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ES479931A1 - Substituted amino-pyridine derivatives, processes for their preparation and pharmaceutical compositions containing them. - Google Patents

Substituted amino-pyridine derivatives, processes for their preparation and pharmaceutical compositions containing them.

Info

Publication number
ES479931A1
ES479931A1 ES479931A ES479931A ES479931A1 ES 479931 A1 ES479931 A1 ES 479931A1 ES 479931 A ES479931 A ES 479931A ES 479931 A ES479931 A ES 479931A ES 479931 A1 ES479931 A1 ES 479931A1
Authority
ES
Spain
Prior art keywords
substituted amino
pyridine derivatives
alkyl
hydrogen
processes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES479931A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of ES479931A1 publication Critical patent/ES479931A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
    • C07D213/85—Nitriles in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

A class of substituted amino pyridine derivatives are of value in the treatment of diabetes. Some of the compounds also possess hypolipidaemic activity. The compounds are represented by the formula (I): < CHEM > wherein R<3> is hydrogen, alkyl or an acidic function R<2> is hydrogen or alkyl R<4> and R<5> are hydrogen, alkyl or halogen Z is hydrogen, phenyl, alkyl or aralkyl Alk is alkylene and x is 0 or 1 R<1> is optionally substituted phenyl or naphthyl. Most of the compounds of formula (I) are novel.
ES479931A 1977-08-06 1979-04-25 Substituted amino-pyridine derivatives, processes for their preparation and pharmaceutical compositions containing them. Expired ES479931A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB3305577 1977-08-06
GB1940678 1978-05-13

Publications (1)

Publication Number Publication Date
ES479931A1 true ES479931A1 (en) 1979-12-01

Family

ID=26254035

Family Applications (4)

Application Number Title Priority Date Filing Date
ES472384A Expired ES472384A1 (en) 1977-08-06 1978-08-04 Substituted amino-pyridine derivatives, processes for their preparation and pharmaceutical compositions containing them.
ES479932A Expired ES479932A1 (en) 1977-08-06 1979-04-25 Substituted amino-pyridine derivatives, processes for their preparation and pharmaceutical compositions containing them.
ES479931A Expired ES479931A1 (en) 1977-08-06 1979-04-25 Substituted amino-pyridine derivatives, processes for their preparation and pharmaceutical compositions containing them.
ES479933A Expired ES479933A1 (en) 1977-08-06 1979-04-25 Substituted amino-pyridine derivatives, processes for their preparation and pharmaceutical compositions containing them.

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES472384A Expired ES472384A1 (en) 1977-08-06 1978-08-04 Substituted amino-pyridine derivatives, processes for their preparation and pharmaceutical compositions containing them.
ES479932A Expired ES479932A1 (en) 1977-08-06 1979-04-25 Substituted amino-pyridine derivatives, processes for their preparation and pharmaceutical compositions containing them.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES479933A Expired ES479933A1 (en) 1977-08-06 1979-04-25 Substituted amino-pyridine derivatives, processes for their preparation and pharmaceutical compositions containing them.

Country Status (7)

