SA519402288B1 - مركب بيريميدين واستخداماته الصيدلانية - Google Patents
مركب بيريميدين واستخداماته الصيدلانيةInfo
- Publication number
- SA519402288B1 SA519402288B1 SA519402288A SA519402288A SA519402288B1 SA 519402288 B1 SA519402288 B1 SA 519402288B1 SA 519402288 A SA519402288 A SA 519402288A SA 519402288 A SA519402288 A SA 519402288A SA 519402288 B1 SA519402288 B1 SA 519402288B1
- Authority
- SA
- Saudi Arabia
- Prior art keywords
- pyrimidine compound
- pharmaceutical use
- pyrimidine
- cancer
- prevention
- Prior art date
Links
- -1 Pyrimidine compound Chemical class 0.000 title abstract 3
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
يتعلق الاختراع الحالي بتقديم مركب بيريميدين pyrimidine compound ممثل بالصيغة 1، طريقة لتحضيره، واستخدام صيدلاني لمركب البيريميدين للوقاية من أو معالجة السرطان.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20170012766 | 2017-01-26 | ||
| PCT/KR2018/001193 WO2018139903A1 (ko) | 2017-01-26 | 2018-01-26 | 피리미딘 화합물 및 그의 의약 용도 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SA519402288B1 true SA519402288B1 (ar) | 2022-03-09 |
Family
ID=62979563
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SA519402288A SA519402288B1 (ar) | 2017-01-26 | 2019-07-24 | مركب بيريميدين واستخداماته الصيدلانية |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US10280154B2 (ar) |
| EP (2) | EP3514153B1 (ar) |
| JP (3) | JP6608565B2 (ar) |
| KR (1) | KR101954369B1 (ar) |
| CN (1) | CN110214138A (ar) |
| AR (1) | AR110778A1 (ar) |
| AU (1) | AU2018211880B2 (ar) |
| BR (1) | BR112019015256A2 (ar) |
| CA (1) | CA3050239A1 (ar) |
| DK (1) | DK3514153T3 (ar) |
| EA (1) | EA039868B1 (ar) |
| ES (1) | ES2890668T3 (ar) |
| HU (1) | HUE056472T2 (ar) |
| IL (2) | IL290745B2 (ar) |
| MX (1) | MX2019008808A (ar) |
| PH (1) | PH12019501690A1 (ar) |
| PL (1) | PL3514153T3 (ar) |
| PT (1) | PT3514153T (ar) |
| SA (1) | SA519402288B1 (ar) |
| SG (1) | SG11201906435SA (ar) |
| TW (1) | TWI810172B (ar) |
| WO (1) | WO2018139903A1 (ar) |
| ZA (1) | ZA201905020B (ar) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE056472T2 (hu) * | 2017-01-26 | 2022-02-28 | Hanmi Pharm Ind Co Ltd | Pirimidin vegyület és annak gyógyszerészeti felhasználása |
| KR101954370B1 (ko) * | 2018-07-25 | 2019-03-05 | 한미약품 주식회사 | 피리미딘 화합물 및 이를 포함하는 암의 예방 또는 치료용 약학 조성물 |
| AU2019203034B1 (en) * | 2018-07-25 | 2019-09-26 | Hanmi Pharm. Co., Ltd. | Pyrimidine compounds and pharmaceutical compositions for preventing or treating cancers including the same |
| US20220110913A1 (en) | 2019-02-22 | 2022-04-14 | Hanmi Pharm. Co., Ltd | Pharmaceutical composition comprising flt3 inhibitor and hypomethylating agent for treating acute myeloid leukemia |
| CA3130244A1 (en) * | 2019-02-22 | 2020-08-27 | Hanmi Pharm. Co., Ltd. | Pharmaceutical composition comprising flt3 inhibitor and hypomethylating agent for treating acute myeloid leukemia |
| WO2020171649A1 (ko) * | 2019-02-22 | 2020-08-27 | 한미약품 주식회사 | Flt3 저해제 및 iap 길항제를 포함하는 급성 골수성 백혈병의 치료를 위한 약학적 조합물 |
| CN111606889B (zh) * | 2019-02-25 | 2023-03-07 | 上海翰森生物医药科技有限公司 | 4-(1-环丙基-1h-吲哚-3-基)-n-苯基嘧啶-2-胺衍生物的制备方法 |
| CA3145391A1 (en) | 2019-06-27 | 2020-12-30 | Hanmi Pharm. Co., Ltd. | Pharmaceutical composition for treating acute myeloid leukemia, containing flt3 inhibitor and chemotherapeutic agents |
| JP2024502175A (ja) * | 2021-01-07 | 2024-01-17 | オンタリオ・インスティテュート・フォー・キャンサー・リサーチ（オーアイシーアール） | Ｎｕａｋキナーゼの阻害剤としてのイソインドリノンアミノピリミジン化合物、その組成物及び使用 |
| WO2023082052A1 (zh) * | 2021-11-09 | 2023-05-19 | 暨南大学 | 环状2-氨基嘧啶类化合物及其用途 |
