MXPA03010867A - Nuevos derivados heterociclicos y uso farmaceutico de los mismos. - Google Patents
Nuevos derivados heterociclicos y uso farmaceutico de los mismos.Info
- Publication number
- MXPA03010867A MXPA03010867A MXPA03010867A MXPA03010867A MXPA03010867A MX PA03010867 A MXPA03010867 A MX PA03010867A MX PA03010867 A MXPA03010867 A MX PA03010867A MX PA03010867 A MXPA03010867 A MX PA03010867A MX PA03010867 A MXPA03010867 A MX PA03010867A
- Authority
- MX
- Mexico
- Prior art keywords
- alkyl
- remedies
- heterocyclic derivatives
- novel heterocyclic
- preventives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
El nuevo derivado heterociclico de la presente invencion es un nuevo derivado heterociclico que tiene la formula (I¦); (ver formula) donde R1 es un atomo de hidrogeno o alquilo C1-6, R7 es -CO-C(R4)=C(R4) -R5, donde R4 es un atomo de hidrogeno o alquilo C1-4, y R5 es alquilo C4-8, alquenilo C2-8, arilo o heterociclo aromatico, -CO-C=C-R6, donde R6 es alquilo C1-8 y similares, R3 es un atomo de hidrogeno o alquilo C1-4, X es un atomo de oxigeno o un atomo de azufre, R20 es fenilo opcionalmente sustituido, y n es un numero entero de 1 a 4, o una sal farmaceuticamente aceptable del mismo. El compuesto (I¦) de la presente invencion es util como agente hipoglucemico, agente hipolipidemico, mejorador de la resistencia a la insulina, agente terapeutico de la diabetes, agente, terapeutico de complicaciones diabeticas, mejorador de la tolerancia a la glucosa, agente anti-arterioesclerosis, agente antiobesidad, agente antiinflamatorio, agente para la profilaxis o el tratamiento de enfermedades mediadas por PPAR y agente para la profilaxis o el tratamiento del sindrome X.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001161488 | 2001-05-29 | ||
| PCT/JP2002/005098 WO2002096904A1 (fr) | 2001-05-29 | 2002-05-27 | Nouveaux derives heterocycliques et utilisation medicale de ces derives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA03010867A true MXPA03010867A (es) | 2004-02-27 |
Family
ID=19004755
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA03010867A MXPA03010867A (es) | 2001-05-29 | 2002-05-27 | Nuevos derivados heterociclicos y uso farmaceutico de los mismos. |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US6872732B2 (es) |
| EP (1) | EP1398313A4 (es) |
| JP (1) | JP4279137B2 (es) |
| KR (1) | KR100874677B1 (es) |
| CN (1) | CN1522253A (es) |
| AR (1) | AR036037A1 (es) |
| AU (1) | AU2002308891B2 (es) |
| BR (1) | BR0209735A (es) |
| CA (1) | CA2448639A1 (es) |
| CO (1) | CO5540322A2 (es) |
| CZ (1) | CZ20033415A3 (es) |
| HU (1) | HUP0400023A2 (es) |
| IL (1) | IL159084A0 (es) |
| MX (1) | MXPA03010867A (es) |
| NO (1) | NO326559B1 (es) |
| NZ (1) | NZ530313A (es) |
| PL (1) | PL367676A1 (es) |
| RU (1) | RU2287529C2 (es) |
| TW (1) | TWI243172B (es) |
| WO (1) | WO2002096904A1 (es) |
| YU (1) | YU94203A (es) |
| ZA (1) | ZA200309513B (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4279136B2 (ja) | 2001-05-29 | 2009-06-17 | 京都薬品工業株式会社 | 新規複素環化合物およびその医薬用途 |
| US6867224B2 (en) * | 2002-03-07 | 2005-03-15 | Warner-Lambert Company | Compounds that modulate PPAR activity and methods of preparation |
| US6833380B2 (en) | 2002-03-07 | 2004-12-21 | Warner-Lambert Company, Llc | Compounds that modulate PPAR activity and methods of preparation |
| JP2006514069A (ja) * | 2003-01-06 | 2006-04-27 | イーライ リリー アンド カンパニー | Ｐｐａｒ調節因子としての融合複素環式誘導体 |
| US7244763B2 (en) * | 2003-04-17 | 2007-07-17 | Warner Lambert Company Llc | Compounds that modulate PPAR activity and methods of preparation |
| US6987118B2 (en) | 2003-05-21 | 2006-01-17 | Pfizer Inc. | Tetrahydroisoquinoline derivatives as PPAR-alpha activators |
| CA2527691C (en) * | 2003-05-30 | 2013-01-22 | Takeda Pharmaceutical Company Limited | Condensed ring compound |
| JP4805552B2 (ja) * | 2003-05-30 | 2011-11-02 | 武田薬品工業株式会社 | 縮合環化合物 |
| TWI359810B (en) * | 2004-11-04 | 2012-03-11 | Mitsubishi Tanabe Pharma Corp | Carboxylic acid derivative containing thiazole rin |
| JP5225076B2 (ja) * | 2006-04-27 | 2013-07-03 | 田辺三菱製薬株式会社 | チアゾール環を含むカルボン酸誘導体の医薬用途 |
| WO2012033195A1 (ja) * | 2010-09-10 | 2012-03-15 | 京都薬品工業株式会社 | 複素環化合物 |
| MX358346B (es) | 2014-04-04 | 2018-08-15 | Syros Pharmaceuticals Inc | Inhibidores de la quinasa dependiente de ciclina 7 (cdk7). |
| WO2020013116A1 (ja) * | 2018-07-10 | 2020-01-16 | 京都薬品工業株式会社 | Ｐｔｐ－１ｂ阻害剤およびその用途 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6051189A (ja) * | 1983-08-30 | 1985-03-22 | Sankyo Co Ltd | チアゾリジン誘導体およびその製造法 |
| AR240698A1 (es) * | 1985-01-19 | 1990-09-28 | Takeda Chemical Industries Ltd | Procedimiento para preparar compuestos de 5-(4-(2-(5-etil-2-piridil)-etoxi)benzil)-2,4-tiazolidindiona y sus sales |
| EP0306228B1 (en) * | 1987-09-04 | 1999-11-17 | Beecham Group Plc | Substituted thiazolidinedione derivatives |
| US5246943A (en) | 1992-05-19 | 1993-09-21 | Warner-Lambert Company | Substituted 1,2,3,4-tetahydroisoquinolines with angiotensin II receptor antagonist properties |
| GB9604242D0 (en) | 1996-02-28 | 1996-05-01 | Glaxo Wellcome Inc | Chemical compounds |
| WO1998000137A1 (en) | 1996-07-01 | 1998-01-08 | Eli Lilly And Company | Hypoglycemic and hypolipidemic compounds |
| IL121203A (en) | 1996-07-01 | 2001-04-30 | Lilly Co Eli | 1, 2, 3, 4-tetrahydroisoquinidines, process for their preparation and pharmaceutical compositions containing the same for treating hyperglycemia and hyperlipidemia |
| GB9817118D0 (en) | 1998-08-07 | 1998-10-07 | Glaxo Group Ltd | Pharmaceutical compounds |
| WO2001040192A1 (fr) * | 1999-12-03 | 2001-06-07 | Kyoto Pharmaceutical Industries, Ltd. | Nouveaux composes heterocycliques et sels de ces derniers, utilisations de ces composes en medecine |
| US20020037897A1 (en) | 2000-08-07 | 2002-03-28 | 3-Dimensional Pharmaceuticals, Inc. | Tetrahydroisoquinoline-3-carboxylic acid alkoxyguanidines as integrin antagonists |
| JP4279136B2 (ja) | 2001-05-29 | 2009-06-17 | 京都薬品工業株式会社 | 新規複素環化合物およびその医薬用途 |
-
2002
- 2002-05-27 MX MXPA03010867A patent/MXPA03010867A/es active IP Right Grant
- 2002-05-27 RU RU2003137576/04A patent/RU2287529C2/ru not_active IP Right Cessation
- 2002-05-27 IL IL15908402A patent/IL159084A0/xx unknown
- 2002-05-27 KR KR1020037015518A patent/KR100874677B1/ko not_active IP Right Cessation
- 2002-05-27 EP EP02774071A patent/EP1398313A4/en not_active Withdrawn
- 2002-05-27 CZ CZ20033415A patent/CZ20033415A3/cs unknown
- 2002-05-27 BR BR0209735-4A patent/BR0209735A/pt not_active IP Right Cessation
- 2002-05-27 CA CA002448639A patent/CA2448639A1/en not_active Abandoned
- 2002-05-27 AU AU2002308891A patent/AU2002308891B2/en not_active Ceased
- 2002-05-27 US US10/478,863 patent/US6872732B2/en not_active Expired - Fee Related
- 2002-05-27 NZ NZ530313A patent/NZ530313A/en unknown
- 2002-05-27 WO PCT/JP2002/005098 patent/WO2002096904A1/ja active IP Right Grant
- 2002-05-27 PL PL02367676A patent/PL367676A1/xx not_active IP Right Cessation
- 2002-05-27 CN CNA028109627A patent/CN1522253A/zh active Pending
- 2002-05-27 JP JP2003500083A patent/JP4279137B2/ja not_active Expired - Fee Related
- 2002-05-27 HU HU0400023A patent/HUP0400023A2/hu unknown
- 2002-05-27 YU YU94203A patent/YU94203A/sh unknown
- 2002-05-28 TW TW091111323A patent/TWI243172B/zh not_active IP Right Cessation
- 2002-05-29 AR ARP020102003A patent/AR036037A1/es unknown
-
2003
- 2003-11-28 NO NO20035332A patent/NO326559B1/no unknown
- 2003-12-08 ZA ZA200309513A patent/ZA200309513B/xx unknown
- 2003-12-29 CO CO03112805A patent/CO5540322A2/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2002096904A1 (fr) | 2002-12-05 |
| NO326559B1 (no) | 2009-01-12 |
| KR20040004663A (ko) | 2004-01-13 |
| CA2448639A1 (en) | 2002-12-05 |
| EP1398313A4 (en) | 2005-11-16 |
| AU2002308891B2 (en) | 2007-09-06 |
| JP4279137B2 (ja) | 2009-06-17 |
| PL367676A1 (en) | 2005-03-07 |
| HUP0400023A2 (hu) | 2004-04-28 |
| US6872732B2 (en) | 2005-03-29 |
| EP1398313A1 (en) | 2004-03-17 |
| CN1522253A (zh) | 2004-08-18 |
| YU94203A (sh) | 2006-08-17 |
| RU2287529C2 (ru) | 2006-11-20 |
| NO20035332D0 (no) | 2003-11-28 |
| CZ20033415A3 (cs) | 2004-06-16 |
| RU2003137576A (ru) | 2005-05-20 |
| CO5540322A2 (es) | 2005-07-29 |
| BR0209735A (pt) | 2004-07-27 |
| ZA200309513B (en) | 2004-12-08 |
| TWI243172B (en) | 2005-11-11 |
| AR036037A1 (es) | 2004-08-04 |
| US20040180924A1 (en) | 2004-09-16 |
| JPWO2002096904A1 (ja) | 2004-09-09 |
| IL159084A0 (en) | 2004-05-12 |
| NZ530313A (en) | 2005-06-24 |
| KR100874677B1 (ko) | 2008-12-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |