[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

MX354068B - Construcciones de tejido bio-diseñadas por ingenieria y metodos para la produccion y uso de las mismas. - Google Patents

Construcciones de tejido bio-diseñadas por ingenieria y metodos para la produccion y uso de las mismas.

Info

Publication number
MX354068B
MX354068B MX2012008215A MX2012008215A MX354068B MX 354068 B MX354068 B MX 354068B MX 2012008215 A MX2012008215 A MX 2012008215A MX 2012008215 A MX2012008215 A MX 2012008215A MX 354068 B MX354068 B MX 354068B
Authority
MX
Mexico
Prior art keywords
producing
extracellular matrix
methods
matrix components
tissue constructs
Prior art date
Application number
MX2012008215A
Other languages
English (en)
Other versions
MX2012008215A (es
Inventor
Wang Xianyan
Ronfard Vincent
Baksh Dolores
Quin-Men Wong Matthew
Cao Lan
Sava Parid
Bollenbach Thomas
Yesilalan Esin
Original Assignee
Organogenesis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Organogenesis Inc filed Critical Organogenesis Inc
Publication of MX2012008215A publication Critical patent/MX2012008215A/es
Publication of MX354068B publication Critical patent/MX354068B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3633—Extracellular matrix [ECM]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3834—Cells able to produce different cell types, e.g. hematopoietic stem cells, mesenchymal stem cells, marrow stromal cells, embryonic stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3886—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells comprising two or more cell types
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3886—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells comprising two or more cell types
    • A61L27/3891—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells comprising two or more cell types as distinct cell layers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0656—Adult fibroblasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0665—Blood-borne mesenchymal stem cells, e.g. from umbilical cord blood
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0667—Adipose-derived stem cells [ADSC]; Adipose stromal stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0668—Mesenchymal stem cells from other natural sources
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/20—Transition metals
    • C12N2500/24—Iron; Fe chelators; Transferrin
    • C12N2500/25—Insulin-transferrin; Insulin-transferrin-selenium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/38—Vitamins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/02—Compounds of the arachidonic acid pathway, e.g. prostaglandins, leukotrienes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/11—Epidermal growth factor [EGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/148—Transforming growth factor alpha [TGF-a]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/39—Steroid hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Developmental Biology & Embryology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Botany (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Molecular Biology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La presente invención se refiere a un método para producir una construcción bio-diseñada por ingeniería que tiene una matriz extracelular porosa con un tamaño de poro promedio diseñado por ingeniería que comprende: a) sembrar células con la capacidad de sintetizar componentes de matriz extracelular dentro de un envase de cultivo; b) cultivar las células para sintetizar, secretar y organizar componentes de matriz extracelular; y c) liofilizar por lo menos los componentes de matriz extracelular resultantes, en donde la liofilización comprende congelar los componentes de la matriz extracelular hasta una temperatura de congelación final de entre -100°C y 0°C, en donde el tamaño de poro promedio de la matriz extracelular porosa se diseña por ingeniería para que sea menor de 100 µm al varia la temperatura de congelación final de modo que el tamaño de poro promedio de la matriz extracelular porosa se incrementa a medida que la temperatura de congelación final se incrementa y posteriormente secar los componentes de la matriz extracelular, para producir de esta manera una construcción de matriz extracelular bio-diseñada por ingeniería que tiene una matriz extracelular con el tamaño de poro promedio diseñado por ingeniería. .
MX2012008215A 2010-01-14 2011-01-14 Construcciones de tejido bio-diseñadas por ingenieria y metodos para la produccion y uso de las mismas. MX354068B (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US29507310P 2010-01-14 2010-01-14
US33793810P 2010-02-12 2010-02-12
US34772510P 2010-05-24 2010-05-24
PCT/US2011/021362 WO2011088365A1 (en) 2010-01-14 2011-01-14 Bioengineered tissue constructs and methods for producing and using thereof

Publications (2)

Publication Number Publication Date
MX2012008215A MX2012008215A (es) 2012-10-15
MX354068B true MX354068B (es) 2018-02-09

Family

ID=43881131

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012008215A MX354068B (es) 2010-01-14 2011-01-14 Construcciones de tejido bio-diseñadas por ingenieria y metodos para la produccion y uso de las mismas.

