NO331834B1 - Stabilt farmasoytisk preparat for oral bruk, fremgangsmate for fremstilling derav, fremgangsmate for a hindre endringer i frigivelsesprofil for et legemiddel, og anvendelse av ferrioksid for dette. - Google Patents
Stabilt farmasoytisk preparat for oral bruk, fremgangsmate for fremstilling derav, fremgangsmate for a hindre endringer i frigivelsesprofil for et legemiddel, og anvendelse av ferrioksid for dette. Download PDFInfo
- Publication number
- NO331834B1 NO331834B1 NO20020516A NO20020516A NO331834B1 NO 331834 B1 NO331834 B1 NO 331834B1 NO 20020516 A NO20020516 A NO 20020516A NO 20020516 A NO20020516 A NO 20020516A NO 331834 B1 NO331834 B1 NO 331834B1
- Authority
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- Prior art keywords
- ferric oxide
- preparation
- weight
- drug
- oxide
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- NDLPOXTZKUMGOV-UHFFFAOYSA-N oxo(oxoferriooxy)iron hydrate Chemical compound O.O=[Fe]O[Fe]=O NDLPOXTZKUMGOV-UHFFFAOYSA-N 0.000 title claims abstract description 79
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- 229960002393 primidone Drugs 0.000 description 1
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- REQCZEXYDRLIBE-UHFFFAOYSA-N procainamide Chemical compound CCN(CC)CCNC(=O)C1=CC=C(N)C=C1 REQCZEXYDRLIBE-UHFFFAOYSA-N 0.000 description 1
- 229960000244 procainamide Drugs 0.000 description 1
- XWIHRGFIPXWGEF-UHFFFAOYSA-N propafenone hydrochloride Chemical compound Cl.CCCNCC(O)COC1=CC=CC=C1C(=O)CCC1=CC=CC=C1 XWIHRGFIPXWGEF-UHFFFAOYSA-N 0.000 description 1
- 229960002443 propafenone hydrochloride Drugs 0.000 description 1
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- 235000007682 pyridoxal 5'-phosphate Nutrition 0.000 description 1
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- 229960001520 ranitidine hydrochloride Drugs 0.000 description 1
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- 230000001105 regulatory effect Effects 0.000 description 1
- 229960002720 reproterol Drugs 0.000 description 1
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- 229960003147 reserpine Drugs 0.000 description 1
- 229940100486 rice starch Drugs 0.000 description 1
- 229960001534 risperidone Drugs 0.000 description 1
- RAPZEAPATHNIPO-UHFFFAOYSA-N risperidone Chemical compound FC1=CC=C2C(C3CCN(CC3)CCC=3C(=O)N4CCCCC4=NC=3C)=NOC2=C1 RAPZEAPATHNIPO-UHFFFAOYSA-N 0.000 description 1
- MDMGHDFNKNZPAU-UHFFFAOYSA-N roserpine Natural products C1C2CN3CCC(C4=CC=C(OC)C=C4N4)=C4C3CC2C(OC(C)=O)C(OC)C1OC(=O)C1=CC(OC)=C(OC)C(OC)=C1 MDMGHDFNKNZPAU-UHFFFAOYSA-N 0.000 description 1
- 229960002052 salbutamol Drugs 0.000 description 1
- 229950009846 scopolamine butylbromide Drugs 0.000 description 1
- 229960003946 selegiline Drugs 0.000 description 1
- MEZLKOACVSPNER-GFCCVEGCSA-N selegiline Chemical compound C#CCN(C)[C@H](C)CC1=CC=CC=C1 MEZLKOACVSPNER-GFCCVEGCSA-N 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 231100000019 skin ulcer Toxicity 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- LROWVYNUWKVTCU-STWYSWDKSA-M sodium sorbate Chemical compound [Na+].C\C=C\C=C\C([O-])=O LROWVYNUWKVTCU-STWYSWDKSA-M 0.000 description 1
