NO317989B1 - Nye dipeptidylpeptidase IV effektorer og anvendelse derav, samt farmasoytisk preparat - Google Patents

Nye dipeptidylpeptidase IV effektorer og anvendelse derav, samt farmasoytisk preparat Download PDF

Info

Publication number: NO317989B1
Authority: NO; Norway
Prior art keywords: pharmaceutical preparation; salts; compound; preparation according; dipeptide
Prior art date: 1998-05-28

Application number

NO20005994A

Other languages

English (en)

Norwegian (no)

Other versions

NO20005994L (no

NO20005994D0 (no

Inventor

Hans-Ulrich Demuth

Konrad Glund

Dagmar Schlenzig

Susanne Kruber

Original Assignee

Prosidion Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-05-28

Filing date

2000-11-27

Publication date

2005-01-17

2000-11-27 Application filed by Prosidion Ltd filed Critical Prosidion Ltd

2000-11-27 Publication of NO20005994D0 publication Critical patent/NO20005994D0/no

2001-01-25 Publication of NO20005994L publication Critical patent/NO20005994L/no

2005-01-17 Publication of NO317989B1 publication Critical patent/NO317989B1/no

Links

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- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
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- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
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- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Diabetes (AREA)
Obesity (AREA)
Hematology (AREA)
Emergency Medicine (AREA)
Urology & Nephrology (AREA)
Endocrinology (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Thiazole And Isothizaole Compounds (AREA)
Pyrrole Compounds (AREA)
Saccharide Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Detergent Compositions (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

NO20005994A 1998-05-28 2000-11-27 Nye dipeptidylpeptidase IV effektorer og anvendelse derav, samt farmasoytisk preparat NO317989B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19823831A DE19823831A1 (de)	1998-05-28	1998-05-28	Neue pharmazeutische Verwendung von Isoleucyl Thiazolidid und seinen Salzen
PCT/EP1999/003712 WO1999061431A1 (fr)	1998-05-28	1999-05-28	Nouveaux effecteurs de dipeptidylpeptidase iv

Publications (3)

Publication Number	Publication Date
NO20005994D0 NO20005994D0 (no)	2000-11-27
NO20005994L NO20005994L (no)	2001-01-25
NO317989B1 true NO317989B1 (no)	2005-01-17

Family

ID=7869159

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Application Number	Title	Priority Date	Filing Date
NO20005994A NO317989B1 (no)	1998-05-28	2000-11-27	Nye dipeptidylpeptidase IV effektorer og anvendelse derav, samt farmasoytisk preparat

Country Status (24)

Country	Link
US (4)	US6548481B1 (fr)
EP (6)	EP1428533B1 (fr)
JP (1)	JP2002516318A (fr)
KR (2)	KR100628668B1 (fr)
CN (4)	CN1332954C (fr)
AT (6)	ATE231497T1 (fr)
AU (1)	AU764262B2 (fr)
BR (1)	BR9910758A (fr)
CA (1)	CA2333603C (fr)
DE (10)	DE19823831A1 (fr)
DK (2)	DK1304327T3 (fr)
ES (5)	ES2238641T3 (fr)
HK (3)	HK1033316A1 (fr)
HU (1)	HUP0102001A3 (fr)
IL (3)	IL139862A0 (fr)
IS (3)	IS5728A (fr)
NO (1)	NO317989B1 (fr)
NZ (2)	NZ508260A (fr)
PL (1)	PL344403A1 (fr)
PT (2)	PT1214936E (fr)
RU (3)	RU2309161C2 (fr)
SI (2)	SI1082314T1 (fr)
UA (1)	UA54599C2 (fr)
WO (1)	WO1999061431A1 (fr)

