NO328575B1 - Anvendelse av suberoylanilidhydroksyaminsyre (SAHA) for fremstilling av et oralt medikament for behandling av mesoteliom - Google Patents

Anvendelse av suberoylanilidhydroksyaminsyre (SAHA) for fremstilling av et oralt medikament for behandling av mesoteliom Download PDF

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Publication number: NO328575B1
Authority: NO; Norway
Prior art keywords: saha; treatment; dose; oral; acid
Prior art date: 2003-08-26

Application number

NO20061348A

Other languages

English (en)

Norwegian (no)

Other versions

NO20061348L (no

Inventor

Victoria M Richon

Nicholas G Bacopoulos

Judy H Chiao

Thomas A Miller

Carolyn M Paradise

Original Assignee

Sloan Kettering Inst Cancer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-08-26

Filing date

2006-03-24

Publication date

2010-03-22

2003-08-26 Priority claimed from US10/650,025 external-priority patent/US7148257B2/en

2003-09-16 Priority claimed from US10/665,079 external-priority patent/US20040127523A1/en

2006-03-24 Application filed by Sloan Kettering Inst Cancer filed Critical Sloan Kettering Inst Cancer

2006-05-23 Publication of NO20061348L publication Critical patent/NO20061348L/no

2010-03-22 Publication of NO328575B1 publication Critical patent/NO328575B1/no

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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids

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Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Organic Chemistry (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Hematology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Prostheses (AREA)
Steroid Compounds (AREA)
Diaphragms For Electromechanical Transducers (AREA)
Electrotherapy Devices (AREA)

NO20061348A 2003-08-26 2006-03-24 Anvendelse av suberoylanilidhydroksyaminsyre (SAHA) for fremstilling av et oralt medikament for behandling av mesoteliom NO328575B1 (no)

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Application Number	Priority Date	Filing Date	Title
US10/650,025 US7148257B2 (en)	2002-03-04	2003-08-26	Methods of treating mesothelioma with suberoylanilide hydroxamic acid
US10/665,079 US20040127523A1 (en)	2002-03-04	2003-09-16	Methods of treating cancer with HDAC inhibitors
PCT/US2004/027943 WO2005018578A2 (en)	2003-08-26	2004-08-26	Method of treating cancer with hdac inhibitors

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US (1)	US20090012175A1 (sl)
EP (2)	EP1663194B1 (sl)
JP (2)	JP4338734B2 (sl)
KR (1)	KR100924737B1 (sl)
CN (1)	CN102188415A (sl)
AT (1)	ATE462426T1 (sl)
AU (1)	AU2004266169B9 (sl)
BR (1)	BRPI0413826A (sl)
CA (1)	CA2535806C (sl)
DE (1)	DE602004026321D1 (sl)
DK (1)	DK1663194T3 (sl)
EC (1)	ECSP066452A (sl)
ES (1)	ES2345775T3 (sl)
HR (1)	HRP20060080A2 (sl)
IL (1)	IL173846A0 (sl)
MA (1)	MA28209A1 (sl)
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NZ (2)	NZ560485A (sl)
PL (2)	PL1663194T3 (sl)
PT (1)	PT1663194E (sl)
RU (1)	RU2356547C2 (sl)
SI (1)	SI1663194T1 (sl)
WO (1)	WO2005018578A2 (sl)