- 235000019250 sodium sorbate Nutrition 0.000 description 1
- 229940084026 sodium valproate Drugs 0.000 description 1
- AEQFSUDEHCCHBT-UHFFFAOYSA-M sodium valproate Chemical compound [Na+].CCCC(C([O-])=O)CCC AEQFSUDEHCCHBT-UHFFFAOYSA-M 0.000 description 1
- 229960002920 sorbitol Drugs 0.000 description 1
- LXMSZDCAJNLERA-ZHYRCANASA-N spironolactone Chemical compound C([C@@H]1[C@]2(C)CC[C@@H]3[C@@]4(C)CCC(=O)C=C4C[C@H]([C@@H]13)SC(=O)C)C[C@@]21CCC(=O)O1 LXMSZDCAJNLERA-ZHYRCANASA-N 0.000 description 1
- 229960002256 spironolactone Drugs 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- MNQYNQBOVCBZIQ-JQOFMKNESA-A sucralfate Chemical compound O[Al](O)OS(=O)(=O)O[C@@H]1[C@@H](OS(=O)(=O)O[Al](O)O)[C@H](OS(=O)(=O)O[Al](O)O)[C@@H](COS(=O)(=O)O[Al](O)O)O[C@H]1O[C@@]1(COS(=O)(=O)O[Al](O)O)[C@@H](OS(=O)(=O)O[Al](O)O)[C@H](OS(=O)(=O)O[Al](O)O)[C@@H](OS(=O)(=O)O[Al](O)O)O1 MNQYNQBOVCBZIQ-JQOFMKNESA-A 0.000 description 1
- 229960004291 sucralfate Drugs 0.000 description 1
- 238000009495 sugar coating Methods 0.000 description 1
- NCEXYHBECQHGNR-QZQOTICOSA-N sulfasalazine Chemical compound C1=C(O)C(C(=O)O)=CC(\N=N\C=2C=CC(=CC=2)S(=O)(=O)NC=2N=CC=CC=2)=C1 NCEXYHBECQHGNR-QZQOTICOSA-N 0.000 description 1
- 229960001940 sulfasalazine Drugs 0.000 description 1
- NCEXYHBECQHGNR-UHFFFAOYSA-N sulfasalazine Natural products C1=C(O)C(C(=O)O)=CC(N=NC=2C=CC(=CC=2)S(=O)(=O)NC=2N=CC=CC=2)=C1 NCEXYHBECQHGNR-UHFFFAOYSA-N 0.000 description 1
- 229960004940 sulpiride Drugs 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 229950006156 teprenone Drugs 0.000 description 1
- 229960000351 terfenadine Drugs 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 229960000278 theophylline Drugs 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 229920001169 thermoplastic Polymers 0.000 description 1
- 239000004416 thermosoftening plastic Substances 0.000 description 1
- UIERGBJEBXXIGO-UHFFFAOYSA-N thiamine mononitrate Chemical compound [O-][N+]([O-])=O.CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N UIERGBJEBXXIGO-UHFFFAOYSA-N 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- 229960001196 thiotepa Drugs 0.000 description 1
- 229940125712 tocolytic agent Drugs 0.000 description 1
- 239000003675 tocolytic agent Substances 0.000 description 1
- 230000003195 tocolytic effect Effects 0.000 description 1
- 229940042585 tocopherol acetate Drugs 0.000 description 1
- 229960005371 tolbutamide Drugs 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 229960001288 triamterene Drugs 0.000 description 1
- 238000009827 uniform distribution Methods 0.000 description 1
- LNPDTQAFDNKSHK-UHFFFAOYSA-N valdecoxib Chemical compound CC=1ON=C(C=2C=CC=CC=2)C=1C1=CC=C(S(N)(=O)=O)C=C1 LNPDTQAFDNKSHK-UHFFFAOYSA-N 0.000 description 1
- 229960002004 valdecoxib Drugs 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 229940100445 wheat starch Drugs 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960004764 zafirlukast Drugs 0.000 description 1
- 239000005019 zein Substances 0.000 description 1
- 229940093612 zein Drugs 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14722299P | 1999-08-04 | 1999-08-04 | |
