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AR037261A1 - Amidas de acido antranilico, un proceso para su preparacion, composiciones farmaceuticas, y el uso de dichas amidas para la preaparacion de un medicamento - Google Patents

Amidas de acido antranilico, un proceso para su preparacion, composiciones farmaceuticas, y el uso de dichas amidas para la preaparacion de un medicamento

Info

Publication number
AR037261A1
AR037261A1 ARP020104236A ARP020104236A AR037261A1 AR 037261 A1 AR037261 A1 AR 037261A1 AR P020104236 A ARP020104236 A AR P020104236A AR P020104236 A ARP020104236 A AR P020104236A AR 037261 A1 AR037261 A1 AR 037261A1
Authority
AR
Argentina
Prior art keywords
preparation
amidas
alkyl
pharmaceutical compositions
alkenyl
Prior art date
Application number
ARP020104236A
Other languages
English (en)
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of AR037261A1 publication Critical patent/AR037261A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/40—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to a carbon atom of a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Reproductive Health (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)

Abstract

Derivados de amida de ácido antranílico de la fórmula (1) en donde Ar está representado por la fórmula (2) en donde Ra representa H ó alquilo inferior; R1 representa H ó perfluoroalquilo inferior; y R2 representa H, halógeno, alquilo C2-7, alquenilo C2-7, o alquinilo inferior; ó Ar está representado por la subfórmula (3), y R1 representa perfluoroalquilo inferior, y R2 representa bromo, yodo, alquilo C2-7, alquenilo C2-7, ó alquinilo inferior, o R1 representa H, y R2 representa flúor, bromo, yodo, etilo, alquilo C5-7, alquenilo C2-7, ó alquinilo inferior; N-óxidos y tautómeros de los mismos, y sales de estas amidas de ácido antranílico, sus N-óxidos y tautómeros; procesos para su preparación; composiciones farmacéuticas y el uso de este compuesto, solo o en combinación con uno o más compuestos farmacéuticamente activos diferentes, para la preparación de una composición farmacéutica para el tratamiento de una enfermedad neoplásica, de retinopatía o degeneración macular relacionada con la edad.
ARP020104236A 2001-11-08 2002-11-06 Amidas de acido antranilico, un proceso para su preparacion, composiciones farmaceuticas, y el uso de dichas amidas para la preaparacion de un medicamento AR037261A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0126901.8A GB0126901D0 (en) 2001-11-08 2001-11-08 Organic compounds
GBGB0212917.9A GB0212917D0 (en) 2001-11-08 2002-06-05 Organic compounds

Publications (1)

Publication Number Publication Date
AR037261A1 true AR037261A1 (es) 2004-11-03

Family

ID=26246753

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP020104236A AR037261A1 (es) 2001-11-08 2002-11-06 Amidas de acido antranilico, un proceso para su preparacion, composiciones farmaceuticas, y el uso de dichas amidas para la preaparacion de un medicamento

Country Status (25)

Country Link
US (1) US7067543B2 (es)
EP (2) EP1446381B1 (es)
JP (1) JP4179989B2 (es)
KR (1) KR100633814B1 (es)
CN (1) CN100467450C (es)
AR (1) AR037261A1 (es)
AT (1) ATE494278T1 (es)
AU (1) AU2002342889B2 (es)
BR (1) BR0213939A (es)
CA (1) CA2462390C (es)
DE (1) DE60238856D1 (es)
GB (2) GB0126901D0 (es)
HR (1) HRP20040412A2 (es)
IL (1) IL161163A0 (es)
MX (1) MXPA04004390A (es)
MY (1) MY136322A (es)
NO (1) NO326986B1 (es)
NZ (1) NZ532587A (es)
PE (1) PE20030540A1 (es)
PL (1) PL368417A1 (es)
PT (1) PT1446381E (es)
RS (1) RS29404A (es)
RU (1) RU2315756C2 (es)
TW (1) TWI260985B (es)
WO (1) WO2003040101A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7307088B2 (en) 2002-07-09 2007-12-11 Amgen Inc. Substituted anthranilic amide derivatives and methods of use
GB0229022D0 (en) * 2002-12-12 2003-01-15 Novartis Ag Organic Compounds
UA89035C2 (ru) 2003-12-03 2009-12-25 Лео Фарма А/С Эфиры гидроксамовых кислот и их фармацевтическое применение
BR122015027139B1 (pt) 2004-01-28 2016-05-10 Mitsui Chemicals Inc compostos derivados de amida, inseticida compreendendo os mesmos e método de uso dos mesmos como inseticida
DE102004009238A1 (de) * 2004-02-26 2005-09-08 Merck Patent Gmbh Arylamid-Derivate
JPWO2006070878A1 (ja) * 2004-12-28 2008-06-12 アステラス製薬株式会社 カルボン酸誘導体またはその塩
EP2145873A1 (fr) * 2008-06-17 2010-01-20 Commissariat A L'energie Atomique Nouveaux composés ayant une activité protectrice vis-à-vis de l'action de toxines et de virus au mode d'action intracellulaire
PL2346827T3 (pl) 2008-08-27 2014-04-30 Leo Pharma As Pochodne pirydyny jako inhibitory receptora VEGFR-2 i białkowej kinazy tyrozynowej
JP2011057661A (ja) * 2009-08-14 2011-03-24 Bayer Cropscience Ag 殺虫性カルボキサミド類

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3226394A (en) * 1964-06-16 1965-12-28 Shulton Inc Pyridylethylated anthranilamides and derivatives thereof
WO1998014449A1 (en) 1996-10-02 1998-04-09 Novartis Ag Fused pyrazole derivatives and processes for their preparation
GB9824579D0 (en) 1998-11-10 1999-01-06 Novartis Ag Organic compounds

Also Published As

Publication number Publication date
AU2002342889B2 (en) 2007-03-01
GB0212917D0 (en) 2002-07-17
MY136322A (en) 2008-09-30
DE60238856D1 (de) 2011-02-17
US7067543B2 (en) 2006-06-27
KR100633814B1 (ko) 2006-10-13
PE20030540A1 (es) 2003-08-05
NZ532587A (en) 2006-02-24
JP4179989B2 (ja) 2008-11-12
KR20050044374A (ko) 2005-05-12
CN1578768A (zh) 2005-02-09
RS29404A (en) 2007-02-05
NO326986B1 (no) 2009-03-30
ATE494278T1 (de) 2011-01-15
US20040248947A1 (en) 2004-12-09
WO2003040101A1 (en) 2003-05-15
BR0213939A (pt) 2004-08-31
CA2462390A1 (en) 2003-05-15
EP2269988A3 (en) 2011-02-16
PT1446381E (pt) 2011-01-31
CA2462390C (en) 2011-01-11
EP1446381B1 (en) 2011-01-05
IL161163A0 (en) 2004-08-31
PL368417A1 (en) 2005-03-21
GB0126901D0 (en) 2002-01-02
CN100467450C (zh) 2009-03-11
EP1446381A1 (en) 2004-08-18
TWI260985B (en) 2006-09-01
MXPA04004390A (es) 2005-05-16
RU2315756C2 (ru) 2008-01-27
HRP20040412A2 (en) 2005-06-30
NO20042137L (no) 2004-05-25
RU2004117548A (ru) 2005-06-10
EP2269988B1 (en) 2012-05-23
TW200300086A (en) 2003-05-16
JP2005508382A (ja) 2005-03-31
EP2269988A2 (en) 2011-01-05

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