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AR037465A1 - Compuesto derivado de 5-sulfanil-4h-1,2,4-triazol, composicion farmaceutica que lo comprende y proceso para su preparacion en fase liquida - Google Patents

Compuesto derivado de 5-sulfanil-4h-1,2,4-triazol, composicion farmaceutica que lo comprende y proceso para su preparacion en fase liquida

Info

Publication number
AR037465A1
AR037465A1 ARP020104601A ARP020104601A AR037465A1 AR 037465 A1 AR037465 A1 AR 037465A1 AR P020104601 A ARP020104601 A AR P020104601A AR P020104601 A ARP020104601 A AR P020104601A AR 037465 A1 AR037465 A1 AR 037465A1
Authority
AR
Argentina
Prior art keywords
alkyl
aryl
amino
heteroaryl
optionally substituted
Prior art date
Application number
ARP020104601A
Other languages
English (en)
Inventor
Marie Odile Galcera
Alban Sidhu
Pierre Roubert
Christophe Thurieau
Original Assignee
Sod Conseils Rech Applic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR0115342A external-priority patent/FR2832710B1/fr
Application filed by Sod Conseils Rech Applic filed Critical Sod Conseils Rech Applic
Publication of AR037465A1 publication Critical patent/AR037465A1/es

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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

Compuesto derivado de 5-sulfanil-4H-1,2,4-triazol que responde a la fórmula general (1) en forma racémica, enantiomérica o cualquier combinación de dichas formas, en donde: uno de los radicales R1, R2 ó R3 representa un radical de fórmula -(CH2)n-[Q]p-(CH2)m-NXY ó -(CH2)n-W en donde W representa un heterocicloalquilo que contiene al menos un átomo de nitrógeno; Q representa -O-, -S-, -C(O)-NH-, -C(Zq)(Zq')-, arilo ó cicloalquilo C3-7; Zq y Zq' representan, independientemente, el átomo de hidrógeno, arilo opcionalmente sustituido por arilo, cicloalquil C3-7-alquilo, arilalquilo, -C(O)O-R ó -C(O)-NH-R'; R representa un alquilo C1-6, arilo ó aralquilo radical, arilo y aralquilo que es opcionalmente sustituido por uno o más sustituyentes idénticos o diferentes seleccionados entre: alcoxi C1-6, hidroxi, halo, nitro ciano, amino, alquilamino C1-6 y di(alquil C1-6)amino; R' representa un alquilo C1-6, arilo, aralquilo, heteroarilo o heteroaril-alquilo radical, estando los radicales arilo, aralquilo, heteroarilo y heteroaril-alquilo opcionalmente sustituido por uno o más sustituyentes idénticos o diferentes seleccionados entre: alcoxi C1-6, hidroxi, halo, nitro ciano, amino, alquilamino C1-6, di(alquil C1-6) amino; X e Y representan, independientemente, el átomo de hidrógeno, alquilo C1-6, alcoxi C1-6-carbonilo ó un heteroaril-alquilo, ó X e Y forman junto con el átomo de nitrógeno al cual están unidos, un heterocicloalquilo opcionalmente sustituido por un alquilo C1-6; p representa 0 ó 1; n y m representan, independientemente, un entero entre 0 y 6; y los otros dos radicales representan, independientemente, un radical de fórmula -(CH2)n'[Q']p'[C(X')(Y')]m'Z' en donde: Q' representa -O-, -S-, -C(O)-, -NH-, -CH=CH-, -C:::C-; ó X', Y' y Z' representan, independientemente un átomo de hidrógeno, alquilo C1-6, alcoxi C1-6, alcoxi C1-6-carbonilo, ciano, amino, alquilamino C1-6, di(alquil C1-6) amino, cicloalquilo C3-7, heterocicloalquilo, arilo o heteroarilo, ó un radical de fórmulas (2), (3), (4), (5); r = 1, 2 ó 3, estando los radicales cicloalquilo C3-7, heterocicloalquilo, arilo y heteroarilo opcionalmente sustituidos por uno o más sustituyentes idénticos o diferentes seleccionados entre: -(CH2)q'-X''-Y'', hidroxi, halo, nitro, ciano, amino, alquilamino C1-6 y di(alquil C1-6) amino; X'' representa -O-, -S-, -C(O)-, -C(O)-O-, -SO2- ó una unión covalente; Y'' representa un radical alquilo C1-6 opcionalmente sustituido por uno o más radicales halo idénticos o diferentes; o radical arilo o heteroarilo opcionalmente sustituido por uno o más sustituyentes idénticos o diferentes seleccionados entre: alcoxi C1-6, hidroxi, halo, nitro ciano, amino, alquilamino C1-6 y di(alquil c1-6) amino; p' representa 0 ó 1; y n', m' y q' representan, independientemente, un entero entre 0 y 6; con exclusión de los compuestos en los cuales i) R1 representa -(CH2)2-W y W morfolino o piperazinilo; R2 fenilo, m-clorofenilo ó 4-piridilo, y R3 hidrógeno; ii) R1 representa -(CH2)2-W y W pirrolidinilo, R2 p-clorofenilo y R3 hidrógeno; o sus sales de adición con ácidos minerales u orgánicos aceptables para uso farmacéutico. Estos productos tienen una buena afinidad por determinados subtipos de receptores de somatostatina, son particularmente útiles para tratar estados patológicos o enfermedades en las cuales participan uno (o más) receptores de somatostatina. También se revelan composiciones farmacéuticas que contienen dichos productos y el proceso para su preparación en fase líquida.
ARP020104601A 2001-11-28 2002-11-28 Compuesto derivado de 5-sulfanil-4h-1,2,4-triazol, composicion farmaceutica que lo comprende y proceso para su preparacion en fase liquida AR037465A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0115342A FR2832710B1 (fr) 2001-11-28 2001-11-28 Derives de 5-sulfanyl-4h-1,2,4-triazoles et leur utilisation en tant que medicaments
FR0207697 2002-06-21

