO2005105817A3 (en) | 2006-01-12 |
| PA8631101A1 (es) | 2006-09-08 |
| US7446211B2 (en) | 2008-11-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |