MX2019013965A - Composiciones solidas para administracion oral. - Google Patents
Composiciones solidas para administracion oral.Info
- Publication number
- MX2019013965A MX2019013965A MX2019013965A MX2019013965A MX2019013965A MX 2019013965 A MX2019013965 A MX 2019013965A MX 2019013965 A MX2019013965 A MX 2019013965A MX 2019013965 A MX2019013965 A MX 2019013965A MX 2019013965 A MX2019013965 A MX 2019013965A
- Authority
- MX
- Mexico
- Prior art keywords
- oral administration
- solid compositions
- glp
- derivative
- sglt2 inhibitor
- Prior art date
Links
- 239000008247 solid mixture Substances 0.000 title abstract 2
- DTHNMHAUYICORS-KTKZVXAJSA-N Glucagon-like peptide 1 Chemical class C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 DTHNMHAUYICORS-KTKZVXAJSA-N 0.000 abstract 2
- 229940123518 Sodium/glucose cotransporter 2 inhibitor Drugs 0.000 abstract 2
- JVHXJTBJCFBINQ-ADAARDCZSA-N Dapagliflozin Chemical compound C1=CC(OCC)=CC=C1CC1=CC([C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)=CC=C1Cl JVHXJTBJCFBINQ-ADAARDCZSA-N 0.000 abstract 1
- 229960003834 dapagliflozin Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Obesity (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Emergency Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Child & Adolescent Psychology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La presente invención se refiere a composiciones sólidas para administración oral que comprenden (i) un derivado de GLP-1 y el inhibidor de SGLT2 dapagliflozina o (ii) un derivado de GLP-1 y una sal de NAC en combinación con un inhibidor de SGLT2.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17175131 | 2017-06-09 | ||
| PCT/EP2018/065266 WO2018224689A2 (en) | 2017-06-09 | 2018-06-11 | Solid compositions for oral administration |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2019013965A true MX2019013965A (es) | 2020-01-23 |
Family
ID=59070439
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2019013965A MX2019013965A (es) | 2017-06-09 | 2018-06-11 | Composiciones solidas para administracion oral. |
Country Status (28)
| Country | Link |
|---|---|
| US (2) | US11167014B2 (es) |
| EP (1) | EP3634468B1 (es) |
| JP (1) | JP7239495B2 (es) |
| KR (1) | KR20200015564A (es) |
| CN (1) | CN110769846A (es) |
| AR (1) | AR112015A1 (es) |
| AU (1) | AU2018280875A1 (es) |
| BR (1) | BR112019025769A2 (es) |
| CA (1) | CA3064677A1 (es) |
| CL (1) | CL2019003402A1 (es) |
| CO (1) | CO2019013047A2 (es) |
| DK (1) | DK3634468T5 (es) |
| ES (1) | ES2938050T3 (es) |
| FI (1) | FI3634468T3 (es) |
| HR (1) | HRP20230075T1 (es) |
| HU (1) | HUE060962T2 (es) |
| IL (1) | IL270812B2 (es) |
| MA (1) | MA49253A (es) |
| MX (1) | MX2019013965A (es) |
| MY (1) | MY197488A (es) |
| PE (1) | PE20200606A1 (es) |
| PH (1) | PH12019550249A1 (es) |
| PL (1) | PL3634468T3 (es) |
| PT (1) | PT3634468T (es) |
| RS (1) | RS64045B1 (es) |
| SI (1) | SI3634468T1 (es) |
| TW (1) | TWI797133B (es) |
| WO (1) | WO2018224689A2 (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RS57727B1 (sr) | 2012-03-22 | 2018-12-31 | Novo Nordisk As | Kompozicije glp-1 peptida i njihovo dobijanje |
| IL275778B2 (en) | 2018-02-02 | 2023-12-01 | Novo Nordisk As | Solid compounds that make up glp-1 agonist n-8-2-hydroxybenzoyl salt |
| TWI829687B (zh) | 2018-05-07 | 2024-01-21 | 丹麥商諾佛 儂迪克股份有限公司 | 包含glp-1促效劑與n-(8-(2-羥基苯甲醯基)胺基)辛酸之鹽的固體組成物 |
| KR102376009B1 (ko) * | 2018-12-21 | 2022-03-18 | (주)휴온스 | 엠파글리플로진 및 시타글립틴을 포함하는 약학적 조성물 |
| US20220265777A1 (en) * | 2019-08-07 | 2022-08-25 | Novo Nordisk A/S | Solid compositions comprising a glp-1 agonist, an sglt2 inhibitor and a salt of n-(8-(2-hydroxybenzoyl)amino)caprylic acid |
| WO2021089752A1 (en) * | 2019-11-07 | 2021-05-14 | Novo Nordisk A/S | Solid compositions comprising a glp-1 agonist, an sglt2 inhibitor and a salt of n-(8-(2-hydroxybenzoyl)amino)caprylic acid |
| WO2023065231A1 (en) * | 2021-10-21 | 2023-04-27 | Guangzhou Dazhou Biomedicine Ltd. | Oral delivery of therapeutic agents |
| CN118742326A (zh) * | 2021-12-29 | 2024-10-01 | 广州大洲生物医药科技有限公司 | 口服递送 |
| EP4299052A1 (en) * | 2022-06-30 | 2024-01-03 | Adocia | Solid compositions comprising a peptide or a protein and a permeation enhancer |
| CN114984191B (zh) * | 2022-07-04 | 2022-10-25 | 北京惠之衡生物科技有限公司 | 一种多肽类药物口服递送组合物 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5650386A (en) | 1995-03-31 | 1997-07-22 | Emisphere Technologies, Inc. | Compositions for oral delivery of active agents |
| DE60023841T2 (de) | 1999-02-05 | 2006-05-24 | Emisphere Technologies, Inc. | Verfahren zur herstellung alkylierter salicylamide |
| US6515117B2 (en) | 1999-10-12 | 2003-02-04 | Bristol-Myers Squibb Company | C-aryl glucoside SGLT2 inhibitors and method |
| AU2001275231A1 (en) | 2000-06-02 | 2001-12-11 | Emisphere Technologies, Inc. | Method of preparing salicylamides |
| US6936590B2 (en) | 2001-03-13 | 2005-08-30 | Bristol Myers Squibb Company | C-aryl glucoside SGLT2 inhibitors and method |
| TWI372629B (en) | 2005-03-18 | 2012-09-21 | Novo Nordisk As | Acylated glp-1 compounds |
| US7772191B2 (en) | 2005-05-10 | 2010-08-10 | Boehringer Ingelheim International Gmbh | Processes for preparing of glucopyranosyl-substituted benzyl-benzene derivatives and intermediates therein |
| AR056195A1 (es) | 2005-09-15 | 2007-09-26 | Boehringer Ingelheim Int | Procedimientos para preparar derivados de (etinil-bencil)-benceno sustituidos de glucopiranosilo y compuestos intermedios de los mismos |
| ATE517099T1 (de) | 2006-02-15 | 2011-08-15 | Boehringer Ingelheim Int | Glucopyranosyl-substituierte benzonitril-derivate,pharmazeutische zusammensetzungen mit derartigen verbindungen, ihre verwendung und herstellungsverfahren dafür |
| WO2007121318A2 (en) | 2006-04-12 | 2007-10-25 | Emisphere Technologies, Inc. | Formulations for delivering insulin |
| US7919598B2 (en) | 2006-06-28 | 2011-04-05 | Bristol-Myers Squibb Company | Crystal structures of SGLT2 inhibitors and processes for preparing same |
| AU2007293916B2 (en) | 2006-09-07 | 2011-02-03 | Emisphere Technologies, Inc. | A process for the manufacture of SNAC (salcaprozate sodium) |
| PE20090185A1 (es) | 2007-03-22 | 2009-02-28 | Bristol Myers Squibb Co | Formulaciones farmaceuticas que contienen un inhibidor sglt2 |
| CN101754972A (zh) | 2007-05-18 | 2010-06-23 | 百时美施贵宝公司 | Sglt2抑制剂的晶体结构及其制备方法 |
| CN101868476B (zh) | 2007-09-05 | 2015-02-25 | 诺沃-诺迪斯克有限公司 | 胰高血糖素样肽-1衍生物及其制药用途 |
| EP2435033A1 (en) | 2009-05-27 | 2012-04-04 | Bristol-Myers Squibb Company | Methods for treating type 2 diabetes in patients resistant to previous treatment with other anti-diabetic drugs employing an sglt2 inhibitor and compositions thereof |
| RS57926B1 (sr) | 2009-11-13 | 2019-01-31 | Astrazeneca Ab | Formulacije tablete sa trenutnim oslobađanjem |
| JP2013514322A (ja) | 2009-12-16 | 2013-04-25 | ノヴォ ノルディスク アー／エス | 修飾されたｎ末端を有するｇｌｐ−１受容体アゴニスト化合物 |
| EP2651398B1 (en) | 2010-12-16 | 2017-12-13 | Novo Nordisk A/S | Solid compositions comprising a glp-1 agonist and a salt of n-(8-(2-hydroxybenzoyl)amino)caprylic acid |
| US20130035281A1 (en) | 2011-02-09 | 2013-02-07 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, methods for treating and uses thereof |