Country Status (12)

Country Link
US (1) US20110293667A1 (es)
EP (1) EP2524034A1 (es)
JP (3) JP2013517292A (es)
CN (2) CN102892880A (es)
AU (1) AU2011205674A1 (es)
BR (1) BR112012017463A2 (es)
CA (1) CA2787050A1 (es)
IL (1) IL220903A0 (es)
MX (1) MX354068B (es)
RU (1) RU2645473C2 (es)
SG (1) SG182508A1 (es)
WO (1) WO2011088365A1 (es)

Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8986377B2 (en) 2009-07-21 2015-03-24 Lifecell Corporation Graft materials for surgical breast procedures
US20120143228A1 (en) 2010-08-30 2012-06-07 Agency For Science Technology And Research Adhesive structure with stiff protrusions on adhesive surface
US9492952B2 (en) 2010-08-30 2016-11-15 Endo-Surgery, Inc. Super-hydrophilic structures
EP2714111B1 (en) * 2011-05-31 2021-03-17 LifeCell Corporation Adipose tissue matrices
US20130066370A1 (en) * 2011-09-06 2013-03-14 The Stem Cell Suture Company, LLC Surgical sutures and methods of making and using same
ES2725564T3 (es) 2011-11-08 2019-09-24 Auxocell Laboratories Inc Sistemas y métodos de procesamiento celular
CN104220079B (zh) * 2011-12-29 2018-01-12 伊西康公司 在其表面上具有组织穿刺突起的粘合结构
US9549812B2 (en) 2012-01-13 2017-01-24 Lifecell Corporation Breast prostheses, methods of manufacturing breast prostheses, and methods of treatment using breast prostheses
CN102599991A (zh) * 2012-03-20 2012-07-25 中山大学中山眼科中心 美容性角膜镜片的应用
US8926881B2 (en) 2012-04-06 2015-01-06 DePuy Synthes Products, LLC Super-hydrophobic hierarchical structures, method of forming them and medical devices incorporating them
US8969648B2 (en) 2012-04-06 2015-03-03 Ethicon, Inc. Blood clotting substrate and medical device
EP3556320A1 (en) * 2012-06-21 2019-10-23 LifeCell Corporation Implantable prosthesis having acellular tissue attachments
US9498559B2 (en) * 2012-10-08 2016-11-22 Cormatrix Cardiovascular, Inc. Reinforced vascular protheses
KR102223440B1 (ko) * 2013-02-08 2021-03-05 아셀, 인크. 세포외 기질 재료로부터의 생리활성 겔의 제조 방법
KR102252223B1 (ko) 2013-02-12 2021-05-14 리플리셀 라이프 사이언시스 인크. 힘줄 치료 및 회복을 위한 조성물 및 방법
WO2014125505A1 (en) * 2013-02-14 2014-08-21 Council Of Scientific & Industrial Research Silk based porous scaffold and a process for the preparation thereof
EP3027235A1 (en) 2013-07-30 2016-06-08 Musculoskeletal Transplant Foundation Acellular soft tissue-derived matrices and methods for preparing same
WO2015022670A1 (en) * 2013-08-14 2015-02-19 Stempeutics Research Pvt. Ltd. Management of osteoarthritis using pooled allogeneic mesenchymal stem cells
CN105611950A (zh) * 2013-09-25 2016-05-25 富士胶片株式会社 生物相容性高分子多孔体的制造方法、生物相容性高分子多孔体、生物相容性高分子块体及细胞构建体
US10959839B2 (en) * 2013-10-08 2021-03-30 Edwards Lifesciences Corporation Method for directing cellular migration patterns on a biological tissue
