NO20060314L - Nicotinamid-derivater anvendbare som PDE4-inhibitorer - Google Patents

Nicotinamid-derivater anvendbare som PDE4-inhibitorer

Info

Publication number: NO20060314L
Authority: NO; Norway
Prior art keywords: pde4 inhibitors; derivatives useful; nicotinamide derivatives; nicotinamide; preparation
Prior art date: 2003-07-25

Application number

NO20060314A

Other languages

English (en)

Norwegian (no)

Inventor

Mark Edward Bunnage

John Paul Mathias

Christopher Gordon Barber

John Wilson Harvey

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-07-25

Filing date

2006-01-20

Publication date

2006-04-06

2006-01-20 Application filed by Pfizer filed Critical Pfizer

2006-04-06 Publication of NO20060314L publication Critical patent/NO20060314L/no

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Physical Education & Sports Medicine (AREA)
Neurology (AREA)
Virology (AREA)
Immunology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Oncology (AREA)
Diabetes (AREA)
Rheumatology (AREA)
Pulmonology (AREA)
Communicable Diseases (AREA)
Orthopedic Medicine & Surgery (AREA)
Cardiology (AREA)
Hematology (AREA)
Molecular Biology (AREA)
Pain & Pain Management (AREA)
Dermatology (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Psychiatry (AREA)
Tropical Medicine & Parasitology (AREA)
Biophysics (AREA)
Endocrinology (AREA)
Psychology (AREA)

NO20060314A 2003-07-25 2006-01-20 Nicotinamid-derivater anvendbare som PDE4-inhibitorer NO20060314L (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GBGB0317498.4A GB0317498D0 (en)	2003-07-25	2003-07-25	Compounds
US49712003P	2003-08-22	2003-08-22
PCT/IB2004/002367 WO2005009994A1 (en)	2003-07-25	2004-07-13	Nicotinamide derivatives useful as pde4 inhibitors

Publications (1)

Publication Number	Publication Date
NO20060314L true NO20060314L (no)	2006-04-06

Family

ID=27772727

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
NO20060314A NO20060314L (no)	2003-07-25	2006-01-20	Nicotinamid-derivater anvendbare som PDE4-inhibitorer
NO20060963A NO20060963L (no)	2003-07-25	2006-02-27	Nikotinamidderivater anvendelige som PDE4-inhibitorer

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
NO20060963A NO20060963L (no)	2003-07-25	2006-02-27	Nikotinamidderivater anvendelige som PDE4-inhibitorer

Country Status (39)