Families Citing this family (242)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20020006899A1 (en) *	1998-10-06	2002-01-17	Pospisilik Andrew J.	Use of dipeptidyl peptidase IV effectors for lowering blood pressure in mammals
DE69837393T2 (de) *	1997-09-29	2007-12-06	Point Therapeutics, Inc., Boston	Stimulierung von hämatopoietischen zellen im vitro
DE19823831A1 (de) *	1998-05-28	1999-12-02	Probiodrug Ges Fuer Arzneim	Neue pharmazeutische Verwendung von Isoleucyl Thiazolidid und seinen Salzen
DE19828113A1 (de)	1998-06-24	2000-01-05	Probiodrug Ges Fuer Arzneim	Prodrugs von Inhibitoren der Dipeptidyl Peptidase IV
DE19834591A1 (de) *	1998-07-31	2000-02-03	Probiodrug Ges Fuer Arzneim	Verfahren zur Steigerung des Blutglukosespiegels in Säugern
US6979697B1 (en) *	1998-08-21	2005-12-27	Point Therapeutics, Inc.	Regulation of substrate activity
US20030176357A1 (en) *	1998-10-06	2003-09-18	Pospisilik Andrew J.	Dipeptidyl peptidase IV inhibitors and their uses for lowering blood pressure levels
AU3960400A (en) *	1999-03-05	2000-09-28	Molteni L. E C. Dei Fratelli Alitti Societa' Di Esercizio S.P.A.	Use of metformin in the preparation of pharmaceutical compositions capable of inhibiting the enzyme dipeptidyl peptidase iv
US6548529B1 (en)	1999-04-05	2003-04-15	Bristol-Myers Squibb Company	Heterocyclic containing biphenyl aP2 inhibitors and method
US6890904B1 (en) *	1999-05-25	2005-05-10	Point Therapeutics, Inc.	Anti-tumor agents
DE19940130A1 (de)	1999-08-24	2001-03-01	Probiodrug Ges Fuer Arzneim	Neue Effektoren der Dipeptidyl Peptidase IV zur topischen Anwendung
WO2001044179A1 (fr) *	1999-12-17	2001-06-21	Versicor, Inc.	Nouveaux composes a base de succinate, compositions les contenant, et procedes d'utilisation et de preparation de ceux-ci
BRPI0107715B8 (pt) *	2000-01-21	2021-05-25	Novartis Ag	produto farmacêutico compreendendo um inibidor de dipeptidilpeptidase-iv e metformina, bem como usos do dito produto farmacêutico e do inibidor de dipeptidilpeptidase-iv
US20080076811A1 (en) *	2000-01-21	2008-03-27	Bork Balkan	Combinations comprising depeptidypeptidase-iv inhibitors and antidiabetic agents
WO2001062266A2 (fr) *	2000-02-25	2001-08-30	Novo Nordisk A/S	Inhibition de la degenerescence des cellules beta
DK2055302T3 (da) †	2000-03-31	2014-10-27	Royalty Pharma Collection Trust	Fremgangsmåde til forbedring af signalering af øceller ved diabetes mellitus og til forebyggelse deraf
GB0010183D0 (en) *	2000-04-26	2000-06-14	Ferring Bv	Inhibitors of dipeptidyl peptidase IV
GB0014969D0 (en) *	2000-06-19	2000-08-09	Smithkline Beecham Plc	Novel method of treatment
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- 1999-05-28 AT AT99926464T patent/ATE231497T1/de active
- 1999-05-28 AT AT03026947T patent/ATE338546T1/de not_active IP Right Cessation
- 1999-05-28 DE DE59904100T patent/DE59904100D1/de not_active Expired - Lifetime
- 1999-05-28 JP JP2000550837A patent/JP2002516318A/ja active Pending
- 1999-05-28 DK DK03001324T patent/DK1304327T3/da active
- 1999-05-28 DE DE29909210U patent/DE29909210U1/de not_active Expired - Lifetime
- 1999-05-28 CA CA002333603A patent/CA2333603C/fr not_active Expired - Fee Related
- 1999-05-28 SI SI9930209T patent/SI1082314T1/xx unknown
- 1999-05-28 SI SI9930771T patent/SI1304327T1/xx unknown
- 1999-05-28 KR KR1020007013350A patent/KR100628668B1/ko not_active IP Right Cessation
- 1999-05-28 EP EP04005976A patent/EP1428533B1/fr not_active Expired - Lifetime
- 1999-05-28 RU RU2003121766/04A patent/RU2309161C2/ru not_active IP Right Cessation
- 1999-05-28 DK DK02005353T patent/DK1214936T3/da active
- 1999-05-28 RU RU2000133251/04A patent/RU2227800C2/ru not_active IP Right Cessation
- 1999-05-28 EP EP99926464A patent/EP1082314B1/fr not_active Expired - Lifetime
- 1999-05-28 ES ES04005976T patent/ES2271723T3/es not_active Expired - Lifetime
- 1999-05-28 EP EP02005352A patent/EP1215207B1/fr not_active Expired - Lifetime
- 1999-05-28 EP EP02005353A patent/EP1214936B1/fr not_active Expired - Lifetime
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- 1999-05-28 DE DE59911670T patent/DE59911670D1/de not_active Expired - Fee Related
- 1999-05-28 PT PT02005353T patent/PT1214936E/pt unknown
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- 1999-05-28 DE DE59910083T patent/DE59910083D1/de not_active Expired - Fee Related
- 1999-05-28 CN CNA2004100833079A patent/CN1637018A/zh active Pending
- 1999-05-28 EP EP03001324A patent/EP1304327B1/fr not_active Expired - Lifetime
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- 1999-05-28 CN CNA2007101369808A patent/CN101095675A/zh active Pending
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- 1999-05-28 AU AU43709/99A patent/AU764262B2/en not_active Ceased
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- 1999-05-28 EP EP03026947A patent/EP1398030B1/fr not_active Expired - Lifetime
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2001
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2002
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2003
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- 2003-07-14 HK HK03105067.4A patent/HK1052708B/zh not_active IP Right Cessation
- 2003-12-02 US US10/727,209 patent/US20050203030A1/en not_active Abandoned
2004
- 2004-01-15 RU RU2004101292/15A patent/RU2004101292A/ru not_active Application Discontinuation
2005
- 2005-03-21 IS IS7764A patent/IS2130B/xx unknown
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2006
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Also Published As

