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TNSN06026A1 - Derives de nicotinamide utiles comme inhibiteurs de pde4 - Google Patents

Derives de nicotinamide utiles comme inhibiteurs de pde4

Info

Publication number
TNSN06026A1
TNSN06026A1 TNP2006000026A TNSN06026A TNSN06026A1 TN SN06026 A1 TNSN06026 A1 TN SN06026A1 TN P2006000026 A TNP2006000026 A TN P2006000026A TN SN06026 A TNSN06026 A TN SN06026A TN SN06026 A1 TNSN06026 A1 TN SN06026A1
Authority
TN
Tunisia
Prior art keywords
des
dans
pde4 inhibitors
derivatives useful
nicotinamide derivatives
Prior art date
Application number
TNP2006000026A
Other languages
English (en)
Inventor
Mark Edward Bunnage
John Wilson Harvey
John Paul Mathias
Christopher Gordon Barber
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of TNSN06026A1 publication Critical patent/TNSN06026A1/fr

Links

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
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Abstract

La présente invention concerne des dérivés de nicotinamide de formule générale (I), Dans laquelle R1, Z et R2 répondent aux définitions figurant dans le présent mémoire, et des procédés pour la préparation de, les intermédiaires utilisés dans la préparation de, des compositions contenant, et les utilisations de, ces dérivés.
TNP2006000026A 2003-07-25 2006-01-25 Derives de nicotinamide utiles comme inhibiteurs de pde4 TNSN06026A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0317498.4A GB0317498D0 (en) 2003-07-25 2003-07-25 Compounds
PCT/IB2004/002380 WO2005009995A1 (fr) 2003-07-25 2004-07-13 Derives de nicotinamide agissant comme inhibiteurs de pde4

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TNSN06026A1 true TNSN06026A1 (fr) 2007-10-03

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TNP2006000027A TNSN06027A1 (fr) 2003-07-25 2006-01-25 Derives de nicotinamide utiles comme inhibiteurs de pde4
TNP2006000026A TNSN06026A1 (fr) 2003-07-25 2006-01-25 Derives de nicotinamide utiles comme inhibiteurs de pde4

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JP (2) JP4016059B2 (fr)
KR (2) KR20060039012A (fr)
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AP (2) AP2006003484A0 (fr)
AR (2) AR045090A1 (fr)
AT (2) ATE362930T1 (fr)
AU (2) AU2004259133A1 (fr)
BR (2) BRPI0412834A (fr)
CA (2) CA2533624A1 (fr)
CR (1) CR8205A (fr)
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DE (2) DE602004004794T2 (fr)
DK (2) DK1651641T3 (fr)
EA (2) EA200600100A1 (fr)
EC (2) ECSP066304A (fr)
ES (2) ES2280980T3 (fr)
GB (1) GB0317498D0 (fr)
GT (2) GT200400142A (fr)
HR (2) HRP20051021A2 (fr)
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MA (2) MA27931A1 (fr)
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PA (2) PA8607701A1 (fr)
PE (2) PE20050713A1 (fr)
PL (2) PL1651640T3 (fr)
PT (2) PT1651641E (fr)
RS (1) RS20060051A (fr)
SI (2) SI1651641T1 (fr)
TN (2) TNSN06027A1 (fr)
TW (2) TW200521127A (fr)
UY (2) UY28433A1 (fr)
WO (2) WO2005009994A1 (fr)
ZA (2) ZA200510421B (fr)

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PE20060272A1 (es) 2004-05-24 2006-05-22 Glaxo Group Ltd (2r,3r,4s,5r,2'r,3'r,4's,5's)-2,2'-{trans-1,4-ciclohexanodiilbis-[imino(2-{[2-(1-metil-1h-imidazol-4-il)etil]amino}-9h-purin-6,9-diil)]}bis[5-(2-etil-2h-tetrazol-5-il)tetrahidro-3,4-furanodiol] como agonista a2a
EP1683795A1 (fr) * 2005-01-21 2006-07-26 Pfizer Limited Formes crystallines de cis-5-fluoro-N-¬4-(2-hydroxy-4-methylbenzamido)cyclohexyl|-2-(tetrahydrothiopyran-4-yloxy)nicotinamide
EP1844040A1 (fr) * 2005-01-21 2007-10-17 Pfizer Limited Formes crystallines de cis-5-fluoro-n-[4-(2-hydroxy-4-methylbenzamido)cyclohexyl]-2-(tetrahydrothiopyran-4-yloxy)nicotinamide
EP1874309A1 (fr) * 2005-04-19 2008-01-09 Nycomed GmbH Utilisation de roflumilast pour traiter l'hypertension pulmonaire
GB0514809D0 (en) 2005-07-19 2005-08-24 Glaxo Group Ltd Compounds
US7926591B2 (en) * 2006-02-10 2011-04-19 Halliburton Energy Services, Inc. Aqueous-based emulsified consolidating agents suitable for use in drill-in applications
WO2007101161A2 (fr) * 2006-02-24 2007-09-07 Ironwood Pharmaceuticals, Inc. Méthodes et compositions servant au traitement de troubles gastro-intestinaux
EA019882B1 (ru) * 2008-03-18 2014-07-30 Арена Фармасьютикалз, Инк. Модуляторы рецептора простациклина (pgi2), пригодные для лечения связанных с ним расстройств
CN103880757B (zh) * 2014-04-15 2016-02-24 上海毕得医药科技有限公司 一种5-羟基嘧啶-2-羧酸的合成方法
CA3054835A1 (fr) 2017-03-01 2018-09-07 Arena Pharmaceuticals, Inc. Compositions comprenant des agonistes du recepteur pgi2 et procedes de preparation associes
WO2021133915A1 (fr) * 2019-12-23 2021-07-01 Sanford Burnham Prebys Medical Discovery Institute Modulateurs d'ectonucléotides pyrophosphatases/phosphodiestérases 1 (enpp1) et leurs utilisations
WO2021155081A1 (fr) * 2020-01-31 2021-08-05 The Lubrizol Corporation Procédés de production d'acides alkylsalicyliques et détergents surbasiques dérivés de ceux-ci
CN111302945B (zh) * 2020-02-21 2023-06-13 上海再启生物技术有限公司 3-羟基-4-甲氧基-2-硝基苯甲酸的制备方法
DE102020107795A1 (de) 2020-03-20 2021-09-23 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eingetragener Verein Elektronen emittierende Keramik
AU2023222747A1 (en) 2022-02-15 2024-08-22 United Therapeutics Corporation Crystalline prostacyclin (ip) receptor agonist and uses thereof

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IL132033A0 (en) * 1997-04-04 2001-03-19 Pfizer Prod Inc Nicotinamide derivatives
US20020111495A1 (en) * 1997-04-04 2002-08-15 Pfizer Inc. Nicotinamide acids, amides, and their mimetics active as inhibitors of PDE4 isozymes
BR0107964A (pt) * 2000-01-31 2002-10-29 Pfizer Prod Inc Derivados de nicotinamida benzofundida com heterociclica úteis como inibidores seletivos de isozimas pde4
KR20020071029A (ko) * 2000-01-31 2002-09-11 화이자 프로덕츠 인크. Ｐｄｅ４ 이소자임 억제제로 유용한 피리미딘카르복스아미드
CN1489588A (zh) * 2001-01-31 2004-04-14 �Ʒ� 用作pde4同功酶抑制剂的噻唑基,噁唑基,吡咯基,和咪唑基羧酸酰胺衍生物
JP2004520386A (ja) * 2001-01-31 2004-07-08 ファイザー・プロダクツ・インク Ｐｄｅ４アイソザイムの阻害剤として有用なニコチンアミドビアリール誘導体

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MXPA06000986A (es) 2006-04-11
NL1026716C2 (nl) 2005-10-05
IS8201A (is) 2005-12-27
CN1829712A (zh) 2006-09-06
PL1651640T3 (pl) 2007-06-29
GT200400142A (es) 2005-03-03
ES2280980T3 (es) 2007-09-16
ZA200510421B (en) 2007-01-31
EP1651640A1 (fr) 2006-05-03
US20090035313A1 (en) 2009-02-05
CA2533624A1 (fr) 2005-02-03
JP4012935B2 (ja) 2007-11-28
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ZA200600695B (en) 2007-05-30
CN1860113A (zh) 2006-11-08
NO20060963L (no) 2006-02-27
CR8205A (es) 2006-07-14
GB0317498D0 (en) 2003-08-27
CY1106343T1 (el) 2011-10-12
PT1651641E (pt) 2007-07-13
BRPI0412834A (pt) 2006-09-26
HRP20051021A2 (en) 2006-05-31
JP2006528657A (ja) 2006-12-21
WO2005009994A1 (fr) 2005-02-03
MA27930A1 (fr) 2006-06-01
DE602004004794D1 (de) 2007-03-29
PT1651640E (pt) 2007-04-30
AU2004259133A1 (en) 2005-02-03
BRPI0412910A (pt) 2006-09-26
EP1651640B1 (fr) 2007-02-14
EP1651641B1 (fr) 2007-05-23
TW200521127A (en) 2005-07-01
ECSP066317A (es) 2006-07-28
AU2004259526A1 (en) 2005-02-03
OA13193A (en) 2006-12-13
KR20060039012A (ko) 2006-05-04
RS20060051A (en) 2008-06-05
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