MX2024002632A - Enlazadores que contienen peptido para conjugados anticuerpo-farmaco. - Google Patents
Enlazadores que contienen peptido para conjugados anticuerpo-farmaco.Info
- Publication number
- MX2024002632A MX2024002632A MX2024002632A MX2024002632A MX2024002632A MX 2024002632 A MX2024002632 A MX 2024002632A MX 2024002632 A MX2024002632 A MX 2024002632A MX 2024002632 A MX2024002632 A MX 2024002632A MX 2024002632 A MX2024002632 A MX 2024002632A
- Authority
- MX
- Mexico
- Prior art keywords
- antibody
- peptide
- drug conjugates
- containing linkers
- conjugates
- Prior art date
Links
- 239000000611 antibody drug conjugate Substances 0.000 title abstract 3
- 229940049595 antibody-drug conjugate Drugs 0.000 title abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
- 239000000562 conjugate Substances 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 1
- 230000008685 targeting Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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- A—HUMAN NECESSITIES
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- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/07—Tetrapeptides
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
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- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
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- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
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- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
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- A61K47/6855—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from breast cancer cell
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- A61K47/6883—Polymer-drug antibody conjugates, e.g. mitomycin-dextran-Ab; DNA-polylysine-antibody complex or conjugate used for therapy
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- A61K47/6817—Toxins
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
La presente divulgación se refiere en general a conjugados de anticuerpo-fármaco que comprenden enlazadores que contienen péptido y a métodos de uso de estos conjugados como agentes terapéuticos y/o diagnósticos. También se divulgan aquí armazones que contienen péptido útiles para conjugarse con una porción de direccionamiento (p. ej., un anticuerpo), un fármaco, o ambos, para producir los conjugados anticuerpo-fármaco.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662425895P | 2016-11-23 | 2016-11-23 | |
US201762572010P | 2017-10-13 | 2017-10-13 | |
US15/819,650 US11135307B2 (en) | 2016-11-23 | 2017-11-21 | Peptide-containing linkers for antibody-drug conjugates |
Publications (1)
Publication Number | Publication Date |
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MX2024002632A true MX2024002632A (es) | 2024-03-22 |
Family
ID=62196072
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2019005879A MX2019005879A (es) | 2016-11-23 | 2017-11-22 | Enlazadores que contienen peptido para conjugados anticuerpo-farmaco. |
MX2024002632A MX2024002632A (es) | 2016-11-23 | 2019-05-20 | Enlazadores que contienen peptido para conjugados anticuerpo-farmaco. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2019005879A MX2019005879A (es) | 2016-11-23 | 2017-11-22 | Enlazadores que contienen peptido para conjugados anticuerpo-farmaco. |
Country Status (12)
Country | Link |
---|---|
US (2) | US11135307B2 (es) |
EP (1) | EP3544635A2 (es) |
JP (2) | JP7291629B2 (es) |
KR (2) | KR20240018696A (es) |
CN (1) | CN110234357A (es) |
AU (1) | AU2017363246A1 (es) |
BR (1) | BR112019008854A2 (es) |
CA (1) | CA3041559A1 (es) |
IL (2) | IL312814A (es) |
MX (2) | MX2019005879A (es) |
TW (1) | TW201827082A (es) |
WO (1) | WO2018098269A2 (es) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11135307B2 (en) * | 2016-11-23 | 2021-10-05 | Mersana Therapeutics, Inc. | Peptide-containing linkers for antibody-drug conjugates |
EP3717021A1 (en) | 2017-11-27 | 2020-10-07 | Mersana Therapeutics, Inc. | Pyrrolobenzodiazepine antibody conjugates |
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-
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- 2017-11-21 US US15/819,650 patent/US11135307B2/en active Active
- 2017-11-22 JP JP2019547601A patent/JP7291629B2/ja active Active
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- 2017-11-22 KR KR1020247003928A patent/KR20240018696A/ko active Search and Examination
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EP3544635A2 (en) | 2019-10-02 |
US11964025B2 (en) | 2024-04-23 |
KR20240018696A (ko) | 2024-02-13 |
JP2023058642A (ja) | 2023-04-25 |
IL266310A (en) | 2019-06-30 |
JP2020510669A (ja) | 2020-04-09 |
US20180154018A1 (en) | 2018-06-07 |
IL312814A (en) | 2024-07-01 |
JP7291629B2 (ja) | 2023-06-15 |
BR112019008854A2 (pt) | 2019-07-09 |
US11135307B2 (en) | 2021-10-05 |
CN110234357A (zh) | 2019-09-13 |
IL266310B2 (en) | 2024-10-01 |
AU2017363246A1 (en) | 2019-05-16 |
TW201827082A (zh) | 2018-08-01 |
CA3041559A1 (en) | 2018-05-31 |
WO2018098269A2 (en) | 2018-05-31 |
MX2019005879A (es) | 2019-12-09 |
IL266310B1 (en) | 2024-06-01 |
WO2018098269A3 (en) | 2018-06-28 |
KR20190087535A (ko) | 2019-07-24 |
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