NO931795D0 - Dobbeltvirkende inhibitorer - Google Patents

Dobbeltvirkende inhibitorer

Info

Publication number: NO931795D0
Authority: NO; Norway
Prior art keywords: double; effective inhibitors; compounds; disclosed; inhibotory
Prior art date: 1992-05-18

Application number

NO931795A

Other languages

English (en)

Other versions

NO304372B1 (no

NO931795L (no

Inventor

Donald S Karanewsky

Joel C Barrish

Edward W Petrillo

Jeffrey A Robl

Denis E Ryono

Original Assignee

Squibb & Sons Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-05-18

Filing date

1993-05-18

Publication date

1993-05-18

1993-05-18 Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc

1993-05-18 Publication of NO931795D0 publication Critical patent/NO931795D0/no

1993-11-19 Publication of NO931795L publication Critical patent/NO931795L/no

1998-12-07 Publication of NO304372B1 publication Critical patent/NO304372B1/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
- C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
- C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
- C07D211/76—Oxygen atoms attached in position 2 or 6
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D223/08—Oxygen atoms
- C07D223/10—Oxygen atoms attached in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D223/12—Nitrogen atoms not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D267/14—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Gastroenterology & Hepatology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Peptides Or Proteins (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Hydrogenated Pyridines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

NO931795A 1992-05-18 1993-05-18 Dobbeltvirkende inhibitorer og farmas°ytiske blandinger inneholdende disse NO304372B1 (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US88466492A	1992-05-18	1992-05-18

Publications (3)

Publication Number	Publication Date
NO931795D0 true NO931795D0 (no)	1993-05-18
NO931795L NO931795L (no)	1993-11-19
NO304372B1 NO304372B1 (no)	1998-12-07

Family

ID=25385092

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO931795A NO304372B1 (no)	1992-05-18	1993-05-18	Dobbeltvirkende inhibitorer og farmas°ytiske blandinger inneholdende disse

Country Status (28)

Country	Link
EP (2)	EP0783002A3 (no)
JP (1)	JP3487611B2 (no)
KR (2)	KR100288722B1 (no)
CN (1)	CN1039008C (no)
AT (1)	ATE162800T1 (no)
AU (2)	AU659550B2 (no)
BR (1)	BR1101081A (no)
CA (1)	CA2096460C (no)
CY (1)	CY2093B1 (no)
CZ (1)	CZ289824B6 (no)
DE (1)	DE69316717T2 (no)
DK (1)	DK0599444T3 (no)
ES (1)	ES2111712T3 (no)
FI (1)	FI103337B1 (no)
GR (1)	GR3026665T3 (no)
HK (1)	HK1003597A1 (no)
HU (1)	HU217078B (no)
IL (1)	IL105729A (no)
MX (1)	MX9302876A (no)
MY (1)	MY111370A (no)
NO (1)	NO304372B1 (no)
NZ (1)	NZ247642A (no)
PL (1)	PL173036B1 (no)
RU (1)	RU2124503C1 (no)
SG (1)	SG54138A1 (no)
SK (1)	SK283556B6 (no)
TW (1)	TW290544B (no)
ZA (1)	ZA933461B (no)

Families Citing this family (81)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5430145A (en) *	1990-10-18	1995-07-04	Merrell Dow Pharmaceuticals Inc.	Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
US5455242A (en) *	1991-09-27	1995-10-03	Merrell Dow Pharmaceuticals Inc.	Carboxyalkyl tricyclic derivatives useful as inhibitors of enkephalinase and ace
CA2078759C (en) *	1991-09-27	2003-09-16	Alan M. Warshawsky	Novel carboxyalkyl derivatives useful as inhibitors of enkephalinase and ace
CA2078758C (en) *	1991-09-27	2003-12-09	Alan M. Warshawsky	2-substituted indane-2-mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
US5457196A (en) *	1991-09-27	1995-10-10	Merrell Dow Pharmaceuticals Inc.	2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE
US5565449A (en) *	1991-10-18	1996-10-15	Genentech, Inc.	Nonpeptidyl integrin inhibitors having specificity for the GPIIb IIIa receptor
US5250679A (en) *	1991-10-18	1993-10-05	Genentech, Inc.	Nonpeptidyl platelet aggregation inhibitors having specificity for the GPIIb III.sub. receptor
JP3460838B2 (ja) *	1992-02-14	2003-10-27	メレルファーマスーティカルズインコーポレイテッド	エンケファリナーゼ及びａｃｅの阻害剤として有用な，アミノアセチルメルカプトアセチルアミド誘導体類
US5552397A (en) *	1992-05-18	1996-09-03	E. R. Squibb & Sons, Inc.	Substituted azepinone dual inhibitors of angiotensin converting enzyme and neutral exdopeptidase
US5420271A (en) *	1992-08-24	1995-05-30	Merrell Dow Pharmaceuticals, Inc.	2-substituted indane-2-mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase
US5504080A (en) *	1992-10-28	1996-04-02	Bristol-Myers Squibb Co.	Benzo-fused lactams
GB9310075D0 (en) *	1993-05-17	1993-06-30	Fujisawa Pharmaceutical Co	New mercapto-amide derivatives,processes for the preparation thereof and pharmaceutical composition comprising the same
CA2140553A1 (en) *	1993-06-11	1994-12-22	Hitoshi Oinuma	Amino acid derivative
ES2076096B1 (es) *	1993-07-14	1996-03-16	Squibb & Sons Inc	Compuestos inhibidores de la enzima convertidora de angiotensinas y dela endopeptidasa neutra, y metodos para prepararlos.
US5525723A (en) *	1993-11-18	1996-06-11	Bristol-Myers Squibb Co.	Compounds containing a fused multiple ring lactam
CA2183315C (en) *	1994-02-14	1999-08-31	Gary A. Flynn	Novel mercaptoacetylamido 1,3,4,5-tetrahydro-benzo[c]azepin-3-one disulfide derivatives useful as inhibitors of enkephalinase and ace
US5530013A (en) *	1994-02-14	1996-06-25	American Home Products Corporation	Venlafaxine in the inducement of cognition enhancement
US5750521A (en) *	1994-02-14	1998-05-12	Hoechst Marion Roussel Inc.	Mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ACE
DE69524064T2 (de) *	1994-02-14	2002-07-11	Merrell Pharmaceuticals Inc., Cincinnati	Indan-2-mercaptoacetylamid disulfidderivate als enkephalinase inhibitoren
AU689192B2 (en) *	1994-02-14	1998-03-26	Merrell Pharmaceuticals Inc.	Novel 2-substituted indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ace
US5484783A (en) *	1994-03-24	1996-01-16	Merrell Dow Pharmaceuticals Inc.	Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide and benzazapine derivatives
CN1144487A (zh) *	1994-03-24	1997-03-05	默里尔药物公司	降低胆固醇、抗动脉粥样硬化和降低甘油三酯的巯基乙酰胺衍生物
EP0751774B1 (en) *	1994-03-24	2003-08-13	Merrell Pharmaceuticals Inc.	Hypocholesterolemic mercaptoacetylamide disulfide derivatives
DK0719779T3 (da) *	1994-07-18	2004-03-22	Eisai Co Ltd	Substituerede thiazolo[3,2-alpha]azepinderivater
US5641880A (en) *	1994-12-21	1997-06-24	Hoechst Marion Roussel, Inc.	Processes for preparing intermediates of inhibitors of enkephalinase and angiotensin converting enzyme and intermediates thereof
SI0800527T1 (en) *	1994-12-21	2000-08-31	Hoechst Marion Roussel, Inc.	Novel processes for preparing intermediates of inhibitors of enkephalinase and angiotensin converting enzyme and intermediates thereof
CN1049830C (zh) *	1995-01-13	2000-03-01	李勤	一种治疗癌痛的热力敷
US5587375A (en) *	1995-02-17	1996-12-24	Bristol-Myers Squibb Company	Azepinone compounds useful in the inhibition of ACE and NEP
DE19510566A1 (de) *	1995-03-23	1996-09-26	Kali Chemie Pharma Gmbh	Benzazepin-, Benzoxazepin- und Benzothiazepin-N-essigsäurederivate sowie Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
US5877313A (en)	1995-05-17	1999-03-02	Bristol-Myers Squibb	Benzo-fused azepinone and piperidinone compounds useful in the inhibition of ACE and NEP
US5635504A (en) *	1995-06-07	1997-06-03	Bristol-Myers Squibb Co.	Diazepine containing dual action inhibitors
US5650408A (en) *	1995-06-07	1997-07-22	Karanewsky; Donald S.	Thiazolo benzazepine containing dual action inhibitors
WO1997017972A1 (fr) *	1995-11-13	1997-05-22	Eisai Co., Ltd.	Composition abaissant le taux de cholesterol
WO1997038705A1 (en) *	1996-04-12	1997-10-23	Bristol-Myers Squibb Company	N-formyl hydroxylamine containing compounds useful as ace inhibitors and/or nep inhibitors
US6777550B1 (en)	1996-04-12	2004-08-17	Bristol-Myers Squibb Company	N-formyl hydroxylamine containing compounds useful as ACE inhibitors and/or NEP inhibitors
US6117896A (en) *	1997-02-10	2000-09-12	Molecumetics Ltd.	Methods for regulating transcription factors
US6340752B1 (en) *	1998-01-06	2002-01-22	Bristol-Myers Squibb Co.	Deprotection and recrystallization processes
AU750122C (en)	1998-06-17	2003-02-27	Bristol-Myers Squibb Company	Preventing cerebral infarction through administration of ADP-receptor antiplatelet and antihypertensive drugs in combination
EP1150957A1 (en) *	1998-12-31	2001-11-07	Aventis Pharmaceuticals Inc.	N-carboxymethyl substituted benzolactams as inhibitors of matrix metalloproteinase
US6770640B1 (en)	1998-12-31	2004-08-03	Aventis Pharmaceuticals Inc.	1-Carboxymethyl-2-oxo-azepan derivatives useful as selective inhibitors of MMP-12
US6262080B1 (en)	1998-12-31	2001-07-17	Avantis Pharmaceuticals Inc.	3-(thio-substitutedamido)-lactams useful as inhibitors of matrix metalloproteinase
EP1251115A4 (en)	2000-01-25	2008-05-14	Kaneka Corp	METHOD FOR THE PRODUCTION OF OPTICALLY ACTIVE IN 2-POSITION OF SUBSTITUTED CARBOXYLIC ACIDS
US6509330B2 (en)	2000-02-17	2003-01-21	Bristol-Myers Squibb Company	Hydroxamic acid containing compounds useful as ACE inhibitors and/or NEP inhibotors
DE10020818A1 (de)	2000-04-28	2001-10-31	Degussa	2,6-Diamino-6-methyl-heptansäure und Derivate, Verfahren zu deren Herstellung und deren Verwendung
EP1324975B1 (en)	2000-09-29	2005-11-16	Bristol-Myers Squibb Company	Dynamic resolution of isomers and resolved isomers
GB0119305D0 (en)	2001-04-12	2001-10-03	Aventis Pharma Gmbh	Mercaptoacetylamide derivatives,a process for their preparation and their use
EP1395560A1 (en)	2001-05-23	2004-03-10	Ucb, S.A.	2-oxo-piperidinyl- and 2-oxo-azepanyl alkanoic acid derivativ es for the treatment of epilepsy and other neurological disorders
EP1443919A4 (en)	2001-11-16	2006-03-22	Bristol Myers Squibb Co	DOUBLE INHIBITORS OF THE FATTY ACID BINDING PROTEIN OF THE ADIPOCYTES AND THE FATTY ACID BINDING PROTEIN OF KERATINOCYTES
WO2003068237A1 (en)	2002-02-14	2003-08-21	Myriad Genetics, Inc.	Beta-sheet mimetics and composition and methods relating thereto
CA2477088A1 (en)	2002-02-22	2003-10-02	New River Pharmaceuticals Inc.	Active agent delivery systems and methods for protecting and administering active agents
