AR006606A1 - Derivados de isatina como inhibidores de la acetilcolinesterasa y analgesicos, composicion farmaceutica, metodos de tratamaiento, usos yprocedimiento de dichos derivados. - Google Patents
Derivados de isatina como inhibidores de la acetilcolinesterasa y analgesicos, composicion farmaceutica, metodos de tratamaiento, usos yprocedimiento de dichos derivados.Info
- Publication number
- AR006606A1 AR006606A1 ARP970101447A ARP970101447A AR006606A1 AR 006606 A1 AR006606 A1 AR 006606A1 AR P970101447 A ARP970101447 A AR P970101447A AR P970101447 A ARP970101447 A AR P970101447A AR 006606 A1 AR006606 A1 AR 006606A1
- Authority
- AR
- Argentina
- Prior art keywords
- derivatives
- analgesic
- acetylcholinesterase
- inhibitors
- alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
Derivados de isatina como inhibidores de acetilcolinesterasa y analgésico que poseen la fórmula (I), donde R es hidrógeno, alquilo (C1-C6) ohidroxialquilo (C1-C6); X es hidrógeno, hidroxi, alcoxi (C1-C6), fenilalcoxi (C1-C6) o -O(C-O)NR1R2, e Y es hidrógeno o halógeno, donde R1 es alquilo(C1-C6), fenilo o fenilalquilo (C1-C6), donde el grupo fenilo está eventualmente substituido por alquilo (C1-C6), alcoxi (C1-C6), halógeno otrifluorometilo; R2 es hidrógeno o alquilo(C1-C6); o R1 y R2 tomados junto con el nitrógeno al que están unidos forman un grupotetrahidroisoquinolina; y sus sales de adición de ácido farmacéuticamente aceptables.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63187096A | 1996-04-12 | 1996-04-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR006606A1 true AR006606A1 (es) | 1999-09-08 |
Family
ID=24533114
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP970101447A AR006606A1 (es) | 1996-04-12 | 1997-04-11 | Derivados de isatina como inhibidores de la acetilcolinesterasa y analgesicos, composicion farmaceutica, metodos de tratamaiento, usos yprocedimiento de dichos derivados. |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP0892796B1 (es) |
| JP (1) | JP4109718B2 (es) |
| KR (1) | KR20000005379A (es) |
| CN (1) | CN1215399A (es) |
| AR (1) | AR006606A1 (es) |
| AT (1) | ATE207483T1 (es) |
| BR (1) | BR9708655A (es) |
| CA (1) | CA2252039C (es) |
| DE (1) | DE69707659T2 (es) |
| DK (1) | DK0892796T3 (es) |
| ES (1) | ES2165586T3 (es) |
| GR (1) | GR3037006T3 (es) |
| HU (1) | HUP9903473A3 (es) |
| IL (1) | IL126308A0 (es) |
| NO (1) | NO984740D0 (es) |
| PT (1) | PT892796E (es) |
| TW (1) | TW426678B (es) |
| WO (1) | WO1997038993A1 (es) |
| ZA (1) | ZA972990B (es) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6218383B1 (en) | 1998-08-07 | 2001-04-17 | Targacept, Inc. | Pharmaceutical compositions for the prevention and treatment of central nervous system disorders |
| EP2089383B1 (en) | 2006-11-09 | 2015-09-16 | Probiodrug AG | 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases |
| US9126987B2 (en) | 2006-11-30 | 2015-09-08 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
| WO2008104580A1 (en) | 2007-03-01 | 2008-09-04 | Probiodrug Ag | New use of glutaminyl cyclase inhibitors |
| US9656991B2 (en) | 2007-04-18 | 2017-05-23 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
| JP5934645B2 (ja) | 2009-09-11 | 2016-06-15 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤としてのヘテロ環式誘導体 |
| CN102905532A (zh) | 2010-02-09 | 2013-01-30 | 约翰斯.霍普金斯大学 | 用于改善认知功能的方法和组合物 |
| WO2011101774A1 (en) | 2010-02-16 | 2011-08-25 | Pfizer Inc. | (r)-4-((4-((4-(tetrahydrofuran-3-yloxy)benzo[d]isoxazol-3-yloxy)methyl)piperidin-1-yl)methyl)tetrahydro-2h-pyran-4-ol, a partial agonist of 5-ht4 receptors |
| WO2011107530A2 (en) | 2010-03-03 | 2011-09-09 | Probiodrug Ag | Novel inhibitors |
| SG183229A1 (en) | 2010-03-10 | 2012-09-27 | Probiodrug Ag | Heterocyclic inhibitors of glutaminyl cyclase (qc, ec 2.3.2.5) |
| US8541596B2 (en) | 2010-04-21 | 2013-09-24 | Probiodrug Ag | Inhibitors |
