AR030108A1 - Procedimientos para elaborar acido lipoico y acido dihidrolipoico - Google Patents
Procedimientos para elaborar acido lipoico y acido dihidrolipoicoInfo
- Publication number
- AR030108A1 AR030108A1 ARP010103687A ARP010103687A AR030108A1 AR 030108 A1 AR030108 A1 AR 030108A1 AR P010103687 A ARP010103687 A AR P010103687A AR P010103687 A ARP010103687 A AR P010103687A AR 030108 A1 AR030108 A1 AR 030108A1
- Authority
- AR
- Argentina
- Prior art keywords
- acid
- dihydrolipoic acid
- procedures
- dihidrolipoic
- dihydrolipoic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
- C07D339/02—Five-membered rings
- C07D339/04—Five-membered rings having the hetero atoms in positions 1 and 2, e.g. lipoic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
- C07C319/18—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by addition of thiols to unsaturated compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C321/00—Thiols, sulfides, hydropolysulfides or polysulfides
- C07C321/02—Thiols having mercapto groups bound to acyclic carbon atoms
- C07C321/04—Thiols having mercapto groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Procedimientos para elaborar ácido R-lipoico o ácido S-lipoico que contienen un paso de procedimiento seleccionado entre (a) destilacion del ácido dihidrolipoico, (b) transformacion de compuestos de formula (1) o su estereoisomero, donde Ms representa SO2-R' y R y R', independientemente entre sí, significan C1-6-alquilo, C3-8-cicloalquilo, C3-8-cicloalquilalquilo, arilo o aralquilo, con sulfuro de sodio y azufre en etanol y transformacion con un hidruro complejo, (c) la extraccion de una solucion protica de ácido R-dihidrolipoico o ácido S-dihidrolipoico con un solvente orgánico, a un valor de pH de 9 a 10, o (d) la extraccion de ácido R-dihidrolipoico o ácido S-dihidrolipoico con un solvente orgánico, de una solucion protica a un valor de pH de 4 a 5, o una combinacion de pasos individuales o varios pasos de (a) a (d), como también procedimientos para elaborar ácido dihidrolipoico y el compuesto 1, 6, 8-octanotriol.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2000138038 DE10038038A1 (de) | 2000-08-02 | 2000-08-02 | Verfahren zur Herstellung von Liponsäure und Dihydroliponsäure |
| DE2000144000 DE10044000A1 (de) | 2000-09-05 | 2000-09-05 | Verfahren zur Herstellung von Liponsäure und Dihydroliponsäure |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR030108A1 true AR030108A1 (es) | 2003-08-13 |
Family
ID=26006609
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP010103687A AR030108A1 (es) | 2000-08-02 | 2001-08-02 | Procedimientos para elaborar acido lipoico y acido dihidrolipoico |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6906210B2 (es) |
| EP (1) | EP1307442A2 (es) |
| JP (1) | JP2004509856A (es) |
| CN (2) | CN1218945C (es) |
| AR (1) | AR030108A1 (es) |
| AU (1) | AU2001291677A1 (es) |
| BR (1) | BR0112848A (es) |
| CA (1) | CA2417842A1 (es) |
| TW (1) | TW200519076A (es) |
| WO (1) | WO2002010151A2 (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8697109B2 (en) * | 2000-08-16 | 2014-04-15 | Encore Health, Llc | Caged mercaptan and seleno-mercaptan compounds and methods of using them |
| US20050112113A1 (en) * | 2000-08-16 | 2005-05-26 | Till Jonathan S. | Presbyopia treatment by lens alteration |
| US8647612B2 (en) * | 2008-03-05 | 2014-02-11 | Encore Health, Llc | Dithiol compounds, derivatives, and treatment of presbyopia |
| US8147816B2 (en) * | 2000-08-16 | 2012-04-03 | Encore Health, Llc | Presbyopia treatment by lens alteration |
| US7914815B2 (en) * | 2000-08-16 | 2011-03-29 | Encore Health, Llc | Method for delivery of pharmaceuticals for treating or preventing presbyopia |
| US7935332B2 (en) | 2000-08-16 | 2011-05-03 | Encore Health, Llc | Presbyopia treatment by lens alteration |
| CA2430073A1 (en) * | 2000-11-30 | 2002-06-06 | Basf Aktiengesellschaft | Method for producing lipoic acid and dihydrolipoic acid |
| CN100387593C (zh) * | 2006-01-26 | 2008-05-14 | 南京师范大学 | 连续逆流液液萃取分离二硫辛酸与乙醇及碱水溶液的方法 |
