AR002259A1 - Derivados de 1-oxo-2-(fenilsulfonilamino)pentilpiperidina, su preparacion, compuestos intermedios y composicion que contiene a dichos derivados. - Google Patents
Derivados de 1-oxo-2-(fenilsulfonilamino)pentilpiperidina, su preparacion, compuestos intermedios y composicion que contiene a dichos derivados.Info
- Publication number
- AR002259A1 AR002259A1 ARP950100624A AR10062495A AR002259A1 AR 002259 A1 AR002259 A1 AR 002259A1 AR P950100624 A ARP950100624 A AR P950100624A AR 10062495 A AR10062495 A AR 10062495A AR 002259 A1 AR002259 A1 AR 002259A1
- Authority
- AR
- Argentina
- Prior art keywords
- derivatives
- carbon atoms
- straight
- group
- alkyl group
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
Derivados de 1-oxo-2-(fenilsulfonilamino)-pentilpiperidina que responden a la fórmula (I), en la cual R1, representa, ya sea un átomo de hidrógeno, o bienun grupo alquilo con 1 a 4 átomos de carbono, R2 representa, ya sea un átomo de hidrógeno, o bien un grupo alquilo con 1 a 4 átomos de carbono de cadena rectao ramificada,R3 representa ya sea un grupo alquilo con 1 a 7 átomos de carbono, de cadena recta o ramificada o bien un grupo (CH2)nOCH3 (en el que n es 1, 2 ó3), o bien un grupo - CH2O(C2H4O)m CH2 (en el que m es 1, 2 ó 3), R4 representa, ya sea un átomo de hidrógeno o bien un átomo de halógeno; R5representa un grupo alquilo con 1 a 4 átomos de carbono de cadena recta o ramificada y A representa, ya sea un grupo fenilo, eventualmente substituidopor uno o varios substituyentes seleccionados entre átomos de halógeno y grupos alquilo con 1 a 4 átomos de carbono de cadena recta o ramificada, alcoxi con 1a 4 átomos de carbono de cadena recta o ramificada y trifluormetilo, o bien un heterociclo seleccionado entre grupos piridinilo,tienilo, furilo, eventualmentesubstituidos como se ha senalado arriba, o bien un grupo cicloalquilo con 5 a 8 átomos de carbono, en forma de base libre o como sales de adición de ácidosfarmacéuticamente aceptables; su procedimiento de preparación, compuestos intermedios utilizados en dicho procedimiento y medicamento y composiciónterapéutica que contienen a dichos derivados.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9415549A FR2728570B1 (fr) | 1994-12-23 | 1994-12-23 | Derives de 1-oxo-2-(phenylsulfonylamino)pentylpiperidine, leur preparation et leur application en therapeutique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR002259A1 true AR002259A1 (es) | 1998-03-11 |
Family
ID=9470166
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP950100624A AR002259A1 (es) | 1994-12-23 | 1995-12-19 | Derivados de 1-oxo-2-(fenilsulfonilamino)pentilpiperidina, su preparacion, compuestos intermedios y composicion que contiene a dichos derivados. |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US5602149A (es) |
| EP (1) | EP0718307A2 (es) |
| JP (1) | JPH08239380A (es) |
| KR (1) | KR960022504A (es) |
| CN (1) | CN1131153A (es) |
| AR (1) | AR002259A1 (es) |
| AU (1) | AU4062995A (es) |
| BR (1) | BR9506062A (es) |
| CA (1) | CA2166032A1 (es) |
| CO (1) | CO4700285A1 (es) |
| CZ (1) | CZ346095A3 (es) |
| FI (1) | FI956251A (es) |
| FR (1) | FR2728570B1 (es) |
| HU (1) | HUT75114A (es) |
| IL (1) | IL116532A0 (es) |
| NO (1) | NO955242L (es) |
| NZ (1) | NZ280735A (es) |
| PL (1) | PL312028A1 (es) |
| SK (1) | SK163895A3 (es) |
| TW (1) | TW321647B (es) |
| ZA (1) | ZA9510930B (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2728570B1 (fr) * | 1994-12-23 | 1997-04-11 | Synthelabo | Derives de 1-oxo-2-(phenylsulfonylamino)pentylpiperidine, leur preparation et leur application en therapeutique |
| FR2749584B1 (fr) * | 1996-06-11 | 1998-07-10 | Synthelabo | Derives de 1-oxo-2-(1h-imidazol-4-yl)pentylpiperidine, leur preparation et leur application en therapeutique |
| FR2756285B1 (fr) * | 1996-11-22 | 1998-12-18 | Synthelabo | Derives de n-(imidazolylbutyle)benzenesulfonamide, leur preparation et leur application en therapeutique |
| FR2758326B1 (fr) * | 1997-01-16 | 1999-02-12 | Synthelabo | Derives de pyridone, leur prepaparation et leur utilisation comme intermediaires de synthese |
| FR2765220B1 (fr) * | 1997-06-25 | 1999-07-30 | Synthelabo | Derives de 1-oxo-2-(phenylsulfonyl)aminopentyle, leur preparation et leur application en therapeutique |
| FR2771094B1 (fr) * | 1997-11-19 | 2000-02-04 | Synthelabo | Derives de piperidine-2-carboxylate, leur preparation et leur application en therapeutique |