Publication number	Publication date
HK1052708B (zh)	2005-05-27
HK1047887A1 (en)	2003-03-14
WO1999061431A1 (fr)	1999-12-02
ES2271723T3 (es)	2007-04-16
RU2003121766A (ru)	2005-02-10
US6548481B1 (en)	2003-04-15
JP2002516318A (ja)	2002-06-04
DE59911670D1 (de)	2005-03-31
NO20005994L (no)	2001-01-25
IS7763A (is)	2005-03-21
EP1214936A3 (fr)	2002-07-03
ATE336248T1 (de)	2006-09-15
EP1214936B1 (fr)	2004-07-28
NZ525799A (en)	2004-09-24
PT1214936E (pt)	2004-12-31
DK1214936T3 (da)	2004-12-06
AU764262B2 (en)	2003-08-14
CA2333603C (fr)	2007-07-31
ES2238641T3 (es)	2005-09-01
KR20010071335A (ko)	2001-07-28
EP1082314B1 (fr)	2003-04-23
US20050203030A1 (en)	2005-09-15
ES2223981T3 (es)	2005-03-01
CA2333603A1 (fr)	1999-12-02
RU2309161C2 (ru)	2007-10-27
EP1398030A2 (fr)	2004-03-17
HK1033316A1 (en)	2001-08-24
CN101095675A (zh)	2008-01-02
BR9910758A (pt)	2001-02-13
US20080182798A1 (en)	2008-07-31
KR100628668B1 (ko)	2006-09-27
ATE289598T1 (de)	2005-03-15
ES2271458T3 (es)	2007-04-16
RU2227800C2 (ru)	2004-04-27
KR100630258B1 (ko)	2006-10-02
NO20005994D0 (no)	2000-11-27
IS2089B (is)	2006-03-15
HK1052708A1 (en)	2003-09-26
EP1214936A2 (fr)	2002-06-19
ATE231497T1 (de)	2003-02-15
ATE271869T1 (de)	2004-08-15
EP1304327A3 (fr)	2003-05-02
EP1304327B1 (fr)	2005-02-23
SI1304327T1 (fr)	2005-08-31
EP1398030A3 (fr)	2004-04-07
IS5728A (is)	2000-11-24
DE19823831A1 (de)	1999-12-02
CN1637018A (zh)	2005-07-13
DE59910084D1 (de)	2004-09-02
DE59910083D1 (de)	2004-09-02
SI1082314T1 (en)	2003-08-31
EP1082314A1 (fr)	2001-03-14
IL139862A0 (en)	2002-02-10
ES2193709T3 (es)	2003-11-01
ATE272059T1 (de)	2004-08-15
DE59913784D1 (de)	2006-09-28
DE29909210U1 (de)	1999-09-09
ATE338546T1 (de)	2006-09-15
DE29909211U1 (de)	1999-09-23
KR20040063979A (ko)	2004-07-15
IS7764A (is)	2005-03-21
IL139862A (en)	2006-08-20
IS2130B (is)	2006-07-14
CN1332954C (zh)	2007-08-22
EP1215207B1 (fr)	2004-07-28
EP1215207A2 (fr)	2002-06-19
IL175407A0 (en)	2006-09-05
EP1428533B1 (fr)	2006-08-16
PL344403A1 (en)	2001-11-05
DK1304327T3 (da)	2005-06-27
UA54599C2 (uk)	2003-03-17
CN1303381A (zh)	2001-07-11
AU4370999A (en)	1999-12-13
RU2004101292A (ru)	2005-06-20
NZ508260A (en)	2003-06-30
HUP0102001A2 (hu)	2001-11-28
US20030134802A1 (en)	2003-07-17
HUP0102001A3 (en)	2001-12-28
CN1636593A (zh)	2005-07-13
PT1304327E (pt)	2005-07-29
EP1428533A3 (fr)	2004-06-23
EP1304327A2 (fr)	2003-04-23
EP1428533A2 (fr)	2004-06-16
EP1215207A3 (fr)	2002-07-03
DE59904100D1 (de)	2003-02-27
DE29909208U1 (de)	1999-09-09
EP1398030B1 (fr)	2006-09-06
DE59913840D1 (de)	2006-10-19
HK1047887B (zh)	2005-05-13