GB201317889D0 (en) 2013-10-09 2013-11-20 Reneuron Ltd Product and use
CL2013003066A1 (es) * 2013-10-22 2014-07-25 Univ Chile Composicion para tratamiento de heridas porque comprende matriz soporte y células troncalesmesenquiámicas de gelatina de wharton; metodo para tratar heridas que comprende aplicar dicha composicion
RU2559921C2 (ru) * 2013-11-01 2015-08-20 Игорь Иванович Агапов Способ восстановления целостности тонкой кишки
CN104726398A (zh) * 2013-12-20 2015-06-24 江阴司特易生物技术有限公司 固定化的全人源ecm包被基质的制备方法
US10500233B2 (en) 2014-02-12 2019-12-10 Replicel Life Sciences Inc. Compositions and methods for treating bone, joints and cartilage
PT3142586T (pt) * 2014-05-14 2021-01-05 Harvard College Dispositivo de cateter para transmitir e refletir luz
US9993748B2 (en) 2014-08-11 2018-06-12 Auxocell Laboratories, Inc. Centrifuge clip and method
USD748462S1 (en) 2014-08-11 2016-02-02 Auxocell Laboratories, Inc. Centrifuge clip
CN107530476A (zh) * 2015-03-12 2018-01-02 般财团法人化学及血清疗法研究所 使用脱细胞化组织的抗粘连材料和代用生物膜
CN104800891B (zh) * 2015-05-20 2017-03-29 苏州大学附属第一医院 一种增强体外培养间充质干细胞生物抗氧化功能的细胞外基质生物材料、制备方法及其应用
CN105769381B (zh) * 2015-05-26 2018-04-17 南通大学 一种用于组织损伤修复的生物补片
CN104958319A (zh) * 2015-06-01 2015-10-07 成都清科生物科技有限公司 具有卵巢早衰及围绝经期综合征治疗作用的间充质干细胞及其细胞因子制剂及其制备方法
WO2017003877A1 (en) * 2015-06-30 2017-01-05 Lattice Biologics Inc. Modified extracellular matrix for enhanced stem cell homing and engraftment
US10912864B2 (en) 2015-07-24 2021-02-09 Musculoskeletal Transplant Foundation Acellular soft tissue-derived matrices and methods for preparing same
US11052175B2 (en) 2015-08-19 2021-07-06 Musculoskeletal Transplant Foundation Cartilage-derived implants and methods of making and using same
CA2996287A1 (en) 2015-08-21 2017-03-02 Lifecell Corporation Breast treatment device
US20180318359A1 (en) 2015-09-29 2018-11-08 Anicell Biotech, Llc Methods and articles of manufacture for the treatment of animals
CN105535946A (zh) * 2015-12-14 2016-05-04 北京大学第一医院 转谷氨酰胺酶在加强角膜力学性质中的应用及生物制剂
EP3436035B1 (en) * 2016-03-29 2024-09-04 SmsBiotech, Inc. Compositions and methods for using small mobile stem cells
AU2017243945A1 (en) * 2016-03-30 2018-10-18 Stembiosys, Inc. Bone marrow stromal cell derived extracellular matrix protein extract and uses thereof
US11045579B2 (en) 2016-08-31 2021-06-29 Lifecell Corporation Breast treatment device
US11730696B2 (en) * 2016-10-20 2023-08-22 Australian Foundation for Diabetes Research Cell associated scaffolds for delivery of agents
CN106581760A (zh) * 2016-11-08 2017-04-26 华南生物医药研究院 增强细胞活性的特殊处理方法
CN106563161A (zh) * 2016-11-08 2017-04-19 华南生物医药研究院 可用于美容的新型药物组合剂
CN106619721A (zh) * 2016-11-08 2017-05-10 中国人民解放军军事医学科学院野战输血研究所 一种增强细胞活性的新方法