| CN116102575A (zh) * | 2021-11-09 | 2023-05-12 | 暨南大学 | 环状2-氨基嘧啶类化合物及其用途 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0500492D0 (en) * | 2005-01-11 | 2005-02-16 | Cyclacel Ltd | Compound |
| WO2010042337A1 (en) * | 2008-10-07 | 2010-04-15 | Merck Sharp & Dohme Corp. | Novel 6-azaindole aminopyrimidine derivatives having nik inhibitory activity |
| CN101723936B (zh) | 2008-10-27 | 2014-01-15 | 上海睿星基因技术有限公司 | 激酶抑制剂及其在药学中的用途 |
| US20100105655A1 (en) | 2008-10-29 | 2010-04-29 | Astrazeneca Ab | Novel compounds 515 |
| US20110005173A1 (en) * | 2009-07-08 | 2011-01-13 | Kraft Foods Global Brands Llc | Method and Apparatus to Create a Contoured Flow Wrap Package |
| CA2767089A1 (en) * | 2009-07-15 | 2011-01-20 | Abbott Laboratories | Pyrrolopyridine inhibitors of kinases |
| TW201219383A (en) * | 2010-08-02 | 2012-05-16 | Astrazeneca Ab | Chemical compounds |
| RS62542B1 (sr) | 2011-07-27 | 2021-12-31 | Astrazeneca Ab | 2-(2,4,5-supstituisani-anilino) pirimidinski derivati |
| US9187453B2 (en) * | 2012-03-28 | 2015-11-17 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| WO2014155300A2 (en) * | 2013-03-28 | 2014-10-02 | Aurigene Discovery Technologies Limited | Substitued pyrimidine amine derivatives as tak-1 inhibitors |
| MX358346B (es) * | 2014-04-04 | 2018-08-15 | Syros Pharmaceuticals Inc | Inhibidores de la quinasa dependiente de ciclina 7 (cdk7). |
| WO2016029839A1 (zh) * | 2014-08-25 | 2016-03-03 | 四川海思科制药有限公司 | 一种（取代的苯基）（取代的嘧啶）胺基衍生物及其制备方法和药物用途 |
| KR102659213B1 (ko) * | 2017-01-17 | 2024-04-18 | 아스트라제네카 아베 | Jak1 선택적 억제제 |
| HUE056472T2 (hu) | 2017-01-26 | 2022-02-28 | Hanmi Pharm Ind Co Ltd | Pirimidin vegyület és annak gyógyszerészeti felhasználása |
-
2018
- 2018-01-26 HU HUE18744290A patent/HUE056472T2/hu unknown
- 2018-01-26 SG SG11201906435SA patent/SG11201906435SA/en unknown
- 2018-01-26 EP EP18744290.0A patent/EP3514153B1/en active Active
- 2018-01-26 PL PL18744290T patent/PL3514153T3/pl unknown
- 2018-01-26 TW TW107102879A patent/TWI810172B/zh active
- 2018-01-26 KR KR1020180010226A patent/KR101954369B1/ko active IP Right Grant
- 2018-01-26 ES ES18744290T patent/ES2890668T3/es active Active
- 2018-01-26 EA EA201991580A patent/EA039868B1/ru unknown
- 2018-01-26 AU AU2018211880A patent/AU2018211880B2/en active Active
- 2018-01-26 AR ARP180100179A patent/AR110778A1/es unknown
- 2018-01-26 WO PCT/KR2018/001193 patent/WO2018139903A1/ko unknown
- 2018-01-26 CA CA3050239A patent/CA3050239A1/en active Pending
- 2018-01-26 EP EP20201112.8A patent/EP3789386A1/en not_active Withdrawn
- 2018-01-26 BR BR112019015256A patent/BR112019015256A2/pt active Search and Examination
- 2018-01-26 IL IL290745A patent/IL290745B2/en unknown
- 2018-01-26 MX MX2019008808A patent/MX2019008808A/es unknown
- 2018-01-26 DK DK18744290.0T patent/DK3514153T3/da active
- 2018-01-26 CN CN201880008683.1A patent/CN110214138A/zh active Pending
- 2018-01-26 PT PT187442900T patent/PT3514153T/pt unknown
- 2018-01-26 JP JP2019519419A patent/JP6608565B2/ja active Active
- 2018-09-11 US US16/127,487 patent/US10280154B2/en active Active
- 2018-12-19 US US16/226,070 patent/US10519141B2/en active Active
-
2019
- 2019-07-11 IL IL268010A patent/IL268010B/en unknown
- 2019-07-23 PH PH12019501690A patent/PH12019501690A1/en unknown
- 2019-07-24 SA SA519402288A patent/SA519402288B1/ar unknown
- 2019-07-30 ZA ZA2019/05020A patent/ZA201905020B/en unknown
- 2019-10-23 JP JP2019192510A patent/JP7191799B2/ja active Active
-
2022
- 2022-12-07 JP JP2022195974A patent/JP2023027203A/ja active Pending
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