MXPA04004365A - Novedosas sales mandelato de derivados de tetrahidrofurano tetraciclico sustituido. - Google Patents
Novedosas sales mandelato de derivados de tetrahidrofurano tetraciclico sustituido.Info
- Publication number
- MXPA04004365A MXPA04004365A MXPA04004365A MXPA04004365A MXPA04004365A MX PA04004365 A MXPA04004365 A MX PA04004365A MX PA04004365 A MXPA04004365 A MX PA04004365A MX PA04004365 A MXPA04004365 A MX PA04004365A MX PA04004365 A MXPA04004365 A MX PA04004365A
- Authority
- MX
- Mexico
- Prior art keywords
- mandelate
- mandelate salts
- novel
- salts according
- salts
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Anesthesiology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
- Furan Compounds (AREA)
Abstract
El objetivo de la presente invencion es presentar una novedosa sal mandelato de un derivado de tetrahidrofurano tetraciclico sustituido de acuerdo con la formula (I) ver formula (I) las formas de N-oxido y las formas estereoquimicamente isomericas de los mismos, en los cuales cada uno de R1 y R2 es independientemente hidrogeno o alquilo C1-C6 y cada uno de R3 y R4 es independientemente hidrogeno o halogeno; en las definiciones que anteceden, alquilo C1-C6 define radicales hidrocarburo de cadena recta o ramificada con 1 a 6 atomos de carbono tales como, por ejemplo, metilo, etilo, propilo, butilo, 1-metilpropilo, 1,1-dimetiletilo, pentilo y hexilo; la novedosa sal mandelato no es fotosensible y es mucho mas estable que las sales de la tecnica anterior a temperatura ambiente, a temperatura incrementada y a humedades relativas elevadas, asi como en medios acuosos; tambien se describen composiciones farmaceuticas que comprenden las sales mandelato de acuerdo con la presente invencion, las sales madelato de acuerdo con la presente invencion para usar como medicamento, un procedimiento para la preparacion de las sales mandelato de acuerdo con la presente invencion y el uso de las sales mandelato y composiciones farmaceuticas que comprende sales mandelato de acuerdo con la invencion para el tratamiento o la prevencion de trastornos del SNC, trastornos cardiovasculares y trastornos gastrointestinales.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01204465 | 2001-11-09 | ||
| PCT/EP2002/011136 WO2003040122A1 (en) | 2001-11-09 | 2002-11-08 | Novel mandelate salts of substituted tetracyclic tetrahydrofuran derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA04004365A true MXPA04004365A (es) | 2004-08-11 |
Family
ID=8181272
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA04004365A MXPA04004365A (es) | 2001-11-09 | 2002-11-08 | Novedosas sales mandelato de derivados de tetrahidrofurano tetraciclico sustituido. |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US7317115B2 (es) |
| EP (1) | EP1446397B1 (es) |
| JP (1) | JP2005508988A (es) |
| KR (1) | KR100962325B1 (es) |
| CN (1) | CN1582282B (es) |
| AR (1) | AR037285A1 (es) |
| AT (1) | ATE299138T1 (es) |
| AU (1) | AU2002349327B2 (es) |
| BR (1) | BR0212770A (es) |
| CA (1) | CA2465043C (es) |
| DE (1) | DE60204982T2 (es) |
| EA (1) | EA006980B1 (es) |
| ES (1) | ES2244818T3 (es) |
| HR (1) | HRP20040395A2 (es) |
| HU (1) | HUP0402224A3 (es) |
| IL (2) | IL161866A0 (es) |
| MX (1) | MXPA04004365A (es) |
| MY (1) | MY128237A (es) |
| NO (1) | NO328548B1 (es) |
| NZ (1) | NZ531739A (es) |
| PL (1) | PL368456A1 (es) |
| TW (1) | TW200407117A (es) |
| UA (1) | UA79248C2 (es) |
| WO (1) | WO2003040122A1 (es) |
| ZA (1) | ZA200403454B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUP0402152A3 (en) * | 2001-12-07 | 2007-03-28 | Janssen Pharmaceutica Nv | Preparation of trans-fused 3,3a,8,12b-tetrahydro-2h-dibenzo[3,4:6,7]cyclohepta[1,2-b]furan derivatives |
| WO2005013969A1 (en) * | 2003-07-15 | 2005-02-17 | Janssen Pharmaceutica N.V. | Antipsychotic agent with socializing properties |
| RU2401257C2 (ru) | 2004-12-07 | 2010-10-10 | Янссен Фармацевтика Н.В. | Новые замещенные тетрациклические производные тетрагидрофурана, пирролидина и тетрагидротиофена |
| EA013595B1 (ru) | 2005-01-27 | 2010-06-30 | Янссен Фармацевтика Н.В. | Гетероциклические, тетрациклические производные гидрофурана в качестве ингибиторов 5htв терапии расстройств цнс |
| DE602006012832D1 (de) | 2005-06-17 | 2010-04-22 | Janssen Pharmaceutica Nv | Neue tetracyclische tetrahydrofuran-derivate mit cyclischer aminseitenkette |
| US8507040B2 (en) | 2008-05-08 | 2013-08-13 | Air Products And Chemicals, Inc. | Binary and ternary metal chalcogenide materials and method of making and using same |
| US8765223B2 (en) * | 2008-05-08 | 2014-07-01 | Air Products And Chemicals, Inc. | Binary and ternary metal chalcogenide materials and method of making and using same |
| US8962675B1 (en) * | 2013-09-12 | 2015-02-24 | Abbvie Inc. | Atrasentan mandelate salts |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3644462A1 (de) | 1986-12-24 | 1988-07-07 | Basf Ag | Verfahren zur herstellung von 5h-dibenzo(a,d)cyclohepten-5-onen |
| JP2656720B2 (ja) * | 1992-12-09 | 1997-09-24 | 武田薬品工業株式会社 | 光学活性アミノクマラン誘導体 |
| ATE201680T1 (de) * | 1994-03-16 | 2001-06-15 | Cenes Ltd | 2,3,4,5-tetrahydro-1h-3-benzazepin säure- additions-salze |
| PL190960B1 (pl) | 1996-04-12 | 2006-02-28 | Janssen Pharmaceutica Nv | Tetracykliczna pochodna tetrahydrofuranu, kompozycja farmaceutyczna i sposób wytwarzania tetracyklicznej pochodnej tetrahydrofuranu |
| SK284145B6 (sk) | 1996-05-20 | 2004-10-05 | Janssen Pharmaceutica N. V. | Antifungálne prostriedky so zlepšenou biologickou dostupnosťou |
| UA52778C2 (uk) * | 1997-10-10 | 2003-01-15 | Янссен Фармацевтика Н.В. | Галогенозаміщені тетрациклічні похідні тетрагідрофурану, спосіб їх отримання та композиція на їх основі |
| US6281247B1 (en) * | 1998-03-03 | 2001-08-28 | Novo Nordisk A/S | Salt forms of (2E)-5-amino-5-methylhex-2-enoic acid N-methyl-N-((1R)-1-(N-methyl-N-((1R)-1-(methylcarbamoyl)-2-phenylethyl)carbamoyl)-2-(2-naphthyl)ethyl)amide |
| HUP9904624A2 (hu) * | 1999-12-17 | 2002-01-28 | Sanofi-Synthelabo | Szacharinszármazékok, eljárás előállításukra, az ezeket tartalmazó gyógyszerkészítmények és intermedierjeik |
| EP1186303A3 (en) * | 2000-09-06 | 2003-12-10 | Pfizer Products Inc. | Pharmaceutical combinations, for the treatment of stroke and traumatic brain injury, containing a neutrophil inhibiting factor and an selective NMDA-NR2B receptor antagonist |
-
2002