WO2018123814A1 (ja) * 2016-12-28 2018-07-05 株式会社高研 高強度コラーゲンスポンジ
US10368991B2 (en) * 2017-02-06 2019-08-06 C. R. Bard, Inc. Device and associated percutaneous minimally invasive method for creating a venous valve
KR20180099482A (ko) * 2017-02-27 2018-09-05 고려대학교 산학협력단 하이드로겔 중합체를 이용한 탈세포화 조직의 제조방법 및 이로부터 제조된 탈세포화 조직
EP3638310A4 (en) * 2017-06-12 2021-04-14 The University Of North Carolina At Chapel Hill PATCH GRAFT COMPOSITIONS FOR CELLULAR TRANSPLANTATION
CN107550935A (zh) * 2017-09-11 2018-01-09 上海亚睿生物科技有限公司 一种治疗关节疾病的生物凝胶剂及其应用
CL2017002357A1 (es) * 2017-09-16 2018-04-20 Cells For Cells S A Método de obtención de una composición que contiene una población específica de células mesenquimales de cordón umbilical y sus usos
US11285177B2 (en) 2018-01-03 2022-03-29 Globus Medical, Inc. Allografts containing viable cells and methods thereof
CN108144128B (zh) * 2018-02-07 2021-11-05 陕西佰傲再生医学有限公司 一种多次交联乳房补片及其制备方法
CN108543116B (zh) * 2018-05-02 2021-04-27 深圳市华异生物科技有限责任公司 海藻酸钠与明胶复合水凝胶3d胰岛支架及其制备方法
US11180732B2 (en) 2018-10-03 2021-11-23 Stembiosys, Inc. Amniotic fluid cell-derived extracellular matrix and uses thereof
CN109793927A (zh) * 2019-01-24 2019-05-24 中国人民解放军军事科学院军事医学研究院 基于细胞外衍生基质修饰的丝素蛋白多孔支架的制备方法
KR102639023B1 (ko) 2019-02-21 2024-02-20 스템바이오시스, 인크. 양수 세포-유래 ecm 상에서 심근세포 성숙을 위한 방법, 세포 구조, 및 약물 화합물의 심장 독성 및 전부정맥 스크리닝을 위한 용도
CN110075357A (zh) * 2019-04-02 2019-08-02 浙江大学 一种脂肪干细胞与纳米丝素复合的骨修复材料的制备方法
WO2020207426A1 (zh) * 2019-04-10 2020-10-15 上海交通大学医学院附属上海儿童医学中心 一种体内植入性微孔囊袋及其使用方法和应用
US11298220B2 (en) 2019-05-03 2022-04-12 Lifecell Corporation Breast treatment device
CN110106148B (zh) * 2019-05-16 2020-10-13 中国人民解放军军事科学院军事医学研究院 一种组织工程化神经组织及其构建方法
CN110409059A (zh) * 2019-07-30 2019-11-05 北京化工大学常州先进材料研究院 甲基丙烯酸二甲氨基乙酯增强的丙烯酰化pgs纳米纤维膜的制备方法
CN112342187A (zh) * 2019-08-06 2021-02-09 中晶生物技术股份有限公司 一种软骨细胞培养基及其制备方法
CN110904044B (zh) * 2019-12-17 2022-07-19 陕西师范大学 一种肿瘤干细胞的三维培养方法
CN111407353A (zh) * 2020-02-26 2020-07-14 邹洪 一种新型蚕丝蛋白材料制作的结扎钉夹
US11725112B2 (en) * 2020-02-28 2023-08-15 Lawrence Livermore National Security, Llc Three-dimensional printed porous silicone matrix using leachable porogen
RU2749801C1 (ru) * 2020-03-06 2021-06-17 Галина Мироновна Могильная Способ восстановления утраченного объема дермы в эксперименте на крысах
CN111690604A (zh) * 2020-06-24 2020-09-22 杭州原生生物科技有限公司 一种msc体外扩增方法
KR102527152B1 (ko) * 2021-02-15 2023-04-28 울산과학기술원 강유전성 생분해 고분자층을 포함하는 전자 피부
CN113456893B (zh) * 2021-07-26 2022-04-26 温州医科大学附属眼视光医院 一种包被纤维蛋白原的蓝染羊膜基底膜的制备方法
CN115105637B (zh) * 2022-07-28 2023-11-10 上海交通大学医学院附属第九人民医院 结膜下成纤维细胞脱细胞基质在结膜重建方面的应用
WO2024092220A2 (en) * 2022-10-28 2024-05-02 University Of Connecticut Prosthetic device for tissue regeneration
CN117582557B (zh) * 2024-01-19 2024-03-19 四川恒普科技有限公司 脱矿骨纤维及其制备方法