US7045653B2 (en)	2002-12-23	2006-05-16	Pfizer, Inc.	Pharmaceuticals
US7459474B2 (en)	2003-06-11	2008-12-02	Bristol-Myers Squibb Company	Modulators of the glucocorticoid receptor and method
US7371759B2 (en)	2003-09-25	2008-05-13	Bristol-Myers Squibb Company	HMG-CoA reductase inhibitors and method
US7420059B2 (en)	2003-11-20	2008-09-02	Bristol-Myers Squibb Company	HMG-CoA reductase inhibitors and method
US7273881B2 (en)	2004-01-16	2007-09-25	Bristol-Myers Squibb Company	Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
EP2457895A1 (en) *	2004-07-12	2012-05-30	Idun Pharmaceuticals, Inc.	Tetrapeptide analogs
US7888381B2 (en)	2005-06-14	2011-02-15	Bristol-Myers Squibb Company	Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity, and use thereof
US7592461B2 (en)	2005-12-21	2009-09-22	Bristol-Myers Squibb Company	Indane modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
US7795291B2 (en)	2006-07-07	2010-09-14	Bristol-Myers Squibb Company	Substituted acid derivatives useful as anti-atherosclerotic, anti-dyslipidemic, anti-diabetic and anti-obesity agents and method
WO2008057862A2 (en)	2006-11-01	2008-05-15	Bristol-Myers Squibb Company	MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-ϰB ACTIVITY AND USE THEREOF
WO2008057855A2 (en)	2006-11-01	2008-05-15	Bristol-Myers Squibb Company	Heterocyclic compounds as modulators of glucocorticoid receptor, ap-i, and/or np-kappa-b activity
JP2010508358A (ja)	2006-11-01	2010-03-18	ブリストル−マイヤーズスクイブカンパニー	グルココルチコイド受容体、ＡＰ−１、および／またはＮＦ−κＢ活性の調節剤、並びにその使用
JP5546451B2 (ja)	2007-06-04	2014-07-09	シナジーファーマシューティカルズインコーポレイテッド	胃腸の障害、炎症、癌および他の障害の処置に有用なグアニル酸シクラーゼのアゴニスト
US8969514B2 (en)	2007-06-04	2015-03-03	Synergy Pharmaceuticals, Inc.	Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
JP4718534B2 (ja) *	2007-11-09	2011-07-06	カルピス株式会社	Ｆｉｓｃｈｅｒ比低下抑制剤
EP2810951B1 (en)	2008-06-04	2017-03-15	Synergy Pharmaceuticals Inc.	Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
CN102149710A (zh)	2008-06-24	2011-08-10	百时美施贵宝公司	糖皮质激素受体、AP-1和/或NF-κB 活性的环戊噻吩调节剂及其用途
EP3241839B1 (en)	2008-07-16	2019-09-04	Bausch Health Ireland Limited	Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
WO2010132127A1 (en)	2009-05-13	2010-11-18	Intra-Cellular Therapies, Inc.	Organic compounds
US9616097B2 (en)	2010-09-15	2017-04-11	Synergy Pharmaceuticals, Inc.	Formulations of guanylate cyclase C agonists and methods of use
US8993631B2 (en)	2010-11-16	2015-03-31	Novartis Ag	Method of treating contrast-induced nephropathy
EP2956141A4 (en)	2013-02-17	2016-10-26	Intra Cellular Therapies Inc	NEW USES
EP2968439A2 (en)	2013-03-15	2016-01-20	Synergy Pharmaceuticals Inc.	Compositions useful for the treatment of gastrointestinal disorders
JP2016514671A (ja)	2013-03-15	2016-05-23	シナジーファーマシューティカルズインコーポレイテッド	グアニル酸シクラーゼのアゴニストおよびその使用
EP4424697A2 (en)	2013-06-05	2024-09-04	Bausch Health Ireland Limited	Ultra-pure agonists of guanylate cyclase c, method of making and using same
WO2015027021A1 (en)	2013-08-22	2015-02-26	Bristol-Myers Squibb Company	Imide and acylurea derivatives as modulators of the glucocorticoid receptor
WO2016022893A1 (en)	2014-08-07	2016-02-11	Intra-Cellular Therapies, Inc.	Organic compounds
US10961258B2 (en)	2015-12-21	2021-03-30	Glaxosmithkline Intellectual Property Development Limited	Heterocyclic amides as kinase inhibitors
JP2019510039A (ja)	2016-03-28	2019-04-11	イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−ＣｅｌｌｕｌａｒＴｈｅｒａｐｉｅｓ，Ｉｎｃ．	新規組成物および方法
CN106674228B (zh) *	2016-12-09	2018-12-04	河南农业大学	多元杂环化合物及其制备方法和用途
JP7401442B2 (ja)	2018-01-31	2023-12-19	イントラ－セルラー・セラピーズ・インコーポレイテッド	新規使用

