MX347112B - Composiciones y metodos para regular osmolaridad celular. - Google Patents
Composiciones y metodos para regular osmolaridad celular.Info
- Publication number
- MX347112B MX347112B MX2014007030A MX2014007030A MX347112B MX 347112 B MX347112 B MX 347112B MX 2014007030 A MX2014007030 A MX 2014007030A MX 2014007030 A MX2014007030 A MX 2014007030A MX 347112 B MX347112 B MX 347112B
- Authority
- MX
- Mexico
- Prior art keywords
- methods
- compositions
- regulating cell
- cells
- osmolarity
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
- C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA
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- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
La presente invención se refiere a un método para expresar una proteína de interés en una célula bajo condiciones de hiperosmolalidad, el método comprende: A) introducir un polinucleótido en la célula, en donde dicho polinucleótido comprende: (i) una molécula de ácido nucleico que codifica una proteína de unión mejorada de tonicidad (TonEBP), y (ii) una molécula de ácido nucleico que comprende al menos un elemento regulador transcripcional osmo-responsivo (OR-TRE), en donde el OR-TRE comprende: a) una secuencia de ácido nucleico que comprende un mejorador transcripcional que responde a TonEBP unido operativamente aun promotor, en donde el mejorador transcripcional que responde a TonEBP comprende la secuencia de ácido nucleico de SEQ ID NO: 1, o la secuencia de ácido nucleico SEQ ID NO:4, o la secuencia de ácido nucleico que comprende un mejorador transcripcional que responde a NFATc unido operativamente a un promotor, en donde le mejorador tanscripcional que responde a NFATc comprende la secuencia de ácido nucleico de SEQ ID NO: 2, o la secuencia de ácido nucleico SEQ ID NO: 4, o la secuencia de ácido nucleico SEQ ID NO: 5, y b) una secuencia de ácido nucleico que comprende un mejorador transcripcional que responde a la Proteína Activadora 1 (AP-1), unido operativamente al mejorador transcripcional que responde a Ton EBP o al mejorador transcripcional que responde a NFATc; y (B) introducir unpolinucleótido dentro de la célula, en donde el polinucleótido codifica una segunda proteína de interés unida operativamente a un segundo OR-TRE; y (C) cultivar la célula bajo condiciones de osmolalidad incrementada, en donde bajo condiciones de osmolalidad incrementa la proteína TonEBP se expresa, y en donde la proteína TonEBP regula positivamente la expresión de Ton EBP y la segunda proteína de interés.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9714908P | 2008-09-15 | 2008-09-15 | |
| PCT/US2009/057031 WO2010031074A2 (en) | 2008-09-15 | 2009-09-15 | Compositions and methods for regulating cell osmolarity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX347112B true MX347112B (es) | 2017-04-12 |
Family
ID=42005828
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2014007030A MX347112B (es) | 2008-09-15 | 2009-09-15 | Composiciones y metodos para regular osmolaridad celular. |
| MX2011002638A MX2011002638A (es) | 2008-09-15 | 2009-09-15 | Composiciones y metodos para regular osmolaridad celular. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2011002638A MX2011002638A (es) | 2008-09-15 | 2009-09-15 | Composiciones y metodos para regular osmolaridad celular. |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US20110269233A1 (es) |
| EP (1) | EP2326720B1 (es) |
| JP (4) | JP5524214B2 (es) |
| KR (5) | KR102018475B1 (es) |
| CN (2) | CN103937797B (es) |
| AU (1) | AU2009290563A1 (es) |
| BR (1) | BRPI0913475B8 (es) |
| CA (1) | CA2734922C (es) |
| ES (1) | ES2670368T3 (es) |
| HK (1) | HK1199906A1 (es) |
| HR (1) | HRP20180738T1 (es) |
| IL (1) | IL211368B (es) |
| MX (2) | MX347112B (es) |
| PL (1) | PL2326720T3 (es) |
| SI (1) | SI2326720T1 (es) |
| WO (1) | WO2010031074A2 (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5524214B2 (ja) | 2008-09-15 | 2014-06-18 | ジェネンテック， インコーポレイテッド | 細胞容積モル浸透圧濃度を調節するための組成物および方法 |
| US9708582B2 (en) * | 2009-10-13 | 2017-07-18 | Stemcell Technologies Inc. | Method of differentiating stem cells |
| JP5843775B2 (ja) | 2009-10-13 | 2016-01-13 | ステムセル テクノロジーズ インコーポレーティッド | 幹細胞を分化させるための重量オスモル濃度の操作法 |
| PL2576580T3 (pl) | 2010-05-28 | 2017-03-31 | F.Hoffmann-La Roche Ag | Zmniejszenie poziomu mleczanu i zwiększenie wytwarzania polipeptydu przez obniżenie poziomu ekspresji dehydrogenazy mleczanowej i kinazy dehydrogenazy pirogronianowej |
| US9879229B2 (en) * | 2011-03-14 | 2018-01-30 | National Research Council Of Canada | Method of viral production in cells |
| HUE049119T2 (hu) | 2011-07-01 | 2020-09-28 | Amgen Inc | Emlõssejt-tenyészet |
| WO2014012108A1 (en) * | 2012-07-13 | 2014-01-16 | Holtzman Jordan L | Cellular and animal models for screening therapeutic agents for the treatment of alzheimer's disease |
| KR102007930B1 (ko) | 2014-12-31 | 2019-08-06 | 주식회사 엘지화학 | 재조합 당단백질의 글리코실화 조절 방법 |
| US10571480B2 (en) | 2017-04-12 | 2020-02-25 | Tempo Bioscience, Inc. | Biosensors for cellular osmolarity |
| US10640766B2 (en) | 2017-04-12 | 2020-05-05 | Tempo Bioscience, Inc. | Biosensors for chloride ions |
| KR102647165B1 (ko) * | 2017-06-16 | 2024-03-14 | 론자 리미티드 | 생물 제제 생산을 위한 범용 자체 조절 포유동물 세포주 플랫폼 |
| IL314004A (en) * | 2022-01-04 | 2024-08-01 | Ronawk Inc | A genetically reprogrammed extracellular matrix |
| CN115299264B (zh) * | 2022-09-02 | 2023-12-19 | 福建农林大学 | 正癸烷在促进杉木生长中的应用和方法 |
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| US7290669B1 (en) | 2006-10-27 | 2007-11-06 | Utah State University | Upflow bioreactor having a septum and an auger and drive assembly |
| US20080119909A1 (en) | 2006-11-21 | 2008-05-22 | Neurotrophincell Pty Limited | Cell implantation to prevent and/or treat hearing loss |
| KR20080051337A (ko) * | 2006-12-05 | 2008-06-11 | 부산대학교 산학협력단 | 스트레스－유도적 프로모터 및 제아잔틴 에폭시데이즈유전자가 도입되어 있는 스트레스 저항성 식물체 |
| JP5524214B2 (ja) | 2008-09-15 | 2014-06-18 | ジェネンテック， インコーポレイテッド | 細胞容積モル浸透圧濃度を調節するための組成物および方法 |
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