PCT/JP2000/005075 WO2001010466A1 (fr) | 1999-08-04 | 2000-08-01 | Compositions medicinales stables pour administration orale |
Publications (3)
Publication Number | Publication Date |
---|---|
NO20020516L NO20020516L (no) | 2002-02-01 |
NO20020516D0 NO20020516D0 (no) | 2002-02-01 |
NO331834B1 true NO331834B1 (no) | 2012-04-16 |
Family
ID=22520720
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20020516A NO331834B1 (no) | 1999-08-04 | 2002-02-01 | Stabilt farmasoytisk preparat for oral bruk, fremgangsmate for fremstilling derav, fremgangsmate for a hindre endringer i frigivelsesprofil for et legemiddel, og anvendelse av ferrioksid for dette. |
Country Status (17)
Country | Link |
---|---|
EP (1) | EP1205190B1 (zh) |
JP (1) | JP3462490B2 (zh) |
KR (1) | KR100507400B1 (zh) |
CN (1) | CN1193792C (zh) |
AT (1) | ATE324909T1 (zh) |
AU (1) | AU769807B2 (zh) |
CA (1) | CA2387705C (zh) |
DE (1) | DE60027728T2 (zh) |
DK (1) | DK1205190T3 (zh) |
ES (1) | ES2262528T3 (zh) |
HU (1) | HU229295B1 (zh) |
MX (1) | MXPA02001267A (zh) |
NO (1) | NO331834B1 (zh) |
PL (1) | PL200645B1 (zh) |
PT (1) | PT1205190E (zh) |
RU (1) | RU2220715C2 (zh) |
WO (1) | WO2001010466A1 (zh) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2005523334A (ja) * | 2002-04-24 | 2005-08-04 | サイプレス バイオサイエンス, インコーポレイテッド | ストレス関連障害を含む機能的身体障害の予防および処置 |
US7776314B2 (en) | 2002-06-17 | 2010-08-17 | Grunenthal Gmbh | Abuse-proofed dosage system |
ZA200409537B (en) * | 2003-01-31 | 2006-10-25 | Yamanouchi Pharma Co Ltd | Stable solid medicinal composition for oral administration |
US7442387B2 (en) * | 2003-03-06 | 2008-10-28 | Astellas Pharma Inc. | Pharmaceutical composition for controlled release of active substances and manufacturing method thereof |
DE10336400A1 (de) | 2003-08-06 | 2005-03-24 | Grünenthal GmbH | Gegen Missbrauch gesicherte Darreichungsform |
DE10361596A1 (de) | 2003-12-24 | 2005-09-29 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
DE102005005446A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Bruchfeste Darreichungsformen mit retardierter Freisetzung |
JP2005162736A (ja) * | 2003-11-10 | 2005-06-23 | Astellas Pharma Inc | 徐放性医薬組成物 |
JP2005162737A (ja) * | 2003-11-10 | 2005-06-23 | Astellas Pharma Inc | 徐放性医薬組成物 |
US7358270B2 (en) | 2004-01-30 | 2008-04-15 | Astellas Pharma Inc. | Treating agent for irritable bowel syndrome |
DE102004032049A1 (de) | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Gegen Missbrauch gesicherte, orale Darreichungsform |
DE102005005449A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
JP4632204B2 (ja) * | 2005-09-21 | 2011-02-16 | アステラス製薬株式会社 | 下痢型過敏性腸症候群治療剤 |
TWI478712B (zh) | 2008-09-30 | 2015-04-01 | Astellas Pharma Inc | 釋控性醫藥組成物 |
JP2012515757A (ja) * | 2009-01-20 | 2012-07-12 | マイクロ ラブス リミテッド | トリメタジジンの放出調節固形薬剤組成物及びその製造方法 |
ES2534908T3 (es) | 2009-07-22 | 2015-04-30 | Grünenthal GmbH | Forma de dosificación de liberación controlada extruida por fusión en caliente |
RU2567723C2 (ru) | 2009-07-22 | 2015-11-10 | Грюненталь Гмбх | Стабильная при окислении, прочная на излом лекарственная форма |