- 2002-08-11 UA UA20040604168A patent/UA79248C2/uk unknown
- 2002-11-07 MY MYPI20024166A patent/MY128237A/en unknown
- 2002-11-08 PL PL02368456A patent/PL368456A1/xx unknown
- 2002-11-08 MX MXPA04004365A patent/MXPA04004365A/es active IP Right Grant
- 2002-11-08 AT AT02781214T patent/ATE299138T1/de not_active IP Right Cessation
- 2002-11-08 NZ NZ531739A patent/NZ531739A/en not_active IP Right Cessation
- 2002-11-08 DE DE60204982T patent/DE60204982T2/de not_active Expired - Lifetime
- 2002-11-08 US US10/491,799 patent/US7317115B2/en not_active Expired - Fee Related
- 2002-11-08 JP JP2003542168A patent/JP2005508988A/ja active Pending
- 2002-11-08 TW TW091132840A patent/TW200407117A/zh unknown
- 2002-11-08 AR ARP020104298A patent/AR037285A1/es unknown
- 2002-11-08 CA CA2465043A patent/CA2465043C/en not_active Expired - Fee Related
- 2002-11-08 HU HU0402224A patent/HUP0402224A3/hu unknown
- 2002-11-08 EA EA200400656A patent/EA006980B1/ru not_active IP Right Cessation
- 2002-11-08 AU AU2002349327A patent/AU2002349327B2/en not_active Ceased
- 2002-11-08 ES ES02781214T patent/ES2244818T3/es not_active Expired - Lifetime
- 2002-11-08 KR KR1020047002379A patent/KR100962325B1/ko not_active IP Right Cessation
- 2002-11-08 CN CN02821918XA patent/CN1582282B/zh not_active Expired - Fee Related
- 2002-11-08 IL IL16186602A patent/IL161866A0/xx unknown
- 2002-11-08 EP EP02781214A patent/EP1446397B1/en not_active Expired - Lifetime
- 2002-11-08 WO PCT/EP2002/011136 patent/WO2003040122A1/en active IP Right Grant
- 2002-11-08 BR BR0212770-9A patent/BR0212770A/pt not_active IP Right Cessation
-
2004
- 2004-05-05 NO NO20041848A patent/NO328548B1/no not_active IP Right Cessation
- 2004-05-05 HR HR20040395A patent/HRP20040395A2/hr not_active Application Discontinuation
- 2004-05-06 ZA ZA200403454A patent/ZA200403454B/en unknown
- 2004-05-06 IL IL161866A patent/IL161866A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| KR100962325B1 (ko) | 2010-06-11 |
| EP1446397A1 (en) | 2004-08-18 |
| DE60204982D1 (de) | 2005-08-11 |
| DE60204982T2 (de) | 2006-04-27 |
| JP2005508988A (ja) | 2005-04-07 |
| WO2003040122A1 (en) | 2003-05-15 |
| US20050085533A1 (en) | 2005-04-21 |
| ATE299138T1 (de) | 2005-07-15 |
| IL161866A0 (en) | 2005-11-20 |
| BR0212770A (pt) | 2004-10-13 |
| CN1582282B (zh) | 2012-06-06 |
| CN1582282A (zh) | 2005-02-16 |
| CA2465043A1 (en) | 2003-05-15 |
| HUP0402224A2 (hu) | 2005-02-28 |
| NO20041848L (no) | 2004-05-05 |
| UA79248C2 (en) | 2007-06-11 |
| AR037285A1 (es) | 2004-11-03 |
| NZ531739A (en) | 2005-02-25 |
| KR20050044310A (ko) | 2005-05-12 |
| EA006980B1 (ru) | 2006-06-30 |
| TW200407117A (en) | 2004-05-16 |
| HRP20040395A2 (en) | 2005-04-30 |
| ES2244818T3 (es) | 2005-12-16 |
| US7317115B2 (en) | 2008-01-08 |
| HUP0402224A3 (en) | 2007-05-29 |
| NO328548B1 (no) | 2010-03-15 |
| IL161866A (en) | 2010-04-29 |
| MY128237A (en) | 2007-01-31 |
| ZA200403454B (en) | 2005-08-31 |
| CA2465043C (en) | 2011-02-15 |
| PL368456A1 (en) | 2005-03-21 |
| AU2002349327B2 (en) | 2008-10-23 |
| EP1446397B1 (en) | 2005-07-06 |
| EA200400656A1 (ru) | 2004-10-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration | ||
| GB | Transfer or rights |