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NO20061446L - FSH-glykosyleringsmutant - Google Patents

FSH-glykosyleringsmutant

Info

Publication number
NO20061446L
NO20061446L NO20061446A NO20061446A NO20061446L NO 20061446 L NO20061446 L NO 20061446L NO 20061446 A NO20061446 A NO 20061446A NO 20061446 A NO20061446 A NO 20061446A NO 20061446 L NO20061446 L NO 20061446L
Authority
NO
Norway
Prior art keywords
fsh
glykosyleringsmutant
mutant
lifes
permits
Prior art date
Application number
NO20061446A
Other languages
English (en)
Inventor
Robert K Campbell
Stephen J Arkinstall
Xuliang Jiang
Sean D Mckenna
Louise M Garone
William H Brondyk
Mark Tepper
Original Assignee
Applied Research Systems
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems filed Critical Applied Research Systems
Publication of NO20061446L publication Critical patent/NO20061446L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Endocrinology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Reproductive Health (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Det er beskrevet en ny FSH-mutant med forhøyet glykosylering og lengre halvliv som kan brukes for å indusere follikkulogenese i humane pasienter. FSH-mutanten gjør det mulig å bruke lavere kumulative doser av FSH for å oppnå det samme eller bedre kliniske resultater.
NO20061446A 2003-09-02 2006-03-30 FSH-glykosyleringsmutant NO20061446L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49980203P 2003-09-02 2003-09-02
PCT/US2004/029042 WO2005020934A2 (en) 2003-09-02 2004-09-02 Fsh glycosylation mutant

Publications (1)

Publication Number Publication Date
NO20061446L true NO20061446L (no) 2006-03-30

Family

ID=34272871

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20061446A NO20061446L (no) 2003-09-02 2006-03-30 FSH-glykosyleringsmutant

Country Status (24)