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2018228C (en) 1989-06-05 1996-02-27 Nancy L. Parenteau Cell culture systems and media
US5460962A (en) 1994-01-04 1995-10-24 Organogenesis Inc. Peracetic acid sterilization of collagen or collagenous tissue
EP0759932A4 (en) 1994-05-11 1997-11-19 Organo Genesis Inc COLLECTIONS FROM CELL CULTURES
EP0953041A4 (en) * 1996-08-30 2003-01-29 Life Technologies Inc SERUM-FREE CULTURAL MEDIUM FOR MAMMAL CELLS AND THEIR USE
US5993844A (en) * 1997-05-08 1999-11-30 Organogenesis, Inc. Chemical treatment, without detergents or enzymes, of tissue to form an acellular, collagenous matrix
US6291240B1 (en) * 1998-01-29 2001-09-18 Advanced Tissue Sciences, Inc. Cells or tissues with increased protein factors and methods of making and using same
JP2002530069A (ja) 1998-11-19 2002-09-17 オルガノジェネシス インク． 生物工学的組織構築物およびそれを生成および使用する方法
US6372494B1 (en) * 1999-05-14 2002-04-16 Advanced Tissue Sciences, Inc. Methods of making conditioned cell culture medium compositions
NZ517002A (en) * 1999-08-05 2004-06-25 Mcl Llc Multipotent adult stem cells and methods for isolation
WO2003007789A2 (en) * 2001-07-16 2003-01-30 Depuy Products, Inc. Porous extracellular matrix scaffold and method
EP1452586B1 (en) * 2001-10-30 2012-05-30 Nc Medical Research Inc. Method of inducing differentiation of mesodermal stem cells into nervous system cells
WO2003050266A2 (en) * 2001-12-11 2003-06-19 Cytograft Tissue Engineering, Inc. Tissue engineered cellular sheets, methods of making and use thereof
WO2004072273A1 (en) * 2003-02-11 2004-08-26 Davies John E Progenitor cells from wharton's jelly of human umbilical cord
WO2005012512A1 (en) * 2003-08-01 2005-02-10 Norimasa Nakamura Scaffold-free self-organized 3d synthetic tissue
US20050288796A1 (en) * 2004-06-23 2005-12-29 Hani Awad Native soft tissue matrix for therapeutic applications
CA2585547A1 (en) * 2004-10-29 2006-05-11 Centocor, Inc. Chemically defined media compositions
US8728463B2 (en) * 2005-03-11 2014-05-20 Wake Forest University Health Science Production of tissue engineered digits and limbs
WO2006102063A2 (en) * 2005-03-19 2006-09-28 Cook Biotech Incorporated Prosthetic implants including ecm composite material
JP4745750B2 (ja) * 2005-08-01 2011-08-10 株式会社ツーセル 動物幹細胞培養用無血清培地
AU2006282783B2 (en) * 2005-08-26 2013-06-06 Miromatrix Medical Inc. Decellularization and recellularization of organs and tissues
WO2007024036A1 (en) * 2005-08-26 2007-03-01 Seoul National University Industry Foundation Multipotent stem cells isolated from umbilical cord blood and the cellular therapeutic agent comprisin the same for treating ischemic disease
WO2007103865A2 (en) * 2006-03-03 2007-09-13 Organogenesis, Inc. Oral tissue regeneration and repair
CN101412985B (zh) * 2007-10-15 2012-06-13 华东理工大学 用于骨髓间充质干细胞体外培养和扩增的无血清培养基
CN100563728C (zh) * 2007-10-19 2009-12-02 中国人民解放军第四军医大学 含有外周血干细胞的组织工程皮肤及其制备方法
US20110293666A1 (en) * 2007-11-28 2011-12-01 Xianyan Wang Bioengineered Tissue Constructs and Methods for Production and Use
WO2009070720A1 (en) * 2007-11-28 2009-06-04 Organogenesis, Inc. Bioengineered tissue constructs and methods for production and use
RU86455U1 (ru) * 2008-04-22 2009-09-10 ФГУ "Московский научно-исследовательский онкологический институт им. П.А. Герцена Федерального агентства по высокотехнологичной медицинской помощи" РФ Биоинженерная конструкция
WO2013090911A1 (en) * 2011-12-16 2013-06-20 Wisconsin Alumni Research Foundation Method for supporting human pluri potent stem cell cultures comprising culturing the cells in a medium comprising thermostable fgf - 1 proteins