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JP2008524246A (ja)	2004-12-16	2008-07-10	タケダサンディエゴインコーポレイテッド	ヒストンデアセチラーゼ阻害剤
US20060135612A1 (en) *	2004-12-17	2006-06-22	U.S. Department Of Veterans Affairs	Method of ameliorating or abrogating the effects of a neurodegenerative disorder, such as amyotrophic lateral sclerosis (ALS), by using a HDAC inhibiting agent
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EP3354265A1 (en)	2005-03-22	2018-08-01	President and Fellows of Harvard College	Treatment of solid tumors
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TWI415603B (zh) *	2005-05-20	2013-11-21	Merck Sharp & Dohme	１，８－辛二醯基苯胺羥胺酸（ｓｕｂｅｒｏｙｌａｎｉｌｉｄｅｈｙｄｒｏｘａｍｉｃａｃｉｄ）之調配物及其製配方法
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WO2007056135A1 (en) *	2005-11-04	2007-05-18	Merck & Co., Inc.	Method of treating cancers with saha and pemetrexed
WO2007056243A2 (en) *	2005-11-04	2007-05-18	Merck & Co. Inc.	Methods of treating cancers with saha and fluorouracil and other combination therapies
JP5377968B2 (ja) *	2005-11-10	2013-12-25	トポターゲットユーケーリミテッド	癌治療のために単独で用いるまたは化学療法薬と併用するヒストンデアセチラーゼ（ｈｄａｃ）阻害剤
WO2008091349A1 (en)	2006-02-14	2008-07-31	The President And Fellows Of Harvard College	Bifunctional histone deacetylase inhibitors
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AU2004266169B9 (en)	2007-05-10
AU2004266169A1 (en)	2005-03-03
US20090012175A1 (en)	2009-01-08
PT1663194E (pt)	2010-07-06
KR20070029617A (ko)	2007-03-14
AU2004266169A2 (en)	2006-04-06
CN102188415A (zh)	2011-09-21
NZ545935A (en)	2009-02-28
NZ560485A (en)	2009-03-31
HRP20060080A2 (en)	2006-07-31
EP1663194A2 (en)	2006-06-07
IL173846A0 (en)	2006-07-05
DK1663194T3 (da)	2010-07-19
CA2535806A1 (en)	2005-03-03
RU2356547C2 (ru)	2009-05-27
ECSP066452A (es)	2006-09-18
AU2004266169B2 (en)	2007-05-03
SI1663194T1 (sl)	2010-08-31
ATE462426T1 (de)	2010-04-15
EP1663194A4 (en)	2007-09-19
PL379887A1 (pl)	2006-11-27
CA2535806C (en)	2009-02-17
JP4914411B2 (ja)	2012-04-11
MA28209A1 (fr)	2006-10-02
JP2007518694A (ja)	2007-07-12
WO2005018578A3 (en)	2005-05-12
DE602004026321D1 (de)	2010-05-12
EP2201947A2 (en)	2010-06-30
EP2201947A3 (en)	2010-08-11
RU2006109467A (ru)	2007-10-10
EP1663194B1 (en)	2010-03-31
ES2345775T3 (es)	2010-10-01
NO20061348L (no)	2006-05-23
PL1663194T3 (pl)	2011-01-31
JP4338734B2 (ja)	2009-10-07
KR100924737B1 (ko)	2009-11-04
WO2005018578A2 (en)	2005-03-03
BRPI0413826A (pt)	2006-10-24
JP2009073834A (ja)	2009-04-09

Publication	Publication Date	Title
NO328575B1 (no)	2010-03-22	Anvendelse av suberoylanilidhydroksyaminsyre (SAHA) for fremstilling av et oralt medikament for behandling av mesoteliom
EP2082737B1 (en)	2014-12-31	Methods of inducing terminal differentiation
US7375137B2 (en)	2008-05-20	Methods of treating cancer with HDAC inhibitors
US8101663B2 (en)	2012-01-24	Polymorphs of suberoylanilide hydroxamic acid
US20080249179A1 (en)	2008-10-09	Methods of treating cancer with HDAC inhibitors
CN1870985B (zh)	2011-11-30	用hdac抑制剂治疗癌症的方法
AU2007203525C1 (en)	2009-02-05	Methods of Inducing Terminal Differentiation
HK1131065A (en)	2010-01-15	Methods of inducing terminal differentiation
HK1158082A (en)	2012-07-13	Methods of inducing terminal differentiation
KR20050020760A (ko)	2005-03-04	말단 분화의 유도 방법

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