Country	Link
US (4)	US20090035313A1 (is)
EP (2)	EP1651640B1 (is)
JP (2)	JP4012935B2 (is)
KR (2)	KR20060034300A (is)
CN (2)	CN1860113A (is)
AP (2)	AP2006003484A0 (is)
AR (2)	AR045091A1 (is)
AT (2)	ATE353893T1 (is)
AU (2)	AU2004259133A1 (is)
BR (2)	BRPI0412834A (is)
CA (2)	CA2533624A1 (is)
CR (1)	CR8205A (is)
CY (1)	CY1106343T1 (is)
DE (2)	DE602004004794T2 (is)
DK (2)	DK1651640T3 (is)
EA (2)	EA200600100A1 (is)
EC (2)	ECSP066304A (is)
ES (2)	ES2286650T3 (is)
GB (1)	GB0317498D0 (is)
GT (2)	GT200400143A (is)
HR (2)	HRP20051021A2 (is)
IL (2)	IL172793A0 (is)
IS (2)	IS8201A (is)
MA (2)	MA27930A1 (is)
MX (2)	MXPA06000986A (is)
NL (2)	NL1026716C2 (is)
NO (2)	NO20060314L (is)
OA (2)	OA13194A (is)
PA (2)	PA8607701A1 (is)
PE (2)	PE20050329A1 (is)
PL (2)	PL1651640T3 (is)
PT (2)	PT1651641E (is)
RS (1)	RS20060051A (is)
SI (2)	SI1651640T1 (is)
TN (2)	TNSN06026A1 (is)
TW (2)	TW200524916A (is)
UY (2)	UY28433A1 (is)
WO (2)	WO2005009995A1 (is)
ZA (2)	ZA200510421B (is)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AR049384A1 (es)	2004-05-24	2006-07-26	Glaxo Group Ltd	Derivados de purina
EP1683795A1 (en) *	2005-01-21	2006-07-26	Pfizer Limited	Crystalline forms of cis-5-fluoro-N-¬4-(2-hydroxy-4-methylbenzamido)cyclohexyl\|-2-(tetrahydrothiopyran-4-yloxy)nicotinamide
WO2006077497A1 (en) *	2005-01-21	2006-07-27	Pfizer Limited	Crystalline forms cis-5-fluoro-n-[4-(2-hydroxy-4-methylbenzamido) cyclohexyl]-2-(tetrahydrothiopyran-a-yloxy) nicotinamide
NZ561746A (en) *	2005-04-19	2011-09-30	Nycomed Gmbh	Roflumilast for the treatment of pulmonary hypertension
GB0514809D0 (en)	2005-07-19	2005-08-24	Glaxo Group Ltd	Compounds
US7926591B2 (en) *	2006-02-10	2011-04-19	Halliburton Energy Services, Inc.	Aqueous-based emulsified consolidating agents suitable for use in drill-in applications
CA2652677A1 (en) *	2006-02-24	2007-09-07	Ironwood Pharmaceuticals, Inc.	Methods and compositions for the treatment of gastrointestinal disorders
KR20220031743A (ko) *	2008-03-18	2022-03-11	아레나 파마슈티칼스, 인크.	프로스타시클린 （ｐｇｉ２） 수용체와 관련된 장애의 치료에 유용한 상기 수용체의 조절제
CN103880757B (zh) *	2014-04-15	2016-02-24	上海毕得医药科技有限公司	一种5-羟基嘧啶-2-羧酸的合成方法
EP3977985B1 (en)	2017-03-01	2023-09-06	Arena Pharmaceuticals, Inc.	Compositions comprising pgi2-receptor agonists and processes for the preparation thereof
EP4081528A4 (en) *	2019-12-23	2024-03-13	Sanford Burnham Prebys Medical Discovery Institute	ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE 1 (ENPP1) MODULATORS AND USES THEREOF
WO2021155081A1 (en) *	2020-01-31	2021-08-05	The Lubrizol Corporation	Processes for producing alkyl salicylic acids and overbased detergents derived therefrom
CN111302945B (zh) *	2020-02-21	2023-06-13	上海再启生物技术有限公司	3-羟基-4-甲氧基-2-硝基苯甲酸的制备方法
DE102020107795A1 (de)	2020-03-20	2021-09-23	Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eingetragener Verein	Elektronen emittierende Keramik
IL314717A (en)	2022-02-15	2024-10-01	United Therapeutics Corp	Crystalline prostacyclin (IP) receptor agonist and uses thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TR200001847T2 (tr) *	1997-04-04	2002-06-21	Pfizer Products Inc.	Nikotinamid Türevleri
US20020111495A1 (en) *	1997-04-04	2002-08-15	Pfizer Inc.	Nicotinamide acids, amides, and their mimetics active as inhibitors of PDE4 isozymes
MXPA02007419A (es) *	2000-01-31	2002-12-09	Pfizer Prod Inc	Derivados de nicotinamida benzocondensada-heterociclilo utiles como inhibidores selectivos de las isozimas pde4.
BR0107934A (pt) *	2000-01-31	2003-03-25	Pfizer Prod Inc	Carboxamidas de pirimidina úteis como inibidores de isozimas pde4
BR0116850A (pt) *	2001-01-31	2004-02-25	Pfizer Prod Inc	Derivados de amida de ácido tiazolil-, oxazolil-, pirrolil- e imidazolil- úteis como inibidores de isoenzimas de pde4
SK8792003A3 (en) *	2001-01-31	2004-09-08	Pfizer Prod Inc	Nicotinamide biaryl derivatives useful as inhibitors of PDE4 isozymes and pharmaceutical composition containing them

