MX2021013218A - Composiciones y metodos para el tratamiento del cancer usando una terapia con celulas t modificadas con tet2. - Google Patents
Composiciones y metodos para el tratamiento del cancer usando una terapia con celulas t modificadas con tet2.Info
- Publication number
- MX2021013218A MX2021013218A MX2021013218A MX2021013218A MX2021013218A MX 2021013218 A MX2021013218 A MX 2021013218A MX 2021013218 A MX2021013218 A MX 2021013218A MX 2021013218 A MX2021013218 A MX 2021013218A MX 2021013218 A MX2021013218 A MX 2021013218A
- Authority
- MX
- Mexico
- Prior art keywords
- cancer
- compositions
- treatment
- methods
- tet2
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 201000011510 cancer Diseases 0.000 title abstract 2
- 238000002659 cell therapy Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 101150012475 TET2 gene Proteins 0.000 abstract 1
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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- A61K39/4632—T-cell receptors [TCR]; antibody T-cell receptor constructs
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- A61K39/46—Cellular immunotherapy
- A61K39/463—Cellular immunotherapy characterised by recombinant expression
- A61K39/4637—Other peptides or polypeptides
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- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
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- A—HUMAN NECESSITIES
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- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464401—Neoantigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C07K14/575—Hormones
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C12N15/09—Recombinant DNA-technology
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- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
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- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases RNAses, DNAses
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
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- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
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- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPRs]
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- C12N2501/23—Interleukins [IL]
- C12N2501/2307—Interleukin-7 (IL-7)
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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- C12N2501/2315—Interleukin-15 (IL-15)
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Abstract
Composiciones y métodos para el tratamiento del cáncer usando una terapia celular basada en neoTCR con una inactivación de la expresión del gen TET2.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962841748P | 2019-05-01 | 2019-05-01 | |
US201962841753P | 2019-05-01 | 2019-05-01 | |
PCT/US2020/030704 WO2020223478A1 (en) | 2019-05-01 | 2020-04-30 | Compositions and methods for the treatment of cancer using a tet2 engineered t cell therapy |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2021013218A true MX2021013218A (es) | 2021-12-10 |
Family
ID=73029470
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2021013225A MX2021013225A (es) | 2019-05-01 | 2020-04-30 | Composiciones y metodos para el tratamiento del cancer utilizando una terapia de celulas t modificadas de cd8. |
MX2021013218A MX2021013218A (es) | 2019-05-01 | 2020-04-30 | Composiciones y metodos para el tratamiento del cancer usando una terapia con celulas t modificadas con tet2. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2021013225A MX2021013225A (es) | 2019-05-01 | 2020-04-30 | Composiciones y metodos para el tratamiento del cancer utilizando una terapia de celulas t modificadas de cd8. |
Country Status (11)
Country | Link |
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US (3) | US20210085720A1 (es) |
EP (2) | EP3962938A4 (es) |
JP (2) | JP2022531231A (es) |
KR (2) | KR20220005050A (es) |
CN (1) | CN113748127A (es) |
AU (2) | AU2020264484A1 (es) |
CA (2) | CA3136740A1 (es) |
IL (2) | IL287639A (es) |
MX (2) | MX2021013225A (es) |
SG (2) | SG11202111532SA (es) |
WO (3) | WO2020223537A1 (es) |
Families Citing this family (22)
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EP3856769A4 (en) * | 2018-09-28 | 2022-08-17 | Memorial Sloan Kettering Cancer Center | IMMUNOREACTIVE CELLS EXPRESSING DOMINANT NEGATIVE FAS AND USES THEREOF |
