NO306303B1 - Kondensert benzazepinderivat og farmasöytisk preparat derav - Google Patents

Kondensert benzazepinderivat og farmasöytisk preparat derav

Info

Publication number: NO306303B1
Authority: NO; Norway
Prior art keywords: pharmaceutical preparation; benzazepine derivative; condensed benzazepine; condensed; derivative
Prior art date: 1993-07-21

Application number

NO960231A

Other languages

English (en)

Norwegian (no)

Other versions

NO960231D0 (no

NO960231L (no

Inventor

Akihiro Tanaka

Hiroyuki Koshio

Nobuaki Taniguchi

Akira Matsuhisa

Ken-Ichiro Sakamoto

Atsuki Yamazaki

Takeyuki Yatsu

Original Assignee

Yamanouchi Pharma Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-07-21

Filing date

1996-01-19

Publication date

1999-10-18

1996-01-19 Application filed by Yamanouchi Pharma Co Ltd filed Critical Yamanouchi Pharma Co Ltd

1996-01-19 Publication of NO960231D0 publication Critical patent/NO960231D0/no

1996-03-21 Publication of NO960231L publication Critical patent/NO960231L/no

1999-10-18 Publication of NO306303B1 publication Critical patent/NO306303B1/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Diabetes (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Hematology (AREA)
Gastroenterology & Hepatology (AREA)
Heart & Thoracic Surgery (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Obesity (AREA)
Cardiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Output Control And Ontrol Of Special Type Engine (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

NO960231A 1993-07-21 1996-01-19 Kondensert benzazepinderivat og farmasöytisk preparat derav NO306303B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP18043593		1993-07-21
PCT/JP1994/001183 WO1995003305A1 (fr)	1993-07-21	1994-07-19	Derive de benzazepine de fusion et composition pharmaceutique renfermant ce derive

Publications (3)

Publication Number	Publication Date
NO960231D0 NO960231D0 (no)	1996-01-19
NO960231L NO960231L (no)	1996-03-21
NO306303B1 true NO306303B1 (no)	1999-10-18

Family

ID=16083198

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO960231A NO306303B1 (no)	1993-07-21	1996-01-19	Kondensert benzazepinderivat og farmasöytisk preparat derav

Country Status (18)

Country	Link
US (2)	US5723606A (es)
EP (2)	EP0709386B1 (es)
KR (1)	KR100304331B1 (es)
CN (1)	CN1040210C (es)
AT (2)	ATE277003T1 (es)
AU (2)	AU683483B2 (es)
CA (1)	CA2167673C (es)
DE (2)	DE69432632T2 (es)
ES (2)	ES2228405T3 (es)
FI (1)	FI113178B (es)
HU (1)	HUT74582A (es)
NO (1)	NO306303B1 (es)
NZ (1)	NZ268671A (es)
PL (1)	PL177738B1 (es)
RU (1)	RU2129123C1 (es)
TW (1)	TW279163B (es)
UA (1)	UA64690C2 (es)
WO (1)	WO1995003305A1 (es)

Families Citing this family (34)