| FR2806722B1 (fr) * | 2000-03-23 | 2002-05-17 | Sanofi Synthelabo | Derives de n-(heterocyclylbutyl) benzene-ou pyridine sulfonamide, leur preparation et leur application en therapeutique |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1338645C (en) * | 1987-01-06 | 1996-10-15 | George R. Pettit | Isolation, structural elucidation and synthesis of novel antineoplastic substances denominated "combretastatins" |
| US5312828A (en) * | 1989-06-14 | 1994-05-17 | Finkelstein Joseph A | Substituted imidazoles having angiotensin II receptor blocking activity |
| US5136043A (en) * | 1989-06-17 | 1992-08-04 | Hoechst Aktiengesellschaft | Process for the preparation of aromatic sulfonyl chlorides |
| FR2689130B1 (fr) * | 1992-03-30 | 1994-05-27 | Synthelabo | Derives de 1-[2 (arylsulfonylamino)ethyl-1-oxo] piperidine, leur preparation et leur application en therapeutique. |
| US5401851A (en) * | 1992-06-03 | 1995-03-28 | Eli Lilly And Company | Angiotensin II antagonists |
| US5612360A (en) * | 1992-06-03 | 1997-03-18 | Eli Lilly And Company | Angiotensin II antagonists |
| DE4240708A1 (de) * | 1992-12-03 | 1994-06-09 | Bayer Ag | Verfahren zur Herstellung von Natriumsalzen nitrogruppenhaltiger aromatischer Sulfinsäuren |
| EP0684830B1 (en) * | 1993-02-12 | 1999-06-16 | Corvas International, Inc. | Inhibitors of thrombosis |
| FR2710066B1 (fr) | 1993-09-14 | 1995-10-20 | Synthelabo | Dérivés de 1-[2-amino-5-[1-(triphénylméthyl-1H-imidazol-4-yl]-1-oxopentyl]piperidine, leur préparation et leur utilisation comme intermédiaires de synthèse. |
| DE69433585D1 (de) * | 1993-12-29 | 2004-04-08 | Syngenta Participations Ag | Vinylcarboxamid-Derivate als Insectizide und Akarizide |
| DE4423061C1 (de) * | 1994-07-01 | 1996-01-18 | Hoechst Ag | Verfahren zur Herstellung von Biphenylen mit Palladacyclen als Katalysatoren |
| FR2728570B1 (fr) * | 1994-12-23 | 1997-04-11 | Synthelabo | Derives de 1-oxo-2-(phenylsulfonylamino)pentylpiperidine, leur preparation et leur application en therapeutique |
-
1994
- 1994-12-23 FR FR9415549A patent/FR2728570B1/fr not_active Expired - Fee Related
-
1995
- 1995-12-07 TW TW084113032A patent/TW321647B/zh active
- 1995-12-18 EP EP95402840A patent/EP0718307A2/fr not_active Withdrawn
- 1995-12-19 AR ARP950100624A patent/AR002259A1/es unknown
- 1995-12-21 ZA ZA9510930A patent/ZA9510930B/xx unknown
- 1995-12-21 NZ NZ280735A patent/NZ280735A/en unknown
- 1995-12-22 FI FI956251A patent/FI956251A/fi unknown
- 1995-12-22 KR KR1019950054400A patent/KR960022504A/ko not_active Application Discontinuation
- 1995-12-22 CZ CZ953460A patent/CZ346095A3/cs unknown
- 1995-12-22 AU AU40629/95A patent/AU4062995A/en not_active Abandoned
- 1995-12-22 PL PL95312028A patent/PL312028A1/xx unknown
- 1995-12-22 CA CA002166032A patent/CA2166032A1/fr not_active Abandoned
- 1995-12-22 IL IL11653295A patent/IL116532A0/xx unknown
- 1995-12-22 HU HU9503782A patent/HUT75114A/hu unknown
- 1995-12-22 JP JP7334927A patent/JPH08239380A/ja active Pending
- 1995-12-22 BR BR9506062A patent/BR9506062A/pt not_active Application Discontinuation
- 1995-12-22 CO CO95061143A patent/CO4700285A1/es unknown
- 1995-12-22 SK SK1638-95A patent/SK163895A3/sk unknown
- 1995-12-22 US US08/577,935 patent/US5602149A/en not_active Expired - Fee Related
- 1995-12-22 NO NO955242A patent/NO955242L/no unknown
- 1995-12-22 CN CN95121452A patent/CN1131153A/zh active Pending
-
1996
- 1996-10-30 US US08/741,290 patent/US5753667A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0718307A3 (es) | 1996-08-07 |
| KR960022504A (ko) | 1996-07-18 |
| NZ280735A (en) | 1997-06-24 |
| FR2728570A1 (fr) | 1996-06-28 |
| PL312028A1 (en) | 1996-06-24 |
| CZ346095A3 (en) | 1996-07-17 |
| CN1131153A (zh) | 1996-09-18 |
| US5753667A (en) | 1998-05-19 |
| HU9503782D0 (en) | 1996-05-28 |
| ZA9510930B (en) | 1996-06-24 |
| EP0718307A2 (fr) | 1996-06-26 |
| IL116532A0 (en) | 1996-03-31 |
| JPH08239380A (ja) | 1996-09-17 |
| FI956251A0 (fi) | 1995-12-22 |
| CA2166032A1 (fr) | 1996-06-24 |
| FR2728570B1 (fr) | 1997-04-11 |
| CO4700285A1 (es) | 1998-12-29 |
| AU4062995A (en) | 1996-07-04 |
| FI956251A (fi) | 1996-06-24 |
| BR9506062A (pt) | 1997-12-23 |
| NO955242L (no) | 1996-06-24 |
| US5602149A (en) | 1997-02-11 |
| TW321647B (es) | 1997-12-01 |
| SK163895A3 (en) | 1996-09-04 |
| NO955242D0 (no) | 1995-12-22 |
| HUT75114A (en) | 1997-04-28 |
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