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MX2022000656A - Derivados de imidazo[4,5-c]piridina como agonistas del receptor tipo toll. - Google Patents

Derivados de imidazo[4,5-c]piridina como agonistas del receptor tipo toll.

Info

Publication number
MX2022000656A
MX2022000656A MX2022000656A MX2022000656A MX2022000656A MX 2022000656 A MX2022000656 A MX 2022000656A MX 2022000656 A MX2022000656 A MX 2022000656A MX 2022000656 A MX2022000656 A MX 2022000656A MX 2022000656 A MX2022000656 A MX 2022000656A
Authority
MX
Mexico
Prior art keywords
imidazo
agonsits
toll
receptor
pyridine derivatives
Prior art date
Application number
MX2022000656A
Other languages
English (en)
Inventor
Lei Zhang
Andrew Fensome
Jun Xiao
Erik Alphie Lachapelle
Omar Ahmad
Ethan Lawrence Fisher
UNWALLA Rayomand J
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of MX2022000656A publication Critical patent/MX2022000656A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invención se refiere a compuestos imidazo-piridinilo, o una sal de estos aceptable desde el punto de vista farmacéutico, a composiciones farmacéuticas que comprenden dichos compuestos y sales, y a métodos y usos de dichos compuestos, sales y composiciones para el tratamiento de crecimiento celular anormal, que incluye cáncer, en un sujeto que lo necesita.
MX2022000656A 2019-07-17 2020-07-14 Derivados de imidazo[4,5-c]piridina como agonistas del receptor tipo toll. MX2022000656A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962875465P 2019-07-17 2019-07-17
US202062961288P 2020-01-15 2020-01-15
PCT/IB2020/056605 WO2021009676A1 (en) 2019-07-17 2020-07-14 Imidazo[4,5-c]pyridine derivatives as toll-like receptor agonsits

Publications (1)

Publication Number Publication Date
MX2022000656A true MX2022000656A (es) 2022-02-16

Family

ID=71728839

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022000656A MX2022000656A (es) 2019-07-17 2020-07-14 Derivados de imidazo[4,5-c]piridina como agonistas del receptor tipo toll.

Country Status (20)

Country Link
US (2) US11339159B2 (es)
EP (1) EP3999507A1 (es)
JP (1) JP7137733B2 (es)
KR (1) KR20220034862A (es)
CN (1) CN114364677B (es)
AU (1) AU2020315210B2 (es)
BR (1) BR112022000341A2 (es)
CA (1) CA3147266C (es)
CL (1) CL2022000032A1 (es)
CO (1) CO2022000259A2 (es)
CR (1) CR20220018A (es)
CU (1) CU20220003A7 (es)
EC (1) ECSP22003665A (es)
IL (1) IL289877A (es)
MX (1) MX2022000656A (es)
PE (1) PE20220342A1 (es)
TW (1) TWI755788B (es)
UY (1) UY38786A (es)
WO (1) WO2021009676A1 (es)
ZA (1) ZA202201330B (es)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115317603A (zh) 2016-07-07 2022-11-11 小利兰·斯坦福大学托管委员会 抗体佐剂缀合物
CN113993549A (zh) 2019-03-15 2022-01-28 博尔特生物治疗药物有限公司 靶向her2的免疫缀合物
US11339159B2 (en) * 2019-07-17 2022-05-24 Pfizer Inc. Toll-like receptor agonists
WO2022153157A1 (en) 2021-01-13 2022-07-21 Pfizer Inc. A crystalline form of 2-((4-amino-2-(ethoxymethyl)-6,7-dimethyl-1 h-imidazo[4,5-c]pyridin-1-yl)methyl)-2-methylpropane-1,3-diol free base
WO2023079428A1 (en) 2021-11-03 2023-05-11 Pfizer Inc. Combination therapies using tlr7/8 agonist

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KR0166088B1 (ko) 1990-01-23 1999-01-15 . 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
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WO2006009832A1 (en) 2004-06-18 2006-01-26 3M Innovative Properties Company Substituted imidazo ring systems and methods
JP2008538203A (ja) * 2005-02-23 2008-10-16 コーリー ファーマシューティカル グループ，インコーポレイテッド インターフェロンの生合成を優先的に誘導する方法
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CA2707773C (en) 2007-12-14 2017-01-10 Pfizer Inc. Binding molecules to the human ox40 receptor
SA112330278B1 (ar) 2011-02-18 2015-10-09 ستيم سينتركس، انك. مواد ضابطة جديدة وطرق للاستخدام
PT3327027T (pt) 2011-11-17 2021-02-15 Pfizer Péptidos citotóxicos e seus conjugados de anticorpos e fármacos
WO2015162075A1 (en) * 2014-04-22 2015-10-29 F. Hoffmann-La Roche Ag 4-amino-imidazoquinoline compounds
US9884921B2 (en) 2014-07-01 2018-02-06 Pfizer Inc. Bispecific heterodimeric diabodies and uses thereof
HUE053704T2 (hu) * 2014-12-08 2021-07-28 Hoffmann La Roche 3-szubsztitutált 5-amino-6H-tiazolo[4,5-d]pirimidin-2,7-dion vegyületek vírusfertõzések kezelésére és megelõzésére
BR112017019785B1 (pt) 2015-04-13 2022-11-16 Pfizer Inc Anticorpo biespecífico, seu uso e composição farmacêutica
CN108368140A (zh) * 2015-12-14 2018-08-03 葛兰素史密丝克莱恩生物有限公司 作为tlr7和tlr8激动剂的peg化的咪唑并喹啉类
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CN118515666A (zh) 2017-04-27 2024-08-20 博笛生物科技有限公司 2-氨基-喹啉衍生物
EP3630835A1 (en) 2017-05-31 2020-04-08 STCube & Co., Inc. Antibodies and molecules that immunospecifically bind to btn1a1 and the therapeutic uses thereof
WO2018220584A1 (en) 2017-06-02 2018-12-06 Pfizer Inc. Antibodies specific for flt3 and their uses
WO2019027858A1 (en) 2017-08-04 2019-02-07 Merck Sharp & Dohme Corp. BENZO [B] STING THIOPHEN AGONISTS FOR THE TREATMENT OF CANCER
US11339159B2 (en) * 2019-07-17 2022-05-24 Pfizer Inc. Toll-like receptor agonists

Also Published As

Publication number Publication date
CU20220003A7 (es) 2022-08-09
CO2022000259A2 (es) 2022-01-17
ECSP22003665A (es) 2022-02-25
JP2022534125A (ja) 2022-07-27
US11339159B2 (en) 2022-05-24
PE20220342A1 (es) 2022-03-14
EP3999507A1 (en) 2022-05-25
WO2021009676A1 (en) 2021-01-21
CL2022000032A1 (es) 2022-09-02
US20210017172A1 (en) 2021-01-21
AU2020315210B2 (en) 2023-01-12
CN114364677B (zh) 2024-07-09
JP7137733B2 (ja) 2022-09-14
CN114364677A (zh) 2022-04-15
WO2021009676A8 (en) 2022-03-03
US11976064B2 (en) 2024-05-07
BR112022000341A2 (pt) 2022-04-12
KR20220034862A (ko) 2022-03-18
UY38786A (es) 2021-02-26
TW202116770A (zh) 2021-05-01
CA3147266A1 (en) 2021-01-21
AU2020315210A1 (en) 2022-02-03
IL289877A (en) 2022-03-01
ZA202201330B (en) 2022-10-26
TWI755788B (zh) 2022-02-21
CA3147266C (en) 2023-09-12
US20220274986A1 (en) 2022-09-01
CR20220018A (es) 2022-02-08

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