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MX2019003887A - Compuestos, dispositivos y usos de los mismos. - Google Patents

Compuestos, dispositivos y usos de los mismos.

Info

Publication number
MX2019003887A
MX2019003887A MX2019003887A MX2019003887A MX2019003887A MX 2019003887 A MX2019003887 A MX 2019003887A MX 2019003887 A MX2019003887 A MX 2019003887A MX 2019003887 A MX2019003887 A MX 2019003887A MX 2019003887 A MX2019003887 A MX 2019003887A
Authority
MX
Mexico
Prior art keywords
compounds
devices
tautomers
solvates
stereoisomers
Prior art date
Application number
MX2019003887A
Other languages
English (en)
Inventor
VEISEH Omid
Heidebrecht Richard
Kevin Wotton Paul
Oberli Matthias
James Miller Robert
Original Assignee
Sigilon Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigilon Therapeutics Inc filed Critical Sigilon Therapeutics Inc
Publication of MX2019003887A publication Critical patent/MX2019003887A/es

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
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    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
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    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
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    • C12N9/2465—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1) acting on alpha-galactose-glycoside bonds, e.g. alpha-galactosidase (3.2.1.22)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01022—Alpha-galactosidase (3.2.1.22)

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Abstract

La presente invención proporciona compuestos, por ejemplo, compuestos de fórmula (I) y sales, solvatos, hidratos, tautómeros, estereoisómeros, derivados marcados isotópicamente y composiciones farmacéuticamente aceptables de los mismos. También se proporcionan elementos implantables (por ejemplo, dispositivos y materiales) que comprenden los mismos, así como métodos de uso de los mismos, por ejemplo, para tratar o prevenir una enfermedad, trastorno o afección.
MX2019003887A 2016-10-03 2017-10-03 Compuestos, dispositivos y usos de los mismos. MX2019003887A (es)

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Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2017338824B2 (en) 2016-10-03 2022-01-27 Sigilon Therapeutics, Inc. Compounds, devices, and uses thereof
KR102230622B1 (ko) * 2017-11-24 2021-03-22 주식회사 엘지화학 포토레지스트 조성물 및 이를 이용한 포토레지스트 필름
AU2019226587A1 (en) * 2018-03-02 2020-09-03 Sigilon Therapeutics, Inc. Afibrotic compounds, devices, and uses thereof
KR102027693B1 (ko) * 2018-04-30 2019-10-02 (주)바이오액츠 벤젠환과 질소환을 포함하는 양친매성 화합물, 이의 제조방법 및 이를 포함하는 계면활성제 조성물
UY38389A (es) * 2018-09-27 2020-04-30 Sigilon Therapeutics Inc Dispositivos implantables para terapia celular y métodos relacionados
US20220267794A1 (en) * 2019-03-27 2022-08-25 Sigilon Therapeutics, Inc. Compositions, devices, and methods for treating fabry disease
US20230123802A1 (en) * 2019-03-27 2023-04-20 Sigilon Therapeutics, Inc. Compositions, devices, and methods for factor vii therapy
CN114269716A (zh) * 2019-08-08 2022-04-01 东亚合成株式会社 2-氰基丙烯酸酯化合物、及粘接剂组合物
WO2021062273A1 (en) * 2019-09-27 2021-04-01 Sigilon Therapeutics, Inc. Methods of evaluating small molecule-modified polymers in compositions
MX2022007285A (es) * 2019-12-13 2022-08-04 Sigilon Therapeutics Inc Compuestos, polimeros, dispositivos y usos de los mismos.
TWI775313B (zh) 2020-02-18 2022-08-21 美商基利科學股份有限公司 抗病毒化合物
TW202322824A (zh) 2020-02-18 2023-06-16 美商基利科學股份有限公司 抗病毒化合物
AU2021224588B2 (en) 2020-02-18 2024-07-18 Gilead Sciences, Inc. Antiviral compounds
US20230303502A1 (en) * 2020-08-04 2023-09-28 Sigilon Therapeutics, Inc. Heteroaryl and heterocyclyl compounds
WO2022060459A1 (en) 2020-09-18 2022-03-24 Massachusetts Institute Of Technology High-throughput method to rapidly add chemical moieties to a small molecule library
JP7563100B2 (ja) 2020-10-14 2024-10-08 東亞合成株式会社 仮固定用硬化性組成物、及び、仮固定方法
JP7563101B2 (ja) 2020-10-14 2024-10-08 東亞合成株式会社 剥離性接着物製造用硬化性組成物、剥離性接着物、並びに、剥離方法
KR102599566B1 (ko) * 2020-11-27 2023-11-07 국방과학연구소 아크릴아미드 화합물 및 이의 유도체의 제조방법
US11697666B2 (en) 2021-04-16 2023-07-11 Gilead Sciences, Inc. Methods of preparing carbanucleosides using amides
US12116380B2 (en) 2021-08-18 2024-10-15 Gilead Sciences, Inc. Phospholipid compounds and methods of making and using the same
EP4457280A2 (en) * 2021-12-30 2024-11-06 Sigilon Therapeutics, Inc. Modified polysaccharide polymers and related compositions and methods thereof
WO2023230524A1 (en) 2022-05-25 2023-11-30 Flagship Pioneering Innovations Vi, Llc Compositions of secretory and/or catalytic cells and methods using the same
WO2023235884A1 (en) 2022-06-03 2023-12-07 Flagship Pioneering Innovations Vi, Llc Compositions and methods
WO2024006544A2 (en) * 2022-07-01 2024-01-04 Sigilon Therapeutics, Inc. Covalently crosslinked polysaccharides and methods of use thereof
TW202428308A (zh) 2022-07-01 2024-07-16 美商希吉隆醫療公司 共價交聯多醣及其使用方法
WO2024081385A1 (en) * 2022-10-14 2024-04-18 Arcus Biosciences, Inc. Hpk1 inhibitors and methods of use thereof
WO2024191428A1 (en) 2023-03-14 2024-09-19 Sigilon Therapeutics, Inc. Hydrogel capsules comprising covalently photocrosslinked polysaccharides and islet cells

