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MX355483B - Tratamientos y métodos de modulación de célula nk para el tratamiento de malignidades hematológicas. - Google Patents

Tratamientos y métodos de modulación de célula nk para el tratamiento de malignidades hematológicas.

Info

Publication number
MX355483B
MX355483B MX2013005673A MX2013005673A MX355483B MX 355483 B MX355483 B MX 355483B MX 2013005673 A MX2013005673 A MX 2013005673A MX 2013005673 A MX2013005673 A MX 2013005673A MX 355483 B MX355483 B MX 355483B
Authority
MX
Mexico
Prior art keywords
treatment
methods
hematological malignancies
cell modulating
modulating treatments
Prior art date
Application number
MX2013005673A
Other languages
English (en)
Other versions
MX2013005673A (es
Inventor
Andre Pascale
Buffet Renaud
Rozencweig Marcel
Tiollier Jerome
Original Assignee
Innate Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Innate Pharma Sa filed Critical Innate Pharma Sa
Publication of MX2013005673A publication Critical patent/MX2013005673A/es
Publication of MX355483B publication Critical patent/MX355483B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

La presente invención se refiere a el uso de una cantidad terapéuticamente efectiva de un anticuerpo anti-NKCIR o fragmento de anticuerpo que se une específicamente e inhibe un NKCIR (receptor del inhibidor de la célula asesina natural), para preparar una composición farmacéutica para tratar una pre-malignidad hematológica o malignidad hematológica en un individuo en donde la cantidad terapéuticamente eficaz del anticuerpo anti-NKCIR está en un intervalo de dosificación de 0.1 mg/kg, de modo que resulta en una saturación sustancialmente completa de NKCIR en células NK durante un período de al menos aproximadamente 1 semana, al menos alrededor de 2 semanas, o al menos alrededor de 1 mes: y en donde el individuo: (i) ha sido tratado previamente para la pre-malignidad hematológica o malignidad hematológica; (ii) tiene una mutación genética que se correlaciona con un mal pronóstico de supervivencia seleccionado del grupo que consiste en una mutación genética en FLT3 y/o NpM1; una trasposición en un gen de inmunoglobulina (Ig) y/o gen receptor de células T; anomalías del cromosoma 5 o cromosoma 7; y un cariotipo complejo (iii) y está experimentando una respuesta parcial o total al tratamiento anterior, está en remisión, es asintomático, tiene un número de células anormalmente bajo y/o tiene una enfermedad no detectable.
MX2013005673A 2010-11-22 2011-11-22 Tratamientos y métodos de modulación de célula nk para el tratamiento de malignidades hematológicas. MX355483B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41597310P 2010-11-22 2010-11-22
PCT/US2011/061840 WO2012071411A2 (en) 2010-11-22 2011-11-22 Nk cell modulating treatments and methods for treatment of hematological malignancies

Publications (2)

Publication Number Publication Date
MX2013005673A MX2013005673A (es) 2013-12-06
MX355483B true MX355483B (es) 2018-04-19

Family

ID=46146390

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013005673A MX355483B (es) 2010-11-22 2011-11-22 Tratamientos y métodos de modulación de célula nk para el tratamiento de malignidades hematológicas.

Country Status (11)

Country Link
US (1) US9844593B2 (es)
EP (1) EP2643350A4 (es)
JP (2) JP6224457B2 (es)
CN (2) CN103298831A (es)
AR (1) AR083957A1 (es)
BR (1) BR112013012138B1 (es)
CA (1) CA2818684C (es)
EA (1) EA035033B1 (es)
MX (1) MX355483B (es)
TW (1) TWI664191B (es)
WO (1) WO2012071411A2 (es)

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Also Published As

Publication number Publication date
WO2012071411A2 (en) 2012-05-31
MX2013005673A (es) 2013-12-06
US9844593B2 (en) 2017-12-19
TW201305210A (zh) 2013-02-01
EP2643350A4 (en) 2015-01-07
JP2016199549A (ja) 2016-12-01
BR112013012138A2 (pt) 2020-09-01
BR112013012138B1 (pt) 2022-02-22
CA2818684C (en) 2023-02-21
EA201390756A1 (ru) 2014-11-28
TWI664191B (zh) 2019-07-01
EP2643350A2 (en) 2013-10-02
CA2818684A1 (en) 2012-05-31
JP2014501729A (ja) 2014-01-23
CN106963947A (zh) 2017-07-21
CN103298831A (zh) 2013-09-11
US20130251711A1 (en) 2013-09-26
AR083957A1 (es) 2013-04-10
EA035033B1 (ru) 2020-04-20
JP6224457B2 (ja) 2017-11-01
WO2012071411A3 (en) 2012-08-16

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