Country Link
US (1) US7700112B2 (no)
EP (1) EP1694271B1 (no)
JP (1) JP4653090B2 (no)
KR (1) KR101099809B1 (no)
CN (1) CN1984926B (no)
AT (1) ATE511829T1 (no)
AU (1) AU2004268683B2 (no)
BR (1) BRPI0413206A (no)
CA (1) CA2535522A1 (no)
CY (1) CY1112439T1 (no)
DK (1) DK1694271T3 (no)
EA (1) EA012175B1 (no)
ES (1) ES2367784T3 (no)
HK (1) HK1101315A1 (no)
HR (1) HRP20110430T1 (no)
IL (1) IL174037A0 (no)
MX (1) MXPA06002119A (no)
NO (1) NO20061446L (no)
PL (1) PL1694271T3 (no)
PT (1) PT1694271E (no)
SI (1) SI1694271T1 (no)
UA (1) UA88879C2 (no)
WO (1) WO2005020934A2 (no)
ZA (1) ZA200601803B (no)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS57549B1 (sr) 2005-08-26 2018-10-31 Ares Trading Sa Proces za pripremu glikoziliranog interferona beta
JP5199112B2 (ja) * 2005-12-09 2013-05-15 アレス トレーディング ソシエテ アノニム Ｆｓｈ又はｆｓｈ変異体を精製するための方法
BRPI0620223A2 (pt) * 2005-12-22 2011-11-01 Serono Lab mutantes de fsh
CA2633844A1 (en) * 2006-01-17 2007-07-26 Laboratoires Serono S.A. Novel fsh glycosylation variant d3n
BRPI0809432A2 (pt) * 2007-03-26 2014-09-09 Novartis Ag Biomarcadores de segurança renal preditivos e assinaturas de biomarcadores para monitorar a função renal
AR081755A1 (es) 2010-04-02 2012-10-17 Hanmi Holdings Co Ltd Formulacion de accion prolongada de la hormona estimuladora de los foliculos donde se usa un fragmento de inmunoglobulina, metodo de preparacion y metodo para tratar a un sujeto que sufre un trastorno reproductivo
CN108676096B (zh) * 2018-05-22 2022-03-29 北京伟杰信生物科技有限公司 重组猪fsh-ctp融合蛋白及其制备方法与应用
EP4055038A4 (en) * 2019-11-06 2023-11-15 The Regents of the University of Colorado, a body corporate MODIFIED FOLLICLE-STIMULATING HORMONE AND METHOD OF USE THEREOF
CN114213523B (zh) * 2021-11-15 2024-07-09 广州源博医药科技有限公司 一种用于重组蛋白的高糖基化修饰序列及其重组猪促卵泡激素和应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4840896A (en) * 1983-11-02 1989-06-20 Integrated Genetics, Inc. Heteropolymeric protein
US4923805A (en) * 1983-11-02 1990-05-08 Integrated Genetics, Inc. Fsh
US5156957A (en) * 1983-11-02 1992-10-20 Genzyme Corporation Follicle stimulating hormone
US5639639A (en) * 1983-11-02 1997-06-17 Genzyme Corporation Recombinant heterodimeric human fertility hormones, and methods, cells, vectors and DNA for the production thereof
US4845077A (en) * 1984-04-03 1989-07-04 Serono Laboratories, Inc. Method of inducing ovulation
US4589402A (en) * 1984-07-26 1986-05-20 Serono Laboratories, Inc. Method of in vitro fertilization
ES2098261T3 (es) * 1989-02-21 1997-05-01 Univ Washington Formas modificadas de hormonas reproductoras.
US5338835A (en) * 1989-02-21 1994-08-16 Washington University CTP-extended form of FSH
US5508261A (en) * 1991-06-18 1996-04-16 University Of Medicine & Dentistry Of New Jersey Analogs of glycoprotein hormones having altered receptor binding specificity and activity and methods for preparing and using same
US6407205B1 (en) * 1997-06-04 2002-06-18 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College FSH-releasing peptides
DK0994718T3 (da) * 1997-06-20 2005-12-19 Akzo Nobel Nv Gonadotropin releasing hormon-antagonist
AU772373B2 (en) * 1998-08-07 2004-04-22 Laboratoires Serono Sa FSH mimetics for the treatment of infertility
SI1250148T2 (sl) * 2000-01-27 2008-10-31 Serono Lab Uporaba fsh za zdravljenje neplodnosti
AU2001231531A1 (en) * 2000-02-11 2001-08-20 Maxygen Aps Follicle stimulating hormones
US20020127652A1 (en) * 2000-02-11 2002-09-12 Schambye Hans Thalsgard Follicle stimulating hormones
JP4310275B2 (ja) * 2001-10-22 2009-08-05 アプライド リサーチ システムズ アース ホールディング エヌ．ヴィ． 変異体糖タンパク質

Also Published As

Publication number Publication date
KR101099809B1 (ko) 2011-12-27
JP2007508245A (ja) 2007-04-05
AU2004268683A2 (en) 2005-03-10
WO2005020934A3 (en) 2007-02-15
CY1112439T1 (el) 2015-12-09
BRPI0413206A (pt) 2006-10-03
HK1101315A1 (en) 2007-10-12
DK1694271T3 (da) 2011-09-12
JP4653090B2 (ja) 2011-03-16
UA88879C2 (en) 2009-12-10
PL1694271T3 (pl) 2011-11-30
CN1984926B (zh) 2012-04-11
ES2367784T3 (es) 2011-11-08
EA200600526A1 (ru) 2007-04-27
AU2004268683A1 (en) 2005-03-10
PT1694271E (pt) 2011-07-07
CN1984926A (zh) 2007-06-20
SI1694271T1 (sl) 2011-08-31
EP1694271B1 (en) 2011-06-08
EP1694271A2 (en) 2006-08-30
AU2004268683B2 (en) 2010-06-24
WO2005020934A2 (en) 2005-03-10
ZA200601803B (en) 2007-05-30
MXPA06002119A (es) 2006-05-31
US20050100989A1 (en) 2005-05-12
KR20070029620A (ko) 2007-03-14
ATE511829T1 (de) 2011-06-15
IL174037A0 (en) 2006-08-01
EA012175B1 (ru) 2009-08-28
CA2535522A1 (en) 2005-03-10
HRP20110430T1 (hr) 2011-07-31
US7700112B2 (en) 2010-04-20

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Representative=s name: ONSAGERS AS, POSTBOKS 6963 ST OLAVS PLASS, 0130 OS

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