Country Link
EP (1) EP0000816A1 (en)
JP (1) JPS5441881A (en)
AU (1) AU3862078A (en)
DK (1) DK346278A (en)
ES (4) ES472384A1 (en)
IL (1) IL55242A0 (en)
IT (1) IT1106623B (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1160229A (en) * 1979-03-13 1984-01-10 Pieter T. Haken Pyridyliminomethylbenzene derivatives
DE3066911D1 (en) * 1979-04-21 1984-04-19 Beecham Group Plc Dihydropyridine derivatives, processes for their preparation and pharmaceutical compositions containing them
JPS5938653B2 (en) * 1980-05-30 1984-09-18 日本ビクター株式会社 How to make needles with electrodes
JPS5798143A (en) * 1980-12-05 1982-06-18 Victor Co Of Japan Ltd Base body of detection type for variation in electrostatic capacity value
DE3124673A1 (en) * 1981-06-24 1983-01-13 Bayer Ag, 5090 Leverkusen SUBSITUATED 2-AMINO-PYRIDINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE IN MEDICINAL PRODUCTS AND THE PRODUCTION THEREOF
US4552960A (en) * 1983-06-20 1985-11-12 Eli Lilly And Company Fungicidal amines
US4774251A (en) * 1984-06-18 1988-09-27 Eli Lilly And Company Method of inhibiting aromatase
US4855308A (en) * 1987-12-04 1989-08-08 Warner-Lambert Company Method of treating senile cognitive decline with N'-substituted aminopyridine adrenergic agents
US4931457B1 (en) * 1989-06-28 1993-11-16 Hoechst-Roussel Pharmaceuticals Incorporated Naphthylamino-and naphthyloxy-pyridineamin compounds useful as topical antiinflammatory agents for the treatment of skin disorders
AU630877B2 (en) * 1989-07-28 1992-11-12 Ah N. Fah Improved automatic plant watering and feeding system
FR2668770A1 (en) * 1990-11-07 1992-05-07 Nyco Sa HETEROCYCLIC AMINO ACID ESTERS AND THEIR DERIVATIVES, AND THEIR APPLICATION AS ANTI-OXIDIZING ADDITIVES FOR HIGH TEMPERATURE LUBRICATING OILS.
GB9514160D0 (en) * 1994-07-25 1995-09-13 Zeneca Ltd Aromatic compounds
GB9420557D0 (en) * 1994-10-12 1994-11-30 Zeneca Ltd Aromatic compounds
TW502026B (en) * 1995-06-20 2002-09-11 Zeneca Ltd Aromatic compounds useful as antagonists of e-type prostaglandins, processes for the preparation thereof, pharmaceutical compositions comprising the compounds, and intermediates
TW434240B (en) * 1995-06-20 2001-05-16 Zeneca Ltd Aromatic compounds, preparation thereof and pharmaceutical composition comprising same
EP0752421B1 (en) * 1995-07-07 2005-10-12 AstraZeneca AB Ortho-substituted aromatic compounds, containing three (het)aryl moieties, their preparation and their use as prostaglandin E2-(PGE2)-antagonists
DE19845406C2 (en) * 1998-10-02 2001-10-18 Aventis Pharma Gmbh Substituted 1,3-diaryl-2-pyridin-2-yl-3- (pyridin-2-ylamino) propanol derivatives, process for their preparation, medicaments containing these compounds and their use
US6503949B1 (en) 1999-05-17 2003-01-07 Noro Nordisk A/S Glucagon antagonists/inverse agonists
HUP0201033A3 (en) * 1999-05-17 2003-03-28 Novo Nordisk As Glucagon antagonists/inverse agonists, process for their preparation and their use
US20020198219A1 (en) * 2000-08-08 2002-12-26 Grant Elfrida R. 2-pyridinamine compositions and related methods
CA2602250A1 (en) * 2005-03-28 2006-10-05 Boehringer Ingelheim International Gmbh Pyridine derivatives useful as inhibitors of pkc-theta
ATE540942T1 (en) 2007-07-02 2012-01-15 Hoffmann La Roche IMIDAZOLE DERIVATIVES AS CCR2 RECEPTOR ANTAGONISTS

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2784138A (en) * 1953-03-07 1957-03-05 Bayer Ag Fungicidal compositions of nu-arylhydroxyarylmethylamines
DE1119274B (en) * 1954-03-19 1961-12-14 Raschig Gmbh Dr F Process for the preparation of 2-amino-4-alkyl-pyridines
NL132603C (en) * 1964-08-29
DE1670522C3 (en) * 1966-05-12 1978-08-31 Deutsche Gold- Und Silber-Scheideanstalt Vormals Roessler, 6000 Frankfurt New Benzylaminopyridines
GB1188154A (en) * 1966-05-28 1970-04-15 Egyt Gyogyszervegyeszeti Gyar New Pyridine Derivatives and process for their preparation
US3450707A (en) * 1966-12-13 1969-06-17 Sterling Drug Inc Certain 2-anilino-pyridine derivatives
US3535328A (en) * 1967-09-01 1970-10-20 Exxon Research Engineering Co Certain substituted aminothioethoxy pyridines
FR2050940A5 (en) * 1969-06-30 1971-04-02 Rhone Poulenc Sa
DE2141418A1 (en) * 1970-08-18 1972-03-09 Roemmers S.A. Industrial Comercial Y Financiera, Buenos Aires Aniline derivatives of nicotinic acid and their salts
FR2155922A2 (en) * 1971-10-15 1973-05-25 Aries Robert Organophosphorus pesticides - stabilized by amino- or aminoalkyl-pyridines
DE2230392A1 (en) * 1972-06-22 1974-01-31 Cassella Farbwerke Mainkur Ag SUBSTITUTED PYRIDINE COMPOUNDS AND PROCESS FOR THEIR PRODUCTION
GB1405308A (en) * 1972-12-13 1975-09-10 Basf Ag Amino-pytidines as coupling components for azo dyes
FR2288798A1 (en) * 1974-10-24 1976-05-21 Popescu Francine Bright zinc electroplating bath - contg pyridine deriv and soluble organic polymer
DE2605467A1 (en) * 1976-02-12 1977-08-18 Basf Ag PYRIDINE COMPOUNDS

Also Published As

Publication number Publication date
IT1106623B (en) 1985-11-11
DK346278A (en) 1979-02-07
EP0000816A1 (en) 1979-02-21
ES472384A1 (en) 1979-10-01
AU3862078A (en) 1980-02-07
IT7850601A0 (en) 1978-08-04
IL55242A0 (en) 1978-09-29
ES479932A1 (en) 1979-12-01
ES479933A1 (en) 1979-12-01
JPS5441881A (en) 1979-04-03

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