TWI231757B
(en)
|
2001-09-21 |
2005-05-01 |
Solvay Pharm Bv |
1H-Imidazole derivatives having CB1 agonistic, CB1 partial agonistic or CB1-antagonistic activity
|
EP1496838B1
(en)
|
2002-03-12 |
2010-11-03 |
Merck Sharp & Dohme Corp. |
Substituted amides
|
US7105526B2
(en)
|
2002-06-28 |
2006-09-12 |
Banyu Pharmaceuticals Co., Ltd. |
Benzimidazole derivatives
|
US7129239B2
(en)
|
2002-10-28 |
2006-10-31 |
Pfizer Inc. |
Purine compounds and uses thereof
|
US7247628B2
(en)
|
2002-12-12 |
2007-07-24 |
Pfizer, Inc. |
Cannabinoid receptor ligands and uses thereof
|
US7772188B2
(en)
|
2003-01-28 |
2010-08-10 |
Ironwood Pharmaceuticals, Inc. |
Methods and compositions for the treatment of gastrointestinal disorders
|
US7329658B2
(en)
|
2003-02-06 |
2008-02-12 |
Pfizer Inc |
Cannabinoid receptor ligands and uses thereof
|
US7176210B2
(en)
|
2003-02-10 |
2007-02-13 |
Pfizer Inc. |
Cannabinoid receptor ligands and uses thereof
|
US7268133B2
(en)
|
2003-04-23 |
2007-09-11 |
Pfizer, Inc. Patent Department |
Cannabinoid receptor ligands and uses thereof
|
US7141669B2
(en)
|
2003-04-23 |
2006-11-28 |
Pfizer Inc. |
Cannabiniod receptor ligands and uses thereof
|
US7145012B2
(en)
|
2003-04-23 |
2006-12-05 |
Pfizer Inc. |
Cannabinoid receptor ligands and uses thereof
|
US7232823B2
(en)
|
2003-06-09 |
2007-06-19 |
Pfizer, Inc. |
Cannabinoid receptor ligands and uses thereof
|
TW200511990A
(en)
*
|
2003-09-02 |
2005-04-01 |
Solvay Pharm Gmbh |
Novel medical uses of 4, 5-dihydro-1h-pyrazole derivatives having cb1-antagonistic activity
|
CA2551037A1
(en)
|
2003-09-22 |
2005-03-31 |
Banyu Pharmaceutical Co., Ltd. |
Novel piperidine derivative
|
RU2006117627A
(ru)
*
|
2003-10-24 |
2007-12-10 |
Зольвай Фармасьютиклз Гмбх (De) |
Новые применения в медицине соединений, обладающих антагонистической активностью по отношению к св1, и комбинированное лечение с применением этих соединений
|
TW200528102A
(en)
*
|
2003-10-24 |
2005-09-01 |
Solvay Pharm Gmbh |
Novel medical combination treatment of obesity involving 4,5-dihydro-1h-pyrazole derivatives having cb1-antagonistic activity
|
WO2005049615A1
(en)
*
|
2003-11-21 |
2005-06-02 |
Pfizer Products Inc. |
Pyrazolo`1,5-a!`1,3,5! triazin -4-one derivatives as cb1 receptor antagonists
|
CA2553970A1
(en)
|
2004-01-28 |
2005-08-18 |
F. Hoffmann-La Roche Ag |
Spiro-benzodioxoles and their use as cb1 antagonists
|
ES2311972T3
(es)
*
|
2004-01-30 |
2009-02-16 |
Solvay Pharmaceuticals B.V. |
Derivados 1,3,5-trisubstituidos de 4,5-dihidro-1h-pirazol que tienen actividad antagonista de cb1.