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4105776A (en)	1976-06-21	1978-08-08	E. R. Squibb & Sons, Inc.	Proline derivatives and related compounds
US4339600A (en)	1976-05-10	1982-07-13	E. R. Squibb & Sons, Inc.	Compounds for alleviating angiotensin related hypertension
US4587050A (en)	1980-08-18	1986-05-06	Merck & Co., Inc.	Substituted enantholactam derivatives as antihypertensives
US4629787A (en)	1980-08-18	1986-12-16	Merck & Co., Inc.	Substituted caprolactam derivatives as antihypertensives
US4415496A (en)	1981-03-23	1983-11-15	Merck & Co., Inc.	Bicyclic lactams
US4587238A (en)	1981-07-06	1986-05-06	Merck & Co., Inc.	Substituted caprylolactam derivatives as anti-hypertensives
EP0094283B1 (fr)	1982-05-04	1985-11-21	Lipha, Lyonnaise Industrielle Pharmaceutique	Forme médicamenteuse de théophylline à action prolongée
US4873235A (en)	1982-06-01	1989-10-10	Merck & Co., Inc.	Benzofused lactams as antihypertensives
US4473575A (en)	1982-07-19	1984-09-25	Ciba-Geigy Corporation	3-Amino-(1)-benzazepin-2-one-1-alkanoic acids
US4465679A (en)	1983-01-31	1984-08-14	Usv Pharmaceutical Corporation	1,2-Diaza-3-one compounds, their use in treating hypertension and pharmaceutical compositions thereof
US4477464A (en)	1983-02-10	1984-10-16	Ciba-Geigy Corporation	Hetero-benzazepine derivatives and their pharmaceutical use
US4470988A (en)	1983-02-10	1984-09-11	Ciba-Geigy Corporation	Benzazocinone and benzazoninone derivatives, and their pharmaceutical use
US4460579A (en)	1983-02-28	1984-07-17	E. R. Squibb & Sons, Inc.	Thiazine and thiazepine containing compounds
US4711884A (en)	1983-02-28	1987-12-08	E. R. Squibb & Sons, Inc.	Thiazine and thiazepine containing compounds
US4617301A (en)	1983-06-22	1986-10-14	Merck & Co., Inc.	Sulfoxide and sulfone derivatives of bicyclic lactams as antihypertensives
US4539150A (en)	1983-06-29	1985-09-03	Mitsui Toatsu Chemicals, Inc.	Benzothiazepine derivatives and their methods of preparation
IL72523A (en)	1983-08-12	1988-06-30	Takeda Chemical Industries Ltd	3-amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine derivatives,their production and pharmaceutical compositions containing them
DE3402310A1 (de)	1984-01-24	1985-07-25	Bayer Ag, 5090 Leverkusen	Harte, geschlossenzellige, flammfeste polyurethanschaumstoffe
US4699905A (en)	1984-04-10	1987-10-13	Sankyo Company, Limited	Perhydrothiazepine derivatives, their preparation and their therapeutic use
JPH0637473B2 (ja)	1985-10-11	1994-05-18	三共株式会社	ラクタム化合物
US4801609B1 (en)	1987-03-27	1993-11-09		Mercapto-acylamino acid antihypertensives
CA2053340C (en) *	1990-10-18	2002-04-02	Timothy P. Burkholder	Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace

1993
- 1993-05-17 RU RU93036185/04A patent/RU2124503C1/ru not_active IP Right Cessation
- 1993-05-18 EP EP97200315A patent/EP0783002A3/en not_active Withdrawn
- 1993-05-18 DK DK93303835T patent/DK0599444T3/da active
- 1993-05-18 JP JP11587493A patent/JP3487611B2/ja not_active Expired - Fee Related
- 1993-05-18 NZ NZ247642A patent/NZ247642A/xx unknown
- 1993-05-18 CZ CZ1993936A patent/CZ289824B6/cs not_active IP Right Cessation
- 1993-05-18 MY MYPI93000910A patent/MY111370A/en unknown
- 1993-05-18 FI FI932249A patent/FI103337B1/fi active
- 1993-05-18 HU HU9301448A patent/HU217078B/hu not_active IP Right Cessation
- 1993-05-18 NO NO931795A patent/NO304372B1/no not_active IP Right Cessation
- 1993-05-18 PL PL93298988A patent/PL173036B1/pl not_active IP Right Cessation
- 1993-05-18 ES ES93303835T patent/ES2111712T3/es not_active Expired - Lifetime
- 1993-05-18 SG SG1996001951A patent/SG54138A1/en unknown
- 1993-05-18 SK SK499-93A patent/SK283556B6/sk unknown
- 1993-05-18 EP EP93303835A patent/EP0599444B1/en not_active Expired - Lifetime
- 1993-05-18 DE DE69316717T patent/DE69316717T2/de not_active Expired - Fee Related
- 1993-05-18 ZA ZA933461A patent/ZA933461B/xx unknown
- 1993-05-18 AU AU38627/93A patent/AU659550B2/en not_active Ceased
- 1993-05-18 IL IL105729A patent/IL105729A/en not_active IP Right Cessation
- 1993-05-18 AT AT93303835T patent/ATE162800T1/de not_active IP Right Cessation
- 1993-05-18 MX MX9302876A patent/MX9302876A/es not_active IP Right Cessation
- 1993-05-18 CA CA002096460A patent/CA2096460C/en not_active Expired - Fee Related
- 1993-05-18 KR KR1019930008448A patent/KR100288722B1/ko not_active IP Right Cessation
- 1993-05-18 CN CN93107593A patent/CN1039008C/zh not_active Expired - Fee Related
- 1993-05-19 TW TW082103946A patent/TW290544B/zh active
1995
- 1995-08-14 AU AU28525/95A patent/AU674629B2/en not_active Ceased
1997
- 1997-05-14 BR BR1101081-9A patent/BR1101081A/pt active IP Right Grant
1998
- 1998-03-27 HK HK98102619A patent/HK1003597A1/xx not_active IP Right Cessation
- 1998-04-15 GR GR980400870T patent/GR3026665T3/el unknown
- 1998-07-01 CY CY9800015A patent/CY2093B1/xx unknown
2000
- 2000-04-28 KR KR1020000022662A patent/KR100277453B1/ko not_active IP Right Cessation