| US8530670B2 (en) | 2011-03-16 | 2013-09-10 | Probiodrug Ag | Inhibitors |
| JP6440625B2 (ja) | 2012-11-14 | 2018-12-19 | ザ・ジョンズ・ホプキンス・ユニバーシティー | 精神分裂病を処置するための方法および組成物 |
| CA2893468C (en) | 2012-12-13 | 2021-01-12 | H. Lundbeck A/S | Use of vortioxetine and donepezil in the treatment of cognitive impairment |
| ES2881081T3 (es) | 2013-03-15 | 2021-11-26 | Agenebio Inc | Procedimientos y composiciones para mejorar la función cognitiva |
| EP2968237A4 (en) | 2013-03-15 | 2016-08-31 | Univ Johns Hopkins | METHOD AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION |
| WO2016179157A1 (en) * | 2015-05-05 | 2016-11-10 | Carafe Drug Innovation, Llc | Substituted 5-hydroxyoxindoles and their use as analgesics and fever reducers |
| AU2016268096B2 (en) | 2015-05-22 | 2021-04-01 | Agenebio, Inc. | Extended release pharmaceutical compositions of levetiracetam |
| EP3461819B1 (en) | 2017-09-29 | 2020-05-27 | Probiodrug AG | Inhibitors of glutaminyl cyclase |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4994472A (en) * | 1989-08-02 | 1991-02-19 | Hoechst-Roussel Pharmaceuticals Incorporated | 1-(pyridinylamino)-2-pyrrolidinones as pain relievers |
| US5006537A (en) * | 1989-08-02 | 1991-04-09 | Hoechst-Roussel Pharmaceuticals, Inc. | 1,3-dihydro-1-(pyridinylamino)-2H-indol-2-ones |
| US5296488A (en) * | 1989-08-02 | 1994-03-22 | Hoechst-Roussel Pharmaceuticals Inc. | Method of using 2,3-dihydro-1-(pyridinylamino)-indoles as anticonvulsants and for the enhancement of memory |
-
1997
- 1997-03-07 DE DE69707659T patent/DE69707659T2/de not_active Expired - Fee Related
- 1997-03-07 EP EP97908942A patent/EP0892796B1/en not_active Expired - Lifetime
- 1997-03-07 HU HU9903473A patent/HUP9903473A3/hu unknown
- 1997-03-07 BR BR9708655A patent/BR9708655A/pt not_active Application Discontinuation
- 1997-03-07 PT PT97908942T patent/PT892796E/pt unknown
- 1997-03-07 DK DK97908942T patent/DK0892796T3/da active
- 1997-03-07 IL IL12630897A patent/IL126308A0/xx unknown
- 1997-03-07 CN CN97193728A patent/CN1215399A/zh active Pending
- 1997-03-07 CA CA002252039A patent/CA2252039C/en not_active Expired - Fee Related
- 1997-03-07 ES ES97908942T patent/ES2165586T3/es not_active Expired - Lifetime
- 1997-03-07 JP JP53708497A patent/JP4109718B2/ja not_active Expired - Fee Related
- 1997-03-07 WO PCT/US1997/003598 patent/WO1997038993A1/en active IP Right Grant
- 1997-03-07 AT AT97908942T patent/ATE207483T1/de not_active IP Right Cessation
- 1997-04-07 TW TW086104363A patent/TW426678B/zh active
- 1997-04-08 ZA ZA9702990A patent/ZA972990B/xx unknown
- 1997-04-11 AR ARP970101447A patent/AR006606A1/es unknown
-
1998
- 1998-10-09 NO NO984740A patent/NO984740D0/no unknown
- 1998-10-12 KR KR1019980708105A patent/KR20000005379A/ko active IP Right Grant
-
2001
- 2001-10-25 GR GR20010401584T patent/GR3037006T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| WO1997038993A1 (en) | 1997-10-23 |
| ZA972990B (en) | 1997-11-03 |
| BR9708655A (pt) | 1999-08-03 |
| EP0892796A1 (en) | 1999-01-27 |
| DE69707659D1 (de) | 2001-11-29 |
| HUP9903473A3 (en) | 2000-09-28 |
| CA2252039A1 (en) | 1997-10-23 |
| CN1215399A (zh) | 1999-04-28 |
| DE69707659T2 (de) | 2002-05-08 |
| GR3037006T3 (en) | 2002-01-31 |
| HUP9903473A2 (hu) | 2000-05-28 |
| DK0892796T3 (da) | 2001-11-19 |
| EP0892796B1 (en) | 2001-10-24 |
| TW426678B (en) | 2001-03-21 |
| ATE207483T1 (de) | 2001-11-15 |
| ES2165586T3 (es) | 2002-03-16 |
| JP4109718B2 (ja) | 2008-07-02 |
| NO984740L (no) | 1998-10-09 |
| JP2001508400A (ja) | 2001-06-26 |
| AU716997B2 (en) | 2000-03-16 |
| CA2252039C (en) | 2002-12-24 |
| NO984740D0 (no) | 1998-10-09 |
| AU2072597A (en) | 1997-11-07 |
| PT892796E (pt) | 2002-03-28 |
| KR20000005379A (en) | 2000-01-25 |
| IL126308A0 (en) | 1999-05-09 |
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