|
US7649002B2
(en)
|
2004-02-04 |
2010-01-19 |
Pfizer Inc |
(3,5-dimethylpiperidin-1yl)(4-phenylpyrrolidin-3-yl)methanone derivatives as MCR4 agonists
|
WO2005097759A1
(en)
|
2004-03-29 |
2005-10-20 |
Merck & Co., Inc. |
Diaryltriazoles as inhibitors of 11-beta-hydroxysteroid dehydrogenase-1
|
EP1734963A4
(en)
|
2004-04-02 |
2008-06-18 |
Merck & Co Inc |
METHOD FOR TREATING PEOPLE WITH METABOLIC AND ANTHROPOMETRIC DISORDER
|
US20060025448A1
(en)
|
2004-07-22 |
2006-02-02 |
Cadila Healthcare Limited |
Hair growth stimulators
|
US7915252B2
(en)
|
2004-08-06 |
2011-03-29 |
Merck Sharp & Dohme |
Sulfonyl compounds as inhibitors of 11-beta-hydroxysteroid dehydrogenase-1
|
CA2577060A1
(en)
|
2004-08-13 |
2006-02-23 |
Amgen Inc. |
Substituted benzofused heterocycles
|
EP1807063A2
(en)
*
|
2004-10-25 |
2007-07-18 |
Solvay Pharmaceuticals GmbH |
Pharmaceutical compositions comprising cb1 cannabinoid receptor antagonists and potassium channel openers for the treatment of diabetes mellitus type i, obesity and related conditions
|
US8394765B2
(en)
|
2004-11-01 |
2013-03-12 |
Amylin Pharmaceuticals Llc |
Methods of treating obesity with two different anti-obesity agents
|
BRPI0518241A
(pt)
|
2004-11-01 |
2008-04-22 |
Amylin Pharmaceuticals Inc |
métodos para tratar obesidade e doenças e distúrbios relacionados à obesidade
|
RU2391337C2
(ru)
|
2004-11-09 |
2010-06-10 |
Ф.Хоффманн-Ля Рош Аг |
Производные дибензосуберона
|
WO2006060201A2
(en)
*
|
2004-11-30 |
2006-06-08 |
Bayer Pharmaceuticals Corporation |
Pyrazole derivatives for the treatment of psychiatric disorders
|
WO2006060186A2
(en)
*
|
2004-11-30 |
2006-06-08 |
Bayer Pharmaceuticals Corporation |
Pyrazole derivatives for the treatment of dementia and related disorders
|
PA8660701A1
(es)
|
2005-02-04 |
2006-09-22 |
Pfizer Prod Inc |
Agonistas de pyy y sus usos
|
US20090286723A1
(en)
|
2005-02-11 |
2009-11-19 |
Amylin Pharmaceuticals, Inc. |
Hybrid Polypeptides with Selectable Properties
|
US7737155B2
(en)
|
2005-05-17 |
2010-06-15 |
Schering Corporation |
Nitrogen-containing heterocyclic compounds and methods of use thereof
|
WO2006129826A1
(ja)
|
2005-05-30 |
2006-12-07 |
Banyu Pharmaceutical Co., Ltd. |
新規ピペリジン誘導体
|
US7923465B2
(en)
|
2005-06-02 |
2011-04-12 |
Glenmark Pharmaceuticals S.A. |
Cannabinoid receptor ligands, pharmaceutical compositions containing them, and process for their preparation
|
AU2006253842A1
(en)
|
2005-06-02 |
2006-12-07 |
Glenmark Pharmaceuticals S.A. |
Novel cannabinoid receptor ligands, pharmaceutical compositions containing them, and process for their preparation
|
EP1757587A1
(en)
*
|
2005-07-15 |
2007-02-28 |
Laboratorios Del Dr. Esteve, S.A. |
Substituted pyrazoline compounds, their preparation and use as medicaments
|
EP1916239A4
(en)
|
2005-08-10 |
2009-10-21 |
Banyu Pharma Co Ltd |
PYRIDONE COMPOUND
|
EP2330125A3
(en)
|
2005-08-11 |
2012-12-12 |
Amylin Pharmaceuticals, Inc. |
Hybrid polypeptides with selectable properties
|
WO2007024004A1
(ja)
|
2005-08-24 |
2007-03-01 |
Banyu Pharmaceutical Co., Ltd. |
フェニルピリドン誘導体
|
BRPI0616463A2
(pt)
|
2005-09-29 |
2011-06-21 |
Merck & Co Inc |
composto, composição farmacêutica, e, uso de um composto
|
US7741317B2
(en)
|
2005-10-21 |
2010-06-22 |
Bristol-Myers Squibb Company |
LXR modulators
|
WO2007049798A1
(ja)
|
2005-10-27 |
2007-05-03 |
Banyu Pharmaceutical Co., Ltd. |
新規ベンゾオキサチイン誘導体
|
EP1953165B1
(en)
|
2005-11-10 |
2012-02-01 |
Msd K.K. |
Aza-substituted spiro derivative
