NO302736B1 - Farmasöytisk preparat omfattende tramadol og ibuprofen - Google Patents

Farmasöytisk preparat omfattende tramadol og ibuprofen Download PDF

Info

Publication number: NO302736B1
Authority: NO; Norway
Prior art keywords: tramadol; ibuprofen; analgesic; opioid; compositions
Prior art date: 1991-10-30

Application number

NO924169A

Other languages

English (en)

Norwegian (no)

Other versions

NO924169L (no

NO924169D0 (no

Inventor

Robert B Raffa

Original Assignee

Mcneilab Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-10-30

Filing date

1992-10-29

Publication date

1998-04-20

1992-10-29 Application filed by Mcneilab Inc filed Critical Mcneilab Inc

1992-10-29 Publication of NO924169D0 publication Critical patent/NO924169D0/no

1993-05-03 Publication of NO924169L publication Critical patent/NO924169L/no

1998-04-20 Publication of NO302736B1 publication Critical patent/NO302736B1/no

Links

TVYLLZQTGLZFBW-ZBFHGGJFSA-N (R,R)-tramadol Chemical compound COC1=CC=CC([C@]2(O)[C@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-ZBFHGGJFSA-N 0.000 title claims abstract description 36
229960004380 tramadol Drugs 0.000 title claims abstract description 36
TVYLLZQTGLZFBW-GOEBONIOSA-N tramadol Natural products COC1=CC=CC([C@@]2(O)[C@@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-GOEBONIOSA-N 0.000 title claims abstract description 36
229960001680 ibuprofen Drugs 0.000 title claims description 38
HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 title claims description 37
239000000825 pharmaceutical preparation Substances 0.000 title claims description 9
239000003814 drug Substances 0.000 claims description 22
229940079593 drug Drugs 0.000 claims description 19
150000003839 salts Chemical class 0.000 claims description 3
230000003637 steroidlike Effects 0.000 claims description 3
230000002757 inflammatory effect Effects 0.000 claims description 2
230000000694 effects Effects 0.000 abstract description 21
239000000203 mixture Substances 0.000 abstract description 11
229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 abstract description 10
239000000041 non-steroidal anti-inflammatory agent Substances 0.000 abstract description 9
230000036407 pain Effects 0.000 abstract description 6
230000000144 pharmacologic effect Effects 0.000 abstract description 5
230000002195 synergetic effect Effects 0.000 abstract description 5
239000000463 material Substances 0.000 abstract description 4
206010010774 Constipation Diseases 0.000 abstract description 3
208000004756 Respiratory Insufficiency Diseases 0.000 abstract description 3
206010038678 Respiratory depression Diseases 0.000 abstract description 3
230000000294 tussive effect Effects 0.000 abstract 1
238000002360 preparation method Methods 0.000 description 21
230000000202 analgesic effect Effects 0.000 description 14
PPKXEPBICJTCRU-XMZRARIVSA-N (R,R)-tramadol hydrochloride Chemical compound Cl.COC1=CC=CC([C@]2(O)[C@H](CCCC2)CN(C)C)=C1 PPKXEPBICJTCRU-XMZRARIVSA-N 0.000 description 11
239000000730 antalgic agent Substances 0.000 description 11
229960003107 tramadol hydrochloride Drugs 0.000 description 11
RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 10
229940121367 non-opioid analgesics Drugs 0.000 description 10
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 10
241000699670 Mus sp. Species 0.000 description 8
229940005483 opioid analgesics Drugs 0.000 description 8
230000036592 analgesia Effects 0.000 description 7
239000012153 distilled water Substances 0.000 description 7
239000000014 opioid analgesic Substances 0.000 description 7
230000003187 abdominal effect Effects 0.000 description 5
OIPILFWXSMYKGL-UHFFFAOYSA-N acetylcholine Chemical compound CC(=O)OCC[N+](C)(C)C OIPILFWXSMYKGL-UHFFFAOYSA-N 0.000 description 5
229960004373 acetylcholine Drugs 0.000 description 5
229940035676 analgesics Drugs 0.000 description 5
229960005489 paracetamol Drugs 0.000 description 5
BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 4
