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MX343296B - Enzimas de acido carboxilico-reductasa (car) y produccion mejorada de alcoholes grasos. - Google Patents

Enzimas de acido carboxilico-reductasa (car) y produccion mejorada de alcoholes grasos.

Info

Publication number
MX343296B
MX343296B MX2014011903A MX2014011903A MX343296B MX 343296 B MX343296 B MX 343296B MX 2014011903 A MX2014011903 A MX 2014011903A MX 2014011903 A MX2014011903 A MX 2014011903A MX 343296 B MX343296 B MX 343296B
Authority
MX
Mexico
Prior art keywords
fatty alcohols
improved production
enzymes
car
car enzymes
Prior art date
Application number
MX2014011903A
Other languages
English (en)
Other versions
MX2014011903A (es
Inventor
l greenfield Derek
J Clarke Elizabeth
S Groban Eli
Hu Zhihao
Arlagadda Vikranth
Lee Sungwon
Li Xuezhi
Zhu Baolong
Original Assignee
Reg Life Sciences Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Reg Life Sciences Llc filed Critical Reg Life Sciences Llc
Publication of MX2014011903A publication Critical patent/MX2014011903A/es
Publication of MX343296B publication Critical patent/MX343296B/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
    • C12Y102/01—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
    • C12Y102/0105—Long-chain-fatty-acyl-CoA reductase (1.2.1.50)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
    • C12Y102/99—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with other acceptors (1.2.99)
    • C12Y102/99006—Carboxylate reductase (1.2.99.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/01041—Beta-ketoacyl-acyl-carrier-protein synthase I (2.3.1.41)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/02—Thioester hydrolases (3.1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P2203/00—Fermentation products obtained from optionally pretreated or hydrolyzed cellulosic or lignocellulosic material as the carbon source
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

La presente invención se refiere a enzimas variantes de ácido carboxílico-reductasa (CAR) para la producción mejorada de alcoholes grasos en células recombinantes.
MX2014011903A 2012-04-02 2013-04-02 Enzimas de acido carboxilico-reductasa (car) y produccion mejorada de alcoholes grasos. MX343296B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261619309P 2012-04-02 2012-04-02
PCT/US2013/035040 WO2013152052A2 (en) 2012-04-02 2013-04-02 Novel car enzymes and improved production of fatty alcohols

Publications (2)

Publication Number Publication Date
MX2014011903A MX2014011903A (es) 2015-05-12
MX343296B true MX343296B (es) 2016-11-01

Family

ID=49237582

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2014011903A MX343296B (es) 2012-04-02 2013-04-02 Enzimas de acido carboxilico-reductasa (car) y produccion mejorada de alcoholes grasos.
MX2016013852A MX358177B (es) 2012-04-02 2013-04-02 Enzimas de acido carboxilico-reductasa (car) y produccion mejorada de alcoholes grasos.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2016013852A MX358177B (es) 2012-04-02 2013-04-02 Enzimas de acido carboxilico-reductasa (car) y produccion mejorada de alcoholes grasos.

Country Status (14)

Country Link
US (4) US9340801B2 (es)
EP (6) EP3385374B1 (es)
JP (1) JP6230594B2 (es)
KR (6) KR20170113710A (es)
CN (1) CN104704113B (es)
AU (2) AU2013243602B2 (es)
BR (2) BR122019026987B1 (es)
CA (1) CA2883064A1 (es)
CO (1) CO7170148A2 (es)
ES (3) ES2666157T3 (es)
MX (2) MX343296B (es)
MY (1) MY170889A (es)
SI (1) SI3385374T1 (es)
WO (1) WO2013152052A2 (es)