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US5693635A (en) *	1993-07-29	1997-12-02	American Cyanamid Company	Tricyclic benzazepine vasopressin antagonists
US5760031A (en) *	1993-07-29	1998-06-02	American Cyanamid Company	Tricyclic benzazepine vasopressin antagonists
AR002459A1 (es) *	1995-01-17	1998-03-25	American Cyanamid Co	Antagonistas de vasopresina de benzacepina triciclicos, una composicion farmaceutica que los contiene, un metodo para tratar enfermedades y unprocedimiento para su preparacion.
US6268359B1 (en)	1998-01-28	2001-07-31	Senju Pharmaceutical Co., Ltd.	Preventives or remedies for vision disorders
AR018818A1 (es) *	1998-04-03	2001-12-12	Yamano Masaki	Una composicion farmaceutica para la terapia de un edema.
WO1999065525A1 (fr) *	1998-06-19	1999-12-23	Wakamoto Pharmaceutical Co., Ltd.	Agents permettant d'abaisser la tension oculaire et derives d'ester phosphorique
US7015212B1 (en)	1999-05-12	2006-03-21	The United States Of America As Represented By The Department Of Health And Human Services	Thiazepine inhibitors of HIV-1 integrase
US6765004B1 (en) *	1999-06-17	2004-07-20	Ortho-Mcneil Pharmaceutical, Inc.	Indoloazepines as vasopressin receptor antagonists
US6437006B1 (en)	1999-09-27	2002-08-20	American Cyanamid Company	Pharmaceutical carrier formulation
US20030103983A1 (en) *	2002-05-09	2003-06-05	Pressler Milton Lethan	Ace inhibitor-vasopressin antagonist combinations
AU2001214778A1 (en)	2000-01-26	2001-08-07	Warner Lambert Company	Method for preventing or treating postoperative ileus
MXPA02006352A (es) *	2000-01-26	2002-11-29	Warner Lambert Co	Combinaciones del inhibidor ace con el antagonista vasopresina.
US20030008860A1 (en) *	2002-05-09	2003-01-09	Bakker-Arkema Rebecca Guggemos	Treatment of congestive heart failure
CA2357833C (en)	2000-10-04	2005-11-15	Warner-Lambert Company	Treatment of pulmonary hypertension using vasopressin antagonist
AU779929B2 (en) *	2000-10-04	2005-02-17	Warner-Lambert Company	Treatment of pulmonary hypertension
AU2002224115A1 (en) *	2000-11-28	2002-06-11	Yamanouchi Pharmaceutical Co., Ltd.	1,4,5,6-tetrahydroimidazo(4,5-d)diazepine derivatives or salts thereof
JP5165586B2 (ja) *	2005-12-28	2013-03-21	バーテックスファーマシューティカルズインコーポレイテッド	嚢胞性線維症の処置のためのＡＴＰ結合カセットトランスポーターのモジュレーターとしての、１−（ベンゾ［ｄ］［１，３］ジオキソール−５−イル）−Ｎ−（フェニル）シクロプロパン−カルボキサミド誘導体および関連化合物
US7671221B2 (en) *	2005-12-28	2010-03-02	Vertex Pharmaceuticals Incorporated	Modulators of ATP-Binding Cassette transporters
US20080221084A1 (en) *	2006-10-30	2008-09-11	Otsuka Pharmaceutical Co., Ltd.	Method for reducing infarction using vasopressin antagonist compounds, and compositions and combinations therefor
US20090069295A1 (en) *	2007-09-09	2009-03-12	Protia, Llc	Deuterium-enriched conivaptan
WO2009089305A1 (en) *	2008-01-07	2009-07-16	Synta Pharmaceuticals Corp.	Compounds for inflammation and immune-related uses
WO2009102761A1 (en) *	2008-02-12	2009-08-20	Bristol-Myers Squibb Company	1,2,3-triazoles as 11-beta hydroxysteroid dehydrogenase type i inhibitors
EP2315751A1 (en) *	2008-06-26	2011-05-04	Amgen Inc.	Alkynyl alcohols as kinase inhibitors
IN2012DN03343A (es) *	2009-10-26	2015-10-23	Otsuka Pharma Co Ltd
US20150238502A1 (en)	2012-10-18	2015-08-27	University Of South Florida	Compositions and Methods for Treating Stroke
CN103497195B (zh) *	2013-10-21	2016-01-27	北京科莱博医药开发有限责任公司	盐酸考尼伐坦新晶型及其制备方法
CN105310978A (zh) *	2014-08-04	2016-02-10	李峰	一种含有活性成分盐酸考尼伐坦的药物组合物及其制剂
CN105884778A (zh) *	2014-09-24	2016-08-24	李峰	一种化合物和制备方法
CN105153168A (zh) *	2015-09-29	2015-12-16	上海天慈国际药业有限公司	N-[4-(2-甲基-4,5-二氢-3H-咪唑并[4,5-d][1]苯并氮杂卓-6-甲酰基)苯基]-2-苯基苯甲酰胺盐酸盐的制备方法
CN106317060B (zh) *	2016-08-22	2019-02-15	山东罗欣药业集团恒欣药业有限公司	一种盐酸考尼伐坦的制备方法
US11498903B2 (en)	2017-08-17	2022-11-15	Bristol-Myers Squibb Company	2-(1,1′-biphenyl)-1H-benzodimidazole derivatives and related compounds as apelin and APJ agonists for treating cardiovascular diseases
TW201938171A (zh)	2017-12-15	2019-10-01	匈牙利商羅特格登公司	作為血管升壓素Ｖ１ａ受體拮抗劑之三環化合物
HU231206B1 (hu)	2017-12-15	2021-10-28	Richter Gedeon Nyrt.	Triazolobenzazepinek
TWI831088B (zh) *	2020-11-26	2024-02-01	大陸商上海濟煜醫藥科技有限公司	新型苯并氮雜卓螺環衍生物

