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MX347077B - Mutantes fc de anticuerpos resistentes a proteasas activas. - Google Patents

Mutantes fc de anticuerpos resistentes a proteasas activas.

Info

Publication number
MX347077B
MX347077B MX2013007291A MX2013007291A MX347077B MX 347077 B MX347077 B MX 347077B MX 2013007291 A MX2013007291 A MX 2013007291A MX 2013007291 A MX2013007291 A MX 2013007291A MX 347077 B MX347077 B MX 347077B
Authority
MX
Mexico
Prior art keywords
mutants
active protease
containing molecules
resistant antibody
host
Prior art date
Application number
MX2013007291A
Other languages
English (en)
Other versions
MX2013007291A (es
Inventor
Robert Jordan
Randall Brezski
Original Assignee
Janssen Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Biotech Inc filed Critical Janssen Biotech Inc
Publication of MX2013007291A publication Critical patent/MX2013007291A/es
Publication of MX347077B publication Critical patent/MX347077B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/53—Hinge
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72—Increased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención se refiere a una molécula que contiene Fc modificado que es resistente a la degradación proteolítica en comparación con una molécula que contiene Fc de IgG1 silvestre, caracterizada porque comprende un dominio Fc de anticuerpo con una región constante de IgG1 mutada, en donde la secuencia de E233-L234-L235-G236 de IgG1 humana se reemplaza con P233-V234-A235 con G236 eliminada, como se define por la numeración de EU, y comprende adicionalmente una o más sustituciones de la secuencia de IgG1 humana silvestre seleccionadas de S239D/I332E; K326A/E333A; E333A/K334A; H268F/S324T/I332E; F243L/R292P/Y300L; S239D/H268F/S324T/I333E; S267/H268F/S324T/I332E; K326A/I332E/E333A; S239D/K326A/E333A; S267E/I332E; y G237X/S239D/I332E donde X es A, D, P, Q o S.
MX2013007291A 2010-12-23 2011-12-15 Mutantes fc de anticuerpos resistentes a proteasas activas. MX347077B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201061426619P 2010-12-23 2010-12-23
US201161540882P 2011-09-29 2011-09-29
PCT/US2011/065174 WO2012087746A1 (en) 2010-12-23 2011-12-15 Active protease-resistant antibody fc mutants

Publications (2)

Publication Number Publication Date
MX2013007291A MX2013007291A (es) 2013-09-13
MX347077B true MX347077B (es) 2017-04-10

Family

ID=46314374

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013007291A MX347077B (es) 2010-12-23 2011-12-15 Mutantes fc de anticuerpos resistentes a proteasas activas.

Country Status (31)

Country Link
US (2) US8871204B2 (es)
EP (1) EP2654780B1 (es)
JP (1) JP6012624B2 (es)
KR (1) KR101900280B1 (es)
CN (1) CN103260640B (es)
AU (1) AU2011349719B2 (es)
BR (1) BR112013018317A2 (es)
CA (1) CA2822366A1 (es)
CO (1) CO6741179A2 (es)
CR (1) CR20130292A (es)
CY (1) CY1118923T1 (es)
DK (1) DK2654780T3 (es)
EA (1) EA028658B1 (es)
EC (1) ECSP13012712A (es)
ES (1) ES2623912T3 (es)
GT (1) GT201300167A (es)
HR (1) HRP20170595T1 (es)
HU (1) HUE033205T2 (es)
IL (1) IL226987A (es)
LT (1) LT2654780T (es)
MX (1) MX347077B (es)
MY (1) MY162489A (es)
NI (1) NI201300057A (es)
NZ (1) NZ612379A (es)
PL (1) PL2654780T3 (es)
PT (1) PT2654780T (es)
RS (1) RS55906B1 (es)
SG (1) SG191233A1 (es)
SI (1) SI2654780T1 (es)
WO (1) WO2012087746A1 (es)
ZA (1) ZA201305538B (es)

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Also Published As

Publication number Publication date
NI201300057A (es) 2014-02-25
CA2822366A1 (en) 2012-06-28
LT2654780T (lt) 2017-03-27
AU2011349719B2 (en) 2016-09-15
IL226987A (en) 2017-07-31
CO6741179A2 (es) 2013-08-30
KR101900280B1 (ko) 2018-11-08
EA028658B1 (ru) 2017-12-29
MY162489A (en) 2017-06-15
ECSP13012712A (es) 2013-08-30
AU2011349719A1 (en) 2013-07-04
CN103260640A (zh) 2013-08-21
JP2014504301A (ja) 2014-02-20
HUE033205T2 (en) 2017-11-28
CY1118923T1 (el) 2018-01-10
US20130011386A1 (en) 2013-01-10
EP2654780B1 (en) 2017-02-01
MX2013007291A (es) 2013-09-13
WO2012087746A1 (en) 2012-06-28
EP2654780A1 (en) 2013-10-30
SG191233A1 (en) 2013-07-31
JP6012624B2 (ja) 2016-10-25
NZ612379A (en) 2014-10-31
KR20140003485A (ko) 2014-01-09
PL2654780T3 (pl) 2017-07-31
CN103260640B (zh) 2015-12-02
DK2654780T3 (en) 2017-04-10
US9611328B2 (en) 2017-04-04
CR20130292A (es) 2013-10-03
HRP20170595T1 (hr) 2017-06-16
US20150139984A1 (en) 2015-05-21
EA201390958A1 (ru) 2013-11-29
PT2654780T (pt) 2017-04-06
GT201300167A (es) 2014-09-26
RS55906B1 (sr) 2017-09-29
BR112013018317A2 (pt) 2017-03-21
ES2623912T3 (es) 2017-07-12
EP2654780A4 (en) 2015-03-18
SI2654780T1 (sl) 2017-06-30
US8871204B2 (en) 2014-10-28
ZA201305538B (en) 2015-01-28

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