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EP2367947B1 (en) * 2008-10-28 2014-07-16 LS9, Inc. Methods for producing fatty alcohols
US9340801B2 (en) * 2012-04-02 2016-05-17 REG Life Sciences, LLC Car enzymes and improved production of fatty alcohols
KR102353113B1 (ko) * 2012-04-02 2022-01-19 게노마티카 인코포레이티드 지방산 유도체들의 개선된 생산
CN109182238A (zh) 2012-08-10 2019-01-11 嘉吉有限公司 用于生产脂肪酸和脂肪酸衍生产物的微生物及方法
US10047383B2 (en) 2013-03-15 2018-08-14 Cargill, Incorporated Bioproduction of chemicals
WO2014145343A1 (en) * 2013-03-15 2014-09-18 Opx Biotechnologies, Inc. Bioproduction of chemicals
US11408013B2 (en) 2013-07-19 2022-08-09 Cargill, Incorporated Microorganisms and methods for the production of fatty acids and fatty acid derived products
WO2015010103A2 (en) 2013-07-19 2015-01-22 Opx Biotechnologies, Inc. Microorganisms and methods for the production of fatty acids and fatty acid derived products
CN111748511A (zh) 2014-07-18 2020-10-09 基因组股份公司 微生物的脂肪二醇产生
EP2993228B1 (en) 2014-09-02 2019-10-09 Cargill, Incorporated Production of fatty acid esters
CN105985987B (zh) * 2015-03-02 2020-01-31 苏州安捷生物科技有限公司 一种生物法制备脂肪醇的方法
EP3430133A1 (en) * 2016-03-17 2019-01-23 INVISTA Textiles (U.K.) Limited Carboxylic acid reductase polypeptides and variants having improved activity, materials and processes relating thereto
WO2018144701A2 (en) 2017-02-02 2018-08-09 Cargill Incorporated Genetically modified cells that produce c6-c10 fatty acid derivatives
CN111094558A (zh) 2017-04-03 2020-05-01 基因组股份公司 对产生中链脂肪酸衍生物具有改善的活性的硫酯酶变体
CA3109062A1 (en) 2018-08-31 2020-03-05 Genomatica, Inc. Xylr mutant for improved xylose utilization or improved co-utilization of glucose and xylose
CN117120616A (zh) 2021-03-30 2023-11-24 旭化成株式会社 具有羧酸还原活性的重组多肽
WO2023178193A1 (en) 2022-03-16 2023-09-21 Genomatica, Inc. Acyl-acp thioesterase variants and uses thereof

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Also Published As

Publication number Publication date
MX358177B (es) 2018-08-08
MY170889A (en) 2019-09-12
US10301603B2 (en) 2019-05-28
AU2013243602B2 (en) 2016-11-24
KR20170113710A (ko) 2017-10-12
AU2016231497B2 (en) 2017-08-31
KR101831331B1 (ko) 2018-02-23
US20160326499A1 (en) 2016-11-10
KR20190076059A (ko) 2019-07-01
EP4186974A1 (en) 2023-05-31
EP3385374A1 (en) 2018-10-10
EP2834350B1 (en) 2016-11-16
SI3385374T1 (sl) 2020-09-30
KR102185762B1 (ko) 2020-12-02
AU2013243602A1 (en) 2014-11-13
JP6230594B2 (ja) 2017-11-15
KR102282677B1 (ko) 2021-07-28
EP3153579B1 (en) 2018-03-14
EP3674399B1 (en) 2021-09-22
ES2666157T3 (es) 2018-05-03
BR122019026987B1 (pt) 2022-01-18
US20200109374A1 (en) 2020-04-09
KR102114841B1 (ko) 2020-05-26
EP3985108A1 (en) 2022-04-20
US11034937B2 (en) 2021-06-15
WO2013152052A2 (en) 2013-10-10
EP3674399A1 (en) 2020-07-01
US20180135028A1 (en) 2018-05-17
US9758769B2 (en) 2017-09-12
ES2786633T3 (es) 2020-10-13
AU2016231497A1 (en) 2016-10-06
CO7170148A2 (es) 2015-01-28
CA2883064A1 (en) 2013-10-10
CN104704113B (zh) 2018-01-23
BR112014024674A2 (pt) 2018-11-21
EP3153579A1 (en) 2017-04-12
CN104704113A (zh) 2015-06-10
EP3385374B1 (en) 2020-01-08
BR112014024674B1 (pt) 2022-06-07
US9340801B2 (en) 2016-05-17
ES2613553T3 (es) 2017-05-24
US20150064757A1 (en) 2015-03-05
KR20190022935A (ko) 2019-03-06
EP2834350A2 (en) 2015-02-11
KR20150032660A (ko) 2015-03-27
WO2013152052A3 (en) 2014-03-13
MX2014011903A (es) 2015-05-12
KR20210095226A (ko) 2021-07-30
KR20200038559A (ko) 2020-04-13
JP2015512645A (ja) 2015-04-30

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