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NO317989B1 (no)	2005-01-17	Nye dipeptidylpeptidase IV effektorer og anvendelse derav, samt farmasoytisk preparat
EP1385508B1 (fr)	2008-05-21	Inhibiteurs de peptidase dipeptidyl destines au traitement ou a la prevention du diabete
US6380398B2 (en)	2002-04-30	Therapeutically active and selective heterocyclic compounds that are inhibitors of the enzyme DPP-IV
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US20020006899A1 (en)	2002-01-17	Use of dipeptidyl peptidase IV effectors for lowering blood pressure in mammals
EA015735B1 (ru)	2011-10-31	Фармацевтические композиции на основе 2-[[6-[(3r)-3-амино-1-пиперидинил]-3,4-дигидро-3-метил-2,4-диоксо-1(2н)-пиримидинил]метил]бензонитрила
WO2001055105A1 (fr)	2001-08-02	2-cyanopyroles et -pyrrolines a substitution n inhibant l'enzyme dpp-iv
US9212179B2 (en)	2015-12-15	Compositions and methods for the treatment of metabolic disorders
AU2003262286B2 (en)	2006-03-23	Novel Effectors of Dipeptidyl Peptidase IV
CN101784285A (zh)	2010-07-21	用于与低氧或局部缺血有关的眼科疾病的组合物
MXPA00011600A (en)	2002-05-09	New dipeptidyl peptidase iv effectors
AU2006202684A1 (en)	2006-07-13	Novel effectors of dipeptidyl peptidase IV
CZ20004427A3 (cs)	2001-05-16	Nové efektory dipeptidylpeptidasy IV