2003
- 2003-07-25 GB GBGB0317498.4A patent/GB0317498D0/en not_active Ceased
2004
- 2004-07-13 CA CA002533624A patent/CA2533624A1/en not_active Abandoned
- 2004-07-13 EA EA200600100A patent/EA200600100A1/ru unknown
- 2004-07-13 KR KR1020067001623A patent/KR20060034300A/ko active IP Right Grant
- 2004-07-13 AT AT04744026T patent/ATE353893T1/de not_active IP Right Cessation
- 2004-07-13 MX MXPA06000986A patent/MXPA06000986A/es unknown
- 2004-07-13 WO PCT/IB2004/002380 patent/WO2005009995A1/en active IP Right Grant
- 2004-07-13 BR BRPI0412834-6A patent/BRPI0412834A/pt not_active IP Right Cessation
- 2004-07-13 US US10/564,693 patent/US20090035313A1/en not_active Abandoned
- 2004-07-13 EP EP04744026A patent/EP1651640B1/en not_active Expired - Lifetime
- 2004-07-13 PT PT04744038T patent/PT1651641E/pt unknown
- 2004-07-13 AU AU2004259133A patent/AU2004259133A1/en not_active Abandoned
- 2004-07-13 JP JP2006521682A patent/JP4012935B2/ja not_active Expired - Fee Related
- 2004-07-13 RS YUP-2006/0051A patent/RS20060051A/sr unknown
- 2004-07-13 OA OA1200600021A patent/OA13194A/en unknown
- 2004-07-13 ES ES04744038T patent/ES2286650T3/es not_active Expired - Lifetime
- 2004-07-13 CN CNA200480027996XA patent/CN1860113A/zh active Pending
- 2004-07-13 PL PL04744026T patent/PL1651640T3/pl unknown
- 2004-07-13 AP AP2006003484A patent/AP2006003484A0/xx unknown
- 2004-07-13 DE DE602004004794T patent/DE602004004794T2/de not_active Expired - Fee Related
- 2004-07-13 AP AP2006003483A patent/AP2006003483A0/xx unknown
- 2004-07-13 PL PL04744038T patent/PL1651641T3/pl unknown
- 2004-07-13 DE DE602004006627T patent/DE602004006627T2/de not_active Expired - Fee Related
- 2004-07-13 MX MXPA06000936A patent/MXPA06000936A/es unknown
- 2004-07-13 CA CA002532249A patent/CA2532249A1/en not_active Abandoned
- 2004-07-13 EP EP04744038A patent/EP1651641B1/en not_active Expired - Lifetime
- 2004-07-13 DK DK04744026T patent/DK1651640T3/da active
- 2004-07-13 SI SI200430219T patent/SI1651640T1/sl unknown
- 2004-07-13 CN CNA2004800215506A patent/CN1829712A/zh active Pending
- 2004-07-13 JP JP2006520935A patent/JP4016059B2/ja not_active Expired - Fee Related
- 2004-07-13 AT AT04744038T patent/ATE362930T1/de not_active IP Right Cessation
- 2004-07-13 OA OA1200600020A patent/OA13193A/en unknown
- 2004-07-13 DK DK04744038T patent/DK1651641T3/da active
- 2004-07-13 AU AU2004259526A patent/AU2004259526A1/en not_active Abandoned
- 2004-07-13 SI SI200430330T patent/SI1651641T1/sl unknown
- 2004-07-13 KR KR1020067001639A patent/KR20060039012A/ko not_active Application Discontinuation
- 2004-07-13 US US10/564,694 patent/US20060178408A1/en not_active Abandoned
- 2004-07-13 BR BRPI0412910-5A patent/BRPI0412910A/pt not_active IP Right Cessation
- 2004-07-13 WO PCT/IB2004/002367 patent/WO2005009994A1/en active IP Right Grant
- 2004-07-13 PT PT04744026T patent/PT1651640E/pt unknown
- 2004-07-13 ES ES04744026T patent/ES2280980T3/es not_active Expired - Lifetime
- 2004-07-13 EA EA200600018A patent/EA200600018A1/ru unknown
- 2004-07-20 US US10/896,068 patent/US20050043326A1/en not_active Abandoned
- 2004-07-20 US US10/896,085 patent/US20050020611A1/en not_active Abandoned
- 2004-07-22 GT GT200400143A patent/GT200400143A/es unknown
- 2004-07-22 PE PE2004000703A patent/PE20050329A1/es not_active Application Discontinuation
- 2004-07-22 GT GT200400142A patent/GT200400142A/es unknown
- 2004-07-22 PE PE2004000702A patent/PE20050713A1/es not_active Application Discontinuation
- 2004-07-23 AR ARP040102622A patent/AR045091A1/es unknown
- 2004-07-23 TW TW093122196A patent/TW200524916A/zh unknown
- 2004-07-23 PA PA20048607701A patent/PA8607701A1/es unknown
- 2004-07-23 UY UY28433A patent/UY28433A1/es not_active Application Discontinuation
- 2004-07-23 AR ARP040102621A patent/AR045090A1/es not_active Application Discontinuation
- 2004-07-23 TW TW093122190A patent/TW200521127A/zh unknown
- 2004-07-23 UY UY28434A patent/UY28434A1/es not_active Application Discontinuation
- 2004-07-23 NL NL1026716A patent/NL1026716C2/nl not_active IP Right Cessation
- 2004-07-23 PA PA20048607801A patent/PA8607801A1/es unknown
- 2004-07-23 NL NL1026717A patent/NL1026717C2/nl not_active IP Right Cessation
2005
- 2005-12-22 HR HR20051021A patent/HRP20051021A2/hr not_active Application Discontinuation
- 2005-12-22 IL IL172793A patent/IL172793A0/en unknown
- 2005-12-22 ZA ZA200510421A patent/ZA200510421B/en unknown
- 2005-12-27 IS IS8201A patent/IS8201A/is unknown
2006
- 2006-01-05 IL IL173001A patent/IL173001A0/en unknown
- 2006-01-16 HR HR20060017A patent/HRP20060017A2/hr not_active Application Discontinuation
- 2006-01-19 CR CR8205A patent/CR8205A/es not_active Application Discontinuation
- 2006-01-19 IS IS8242A patent/IS8242A/is unknown
- 2006-01-20 NO NO20060314A patent/NO20060314L/no not_active Application Discontinuation
- 2006-01-23 EC EC2006006304A patent/ECSP066304A/es unknown
- 2006-01-24 ZA ZA200600695A patent/ZA200600695B/en unknown
- 2006-01-25 TN TNP2006000026A patent/TNSN06026A1/fr unknown
- 2006-01-25 MA MA28751A patent/MA27930A1/fr unknown
- 2006-01-25 TN TNP2006000027A patent/TNSN06027A1/fr unknown
- 2006-01-25 MA MA28752A patent/MA27931A1/fr unknown
- 2006-01-25 EC EC2006006317A patent/ECSP066317A/es unknown
- 2006-02-27 NO NO20060963A patent/NO20060963L/no not_active Application Discontinuation
2007
- 2007-02-27 CY CY20071100273T patent/CY1106343T1/el unknown

Also Published As

Publication number	Publication date
EA200600100A1 (ru)	2006-08-25
EP1651640B1 (en)	2007-02-14
SI1651640T1 (sl)	2007-06-30
TW200524916A (en)	2005-08-01
PL1651640T3 (pl)	2007-06-29
AU2004259526A1 (en)	2005-02-03
CN1860113A (zh)	2006-11-08
JP4016059B2 (ja)	2007-12-05
WO2005009994A1 (en)	2005-02-03
DK1651641T3 (da)	2007-09-03
CY1106343T1 (el)	2011-10-12
JP2006528625A (ja)	2006-12-21
PA8607701A1 (es)	2005-02-04
UY28433A1 (es)	2005-02-28
IS8201A (is)	2005-12-27
GB0317498D0 (en)	2003-08-27
DE602004006627T2 (de)	2008-01-24
DE602004006627D1 (de)	2007-07-05
PA8607801A1 (es)	2005-02-04
GT200400142A (es)	2005-03-03
CA2532249A1 (en)	2005-02-03
MXPA06000936A (es)	2006-03-30
US20050043326A1 (en)	2005-02-24
ATE353893T1 (de)	2007-03-15
ZA200510421B (en)	2007-01-31
CN1829712A (zh)	2006-09-06
EP1651640A1 (en)	2006-05-03
BRPI0412834A (pt)	2006-09-26
TNSN06026A1 (fr)	2007-10-03
NL1026717A1 (nl)	2005-01-26
MA27930A1 (fr)	2006-06-01
AU2004259133A1 (en)	2005-02-03
KR20060034300A (ko)	2006-04-21
NL1026716C2 (nl)	2005-10-05
IS8242A (is)	2006-01-19
AP2006003484A0 (en)	2006-02-28
ES2286650T3 (es)	2007-12-01
UY28434A1 (es)	2005-02-28
NO20060963L (no)	2006-02-27
PT1651640E (pt)	2007-04-30
OA13193A (en)	2006-12-13
CA2533624A1 (en)	2005-02-03
ES2280980T3 (es)	2007-09-16
PE20050713A1 (es)	2005-09-14
JP4012935B2 (ja)	2007-11-28
DE602004004794T2 (de)	2007-12-06
MA27931A1 (fr)	2006-06-01
US20050020611A1 (en)	2005-01-27
SI1651641T1 (sl)	2007-10-31
HRP20051021A2 (en)	2006-05-31
RS20060051A (en)	2008-06-05
ECSP066304A (es)	2006-07-28
ATE362930T1 (de)	2007-06-15
US20090035313A1 (en)	2009-02-05
WO2005009995A1 (en)	2005-02-03
HRP20060017A2 (en)	2006-06-30
ECSP066317A (es)	2006-07-28
EP1651641A1 (en)	2006-05-03
KR20060039012A (ko)	2006-05-04
GT200400143A (es)	2005-03-03
JP2006528657A (ja)	2006-12-21
PT1651641E (pt)	2007-07-13
NL1026717C2 (nl)	2005-11-01
MXPA06000986A (es)	2006-04-11
ZA200600695B (en)	2007-05-30
IL172793A0 (en)	2006-06-11
AP2006003483A0 (en)	2006-02-28
EP1651641B1 (en)	2007-05-23
DK1651640T3 (da)	2007-05-14
BRPI0412910A (pt)	2006-09-26
EA200600018A1 (ru)	2006-08-25
NL1026716A1 (nl)	2005-01-26
US20060178408A1 (en)	2006-08-10
OA13194A (en)	2006-12-13
TNSN06027A1 (fr)	2007-10-03
CR8205A (es)	2006-07-14
PE20050329A1 (es)	2005-05-16
AR045091A1 (es)	2005-10-12
AR045090A1 (es)	2005-10-12
IL173001A0 (en)	2006-06-11
PL1651641T3 (pl)	2007-09-28
DE602004004794D1 (de)	2007-03-29
TW200521127A (en)	2005-07-01