Family Cites Families (10)

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Publication number	Priority date	Publication date	Assignee	Title
US5011628A (en) *	1988-06-15	1991-04-30	Givaudan Corporation	N,N'-diarylbenzamidines useful as ultraviolet light absorbers
EP0346713B1 (en) *	1988-06-15	1992-09-16	L. GIVAUDAN & CIE Société Anonyme	Benzamidines useful as ultraviolet light absorbers
US5225402A (en) *	1989-02-10	1993-07-06	Otsuka Pharmaceutical Co., Ltd.	Carbostyril derivatives
DE122009000062I2 (de) *	1989-10-20	2011-01-13	Otsuka Pharma Co Ltd	Benzoheterozyklische verbindungen
JP2905909B2 (ja) *	1991-04-19	1999-06-14	大塚製薬株式会社	バソプレシン拮抗剤
US5258510A (en) *	1989-10-20	1993-11-02	Otsuka Pharma Co Ltd	Benzoheterocyclic compounds
JPH03255077A (ja) *	1990-03-01	1991-11-13	Taiji Nakayama	ピリミジン誘導体およびそれを有効成分とする血小板凝集阻止剤
CA2066104C (en) *	1991-04-19	2003-05-27	Hidenori Ogawa	Benzazepine derivatives as vasopressin antagonists
US5512563A (en) *	1993-07-29	1996-04-30	American Cyanamid Company	Tricyclic benzazepine vasopressin antagonists
JP3255077B2 (ja) *	1997-04-23	2002-02-12	日本電気株式会社	電話機

1994
- 1994-07-19 DE DE69432632T patent/DE69432632T2/de not_active Expired - Lifetime
- 1994-07-19 ES ES00204704T patent/ES2228405T3/es not_active Expired - Lifetime
- 1994-07-19 CN CN94192831A patent/CN1040210C/zh not_active Expired - Fee Related
- 1994-07-19 EP EP94921117A patent/EP0709386B1/en not_active Expired - Lifetime
- 1994-07-19 EP EP00204704A patent/EP1097920B1/en not_active Expired - Lifetime
- 1994-07-19 US US08/586,686 patent/US5723606A/en not_active Expired - Lifetime
- 1994-07-19 UA UA96010145A patent/UA64690C2/uk unknown
- 1994-07-19 ES ES94921117T patent/ES2198418T3/es not_active Expired - Lifetime
- 1994-07-19 AT AT00204704T patent/ATE277003T1/de not_active IP Right Cessation
- 1994-07-19 PL PL94312654A patent/PL177738B1/pl not_active IP Right Cessation
- 1994-07-19 DE DE69434032T patent/DE69434032T2/de not_active Expired - Lifetime
- 1994-07-19 KR KR1019960700265A patent/KR100304331B1/ko not_active IP Right Cessation
- 1994-07-19 AT AT94921117T patent/ATE239726T1/de not_active IP Right Cessation
- 1994-07-19 CA CA002167673A patent/CA2167673C/en not_active Expired - Lifetime
- 1994-07-19 HU HU9600102A patent/HUT74582A/hu unknown
- 1994-07-19 NZ NZ268671A patent/NZ268671A/en not_active IP Right Cessation
- 1994-07-19 AU AU71957/94A patent/AU683483B2/en not_active Ceased
- 1994-07-19 RU RU96105390/04A patent/RU2129123C1/ru not_active IP Right Cessation
- 1994-07-19 WO PCT/JP1994/001183 patent/WO1995003305A1/ja active IP Right Grant
- 1994-07-20 TW TW083106656A patent/TW279163B/zh not_active IP Right Cessation
1996
- 1996-01-19 NO NO960231A patent/NO306303B1/no not_active IP Right Cessation
- 1996-01-19 FI FI960260A patent/FI113178B/fi active
1997
- 1997-10-02 AU AU39906/97A patent/AU3990697A/en not_active Abandoned
- 1997-11-18 US US08/972,271 patent/US5856564A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
PL312654A1 (en)	1996-04-29
EP0709386B1 (en)	2003-05-07
HUT74582A (en)	1997-01-28
AU7195794A (en)	1995-02-20
EP0709386A1 (en)	1996-05-01
AU683483B2 (en)	1997-11-13
CA2167673C (en)	2004-09-21
DE69432632D1 (de)	2003-06-12
DE69432632T2 (de)	2004-02-19
KR960703917A (ko)	1996-08-31
HU9600102D0 (en)	1996-03-28
US5856564A (en)	1999-01-05
ATE277003T1 (de)	2004-10-15
EP1097920B1 (en)	2004-09-22
EP0709386A4 (en)	1997-06-25
AU3990697A (en)	1997-12-18
NO960231D0 (no)	1996-01-19
ATE239726T1 (de)	2003-05-15
NZ268671A (en)	1997-09-22
US5723606A (en)	1998-03-03
ES2228405T3 (es)	2005-04-16
NO960231L (no)	1996-03-21
ES2198418T3 (es)	2004-02-01
PL177738B1 (pl)	2000-01-31
CN1127508A (zh)	1996-07-24
KR100304331B1 (ko)	2001-11-22
EP1097920A1 (en)	2001-05-09
RU2129123C1 (ru)	1999-04-20
FI960260A (fi)	1996-01-19
DE69434032T2 (de)	2005-09-22
TW279163B (es)	1996-06-21
CA2167673A1 (en)	1995-02-02
DE69434032D1 (de)	2004-10-28
FI113178B (fi)	2004-03-15
FI960260A0 (fi)	1996-01-19
WO1995003305A1 (fr)	1995-02-02
UA64690C2 (en)	2004-03-15
CN1040210C (zh)	1998-10-14