| WO2007093433A1 (de) | 2006-02-17 | 2007-08-23 | Carl Zeiss Smt Ag | Beleuchtungssystem für die mikro-lithographie, projektionsbelichtungsanlage mit einem derartigen beleuchtungssystem |
| US20090078581A1 (en) * | 2007-09-24 | 2009-03-26 | Applied Intellectual Capital | Configurations and Methods of Reduction of Lipoic Acid |
| WO2009111635A2 (en) * | 2008-03-05 | 2009-09-11 | Encore Health, Llc | Dithiol compounds, derivatives, and uses therefor |
| US9044439B2 (en) | 2008-03-05 | 2015-06-02 | Encore Health, Llc | Low dose lipoic and pharmaceutical compositions and methods |
| KR20110103987A (ko) * | 2008-12-01 | 2011-09-21 | 인베이스크 테라퓨틱, 인크. | 레닌-안지오텐신 알도스테론계 억제제 및 리포산 화합물을 포함하는 조성물, 및 레닌-안지오텐신 알도스테론계 관련 질환의 치료를 위한 이의 용도 |
| WO2010147957A2 (en) | 2009-06-15 | 2010-12-23 | Encore Health, Llc | Dithiol compounds, derivatives, and uses therefor |
| DK2442645T3 (en) | 2009-06-15 | 2014-11-24 | Encore Health Llc | choline |
| WO2015134510A1 (en) | 2014-03-03 | 2015-09-11 | Encore Vision Inc. | Lipoic acid choline ester compositions and methods of use |
| US9944960B2 (en) | 2015-11-17 | 2018-04-17 | Premier Research Labs, Lp | Process for microbial production of dihydrolipoic acid and extraction of dihydrolipoic acid with edible oils |
| DE102017000811A1 (de) | 2017-01-28 | 2018-08-02 | Alzchem Trostberg Gmbh | Verfahren zur Herstellung von Dihydroliponsäure |
| CN111377840A (zh) * | 2018-12-29 | 2020-07-07 | 江苏同禾药业有限公司 | 一种r-(+)-二氢硫辛酸的制备方法 |
| CN116102532A (zh) * | 2023-01-09 | 2023-05-12 | 国药集团威奇达药业有限公司 | 从硫辛酸结晶母液中回收硫辛酸的方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2788355A (en) * | 1953-10-19 | 1957-04-09 | American Cyanamid Co | 6, 8-dithioloctanoic acid, salts and esters thereof |
| US3132152A (en) * | 1958-10-04 | 1964-05-05 | Fujisawa Pharmaceutical Co | Production of dithiofatty acid derivatives and intermediates thereof |
| US3223712A (en) * | 1960-07-18 | 1965-12-14 | Yamanouchi Pharma Co Ltd | Synthesis of thioctic acid and thioctic acid amide |
| DE4037440A1 (de) * | 1990-11-24 | 1992-05-27 | Basf Ag | Verfahren zur herstellung von (6s)-6,8-dihydroxyoctansaeureestern |
| DE4137773A1 (de) | 1991-11-16 | 1993-05-19 | Degussa | Herstellung und verwendung von salzen der reinen enantiomere der (alpha)-liponsaeure |
| DE4229914A1 (de) * | 1992-09-08 | 1994-03-10 | Basf Ag | Verbessertes Verfahren zur Herstellung von R/S-Ï-Liponsäure oder R/S-â-Liponsäure |
| DE19533881A1 (de) | 1995-09-13 | 1997-03-20 | Dresden Arzneimittel | Herstellung und Verwendung der reinen Enantiomere der 8-Chlor-6-sulfonyloxy-octansäuren und ihrer Alkylester und der reinen Enantiomere der 6,8-Dichlor-octansäure und ihrer Alkylester |
| DE19834608A1 (de) | 1998-07-31 | 2000-02-03 | Basf Ag | Kristallmodifikation der Liponsäure |
-
2001
- 2001-07-24 JP JP2002515882A patent/JP2004509856A/ja not_active Withdrawn
- 2001-07-24 EP EP01971775A patent/EP1307442A2/de not_active Withdrawn
- 2001-07-24 CA CA002417842A patent/CA2417842A1/en not_active Abandoned
- 2001-07-24 BR BR0112848-5A patent/BR0112848A/pt not_active IP Right Cessation
- 2001-07-24 AU AU2001291677A patent/AU2001291677A1/en not_active Abandoned
- 2001-07-24 WO PCT/EP2001/008523 patent/WO2002010151A2/de not_active Application Discontinuation
- 2001-07-24 US US10/343,034 patent/US6906210B2/en not_active Expired - Fee Related
- 2001-07-24 CN CNB018135781A patent/CN1218945C/zh not_active Expired - Fee Related
- 2001-07-24 CN CNA2005100088649A patent/CN1680364A/zh active Pending
- 2001-08-02 TW TW094102573A patent/TW200519076A/zh unknown
- 2001-08-02 AR ARP010103687A patent/AR030108A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2417842A1 (en) | 2003-01-30 |
| CN1218945C (zh) | 2005-09-14 |
| US20040044227A1 (en) | 2004-03-04 |
| EP1307442A2 (de) | 2003-05-07 |
| WO2002010151A2 (de) | 2002-02-07 |
| AU2001291677A1 (en) | 2002-02-13 |
| JP2004509856A (ja) | 2004-04-02 |
| WO2002010151A3 (de) | 2002-11-14 |
| US6906210B2 (en) | 2005-06-14 |
| CN1680364A (zh) | 2005-10-12 |
| BR0112848A (pt) | 2003-06-24 |
| TW200519076A (en) | 2005-06-16 |
| CN1444580A (zh) | 2003-09-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |