MXPA02012260A - 2-aminoalquil-tieno[2,3-d]pirimidinas. - Google Patents
2-aminoalquil-tieno[2,3-d]pirimidinas.Info
- Publication number
- MXPA02012260A MXPA02012260A MXPA02012260A MXPA02012260A MXPA02012260A MX PA02012260 A MXPA02012260 A MX PA02012260A MX PA02012260 A MXPA02012260 A MX PA02012260A MX PA02012260 A MXPA02012260 A MX PA02012260A MX PA02012260 A MXPA02012260 A MX PA02012260A
- Authority
- MX
- Mexico
- Prior art keywords
- thieno
- pyrimidines
- aminoalkyl
- phosphodiesterase
- aminomethyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Reproductive Health (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Gynecology & Obstetrics (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invencion se refiere a 2-aminometil- tieno [2,3-d]pirimidinas de la formula general (I) (ver formula) donde los radicales R1 a R6 tienen el significado que se indica en el texto. Los compuestos muestran una inhibicion de la fosfodiesterasa V y pueden ser utilizados para el tratamiento de enfermedades del sistema cardiocirculatorio y para el tratamiento de trastornos de la potencia.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10031585A DE10031585A1 (de) | 2000-06-29 | 2000-06-29 | 2-Aminoalkyl-thieno[2,3-d]pyrimidine |
| PCT/EP2001/007379 WO2002000664A1 (de) | 2000-06-29 | 2001-06-28 | 2-aminoalkyl-thieno[2,3-d]pyrimidine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA02012260A true MXPA02012260A (es) | 2003-04-25 |
Family
ID=7647152
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA02012260A MXPA02012260A (es) | 2000-06-29 | 2001-06-28 | 2-aminoalquil-tieno[2,3-d]pirimidinas. |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US7259168B2 (es) |
| EP (1) | EP1294729B1 (es) |
| JP (1) | JP2004501925A (es) |
| KR (1) | KR20030010756A (es) |
| CN (1) | CN1234712C (es) |
| AR (1) | AR031856A1 (es) |
| AT (1) | ATE276260T1 (es) |
| AU (2) | AU2001285785B2 (es) |
| BR (1) | BR0112092A (es) |
| CA (1) | CA2410408C (es) |
| CZ (1) | CZ20024070A3 (es) |
| DE (2) | DE10031585A1 (es) |
| DK (1) | DK1294729T3 (es) |
| ES (1) | ES2227259T3 (es) |
| HU (1) | HUP0301466A3 (es) |
| MX (1) | MXPA02012260A (es) |
| NO (1) | NO20026246L (es) |
| PL (1) | PL358552A1 (es) |
| PT (1) | PT1294729E (es) |
| RU (1) | RU2261863C2 (es) |
| SK (1) | SK17822002A3 (es) |
| WO (1) | WO2002000664A1 (es) |
| ZA (1) | ZA200209729B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10031585A1 (de) * | 2000-06-29 | 2002-01-10 | Merck Patent Gmbh | 2-Aminoalkyl-thieno[2,3-d]pyrimidine |
| AR090037A1 (es) * | 2011-11-15 | 2014-10-15 | Xention Ltd | Derivados de tieno y/o furo-pirimidinas y piridinas inhibidores de los canales de potasio |
| CA2903176A1 (en) | 2013-03-14 | 2014-09-18 | Novartis Ag | 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant idh |
| CN108135906A (zh) * | 2015-07-24 | 2018-06-08 | 路易斯维尔大学研究基金会有限公司 | 治病化合物、组合物、方法、及化合物制备方法 |
| ES2968822T3 (es) * | 2017-12-15 | 2024-05-14 | Union Therapeutics As | Azetidina dihidrotienopirimidinas sustituidas y su uso como inhibidores de la fosfodiesterasa |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9311920D0 (en) | 1993-06-09 | 1993-07-28 | Pfizer Ltd | Therapeutic agents |
| US5869486A (en) * | 1995-02-24 | 1999-02-09 | Ono Pharmaceutical Co., Ltd. | Fused pyrimidines and pyriazines as pharmaceutical compounds |
| DE19632423A1 (de) * | 1996-08-12 | 1998-02-19 | Merck Patent Gmbh | Thienopyrimidine |
| DE19644228A1 (de) * | 1996-10-24 | 1998-04-30 | Merck Patent Gmbh | Thienopyrimidine |
| DE19752952A1 (de) * | 1997-11-28 | 1999-06-02 | Merck Patent Gmbh | Thienopyrimidine |