| KR101972836B1 (ko) | 2011-04-12 | 2019-04-29 | 노보 노르디스크 에이/에스 | 이중 아실화된 ｇｌｐ-1 유도체 |
| WO2013032934A1 (en) | 2011-08-26 | 2013-03-07 | Aegis Therapeutics, Llc | Compositions and methods thereof for oral administration of drugs |
| RS57727B1 (sr) | 2012-03-22 | 2018-12-31 | Novo Nordisk As | Kompozicije glp-1 peptida i njihovo dobijanje |
| TR201903918T4 (tr) | 2012-03-22 | 2019-04-22 | Novo Nordisk As | Bir dağıtım ajanı içeren bileşimler ve bunların hazırlanması. |
| US10335369B2 (en) | 2012-03-22 | 2019-07-02 | Novo Nordisk A/S | Compositions comprising a delivery agent and preparation thereof |
| WO2013189988A1 (en) | 2012-06-20 | 2013-12-27 | Novo Nordisk A/S | Tablet formulation comprising a peptide and a delivery agent |
| EP2976096B1 (en) | 2013-03-20 | 2019-02-27 | Novo Nordisk A/S | Insulin dosing regimen |
| WO2015155151A1 (en) | 2014-04-07 | 2015-10-15 | Novo Nordisk A/S | Double-acylated glp-1 compounds |
| WO2017004623A1 (en) * | 2015-07-02 | 2017-01-05 | Rani Therapeutics, Llc | Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| US11278596B2 (en) | 2016-11-28 | 2022-03-22 | Novo Nordisk A/S | Insulin degludec in cardiovascular conditions |
| CN110099719A (zh) | 2016-11-28 | 2019-08-06 | 诺和诺德股份有限公司 | 用于改善血糖控制以及减少急性和长期糖尿病并发症的德谷胰岛素 |
| WO2018096164A1 (en) | 2016-11-28 | 2018-05-31 | Novo Nordisk A/S | Insulin degludec for treating diabetes |
| US20220265777A1 (en) * | 2019-08-07 | 2022-08-25 | Novo Nordisk A/S | Solid compositions comprising a glp-1 agonist, an sglt2 inhibitor and a salt of n-(8-(2-hydroxybenzoyl)amino)caprylic acid |
-
2018
- 2018-06-08 TW TW107119869A patent/TWI797133B/zh active
- 2018-06-08 AR ARP180101556A patent/AR112015A1/es unknown
- 2018-06-11 MA MA049253A patent/MA49253A/fr unknown
- 2018-06-11 RS RS20230103A patent/RS64045B1/sr unknown
- 2018-06-11 IL IL270812A patent/IL270812B2/en unknown
- 2018-06-11 ES ES18730344T patent/ES2938050T3/es active Active
- 2018-06-11 PL PL18730344.1T patent/PL3634468T3/pl unknown
- 2018-06-11 FI FIEP18730344.1T patent/FI3634468T3/fi active
- 2018-06-11 CN CN201880038208.9A patent/CN110769846A/zh not_active Withdrawn
- 2018-06-11 HR HRP20230075TT patent/HRP20230075T1/hr unknown
- 2018-06-11 WO PCT/EP2018/065266 patent/WO2018224689A2/en active Application Filing
- 2018-06-11 CA CA3064677A patent/CA3064677A1/en not_active Withdrawn
- 2018-06-11 AU AU2018280875A patent/AU2018280875A1/en not_active Withdrawn
- 2018-06-11 EP EP18730344.1A patent/EP3634468B1/en active Active
- 2018-06-11 HU HUE18730344A patent/HUE060962T2/hu unknown
- 2018-06-11 PT PT187303441T patent/PT3634468T/pt unknown
- 2018-06-11 BR BR112019025769-1A patent/BR112019025769A2/pt not_active Application Discontinuation
- 2018-06-11 MX MX2019013965A patent/MX2019013965A/es unknown
- 2018-06-11 DK DK18730344.1T patent/DK3634468T5/da active
- 2018-06-11 PE PE2019002460A patent/PE20200606A1/es unknown
- 2018-06-11 JP JP2019567972A patent/JP7239495B2/ja active Active
- 2018-06-11 US US16/620,363 patent/US11167014B2/en active Active
- 2018-06-11 MY MYPI2019006851A patent/MY197488A/en unknown
- 2018-06-11 KR KR1020197037131A patent/KR20200015564A/ko unknown
- 2018-06-11 SI SI201830839T patent/SI3634468T1/sl unknown
-
2019
- 2019-11-22 CO CONC2019/0013047A patent/CO2019013047A2/es unknown
- 2019-11-22 CL CL2019003402A patent/CL2019003402A1/es unknown
- 2019-11-22 PH PH12019550249A patent/PH12019550249A1/en unknown
-
2021
- 2021-10-08 US US17/496,831 patent/US20220016216A1/en not_active Abandoned
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