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004532234A (ja) * 2001-04-27 2004-10-21 バーテックス　ファーマシューティカルズ　インコーポレイテッド トリアゾール由来キナーゼインヒビターおよびその使用
KR100909141B1 (ko) * 2001-09-21 2009-07-23 브리스톨-마이어스스퀴브컴파니 인자 Ｘａ 억제제로서의 락탐-함유 화합물 및 그의 유도체
AU2002350217A1 (en) * 2001-12-04 2003-06-17 Bristol-Myers Squibb Company Glycinamides as factor xa inhibitors
JP4976651B2 (ja) * 2002-10-03 2012-07-18 ウペエフエル・エコル・ポリテクニック・フェデラル・ドゥ・ローザンヌ Ｏ６−アルキルグアニン−ｄｎａアルキルトランスフェラーゼのための基質
WO2007058646A1 (en) * 2005-11-15 2007-05-24 Bristol-Myers Squibb Company Hiv integrase inhibitors: cyclic pyrimidinone compounds
PE20080906A1 (es) * 2006-08-17 2008-07-05 Kemia Inc Derivados heteroarilo como inhibidores de citocina
US20080242694A1 (en) * 2006-09-18 2008-10-02 D Sidocky Neil R Amino-substituted heterocycles, compositions thereof, and methods of treatment therewith
WO2010033701A2 (en) 2008-09-19 2010-03-25 Genzyme Corporation Inhibitors of sphingosine kinase 1
WO2011089995A1 (ja) * 2010-01-21 2011-07-28 公立大学法人名古屋市立大学 ヒドロキサム酸誘導体及びそれを用いたｈｄａｃ８阻害剤
AU2011338615B2 (en) * 2010-12-07 2017-07-27 Yale University Small-molecule hydrophobic tagging of fusion proteins and induced degradation of same
AU2014230814B2 (en) * 2013-03-14 2017-12-21 Boehringer Ingelheim International Gmbh Substituted 2-Aza-bicyclo[2.2.1]heptane-3-carboxylic acid (benzyl-cyano-methyl)-amides inhibitors of Cathepsin C
ITTO20130356A1 (it) * 2013-05-03 2014-11-04 Uni Degli Studi Del Piemonte Orientale Ame Inibitori di nicotinamide fosforibosil transferasi, relative composizioni, prodotti ed usi
CN104844533B (zh) * 2014-02-17 2019-04-09 中国医学科学院药物研究所 含五元芳杂环的氨基丙二醇类化合物、其制备方法及其医药用途
PT3116316T (pt) * 2014-03-13 2019-09-30 Assembly Biosciences Inc Moduladores alostéricos da proteína do núcleo da hepatite b
CN104072478B (zh) * 2014-05-22 2016-06-01 大连理工大学 一类萘环4位含1,2,3-三唑的萘酰亚胺衍生物的合成及其应用
JP6723169B2 (ja) * 2014-08-01 2020-07-15 マサチューセッツ インスティテュート オブ テクノロジー 抗線維化材料のための修飾されたアルギネートおよび用途
EP3297693A1 (en) 2015-05-17 2018-03-28 Massachusetts Institute of Technology Multi-layer hydrogel capsules for encapsulation of cells and cell aggregates
SG11201803342RA (en) 2015-11-01 2018-05-30 Massachusetts Inst Technology Modified alginates for anti-fibrotic materials and applications
AU2017338824B2 (en) 2016-10-03 2022-01-27 Sigilon Therapeutics, Inc. Compounds, devices, and uses thereof
JP2020534837A (ja) 2017-09-27 2020-12-03 シギロン セラピューティクス， インコーポレイテッドＳｉｇｉｌｏｎ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． 活性細胞を含む方法、組成物、及び移植可能な要素

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AU2017338824A1 (en) 2019-04-18
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