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NO20083919L - Pyridin- og pyrimidinderivater som mGluR2-antagonister - Google Patents

Pyridin- og pyrimidinderivater som mGluR2-antagonister

Info

Publication number
NO20083919L
NO20083919L NO20083919A NO20083919A NO20083919L NO 20083919 L NO20083919 L NO 20083919L NO 20083919 A NO20083919 A NO 20083919A NO 20083919 A NO20083919 A NO 20083919A NO 20083919 L NO20083919 L NO 20083919L
Authority
NO
Norway
Prior art keywords
pyridine
pyrimidine derivatives
mglur2 antagonists
mglur2
antagonists
Prior art date
Application number
NO20083919A
Other languages
English (en)
Other versions
NO344319B1 (no
Inventor
Erwin Goetschi
Silvia Gatti Mcarthur
Juergen Wichmann
Thomas Johannes Woltering
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36862654&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20083919(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NO20083919L publication Critical patent/NO20083919L/no
Publication of NO344319B1 publication Critical patent/NO344319B1/no

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    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/30—Halogen atoms or nitro radicals
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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Abstract

Foreliggende oppfinnelse angår forbindelser med formel (I), en fremgangsmåte for fremstilling av disse, anvendelse av dem for fremstilling av medikamenter for behandling av CNS-lidelser, samt farmasøytiske preparater som inneholder dem: hvor A, B, X, Y, R1, R2, R3 og R4 er som definert i beskrivelsen og kravene.
NO20083919A 2006-03-29 2008-09-15 Pyridin- og pyrimidin-derivater som mGluR2-antagonister NO344319B1 (no)

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