PT2554168T (pt) | 2010-03-29 | 2018-02-28 | Astellas Pharma Inc | Composição farmacêutica de libertação controlada |
BR112013005194A2 (pt) | 2010-09-02 | 2016-05-03 | Gruenenthal Gmbh | forma de dosagem resistente à violação compreendendo sal inorgânico |
KR102027912B1 (ko) | 2011-02-15 | 2019-10-02 | 지엘팜텍주식회사 | 경구투여용 탐술로신 또는 이의 약제학적으로 허용되는 염을 포함하는 서방성 삼중정제 |
CN103857386A (zh) | 2011-07-29 | 2014-06-11 | 格吕伦塔尔有限公司 | 提供药物立即释放的抗破碎片剂 |
JP2014524925A (ja) | 2011-07-29 | 2014-09-25 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 即時薬剤放出を提供するタンパーレジスタント錠剤 |
LT2838512T (lt) | 2012-04-18 | 2018-11-12 | GrĆ¼nenthal GmbH | Pažeidimui atspari ir dozės atpalaidavimo nuokrypiui atspari farmacinė vaisto forma |
US10064945B2 (en) | 2012-05-11 | 2018-09-04 | Gruenenthal Gmbh | Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc |
BR112015026549A2 (pt) | 2013-05-29 | 2017-07-25 | Gruenenthal Gmbh | forma de dosagem à prova de violação contendo uma ou mais partículas |
BR112016000194A8 (pt) | 2013-07-12 | 2019-12-31 | Gruenenthal Gmbh | forma de dosagem resistente à violação contendo o polímero de acetato de etileno-vinila |
BR112016010482B1 (pt) | 2013-11-26 | 2022-11-16 | Grünenthal GmbH | Preparação de uma composição farmacêutica em pó por meio de criomoagem |
AU2015261060A1 (en) | 2014-05-12 | 2016-11-03 | Grunenthal Gmbh | Tamper resistant immediate release capsule formulation comprising Tapentadol |
AU2015266117A1 (en) | 2014-05-26 | 2016-11-24 | Grunenthal Gmbh | Multiparticles safeguarded against ethanolic dose-dumping |
CA2980096C (en) | 2015-03-19 | 2019-12-17 | Daiichi Sankyo Company, Limited | Solid preparations of [(1r,5s,6s)-6-(aminomethyl)-3-ethylbicyclo[3.2.0]hept-3-en-6-yl]acetic acid monobenzenesulfonate stabilized by containing a specific antioxidant, and methodsfor preparing the same |
EP3513788B1 (en) * | 2015-03-19 | 2020-07-29 | Daiichi Sankyo Company, Limited | Solid preparation containing colorant |
EA035434B1 (ru) | 2015-04-24 | 2020-06-15 | Грюненталь Гмбх | Защищенная от применения не по назначению лекарственная форма с немедленным высвобождением и устойчивостью к экстракции растворителями |
TWI722988B (zh) | 2015-06-05 | 2021-04-01 | 瑩碩生技醫藥股份有限公司 | 緩釋性醫藥組合物及其製備方法 |
EP3346991A1 (en) | 2015-09-10 | 2018-07-18 | Grünenthal GmbH | Protecting oral overdose with abuse deterrent immediate release formulations |
PT3360866T (pt) | 2017-02-14 | 2019-02-19 | Tiefenbacher Alfred E Gmbh & Co Kg | Pró-fármacos de mirabegrom |
ES2943883T3 (es) | 2018-07-30 | 2023-06-16 | Daiichi Sankyo Co Ltd | Formulación de fármaco sólido que contiene estabilizador |
EP3722285B1 (en) | 2020-04-08 | 2022-03-30 | Alfred E. Tiefenbacher (GmbH & Co. KG) | Process for preparing mirabegron enacarbil |
US12097189B1 (en) | 2024-02-09 | 2024-09-24 | Astellas Pharma Inc. | Pharmaceutical composition for modified release |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL194389C (nl) * | 1984-06-14 | 2002-03-04 | Novartis Ag | Werkwijze voor het bereiden van een vaste dispersie van een farmaceutisch actief middel dat een lage oplosbaarheid in water heeft, in een vaste matrix van een in water oplosbaar polyalkyleenglycol als drager. |