EP4025689A1 (en) * | 2019-09-06 | 2022-07-13 | CRISPR Therapeutics AG | Genetically engineered t cells having improved persistence in culture |
AU2021261011A1 (en) * | 2020-04-24 | 2022-11-10 | Pact Pharma, Inc. | Methods of determining gene editing efficiencies in cells |
WO2022109277A1 (en) * | 2020-11-20 | 2022-05-27 | Pact Pharma, Inc. | COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER USING A TGFβRII ENGINEERED T CELL THERAPY |
EP4259651A2 (en) * | 2020-12-14 | 2023-10-18 | Fred Hutchinson Cancer Center | Compositions and methods for cellular immunotherapy |
WO2022140361A1 (en) * | 2020-12-22 | 2022-06-30 | Ludwig Institute For Cancer Research Ltd | Genetically engineered lymphocytes for adoptive cell therapy |
WO2022177970A1 (en) * | 2021-02-18 | 2022-08-25 | University Of Florida Research Foundation, Incorporated | Enhancing metabolic fitness of t cells to treat cancer |
JP2024510900A (ja) | 2021-02-25 | 2024-03-12 | ライエル・イミュノファーマ・インコーポレイテッド | Ap-1転写因子をコードするコドン最適化ヌクレオチド配列 |
JP2024510898A (ja) | 2021-02-25 | 2024-03-12 | ライエル・イミュノファーマ・インコーポレイテッド | Ror1を標的とするキメラ抗原受容体 |
CN117836625A (zh) * | 2021-06-11 | 2024-04-05 | Pact制药公司 | 细胞产品的评估方法 |
AU2022376953A1 (en) | 2021-10-28 | 2024-05-02 | Lyell Immunopharma, Inc. | Methods for culturing cells expressing ror1-binding protein |
WO2023077032A1 (en) | 2021-10-28 | 2023-05-04 | Lyell Immunopharma, Inc. | Methods for culturing cells expressing c-jun |
CN114373511B (zh) * | 2022-03-15 | 2022-08-30 | 南方医科大学南方医院 | 基于5hmC分子标志物检测的肠癌模型及肠癌模型构建方法 |
WO2023212507A1 (en) * | 2022-04-26 | 2023-11-02 | Fred Hutchinson Cancer Center | Compositions and methods for cellular immunotherapy |
WO2024026490A1 (en) | 2022-07-28 | 2024-02-01 | Sqz Biotechnologies Company | Polynucleotides encoding linked antigens and uses thereof |
WO2024064606A2 (en) * | 2022-09-19 | 2024-03-28 | Emendobio Inc. | Biallelic knockout of ctla4 |
WO2024064607A2 (en) * | 2022-09-19 | 2024-03-28 | Emendobio Inc. | Biallelic knockout of tet2 |
WO2024064637A2 (en) * | 2022-09-19 | 2024-03-28 | Emendobio Inc. | Biallelic knockout of faslg |
WO2024064958A1 (en) | 2022-09-23 | 2024-03-28 | Lyell Immunopharma, Inc. | Methods for culturing nr4a-deficient cells |
WO2024064952A1 (en) | 2022-09-23 | 2024-03-28 | Lyell Immunopharma, Inc. | Methods for culturing nr4a-deficient cells overexpressing c-jun |
WO2024077174A1 (en) | 2022-10-05 | 2024-04-11 | Lyell Immunopharma, Inc. | Methods for culturing nr4a-deficient cells |
CN116179495A (zh) * | 2022-11-28 | 2023-05-30 | 上海恩凯细胞技术有限公司 | 转基因免疫细胞及其应用 |
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US20210317184A1 (en) * | 2018-09-05 | 2021-10-14 | GlaxoSmithKline Intellectual Property Devolopment Limited | T cell modification |
GB201819540D0 (en) * | 2018-11-30 | 2019-01-16 | Adaptimmune Ltd | T cell modification |
CN113784976A (zh) | 2019-02-12 | 2021-12-10 | 派克特制药公司 | 用于鉴定抗原特异性t细胞的组合物和方法 |
BR112021023782A2 (pt) * | 2019-05-27 | 2022-01-11 | Immatics Us Inc | Vetores, métodos de preparação de células t para imunoterapia, populações de células t expandidas e métodos para tratar de um paciente com câncer e para elicitar uma resposta imune |
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2020
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2022
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SG11202111532SA (en) | 2021-11-29 |
SG11202111865UA (en) | 2021-11-29 |
JP2022530653A (ja) | 2022-06-30 |
CA3151385A1 (en) | 2020-11-05 |
CA3136740A1 (en) | 2020-11-05 |
WO2020223537A1 (en) | 2020-11-05 |
WO2020223625A1 (en) | 2020-11-05 |
AU2020264484A1 (en) | 2021-11-04 |
EP3962938A1 (en) | 2022-03-09 |
KR20220004703A (ko) | 2022-01-11 |
WO2020223478A1 (en) | 2020-11-05 |
MX2021013225A (es) | 2022-01-06 |
US20210085720A1 (en) | 2021-03-25 |
JP2022531231A (ja) | 2022-07-06 |
EP3953379A1 (en) | 2022-02-16 |
AU2020266579A1 (en) | 2021-11-25 |
US20220193139A1 (en) | 2022-06-23 |
WO2020223537A8 (en) | 2021-11-11 |
US20210085721A1 (en) | 2021-03-25 |
EP3962938A4 (en) | 2023-07-05 |
CN113748127A (zh) | 2021-12-03 |
US11304978B2 (en) | 2022-04-19 |
EP3953379A4 (en) | 2023-05-31 |
KR20220005050A (ko) | 2022-01-12 |
IL287639A (en) | 2021-12-01 |
IL287643A (en) | 2021-12-01 |
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