|
US7888376B2
(en)
|
2005-11-23 |
2011-02-15 |
Bristol-Myers Squibb Company |
Heterocyclic CETP inhibitors
|
EP1801098A1
(en)
|
2005-12-16 |
2007-06-27 |
Merck Sante |
2-Adamantylurea derivatives as selective 11B-HSD1 inhibitors
|
SG185849A1
(en)
|
2006-02-23 |
2012-12-28 |
Pfizer Ltd |
Melanocortin type 4 receptor agonist piperidinoylpyrrolidines
|
US7763607B2
(en)
|
2006-04-27 |
2010-07-27 |
Solvay Pharmaceuticals Gmbh |
Pharmaceutical compositions comprising CBx cannabinoid receptor modulators and potassium channel modulators
|
CN101431998A
(zh)
*
|
2006-04-27 |
2009-05-13 |
索尔瓦药物有限公司 |
含有CBx大麻素受体调节剂和钾通道调节剂的药物组合物
|
AU2007283113A1
(en)
|
2006-08-08 |
2008-02-14 |
Sanofi-Aventis |
Arylaminoaryl-alkyl-substituted imidazolidine-2,4-diones, processes for preparing them, medicaments comprising these compounds, and their use
|
EP2946778A1
(en)
|
2006-09-22 |
2015-11-25 |
Merck Sharp & Dohme Corp. |
Method of treatment using fatty acid synthesis inhibitors
|
US20090247560A1
(en)
|
2006-09-28 |
2009-10-01 |
Banyu Pharmaceutical Co., Ltd. |
Diaryl ketimine derivative
|
CA2669311C
(en)
|
2006-11-13 |
2011-09-20 |
Pfizer Products Inc. |
Diaryl, dipyridinyl and aryl-pyridinyl derivatives and uses thereof
|
ES2382009T3
(es)
|
2006-12-01 |
2012-06-04 |
Bristol-Myers Squibb Company |
Derivados de N-((3-bencil)-2,2-(bis-fenil-)-propan-1-amina como inhibidores de CETP para el tratamiento de aterosclerosis y enfermedades cardiovasculares
|
EP1935420A1
(en)
|
2006-12-21 |
2008-06-25 |
Merck Sante |
2-Adamantyl-butyramide derivatives as selective 11beta-HSD1 inhibitors
|
CA2682727C
(en)
|
2007-04-02 |
2016-03-22 |
Banyu Pharmaceutical Co., Ltd. |
Indoledione derivative
|
US8969514B2
(en)
|
2007-06-04 |
2015-03-03 |
Synergy Pharmaceuticals, Inc. |
Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
|
JP5546451B2
(ja)
|
2007-06-04 |
2014-07-09 |
シナジー ファーマシューティカルズ インコーポレイテッド |
胃腸の障害、炎症、癌および他の障害の処置に有用なグアニル酸シクラーゼのアゴニスト
|
CN101318931B
(zh)
*
|
2007-06-04 |
2010-05-19 |
上海阳帆医药科技有限公司 |
二芳基取代吡唑衍生物、其制备方法和用途
|
EP2025674A1
(de)
|
2007-08-15 |
2009-02-18 |
sanofi-aventis |
Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
|
GB2456183A
(en)
*
|
2008-01-04 |
2009-07-08 |
Gw Pharma Ltd |
Anti-psychotic composition comprising cannabinoids and anti-psychotic medicament
|
EP2264026A4
(en)
|
2008-03-06 |
2012-03-28 |
Msd Kk |
ALKYLAMINOPYRIDINE DERIVATIVE
|
US20110015198A1
(en)
|
2008-03-28 |
2011-01-20 |
Banyu Pharmaceutical Co., Inc. |
Diarylmethylamide derivative having melanin-concentrating hormone receptor antagonism
|
EP2110374A1
(en)
|
2008-04-18 |
2009-10-21 |
Merck Sante |
Benzofurane, benzothiophene, benzothiazol derivatives as FXR modulators
|
EP2810951B1
(en)
|
2008-06-04 |
2017-03-15 |
Synergy Pharmaceuticals Inc. |
Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
|
AU2009261248A1
(en)
|
2008-06-19 |
2009-12-23 |
Banyu Pharmaceutical Co., Ltd. |
Spirodiamine-diarylketoxime derivative
|
WO2010003624A2
(en)
|
2008-07-09 |
2010-01-14 |
Sanofi-Aventis |
Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof
|
EP3241839B1
(en)
|
2008-07-16 |
2019-09-04 |
Bausch Health Ireland Limited |
Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
|
US20110124674A1
(en)
|
2008-07-30 |
2011-05-26 |
Hiroyuki Kishino |
5/5-or 5/6-membered condensed ring cycloalkylamine derivative
|
AU2009278838B2
(en)
|
2008-08-06 |
2013-07-25 |
Pfizer Limited |
Diazepine and diazocane compounds as MC4 agonists