US4859470A (en) * | 1988-06-02 | 1989-08-22 | Alza Corporation | Dosage form for delivering diltiazem |
HU206824B (en) * | 1990-08-24 | 1993-01-28 | Biogal Gyogyszergyar | Process for the production of a table crystallizing in the monoclinic system, which contains light-, heat-, and moisture- sensitive active agents |
JP2820829B2 (ja) * | 1991-03-07 | 1998-11-05 | 武田薬品工業株式会社 | 有核散剤およびその製造方法 |
JPH04346929A (ja) * | 1991-05-22 | 1992-12-02 | Takada Seiyaku Kk | 光に安定なメシル酸ブロモクリプチン製剤 |
AU5652796A (en) * | 1995-04-14 | 1996-10-30 | Pharma Pass Llc | Solid compositions containing polyethyleneoxide and a non-am orphous active principle |
CA2299464C (en) * | 1997-08-01 | 2009-02-17 | Elan Corporation, Plc | Controlled release pharmaceutical compositions containing tiagabine |
ATE241341T1 (de) * | 1997-09-10 | 2003-06-15 | Takeda Chemical Industries Ltd | Stabilisierte pharmazeutische zusammensetzung |
-
2000
- 2000-08-01 EP EP00948291A patent/EP1205190B1/en not_active Expired - Lifetime
- 2000-08-01 DE DE60027728T patent/DE60027728T2/de not_active Expired - Lifetime
- 2000-08-01 JP JP2001514982A patent/JP3462490B2/ja not_active Expired - Lifetime
- 2000-08-01 CA CA002387705A patent/CA2387705C/en not_active Expired - Lifetime
- 2000-08-01 RU RU2002102701/15A patent/RU2220715C2/ru active
- 2000-08-01 WO PCT/JP2000/005075 patent/WO2001010466A1/ja active IP Right Grant
- 2000-08-01 PT PT00948291T patent/PT1205190E/pt unknown
- 2000-08-01 HU HU0202495A patent/HU229295B1/hu unknown
- 2000-08-01 AU AU61821/00A patent/AU769807B2/en not_active Expired
- 2000-08-01 ES ES00948291T patent/ES2262528T3/es not_active Expired - Lifetime
- 2000-08-01 KR KR10-2002-7001437A patent/KR100507400B1/ko active IP Right Review Request
- 2000-08-01 MX MXPA02001267A patent/MXPA02001267A/es active IP Right Grant
- 2000-08-01 CN CNB008112517A patent/CN1193792C/zh not_active Expired - Lifetime
- 2000-08-01 DK DK00948291T patent/DK1205190T3/da active
- 2000-08-01 AT AT00948291T patent/ATE324909T1/de active
- 2000-08-01 PL PL353154A patent/PL200645B1/pl unknown
-
2002
- 2002-02-01 NO NO20020516A patent/NO331834B1/no not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
PL353154A1 (en) | 2003-10-20 |
EP1205190B1 (en) | 2006-05-03 |
KR100507400B1 (ko) | 2005-08-10 |
HUP0202495A3 (en) | 2004-05-28 |
AU769807B2 (en) | 2004-02-05 |
PL200645B1 (pl) | 2009-01-30 |
NO20020516L (no) | 2002-02-01 |
EP1205190A4 (en) | 2004-01-21 |
ATE324909T1 (de) | 2006-06-15 |
MXPA02001267A (es) | 2002-08-12 |
RU2220715C2 (ru) | 2004-01-10 |
KR20020046277A (ko) | 2002-06-20 |
CA2387705C (en) | 2009-06-30 |
DK1205190T3 (da) | 2006-08-14 |
PT1205190E (pt) | 2006-09-29 |
CN1193792C (zh) | 2005-03-23 |
EP1205190A1 (en) | 2002-05-15 |
JP3462490B2 (ja) | 2003-11-05 |
DE60027728T2 (de) | 2007-04-26 |
HU229295B1 (en) | 2013-10-28 |
DE60027728D1 (de) | 2006-06-08 |
NO20020516D0 (no) | 2002-02-01 |
AU6182100A (en) | 2001-03-05 |
CA2387705A1 (en) | 2001-02-15 |
CN1373673A (zh) | 2002-10-09 |
ES2262528T3 (es) | 2006-12-01 |
HUP0202495A2 (hu) | 2002-11-28 |
WO2001010466A1 (fr) | 2001-02-15 |
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