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NO3004079T3 - - Google Patents

Info

Publication number
NO3004079T3
NO3004079T3 NO14727562A NO14727562A NO3004079T3 NO 3004079 T3 NO3004079 T3 NO 3004079T3 NO 14727562 A NO14727562 A NO 14727562A NO 14727562 A NO14727562 A NO 14727562A NO 3004079 T3 NO3004079 T3 NO 3004079T3
Authority
NO
Norway
Application number
NO14727562A
Other languages
Norwegian (no)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of NO3004079T3 publication Critical patent/NO3004079T3/no

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
NO14727562A 2013-06-04 2014-06-03 NO3004079T3 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE1350685 2013-06-04
PCT/EP2014/061503 WO2014195323A1 (fr) 2013-06-04 2014-06-03 Composés de pyrimidine et leur utilisation comme modulateurs de la gamma-sécrétase

Publications (1)

Publication Number Publication Date
NO3004079T3 true NO3004079T3 (fr) 2018-06-16

Family

ID=50877325

Family Applications (1)

Application Number Title Priority Date Filing Date
NO14727562A NO3004079T3 (fr) 2013-06-04 2014-06-03

Country Status (9)

Country Link
US (1) US9439904B2 (fr)
EP (1) EP3004079B1 (fr)
JP (1) JP6368777B2 (fr)
CN (1) CN105263923B (fr)
DK (1) DK3004079T3 (fr)
ES (1) ES2665421T3 (fr)
NO (1) NO3004079T3 (fr)
PL (1) PL3004079T3 (fr)
WO (1) WO2014195323A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3481829B1 (fr) * 2016-07-08 2021-04-07 H. Hoffnabb-La Roche Ag Dérivés fusionnés de pyrimidine
CN108191776A (zh) * 2018-01-22 2018-06-22 无锡富泽药业有限公司 一种尿嘧啶的绿色生产工艺
WO2020247707A1 (fr) * 2019-06-05 2020-12-10 Chunyu Wang SYSTÈME ET PROCÉDÉ D'INHIBITION DE LA PRODUCTION DE γ-SÉCRÉTASE ET DE PEPTIDES β-AMYLOÏDES
CN110372603A (zh) * 2019-06-24 2019-10-25 南京普锐达医药科技有限公司 一种2-氯-5-氟-6-乙基嘧啶的合成方法
IL306008A (en) 2021-03-23 2023-11-01 Halia Therapeutics Inc Pyrimidine derivatives are useful as LRRK2 kinase inhibitors

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2348234A1 (fr) * 1998-10-29 2000-05-11 Chunjian Liu Composes derives d'un noyau amine inhibiteurs de l'enzyme impdh
ITMI20030312A1 (it) 2003-02-21 2004-08-22 Chiesi Farma Spa Derivati di acidi 2-fenil-2-alchil-acetici per il trattamento della malattia di alzheimer.
ATE464048T1 (de) 2003-08-07 2010-04-15 Merck Sharp & Dohme Behandlung von alzheimer-krankheit und verwandten zuständen
US20070142453A1 (en) 2003-12-03 2007-06-21 Dirk Beher 1-Alkyl-3-thio-substituted indole-2-alkynoic acids useful for the treatment of alzheimer's disease and related conditions
EP2261218B1 (fr) 2004-05-26 2013-04-03 Eisai R&D Management Co., Ltd. Imidazolverbindung zur Verwendung als Intermediat in der Herstellung von Cinnamid-Verbindungen
CN103626742B (zh) * 2005-11-01 2017-04-26 塔格根公司 激酶的联-芳基间-嘧啶抑制剂
US8389547B2 (en) 2006-04-26 2013-03-05 Yudith Garcia Piperidines and related compounds for the treatment of Alzheimer's disease
WO2007135969A1 (fr) 2006-05-19 2007-11-29 Eisai R & D Management Co., Ltd. Dérivé de cinnamide de type urée
JP2009184924A (ja) 2006-05-31 2009-08-20 Eisai R & D Management Co Ltd 生物学的試薬用化合物
JP2010518080A (ja) 2007-02-08 2010-05-27 メルク・シャープ・エンド・ドーム・コーポレイション 治療薬
WO2008100412A1 (fr) 2007-02-12 2008-08-21 Merck & Co., Inc. Dérivés de la pipéridine
EP2121633A2 (fr) 2007-02-12 2009-11-25 Merck & Co., Inc. Dérivés de pipérazine pour le traitement de la maladie d'alzheimer et des conditions apparentées
US8242150B2 (en) 2007-06-13 2012-08-14 Merck Sharp & Dohme Corp. Triazole derivatives for treating alzheimer'S disease and related conditions
PE20090957A1 (es) 2007-08-06 2009-07-13 Schering Corp Moduladores de gamma secretasa
BRPI0906799A2 (pt) 2008-01-11 2015-07-14 Hoffmann La Roche Moduladores para amiloide beta
AU2009216851B2 (en) * 2008-02-22 2013-11-07 F. Hoffmann-La Roche Ag Modulators for amyloid beta
MX2011003246A (es) * 2008-10-09 2011-04-21 Hoffmann La Roche Moduladores de beta amiloide.
AU2009311756B2 (en) * 2008-11-06 2012-05-03 Astrazeneca Ab Modulators of amyloid beta.
EP2355817A1 (fr) 2008-11-10 2011-08-17 F. Hoffmann-La Roche AG Modulateurs de la gamma secrétase hétérocyclique
TW201030002A (en) 2009-01-16 2010-08-16 Bristol Myers Squibb Co Bicyclic compounds for the reduction of beta-amyloid production
UY32622A (es) * 2009-05-12 2010-12-31 Astrazeneca Ab Nuevos compuestos para el tratamiento de patologías relacionadas con ab(beta)
EA021047B1 (ru) 2009-07-15 2015-03-31 Янссен Фармасьютикалз, Инк. Замещенные производные триазола и имидазола в качестве модуляторов гамма-секретазы
TWI468402B (zh) 2009-07-31 2015-01-11 必治妥美雅史谷比公司 降低β-類澱粉生成之化合物
KR20130028048A (ko) 2010-01-15 2013-03-18 얀센 파마슈티칼즈, 인코포레이티드 감마 세크레타제 조절제로서의 신규 치환된 트리아졸 유도체
US20110190269A1 (en) 2010-02-01 2011-08-04 Karlheinz Baumann Gamma secretase modulators
TW201206946A (en) 2010-07-15 2012-02-16 Bristol Myers Squibb Co Compounds for the reduction of beta-amyloid production

Also Published As

Publication number Publication date
JP6368777B2 (ja) 2018-08-01
EP3004079A1 (fr) 2016-04-13
JP2016520637A (ja) 2016-07-14
PL3004079T3 (pl) 2018-07-31
CN105263923A (zh) 2016-01-20
US9439904B2 (en) 2016-09-13
CN105263923B (zh) 2017-06-23
DK3004079T3 (en) 2018-04-16
ES2665421T3 (es) 2018-04-25
US20160129002A1 (en) 2016-05-12
EP3004079B1 (fr) 2018-01-17
WO2014195323A1 (fr) 2014-12-11

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