Publication	Publication Date	Title
NO20060314L (no)	2006-04-06	Nicotinamid-derivater anvendbare som PDE4-inhibitorer
NO20070557L (no)	2007-01-30	Ftalazinderivater som PARP-inhibitorer
NO20050828L (no)	2005-04-05	lndol-3-svovelderivater
NO20070555L (no)	2007-01-30	Kinazolinonderivater som parp-inhibitorer
NO20071242L (no)	2007-05-07	Triazolpyridinylsulfanylderivater som P38-MAP-kinaseinhibitorer
ATE433447T1 (de)	2009-06-15	Pyrimiidinverbindungen
NO20051165L (no)	2005-03-04	Benzotiazolderivater som har -adrenoerseptorantagonist aktivitet
NO20070526L (no)	2007-01-29	Kinazolindionderivater som parp-inhibitorer
NO20070224L (no)	2007-04-02	2-karbamid-4-fenyltiazolderivater, fremstilling og terapeutisk anvendelse derav
ATE296826T1 (de)	2005-06-15	Pyrazolo(1,5)pyridinderivate
NO20082496L (no)	2008-07-24	Pyrazinderivater
RS70104A (en)	2007-02-05	Nicotinamide derivatives useful as pde4 inhibitors
NO20063129L (no)	2006-07-05	Substituerte 6-cykloheksylalkylsubstituerte 2-kinolinoner og 2-kinoksalinoner som poly(ADP-ribose) polymeraseinhibitorer
NO20063761L (no)	2006-10-23	Sulfonamidderivater for behandling av sykdommer
NO20054905L (no)	2006-01-25	2-acylamino-4-fenyltiazolderivater, fremgangsmate for deres fremstilling og anvendelse av de samme som i terapeutika
BR0213660A (pt)	2004-08-24	Composto, composição farmacêutica e método para tratar pacientes
NO20062256L (no)	2006-06-06	Hydroksyalkylsubstituerte pyrido-7-pyrimidin-7-oner
NO20076145L (no)	2008-01-28	Ureadeviater, fremgangsmater for deres fremstilling og anvendelse derav
NO20061395L (no)	2006-06-22	Nye pyridinderivater
MXPA05012247A (es)	2006-02-10	Derivados de bencimidazol nuevos.
ATE300541T1 (de)	2005-08-15	Pyrazolopyridinderivate
MXPA05010440A (es)	2005-11-04	Amidas del acido isoquinolina-5-sulfonico como inhibidores de la akt (proteina quinasa b).
NO20043016L (no)	2004-07-15	6-aminomorfinan-derivater, fremgangsmate for fremstilling og anvendelse derav
NO20061789L (no)	2006-04-24	Aminopyridinderivater som induserbare NO-syntaseinhibitorer
DK1448562T3 (da)	2007-09-24	Substituerede tetracycliske pyrroloquinolonderivater egnede som phosphodiesteraseinhibitorer

Legal Events

Date	Code	Title	Description
2009-02-23	FC2A	Withdrawal, rejection or dismissal of laid open patent application