206010022998 Irritability Diseases 0.000 description 4
229960001138 acetylsalicylic acid Drugs 0.000 description 4
238000000034 method Methods 0.000 description 4
BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 description 4
235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 4
229920000053 polysorbate 80 Polymers 0.000 description 4
239000003826 tablet Substances 0.000 description 4
-1 aspirin Chemical compound 0.000 description 3
239000002775 capsule Substances 0.000 description 3
206010052804 Drug tolerance Diseases 0.000 description 2
241000699666 Mus <mouse, genus> Species 0.000 description 2
239000004480 active ingredient Substances 0.000 description 2
230000000996 additive effect Effects 0.000 description 2
239000002585 base Substances 0.000 description 2
239000000969 carrier Substances 0.000 description 2
OROGSEYTTFOCAN-DNJOTXNNSA-N codeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC OROGSEYTTFOCAN-DNJOTXNNSA-N 0.000 description 2
150000001875 compounds Chemical class 0.000 description 2
XYYVYLMBEZUESM-UHFFFAOYSA-N dihydrocodeine Natural products C1C(N(CCC234)C)C2C=CC(=O)C3OC2=C4C1=CC=C2OC XYYVYLMBEZUESM-UHFFFAOYSA-N 0.000 description 2
239000003937 drug carrier Substances 0.000 description 2
239000012458 free base Substances 0.000 description 2
230000026781 habituation Effects 0.000 description 2
OROGSEYTTFOCAN-UHFFFAOYSA-N hydrocodone Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OC OROGSEYTTFOCAN-UHFFFAOYSA-N 0.000 description 2
230000003993 interaction Effects 0.000 description 2
239000007788 liquid Substances 0.000 description 2
229960005181 morphine Drugs 0.000 description 2
239000000843 powder Substances 0.000 description 2
239000003755 preservative agent Substances 0.000 description 2
239000007787 solid Substances 0.000 description 2
239000000243 solution Substances 0.000 description 2
235000000346 sugar Nutrition 0.000 description 2
239000000725 suspension Substances 0.000 description 2
229960001017 tolmetin Drugs 0.000 description 2
UPSPUYADGBWSHF-UHFFFAOYSA-N tolmetin Chemical compound C1=CC(C)=CC=C1C(=O)C1=CC=C(CC(O)=O)N1C UPSPUYADGBWSHF-UHFFFAOYSA-N 0.000 description 2
239000003981 vehicle Substances 0.000 description 2
UYHNNWQKLGPQQX-UHFFFAOYSA-N 2-[2-(2-methylpropyl)phenyl]propanoic acid Chemical compound CC(C)CC1=CC=CC=C1C(C)C(O)=O UYHNNWQKLGPQQX-UHFFFAOYSA-N 0.000 description 1
QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 description 1
USSIQXCVUWKGNF-UHFFFAOYSA-N 6-(dimethylamino)-4,4-diphenylheptan-3-one Chemical compound C=1C=CC=CC=1C(CC(C)N(C)C)(C(=O)CC)C1=CC=CC=C1 USSIQXCVUWKGNF-UHFFFAOYSA-N 0.000 description 1
206010011224 Cough Diseases 0.000 description 1
206010060800 Hot flush Diseases 0.000 description 1
241000124008 Mammalia Species 0.000 description 1
229940127450 Opioid Agonists Drugs 0.000 description 1
BRUQQQPBMZOVGD-XFKAJCMBSA-N Oxycodone Chemical compound O=C([C@@H]1O2)CC[C@@]3(O)[C@H]4CC5=CC=C(OC)C2=C5[C@@]13CCN4C BRUQQQPBMZOVGD-XFKAJCMBSA-N 0.000 description 1
241000282320 Panthera leo Species 0.000 description 1
229920002472 Starch Polymers 0.000 description 1
238000000692 Student's t-test Methods 0.000 description 1
241000011102 Thera Species 0.000 description 1
210000003489 abdominal muscle Anatomy 0.000 description 1
ZEHGKSPCAMLJDC-UHFFFAOYSA-M acetylcholine bromide Chemical compound [Br-].CC(=O)OCC[N+](C)(C)C ZEHGKSPCAMLJDC-UHFFFAOYSA-M 0.000 description 1
239000000654 additive Substances 0.000 description 1
239000000443 aerosol Substances 0.000 description 1
239000000556 agonist Substances 0.000 description 1
150000001298 alcohols Chemical class 0.000 description 1
125000003277 amino group Chemical group 0.000 description 1
230000002456 anti-arthritic effect Effects 0.000 description 1
239000002260 anti-inflammatory agent Substances 0.000 description 1
230000003110 anti-inflammatory effect Effects 0.000 description 1
239000002221 antipyretic Substances 0.000 description 1
229940125716 antipyretic agent Drugs 0.000 description 1