Publications (1)

Publication Number Publication Date
AR037465A1 true AR037465A1 (es) 2004-11-10

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ARP020104601A AR037465A1 (es) 2001-11-28 2002-11-28 Compuesto derivado de 5-sulfanil-4h-1,2,4-triazol, composicion farmaceutica que lo comprende y proceso para su preparacion en fase liquida

Country Status (23)

Country Link
US (1) US20050154039A1 (es)
EP (1) EP1465880B1 (es)
JP (1) JP2005513035A (es)
KR (1) KR100961332B1 (es)
CN (1) CN100462359C (es)
AR (1) AR037465A1 (es)
AT (1) ATE438630T1 (es)
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JP2014533299A (ja) 2011-11-14 2014-12-11 シンタ ファーマシューティカルズ コーポレーション Ｂｒａｆ阻害剤とｈｓｐ９０阻害剤の組合せ療法
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CN103755652B (zh) * 2013-12-20 2015-08-05 陕西理工学院 一种磺酰胺类化合物及其应用
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TWI283670B (en) 2007-07-11
HK1070361A1 (en) 2005-06-17
JP2005513035A (ja) 2005-05-12
CZ2004760A3 (cs) 2005-01-12
KR20040062969A (ko) 2004-07-09
ATE438630T1 (de) 2009-08-15
DE60233265D1 (de) 2009-09-17
HUP0402489A3 (en) 2009-09-28
CN100462359C (zh) 2009-02-18
CA2468184A1 (fr) 2003-06-05
AU2002361345A1 (en) 2003-06-10
RU2367655C2 (ru) 2009-09-20
HUP0402489A2 (hu) 2005-05-30
US20050154039A1 (en) 2005-07-14
WO2003045926A1 (fr) 2003-06-05
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ES2330927T3 (es) 2009-12-17
AU2002361345B2 (en) 2008-06-05
NO20042635L (no) 2004-06-23
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BR0214553A (pt) 2004-10-13
PL370140A1 (en) 2005-05-16
CN1617859A (zh) 2005-05-18
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