Also Published As

Publication number Publication date
RU2012132705A (ru) 2014-02-20
JP2016182126A (ja) 2016-10-20
CN107802890A (zh) 2018-03-16
CN102892880A (zh) 2013-01-23
RU2645473C2 (ru) 2018-02-21
US20110293667A1 (en) 2011-12-01
WO2011088365A1 (en) 2011-07-21
EP2524034A1 (en) 2012-11-21
BR112012017463A2 (pt) 2015-09-15
JP2013517292A (ja) 2013-05-16
JP2018117643A (ja) 2018-08-02
SG182508A1 (en) 2012-08-30
MX2012008215A (es) 2012-10-15
CA2787050A1 (en) 2011-07-21
AU2011205674A1 (en) 2012-08-09
IL220903A0 (en) 2012-09-24

Similar Documents

Publication Publication Date Title
MX354068B (es) Construcciones de tejido bio-diseñadas por ingenieria y metodos para la produccion y uso de las mismas.
MX2010005791A (es) Construcciones de tejido hechas mediante bio-ingenieria y metodos para produccion y uso.
MX2015005797A (es) Produccion de vacuna recombinante en e.coli mediante conjugacion enzimatica.
IN2014CN03890A (es)
HK1220993A1 (zh) 使用呈現出蛋白伴侶表達水平升高的細菌提取物在細菌無細胞合成系統中表達生物學活性蛋白
EP2588592A4 (en) USE OF PERFUSION DECELLULARIZED ORGANS FOR AGGREGATE RECELLULARIZATION
MX364229B (es) Composiciones y metodos para tratar enfermedades cardiovasculares.
SG10201907588XA (en) Androgen Receptor Modulators And Uses Thereof
WO2010108126A3 (en) Reprogramming compositions and methods of using the same
MY159971A (en) Multipotent/pluripotent cells and methods
IL225923B (en) Cell culture material derived from a plant, methods for its preparation and uses thereof
MY185016A (en) Progenitor cells of mesodermal lineage
WO2011082038A3 (en) Improved reprogramming compositions
MX2013002975A (es) Moduladores de receptores de estrogenos y usos de los mismos.
BR112015011933A8 (pt) Composições bacterianas sinérgicas e métodos de produção e uso das mesmas
EP2548950A3 (en) Reprogramming T cells and hematopoietic cells
PH12015500276A1 (en) Treatment of immune-related and inflammatory diseases
AU2017241807A1 (en) Medium, methods, cells and secreted factors for stem cell culture and therapy
MY170719A (en) Antibody-drug conjugates
MX2016006625A (es) Receptores de células t humanas con alta afinidad modificados por medio de manipulación genética.
WO2012027514A3 (en) Compositions and methods for cardiac therapy
WO2012106281A3 (en) Multimodal trail molecules and uses in cellular therapies
EP2558124A4 (en) POLYSACCHARID COMPOSITIONS AND METHOD FOR USE THEREOF FOR THE TREATMENT AND PREVENTION OF DISEASES ASSOCIATED WITH PRECURSOR CELL MOBILIZATION
EP2600834A4 (en) COLLAGEN IMPLANTS FOR THE SUSTAINABLE DELIVERY OF MEDICAMENTS
MX2016016142A (es) Metodos de cultivo por perfusion y usos de los mismos.

Legal Events

Date Code Title Description
FG Grant or registration