230000009286 beneficial effect Effects 0.000 description 1
230000008901 benefit Effects 0.000 description 1
239000011230 binding agent Substances 0.000 description 1
IFKLAQQSCNILHL-QHAWAJNXSA-N butorphanol Chemical compound N1([C@@H]2CC3=CC=C(C=C3[C@@]3([C@]2(CCCC3)O)CC1)O)CC1CCC1 IFKLAQQSCNILHL-QHAWAJNXSA-N 0.000 description 1
229960001113 butorphanol Drugs 0.000 description 1
229960004126 codeine Drugs 0.000 description 1
238000013329 compounding Methods 0.000 description 1
230000008602 contraction Effects 0.000 description 1
125000000753 cycloalkyl group Chemical group 0.000 description 1
238000001514 detection method Methods 0.000 description 1
229960000920 dihydrocodeine Drugs 0.000 description 1
RBOXVHNMENFORY-DNJOTXNNSA-N dihydrocodeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC RBOXVHNMENFORY-DNJOTXNNSA-N 0.000 description 1
239000003085 diluting agent Substances 0.000 description 1
239000007884 disintegrant Substances 0.000 description 1
239000002270 dispersing agent Substances 0.000 description 1
239000002552 dosage form Substances 0.000 description 1
231100000673 dose–response relationship Toxicity 0.000 description 1
239000000975 dye Substances 0.000 description 1
238000011156 evaluation Methods 0.000 description 1
230000001747 exhibiting effect Effects 0.000 description 1
238000013401 experimental design Methods 0.000 description 1
210000001035 gastrointestinal tract Anatomy 0.000 description 1
150000002334 glycols Chemical class 0.000 description 1
239000003979 granulating agent Substances 0.000 description 1
LLPOLZWFYMWNKH-CMKMFDCUSA-N hydrocodone Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)CC(=O)[C@@H]1OC1=C2C3=CC=C1OC LLPOLZWFYMWNKH-CMKMFDCUSA-N 0.000 description 1
229960000240 hydrocodone Drugs 0.000 description 1
239000004615 ingredient Substances 0.000 description 1
230000002401 inhibitory effect Effects 0.000 description 1
230000005764 inhibitory process Effects 0.000 description 1
238000002347 injection Methods 0.000 description 1
239000007924 injection Substances 0.000 description 1
238000001990 intravenous administration Methods 0.000 description 1
238000010253 intravenous injection Methods 0.000 description 1
239000000314 lubricant Substances 0.000 description 1
230000007246 mechanism Effects 0.000 description 1
229960001797 methadone Drugs 0.000 description 1
239000003921 oil Substances 0.000 description 1
239000003402 opiate agonist Substances 0.000 description 1
239000006186 oral dosage form Substances 0.000 description 1
229960002085 oxycodone Drugs 0.000 description 1
ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
229940068968 polysorbate 80 Drugs 0.000 description 1
230000002335 preservative effect Effects 0.000 description 1
230000009467 reduction Effects 0.000 description 1
230000004044 response Effects 0.000 description 1
238000010561 standard procedure Methods 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
239000008223 sterile water Substances 0.000 description 1
201000009032 substance abuse Diseases 0.000 description 1
150000008163 sugars Chemical class 0.000 description 1
239000000375 suspending agent Substances 0.000 description 1
230000035900 sweating Effects 0.000 description 1
238000012360 testing method Methods 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
231100000027 toxicology Toxicity 0.000 description 1
LLPOLZWFYMWNKH-UHFFFAOYSA-N trans-dihydrocodeinone Natural products C1C(N(CCC234)C)C2CCC(=O)C3OC2=C4C1=CC=C2OC LLPOLZWFYMWNKH-UHFFFAOYSA-N 0.000 description 1
238000005303 weighing Methods 0.000 description 1
229960003414 zomepirac Drugs 0.000 description 1
ZXVNMYWKKDOREA-UHFFFAOYSA-N zomepirac Chemical compound C1=C(CC(O)=O)N(C)C(C(=O)C=2C=CC(Cl)=CC=2)=C1C ZXVNMYWKKDOREA-UHFFFAOYSA-N 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Pain & Pain Management (AREA)
General Chemical & Material Sciences (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Rheumatology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

NO924169A 1991-10-30 1992-10-29 Farmasöytisk preparat omfattende tramadol og ibuprofen NO302736B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US78513791A	1991-10-30	1991-10-30
JP4328751A JPH06157301A (ja)	1991-10-30	1992-11-13	トラマドール物質及び非ステロイド抗炎症薬を含んで成る組成物

Publications (3)

Publication Number	Publication Date
NO924169D0 NO924169D0 (no)	1992-10-29
NO924169L NO924169L (no)	1993-05-03
NO302736B1 true NO302736B1 (no)	1998-04-20

Family

ID=26572968

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO924169A NO302736B1 (no)	1991-10-30	1992-10-29	Farmasöytisk preparat omfattende tramadol og ibuprofen

Country Status (21)

Country	Link
EP (1)	EP0546676B1 (ko)
JP (1)	JPH06157301A (ko)
KR (1)	KR100236562B1 (ko)
CN (1)	CN1072930C (ko)
AT (1)	ATE285237T1 (ko)
AU (1)	AU661723B2 (ko)
CA (1)	CA2081604C (ko)
DE (1)	DE69233462T2 (ko)
DK (1)	DK0546676T3 (ko)
EG (1)	EG20041A (ko)
ES (1)	ES2235152T3 (ko)
HU (1)	HUT63557A (ko)
IL (1)	IL103594A (ko)
MX (1)	MX9206257A (ko)
NO (1)	NO302736B1 (ko)
NZ (1)	NZ244916A (ko)
PH (1)	PH31378A (ko)
PT (1)	PT546676E (ko)
SG (1)	SG55086A1 (ko)
ZA (1)	ZA928372B (ko)
ZW (1)	ZW17892A1 (ko)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
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US5478577A (en) *	1993-11-23	1995-12-26	Euroceltique, S.A.	Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level
US5968551A (en)	1991-12-24	1999-10-19	Purdue Pharma L.P.	Orally administrable opioid formulations having extended duration of effect
US5958459A (en) *	1991-12-24	1999-09-28	Purdue Pharma L.P.	Opioid formulations having extended controlled released
IL109460A (en)	1993-05-10	1998-03-10	Euro Celtique Sa	Controlled release formulation comprising tramadol
IL110014A (en)	1993-07-01	1999-11-30	Euro Celtique Sa	Solid controlled-release oral dosage forms of opioid analgesics
US7740881B1 (en)	1993-07-01	2010-06-22	Purdue Pharma Lp	Method of treating humans with opioid formulations having extended controlled release
US5879705A (en) *	1993-07-27	1999-03-09	Euro-Celtique S.A.	Sustained release compositions of morphine and a method of preparing pharmaceutical compositions
KR100354702B1 (ko)	1993-11-23	2002-12-28	유로-셀티크 소시에떼 아노뉨	약학조성물의제조방법및서방형조성물
US5891471A (en)	1993-11-23	1999-04-06	Euro-Celtique, S.A.	Pharmaceutical multiparticulates
US5843480A (en)	1994-03-14	1998-12-01	Euro-Celtique, S.A.	Controlled release diamorphine formulation
GB9422154D0 (en)	1994-11-03	1994-12-21	Euro Celtique Sa	Pharmaceutical compositions and method of producing the same
US5965161A (en)	1994-11-04	1999-10-12	Euro-Celtique, S.A.	Extruded multi-particulates
DE19630035A1 (de) *	1996-07-25	1998-01-29	Asta Medica Ag	Tramadol Multiple Unit Formulierungen
DE19641576C1 (de) *	1996-10-09	1998-05-07	Gruenenthal Gmbh	Kombinationspräparat enthaltend Tramadol und einen Calcium-Kanal Antagonisten
DE19712398A1 (de) *	1997-03-25	1998-10-01	Gruenenthal Gmbh	Orale Anwendung von (+)-0-Demethyltramadol als Schmerzmittel
RS49982B (sr)	1997-09-17	2008-09-29	Euro-Celtique S.A.,	Sinergistička analgetička kombinacija analgetičkog opijata i inhibitora ciklooksigenaze-2
US6806294B2 (en)	1998-10-15	2004-10-19	Euro-Celtique S.A.	Opioid analgesic
AU3384200A (en) *	1999-03-01	2000-09-21	Ortho-Mcneil Pharmaceutical, Inc.	Composition comprising a tramadol material and a selective cox-2 inhibitor drug
DE19918325A1 (de)	1999-04-22	2000-10-26	Euro Celtique Sa	Verfahren zur Herstellung von Arzneiformen mit regulierter Wirkstofffreisetzung mittels Extrusion
DE19927688A1 (de) *	1999-06-17	2000-12-21	Gruenenthal Gmbh	Mehrschichttablette zur Verabreichung einer fixen Kombination von Tramadol und Diclofenac
US8173164B2 (en)	1999-06-17	2012-05-08	Gruenenthal Gmbh	Oral administration forms for administering a fixed tramadol and diclofenac combination
DE19927689A1 (de) *	1999-06-17	2000-12-21	Gruenenthal Gmbh	Orale Darreichungsformen zur Verabreichung einer fixen Kombination von Tramadol und Diclofenac
DE19940944B4 (de) *	1999-08-31	2006-10-12	Grünenthal GmbH	Retardierte, orale, pharmazeutische Darreichungsformen
US10179130B2 (en)	1999-10-29	2019-01-15	Purdue Pharma L.P.	Controlled release hydrocodone formulations
EP2295043A1 (en)	1999-10-29	2011-03-16	Euro-Celtique S.A.	Controlled release hydrocodone formulations
CN100518827C (zh)	2000-10-30	2009-07-29	欧罗赛铁克股份有限公司	控释氢可酮制剂
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1992
- 1992-10-26 AU AU27328/92A patent/AU661723B2/en not_active Expired
- 1992-10-28 CA CA002081604A patent/CA2081604C/en not_active Expired - Lifetime
- 1992-10-28 KR KR1019920019908A patent/KR100236562B1/ko not_active IP Right Cessation
- 1992-10-28 NZ NZ244916A patent/NZ244916A/en not_active IP Right Cessation
- 1992-10-29 HU HU9203399A patent/HUT63557A/hu unknown
- 1992-10-29 NO NO924169A patent/NO302736B1/no not_active IP Right Cessation
- 1992-10-29 DK DK92309930T patent/DK0546676T3/da active
- 1992-10-29 ZA ZA928372A patent/ZA928372B/xx unknown
- 1992-10-29 ES ES92309930T patent/ES2235152T3/es not_active Expired - Lifetime
- 1992-10-29 AT AT92309930T patent/ATE285237T1/de active
- 1992-10-29 PH PH45191A patent/PH31378A/en unknown
- 1992-10-29 EG EG66492A patent/EG20041A/xx active
- 1992-10-29 SG SG1996005376A patent/SG55086A1/en unknown
- 1992-10-29 PT PT92309930T patent/PT546676E/pt unknown
- 1992-10-29 ZW ZW17892A patent/ZW17892A1/xx unknown
- 1992-10-29 EP EP92309930A patent/EP0546676B1/en not_active Expired - Lifetime
- 1992-10-29 MX MX9206257A patent/MX9206257A/es unknown
- 1992-10-29 DE DE69233462T patent/DE69233462T2/de not_active Expired - Lifetime
- 1992-10-29 IL IL103594A patent/IL103594A/xx not_active IP Right Cessation
- 1992-10-30 CN CN92113759A patent/CN1072930C/zh not_active Expired - Lifetime
- 1992-11-13 JP JP4328751A patent/JPH06157301A/ja active Pending

