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MX9301703A - Procedimiento de heteroanulacion para la preparacion de piperidonas y tetrahidropiridonas. - Google Patents

Procedimiento de heteroanulacion para la preparacion de piperidonas y tetrahidropiridonas.

Info

Publication number
MX9301703A
MX9301703A MX9301703A MX9301703A MX9301703A MX 9301703 A MX9301703 A MX 9301703A MX 9301703 A MX9301703 A MX 9301703A MX 9301703 A MX9301703 A MX 9301703A MX 9301703 A MX9301703 A MX 9301703A
Authority
MX
Mexico
Prior art keywords
heteroanulation
piperidones
procedure
preparation
tetrahidropiridonas
Prior art date
Application number
MX9301703A
Other languages
English (en)
Inventor
James Edmund Audia
David Ernest Lawhorn
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of MX9301703A publication Critical patent/MX9301703A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/10—Aza-phenanthrenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

Un procedimiento de heteroanulación para la preparación de piperidonas y tetrahidropiridonas mediante la reacción de una enamina adecuadamente sustituída con un derivado acriloilo en donde el grupo de cesión ocupa el carbonilo; igualemente, se proporciona un procedimiento para la escisión de un grupo 1-feniletilo a partir de un grupo amino acilado o de un átomo de nitrógeno heterocíclico adyacente a un átomo carbonilo, en partícular, sobre el átomo de nitrógeno de los productos del procedimiento de heteroanulación.
MX9301703A 1992-04-03 1993-03-26 Procedimiento de heteroanulacion para la preparacion de piperidonas y tetrahidropiridonas. MX9301703A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US86357492A 1992-04-03 1992-04-03

Publications (1)

Publication Number Publication Date
MX9301703A true MX9301703A (es) 1993-10-01

Family

ID=25341325

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9301703A MX9301703A (es) 1992-04-03 1993-03-26 Procedimiento de heteroanulacion para la preparacion de piperidonas y tetrahidropiridonas.

Country Status (9)

Country Link
EP (1) EP0564193A1 (es)
JP (1) JPH0680639A (es)
KR (1) KR930021619A (es)
BR (1) BR9301380A (es)
CA (1) CA2092782A1 (es)
HU (1) HUT64338A (es)
IL (1) IL105168A0 (es)
MX (1) MX9301703A (es)
TW (1) TW224091B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5574160A (en) * 1994-05-26 1996-11-12 Eli Lilly And Company Syntheis of benzoquinolinones
IL113808A (en) * 1994-05-26 1998-12-06 Lilly Co Eli Synthesis of enantiomeric benzoquinolinones
US5578724A (en) * 1994-09-20 1996-11-26 Eli Lilly And Company Process for preparation of benzo[f]quinolinones
US5955471A (en) * 1998-01-13 1999-09-21 Sk Corporation Tetrahydroisoquinolinealkanol derivatives and pharmaceutical compositions containing same
CA2338298A1 (en) * 1998-07-29 2000-02-10 Merck & Co., Inc. Tricyclic compounds
US6770658B2 (en) 1998-09-09 2004-08-03 Inflazyme Pharmaceuticals Ltd. Substituted γ-phenyl-Δ-lactams and uses related thereto

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUT51275A (en) * 1988-01-26 1990-04-28 Sandoz Ag Process for producing ergolin derivatives and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
CA2092782A1 (en) 1993-10-04
JPH0680639A (ja) 1994-03-22
EP0564193A1 (en) 1993-10-06
BR9301380A (pt) 1993-10-13
KR930021619A (ko) 1993-11-22
TW224091B (es) 1994-05-21
HUT64338A (en) 1993-12-28
IL105168A0 (en) 1993-07-08
HU9300927D0 (en) 1993-07-28

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