|
US8410284B2
(en)
|
2008-10-22 |
2013-04-02 |
Merck Sharp & Dohme Corp |
Cyclic benzimidazole derivatives useful as anti-diabetic agents
|
CA2741644C
(en)
|
2008-10-30 |
2013-05-07 |
Merck Sharp & Dohme Corp. |
Isonicotinamide orexin receptor antagonists
|
CN102271509A
(zh)
|
2008-10-31 |
2011-12-07 |
默沙东公司 |
用于抗糖尿病药的新型环苯并咪唑衍生物
|
CA2743489A1
(en)
|
2008-11-17 |
2010-05-20 |
Merck Sharp & Dohme Corp. |
Substituted bicyclic amines for the treatment of diabetes
|
WO2010068601A1
(en)
|
2008-12-08 |
2010-06-17 |
Sanofi-Aventis |
A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof
|
WO2010075068A1
(en)
|
2008-12-16 |
2010-07-01 |
Schering Corporation |
Pyridopyrimidine derivatives and methods of use thereof
|
US20110243940A1
(en)
|
2008-12-16 |
2011-10-06 |
Schering Corporation |
Bicyclic pyranone derivatives and methods of use thereof
|
WO2010079241A1
(es)
|
2009-01-12 |
2010-07-15 |
Fundacion Hospital Nacional De Paraplejicos Para La Investigacion Y La Integracion |
Uso de antagonistas y/o agonistas inversos de los receptores cb1 para la preparación de medicamentos que incrementen la excitabilidad de las motoneuronas
|
WO2011011506A1
(en)
|
2009-07-23 |
2011-01-27 |
Schering Corporation |
Spirocyclic oxazepine compounds as stearoyl-coenzyme a delta-9 desaturase inhibitors
|
CA2768577A1
(en)
|
2009-07-23 |
2011-01-27 |
Schering Corporation |
Benzo-fused oxazepine compounds as stearoyl-coenzyme a delta-9 desaturase inhibitors
|
KR20120060207A
(ko)
|
2009-08-26 |
2012-06-11 |
사노피 |
신규한 결정성 헤테로방향족 플루오로글리코시드 수화물, 이들 화합물을 포함하는 약제 및 이들의 용도
|
JP2013510834A
(ja)
|
2009-11-16 |
2013-03-28 |
メリテク |
[1,5]‐ジアゾシン誘導体
|
JP5540454B2
(ja)
|
2009-12-30 |
2014-07-02 |
シャンハイ フォチョン ファーマシューティカル カンパニー リミテッド |
ジペプチジルペプチダーゼ阻害剤
|
AR079935A1
(es)
*
|
2010-01-29 |
2012-02-29 |
Abbott Healthcare Products Bv |
Sintesis de derivados de pirazolin carboxamidina sustituida
|
CA2786314A1
(en)
|
2010-02-25 |
2011-09-01 |
Merck Sharp & Dohme Corp. |
Novel cyclic benzimidazole derivatives useful anti-diabetic agents
|
WO2011137024A1
(en)
|
2010-04-26 |
2011-11-03 |
Merck Sharp & Dohme Corp. |
Novel spiropiperidine prolylcarboxypeptidase inhibitors
|
EP2568812B1
(en)
|
2010-05-11 |
2016-10-26 |
Merck Sharp & Dohme Corp. |
Novel prolylcarboxypeptidase inhibitors
|
US9006268B2
(en)
|
2010-06-11 |
2015-04-14 |
Merck Sharp & Dohme Corp. |
Prolylcarboxypeptidase inhibitors
|
EP2582709B1
(de)
|
2010-06-18 |
2018-01-24 |
Sanofi |
Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
|
US9616097B2
(en)
|
2010-09-15 |
2017-04-11 |
Synergy Pharmaceuticals, Inc. |
Formulations of guanylate cyclase C agonists and methods of use
|
CN103476258B
(zh)
|
2011-02-25 |
2017-04-26 |
默沙东公司 |
用作抗糖尿病药剂的新的环状氮杂苯并咪唑衍生物
|
WO2012120051A1
(de)
|
2011-03-08 |
2012-09-13 |
Sanofi |
Mit adamantan- oder noradamantan substituierte benzyl-oxathiazinderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
|
EP2766349B1
(de)
|
2011-03-08 |
2016-06-01 |
Sanofi |
Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
|
US8828995B2
(en)
|
2011-03-08 |
2014-09-09 |
Sanofi |
Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
|
EP2683702B1
(de)
|
2011-03-08 |
2014-12-24 |
Sanofi |
Neue substituierte phenyl-oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
|
WO2012120057A1
(de)
|
2011-03-08 |
2012-09-13 |
Sanofi |
Neue substituierte phenyl-oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
|
US8828994B2
(en)
|
2011-03-08 |
2014-09-09 |