Publication	Publication Date	Title
NO306303B1 (no)	1999-10-18	Kondensert benzazepinderivat og farmasöytisk preparat derav
NO302366B1 (no)	1998-02-23	4-merkaptoacetylamino-£2\|benzazepinon(3)-derivater, og farmasöytisk preparat
NO940789L (no)	1994-09-12	Quinolinkarboksylsyrederivater, deres fremstilling og anvendelse
IS6348A (is)	2002-04-17	(1a,3a,5a)(3-amínómetýl bísýkló[3.2.0]hept-3-ýl)-ediksýra, lyfjasamsetningar og notkun efnasambandsins til framleiðslu á lyfjum
NZ234327A (en)	1992-12-23	Quinazoline derivatives and pharmaceutical compositions
FI944217A (fi)	1994-09-13	Substituoidut pipekoliinihappojohdannaiset HIV-proteaasin estäjinä
DK139588A (da)	1989-01-06	Benzodiazepinforbindelse og farmaceutisk praeparat indeholdende en saadan forbindelse
ES2167720T3 (es)	2002-05-16	Compuestos de 1-fenilpirazol y aplicaciones medicinales de los mismos.
DE69021618D1 (de)	1995-09-21	Antagonisten von exzitatorischen Aminosäuren.
NO984331L (no)	1998-11-11	Karboksylsyrederivater med kondensert ring
ATE255117T1 (de)	2003-12-15	Aminophosphonsäure-derivate als arzneimittel
NO921840D0 (no)	1992-05-08	Substituerte karboksylsyrederivater
NO950477D0 (no)	1995-02-09	Aminosyrederivater
MX9204342A (es)	1994-03-31	Indoles.
ES2111871T3 (es)	1998-03-16	Nuevos derivados de aminoacidos, su procedimiento de preparacion y composiciones farmaceuticas que los contienen.
DE59402621D1 (de)	1997-06-12	Fluor-trifluormethylbenzoesäure-Derivate
FI941149A0 (fi)	1994-03-10	2,4-diamino-3-hydroksikarboksyylihapon johdannaisia
NO934032D0 (no)	1993-11-08	Fremgangsmaate for fjerning av allergeniske forbindelser fra en proteinblanding, et saaledes erholdt produkt, og anvendelse derav
FI953361A (fi)	1995-07-07	Menetelmä substituoitujen indolonijohdannaisten valmistamiseksi
NO923266L (no)	1993-02-22	Heksahydrobenzo(f)quinolinoner
KR950702115A (ko)	1995-06-19	디히드로피리딘 유도체의 신규 의약 용도(novel medicinal use of dihydropyridine derivative)
NO912167L (no)	1991-12-09	Fremgangsmaate for fremstilling av ftalsyreanhydrid-derivater.
ES2080445T3 (es)	1996-02-01	Derivados de ursano, su preparacion y formulaciones farmaceuticas de los mismos.
CA2453123A1 (en)	1995-02-02	Intermediate for condensed benzazepine derivatives
TH33723A (es)	1999-07-09

Legal Events

Date	Code	Title	Description
2012-02-20	MM1K	Lapsed by not paying the annual fees