NO931844L - IMPROVED MATRIX METAL PROTEASE INHIBITORS - Google Patents
IMPROVED MATRIX METAL PROTEASE INHIBITORSInfo
- Publication number
- NO931844L NO931844L NO93931844A NO931844A NO931844L NO 931844 L NO931844 L NO 931844L NO 93931844 A NO93931844 A NO 93931844A NO 931844 A NO931844 A NO 931844A NO 931844 L NO931844 L NO 931844L
- Authority
- NO
- Norway
- Prior art keywords
- alkyl
- protease inhibitors
- matrix metal
- lower alkyl
- metal protease
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Abstract
Forbindelser med formler: (1) eller (2) der hver R1 er uavhengig av hverandre H eller alkyl (1-8C) og R2 er alkyl (1-8C) eller der prokslmal R1 og R2 tatt sammen er -(CB2)p¿ hvori p - 3-5; R3 er H eller alkyl (1-4C); R4 er samnensmeltet eller konjugert usubstltuert eller substituert bicykloarylmetylen; n er O, l eller 2; m er O eller 1; og X er OR5 eller NHR5 der R5 er H eller substituert eller usubstltuert alkyl (1-12C), aryl (6-12C), arylalkyl (6- 16C); R7 er lavere alkyl (1-4C) eller en acylgruppe, eller X er et amlnosyreresldu eller amld derav; eller X er residuet av et cykllsk amln eller heterocykllsk amln; Y blir valgt fra gruppen som består av R7ONR6CONR6- , R62NCONOR7-, og R6CONOR7-, der hver R6 er uavhengig av hverandre H eller lavere alkyl (1-4C); R7 er lavere alkyl (1-4C) eller en acylgruppe. der -CONR3- er eventuelt l modifisert Isosterlsk form. Forbindelsene er hemnere av matrlksmetallproteaser .Compounds of formulas: (1) or (2) wherein each R1 is independently H or alkyl (1-8C) and R2 is alkyl (1-8C) or where proxylmal R1 and R2 taken together are - (CB2) p wherein p is 3-5; R 3 is H or alkyl (1-4C); R 4 is fused or conjugated unsubstituted or substituted bicycloarylmethylene; n is 0, 1 or 2; m is 0 or 1; and X is OR5 or NHR5 wherein R5 is H or substituted or unsubstituted alkyl (1-12C), aryl (6-12C), arylalkyl (6-16C); R7 is lower alkyl (1-4C) or an acyl group, or X is an amino acid residue or amide thereof; or X is the residue of a cyclic amine or heterocyclic amine; Y is selected from the group consisting of R7ONR6CONR6-, R62NCONOR7-, and R6CONOR7-, where each R6 is independently H or lower alkyl (1-4C); R7 is lower alkyl (1-4C) or an acyl group. where -CONR3- is optionally in modified Isosteric form. The compounds are inhibitors of metal metal proteases.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/615,798 US5183900A (en) | 1990-11-21 | 1990-11-21 | Matrix metalloprotease inhibitors |
| US07/747,751 US5239078A (en) | 1990-11-21 | 1991-08-20 | Matrix metalloprotease inhibitors |
| PCT/US1991/008722 WO1992009563A1 (en) | 1990-11-21 | 1991-11-21 | Improved matrix metalloprotease inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO931844D0 NO931844D0 (en) | 1993-05-19 |
| NO931844L true NO931844L (en) | 1993-07-09 |
Family
ID=27376843
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO93931844A NO931844L (en) | 1990-11-21 | 1993-05-19 | IMPROVED MATRIX METAL PROTEASE INHIBITORS |
Country Status (1)
| Country | Link |
|---|---|
| NO (1) | NO931844L (en) |
-
1993
- 1993-05-19 NO NO93931844A patent/NO931844L/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO931844D0 (en) | 1993-05-19 |
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