Also Published As

Publication number	Publication date
IL105729A (en)	1998-01-04
HU217078B (hu)	1999-11-29
EP0783002A2 (en)	1997-07-09
TW290544B (no)	1996-11-11
HUT68391A (en)	1995-06-28
JP3487611B2 (ja)	2004-01-19
CN1039008C (zh)	1998-07-08
EP0599444B1 (en)	1998-01-28
DE69316717D1 (de)	1998-03-05
GR3026665T3 (en)	1998-07-31
IL105729A0 (en)	1993-09-22
NO304372B1 (no)	1998-12-07
CZ289824B6 (cs)	2002-04-17
MX9302876A (es)	1993-12-01
MY111370A (en)	1999-12-31
JPH0656790A (ja)	1994-03-01
NO931795L (no)	1993-11-19
CN1084849A (zh)	1994-04-06
CA2096460C (en)	2004-03-16
PL298988A1 (en)	1994-01-24
HU9301448D0 (en)	1993-09-28
PL173036B1 (pl)	1998-01-30
SK49993A3 (en)	1994-08-10
CA2096460A1 (en)	1993-11-19
DE69316717T2 (de)	1998-08-27
ZA933461B (en)	1993-12-14
ES2111712T3 (es)	1998-03-16
KR930023349A (ko)	1993-12-18
SK283556B6 (sk)	2003-09-11
AU3862793A (en)	1993-11-25
AU674629B2 (en)	1997-01-02
ATE162800T1 (de)	1998-02-15
SG54138A1 (en)	1998-11-16
KR100277453B1 (ko)	2000-12-15
AU659550B2 (en)	1995-05-18
FI932249A0 (fi)	1993-05-18
CY2093B1 (en)	2002-04-05
CZ93693A3 (en)	1993-12-15
DK0599444T3 (da)	1998-09-21
KR100288722B1 (ko)	2001-05-02
BR1101081A (pt)	2000-03-28
AU2852595A (en)	1995-10-19
FI103337B (fi)	1999-06-15
HK1003597A1 (en)	1998-10-30
FI103337B1 (fi)	1999-06-15
NZ247642A (en)	1995-09-26
RU2124503C1 (ru)	1999-01-10
FI932249A (fi)	1993-11-19
EP0599444A1 (en)	1994-06-01
EP0783002A3 (en)	1997-07-30

Publication	Publication Date	Title
NO931795D0 (no)	1993-05-18	Dobbeltvirkende inhibitorer
DE3378052D1 (en)	1988-10-27	Phosphonyl hydroxyacyl amino acid derivatives as antihypertensives
IT8922768A0 (it)	1989-12-21	Composti attivi come inibitori dell'enzima hmg-coa reduttasi
ATE171068T1 (de)	1998-10-15	Chinoloncarbonsäurederivate, ihre herstellung und ihre verwendung als zelladhäsion inhibitoren
BR9804214A (pt)	1999-12-14	Compostos.
ES2155069T3 (es)	2001-05-01	Inhibidores de proteasas retrovirales.
ES2059296T3 (es)	1996-07-16	Inhibidores de proteasas retrovirales.
ES2126697T3 (es)	1999-04-01	Inhibidores de enzimas de conversion de angiotensina que contienen lactamas de anillos multiples.
ATE196761T1 (de)	2000-10-15	Inhibitoren retroviraler proteasen
EP0310072A3 (en)	1989-11-29	Non-peptidyl beta-succinamidoacyl aminodiols as anti-hypertensive agents
EP0313847A3 (en)	1989-11-29	Non-peptidyl alpha-succinamidoacyl aminodiols as anti-hypertensive agents
IT8922767A0 (it)	1989-12-21	Composti attivi come inibitori dell'enzima hmg-coa reduttasi
FR2426685A2 (fr)	1979-12-21	Derives d'acides thiazolidinecarboxyliques et d'acides apparentes, utiles comme agents anti-hypertension
MA21068A1 (fr)	1988-04-01	Procede de preparation d'une composition a base d'inhibiteur de l'enzyme de conversion de l'angiotensine .
DE69025817D1 (de)	1996-04-18	3-Keto-HMG-CoA Reduktase-Inhibitoren

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