Also Published As

Publication number	Publication date
NO924169L (no)	1993-05-03
DK0546676T3 (da)	2005-03-07
NO924169D0 (no)	1992-10-29
KR100236562B1 (ko)	2000-03-02
DE69233462T2 (de)	2006-02-16
SG55086A1 (en)	1998-12-21
HUT63557A (en)	1993-09-28
KR930007450A (ko)	1993-05-20
EP0546676B1 (en)	2004-12-22
DE69233462D1 (de)	2005-01-27
EP0546676A1 (en)	1993-06-16
CA2081604C (en)	2004-01-27
PH31378A (en)	1998-10-29
EG20041A (en)	1997-03-27
ES2235152T3 (es)	2005-07-01
JPH06157301A (ja)	1994-06-03
CN1073095A (zh)	1993-06-16
ZW17892A1 (en)	1994-06-01
ATE285237T1 (de)	2005-01-15
IL103594A (en)	1997-03-18
IL103594A0 (en)	1993-03-15
AU661723B2 (en)	1995-08-03
AU2732892A (en)	1993-05-06
ZA928372B (en)	1994-04-29
MX9206257A (es)	1993-11-01
HU9203399D0 (en)	1993-01-28
CN1072930C (zh)	2001-10-17
NZ244916A (en)	1995-04-27
PT546676E (pt)	2005-03-31
CA2081604A1 (en)	1993-05-01

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WO2004026291A1 (fr)	2004-04-01	Formulations orales d'ibuprofene et de tramadol, methodes de preparation de ces dernieres
JPS646169B2 (ko)	1989-02-02
Acri et al.	1995	Characterization of the Discriminative Stimulus Effects of Benztropine, A Potential Cocaine Therapeutic Agent
WO1997048390A1 (en)	1997-12-24	Analgesics combining acetaminophen with meclizine
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MXPA00000522A (en)	2001-12-04	Treatment and prevention of cardiac disorders using selective serotonin re-uptake inhibitors (ssri)

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