| DE19819023A1 (de) * | 1998-04-29 | 1999-11-04 | Merck Patent Gmbh | Thienopyrimidine |
| DE19928146A1 (de) * | 1999-06-19 | 2000-12-21 | Merck Patent Gmbh | Thienopyrimidine |
| DE10010612A1 (de) * | 2000-03-03 | 2001-09-27 | Merck Patent Gmbh | Verwendung von PDE V-Inhibitoren |
| DE10031585A1 (de) * | 2000-06-29 | 2002-01-10 | Merck Patent Gmbh | 2-Aminoalkyl-thieno[2,3-d]pyrimidine |
| DE10031584A1 (de) * | 2000-06-29 | 2002-01-10 | Merck Patent Gmbh | 5-Aminoalkyl-pyrazolo[4,3-d]pyrimidine |
| TWI447508B (zh) | 2010-04-01 | 2014-08-01 | Delta Electronics Inc | 投影裝置以及用於判斷一光點於投影畫面之位置之定位方法 |
-
2000
- 2000-06-29 DE DE10031585A patent/DE10031585A1/de not_active Withdrawn
-
2001
- 2001-06-28 CA CA2410408A patent/CA2410408C/en not_active Expired - Fee Related
- 2001-06-28 PT PT01965045T patent/PT1294729E/pt unknown
- 2001-06-28 WO PCT/EP2001/007379 patent/WO2002000664A1/de active IP Right Grant
- 2001-06-28 MX MXPA02012260A patent/MXPA02012260A/es unknown
- 2001-06-28 AT AT01965045T patent/ATE276260T1/de not_active IP Right Cessation
- 2001-06-28 CZ CZ20024070A patent/CZ20024070A3/cs unknown
- 2001-06-28 CN CNB018117988A patent/CN1234712C/zh not_active Expired - Fee Related
- 2001-06-28 SK SK1782-2002A patent/SK17822002A3/sk unknown
- 2001-06-28 EP EP01965045A patent/EP1294729B1/de not_active Expired - Lifetime
- 2001-06-28 DE DE50103649T patent/DE50103649D1/de not_active Expired - Lifetime
- 2001-06-28 BR BR0112092-1A patent/BR0112092A/pt not_active IP Right Cessation
- 2001-06-28 ES ES01965045T patent/ES2227259T3/es not_active Expired - Lifetime
- 2001-06-28 DK DK01965045T patent/DK1294729T3/da active
- 2001-06-28 PL PL01358552A patent/PL358552A1/xx unknown
- 2001-06-28 US US10/312,767 patent/US7259168B2/en not_active Expired - Fee Related
- 2001-06-28 KR KR1020027017570A patent/KR20030010756A/ko not_active Application Discontinuation
- 2001-06-28 AU AU2001285785A patent/AU2001285785B2/en not_active Ceased
- 2001-06-28 HU HU0301466A patent/HUP0301466A3/hu unknown
- 2001-06-28 AU AU8578501A patent/AU8578501A/xx active Pending
- 2001-06-28 JP JP2002505788A patent/JP2004501925A/ja active Pending
- 2001-06-28 RU RU2003100509/04A patent/RU2261863C2/ru not_active IP Right Cessation
- 2001-06-29 AR ARP010103145A patent/AR031856A1/es unknown
-
2002
- 2002-11-29 ZA ZA200209729A patent/ZA200209729B/en unknown
- 2002-12-27 NO NO20026246A patent/NO20026246L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CN1439012A (zh) | 2003-08-27 |
| JP2004501925A (ja) | 2004-01-22 |
| HUP0301466A2 (hu) | 2003-11-28 |
| CN1234712C (zh) | 2006-01-04 |
| BR0112092A (pt) | 2003-05-06 |
| DK1294729T3 (da) | 2005-01-17 |
| ES2227259T3 (es) | 2005-04-01 |
| PL358552A1 (en) | 2004-08-09 |
| HUP0301466A3 (en) | 2005-04-28 |
| AU2001285785B2 (en) | 2006-04-13 |
| RU2261863C2 (ru) | 2005-10-10 |
| CA2410408C (en) | 2010-06-22 |
| NO20026246D0 (no) | 2002-12-27 |
| ATE276260T1 (de) | 2004-10-15 |
| PT1294729E (pt) | 2005-01-31 |
| WO2002000664A1 (de) | 2002-01-03 |
| US20040044011A1 (en) | 2004-03-04 |
| CA2410408A1 (en) | 2002-11-26 |
| EP1294729A1 (de) | 2003-03-26 |
| AU8578501A (en) | 2002-01-08 |
| ZA200209729B (en) | 2004-03-08 |
| AR031856A1 (es) | 2003-10-08 |
| US7259168B2 (en) | 2007-08-21 |
| DE10031585A1 (de) | 2002-01-10 |
| EP1294729B1 (de) | 2004-09-15 |
| DE50103649D1 (de) | 2004-10-21 |
| KR20030010756A (ko) | 2003-02-05 |
| NO20026246L (no) | 2002-12-27 |
| CZ20024070A3 (cs) | 2003-04-16 |
| SK17822002A3 (sk) | 2003-05-02 |
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