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NO20045137L - Diketohydrazinderivatforbindelser og legemidler inneholdende forbindelser som aktiv ingrediens - Google Patents

Diketohydrazinderivatforbindelser og legemidler inneholdende forbindelser som aktiv ingrediens

Info

Publication number
NO20045137L
NO20045137L NO20045137A NO20045137A NO20045137L NO 20045137 L NO20045137 L NO 20045137L NO 20045137 A NO20045137 A NO 20045137A NO 20045137 A NO20045137 A NO 20045137A NO 20045137 L NO20045137 L NO 20045137L
Authority
NO
Norway
Prior art keywords
compounds
formula
active ingredient
drugs containing
diketohydrazine
Prior art date
Application number
NO20045137A
Other languages
English (en)
Other versions
NO333952B1 (no
Inventor
Kazuyuki Ohmoto
Haruo Imawaka
Akira Hatayama
Hiroshi Tsuruta
Yasuo Ochi
Original Assignee
Ono Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ono Pharmaceutical Co filed Critical Ono Pharmaceutical Co
Publication of NO20045137L publication Critical patent/NO20045137L/no
Publication of NO333952B1 publication Critical patent/NO333952B1/no

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
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Abstract

Foreliggende oppfinnelse vedrører et diketohydrazinderivat med formel (I) og et farmasøytisk akseptabelt salt derav. (Symbolene i formelen har den sarmne betydning som beskrevet i beskrivelsen). Forbindelsen med formel (I) har en hermnende aktivitet overfor cysteinprotease, og den er nyttig for behandling av inflammatoriske sykdorrmier, irrmiimsykdormner, iskemiske sykdorrmier, respiratoriske sykdonmier, sirkulasjonssykdommer, blodsykdommer, neuronale sykdommer, hepatiske eller bihære sykdonmier, ben- eller leddsykdommer, metaboliske sykdonmier, etc, og forbindelsen har inhiberende aktivitet overfor elastase, og den er også nyttig for behandling av eOPD ("chronic obstacle puhnonary diseases").
NO20045137A 2002-04-25 2004-11-25 Diketohydrazinderivatforbindelser og anvendelser inneholdende forbindelsene som aktiv ingrediens NO333952B1 (no)

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