Sanofi |
Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
|
WO2012120058A1
(de)
|
2011-03-08 |
2012-09-13 |
Sanofi |
Mit benzyl- oder heteromethylengruppen substituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
|
WO2012120056A1
(de)
|
2011-03-08 |
2012-09-13 |
Sanofi |
Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
|
EP2683699B1
(de)
|
2011-03-08 |
2015-06-24 |
Sanofi |
Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
|
AR088352A1
(es)
|
2011-10-19 |
2014-05-28 |
Merck Sharp & Dohme |
Antagonistas del receptor de 2-piridiloxi-4-nitrilo orexina
|
US8680131B2
(en)
|
2012-07-25 |
2014-03-25 |
Jenrin Discovery, Inc. |
Cannabinoid receptor antagonists/inverse agonists useful for treating disease conditions, including metabolic disorders and cancers
|
CA2880901A1
(en)
|
2012-08-02 |
2014-02-06 |
Merck Sharp & Dohme Corp. |
Antidiabetic tricyclic compounds
|
IN2015DN03733A
(es)
|
2012-11-13 |
2015-09-18 |
Us Health |
|
US11155521B2
(en)
|
2012-11-13 |
2021-10-26 |
The United States Of America As Represented By The Secretary, Department Of Health And Human Services |
Cannabinoid receptor mediating compounds
|
RU2015140066A
(ru)
|
2013-02-22 |
2017-03-30 |
Мерк Шарп И Доум Корп. |
Противодиабетические бициклические соединения
|
EP2970119B1
(en)
|
2013-03-14 |
2021-11-03 |
Merck Sharp & Dohme Corp. |
Novel indole derivatives useful as anti-diabetic agents
|
EP2968439A2
(en)
|
2013-03-15 |
2016-01-20 |
Synergy Pharmaceuticals Inc. |
Compositions useful for the treatment of gastrointestinal disorders
|
JP2016514671A
(ja)
|
2013-03-15 |
2016-05-23 |
シナジー ファーマシューティカルズ インコーポレイテッド |
グアニル酸シクラーゼのアゴニストおよびその使用
|
EP4424697A2
(en)
|
2013-06-05 |
2024-09-04 |
Bausch Health Ireland Limited |
Ultra-pure agonists of guanylate cyclase c, method of making and using same
|
WO2015051496A1
(en)
|
2013-10-08 |
2015-04-16 |
Merck Sharp & Dohme Corp. |
Antidiabetic tricyclic compounds
|
AU2015255765A1
(en)
|
2014-05-09 |
2016-11-24 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Pyrazole derivatives and their use as cannabinoid receptor mediators
|
WO2016030534A1
(en)
|
2014-08-29 |
2016-03-03 |
Tes Pharma S.R.L. |
INHIBITORS OF α-AMINO-β-CARBOXYMUCONIC ACID SEMIALDEHYDE DECARBOXYLASE
|
EP3423448A1
(en)
*
|
2016-03-04 |
2019-01-09 |
The U.S.A. as represented by the Secretary, Department of Health and Human Services |
Cannabinoid receptor mediating compounds
|
AU2017342083A1
(en)
|
2016-10-14 |
2019-04-11 |
Tes Pharma S.R.L. |
Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase
|
US11072602B2
(en)
|
2016-12-06 |
2021-07-27 |
Merck Sharp & Dohme Corp. |
Antidiabetic heterocyclic compounds
|
CN113302189A
(zh)
|
2018-11-20 |
2021-08-24 |
Tes制药有限责任公司 |
α-氨基-β-羧基己二烯二酸半醛去羧酶的抑制剂
|
US11098029B2
(en)
|
2019-02-13 |
2021-08-24 |
Merck Sharp & Dohme Corp. |
5-alkyl pyrrolidine orexin receptor agonists
|
WO2021026047A1
(en)
|
2019-08-08 |
2021-02-11 |
Merck Sharp & Dohme Corp. |
Heteroaryl pyrrolidine and piperidine orexin receptor agonists
|
JP7443625B2
(ja)
|
2020-08-18 |
2024-03-05 |
メルク・シャープ・アンド・ドーム・エルエルシー |
ビシクロヘプタンピロリジンオレキシン受容体アゴニスト
|
WO2022245627A1
(en)
*
|
2021-05-17 |
2022-11-24 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
A facile and odor-free approach to convert sulfonyl urea derivatives to chalcogenide sulfonyl urea derivatives
|
IL315945A
(en)
*
|
2022-04-07 |
2024-11-01 |
Corbus Pharmaceuticals Inc |
Cannabinoid receptor 1 antagonists/inverse agonists and uses thereof
|