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MX2017017124A - 6-amino-quinolin-3-carbonitrilos como moduladores de cancer osaka tiroides (cot). - Google Patents

6-amino-quinolin-3-carbonitrilos como moduladores de cancer osaka tiroides (cot).

Info

Publication number
MX2017017124A
MX2017017124A MX2017017124A MX2017017124A MX2017017124A MX 2017017124 A MX2017017124 A MX 2017017124A MX 2017017124 A MX2017017124 A MX 2017017124A MX 2017017124 A MX2017017124 A MX 2017017124A MX 2017017124 A MX2017017124 A MX 2017017124A
Authority
MX
Mexico
Prior art keywords
carbonitrils
quinoline
amino
cot
modulators
Prior art date
Application number
MX2017017124A
Other languages
English (en)
Inventor
Phillips Gary
O Link John
M Zipfel Sheila
A Kirschberg Thorsten
j watkins William
M Bacon Elizabeth
J Cottell Jeromy
D Schroeder Scott
Chou Chien-Hung
G Taylor James
L Stevens Kirk
Kim Musong
t clark Christopher
E Wright Nathan
Balan Gayatri
H Squires Neil
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of MX2017017124A publication Critical patent/MX2017017124A/es

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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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    • C07—ORGANIC CHEMISTRY
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    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
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    • C07—ORGANIC CHEMISTRY
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    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
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    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • C07F7/0814—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring said ring is substituted at a C ring atom by Si

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Abstract

La presente descripción se refiere en términos generales a moduladores de Cot (cáncer Osaka Tiroides) y a métodos de uso y fabricación de los mismos.
MX2017017124A 2015-07-06 2016-06-30 6-amino-quinolin-3-carbonitrilos como moduladores de cancer osaka tiroides (cot). MX2017017124A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562189155P 2015-07-06 2015-07-06
US201562269061P 2015-12-17 2015-12-17
PCT/US2016/040552 WO2017007694A1 (en) 2015-07-06 2016-06-30 6-amino-quinoline-3-carbonitrils as cot modulators

Publications (1)

Publication Number Publication Date
MX2017017124A true MX2017017124A (es) 2018-03-09

Family

ID=56497863

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017017124A MX2017017124A (es) 2015-07-06 2016-06-30 6-amino-quinolin-3-carbonitrilos como moduladores de cancer osaka tiroides (cot).

Country Status (19)

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US (2) US9815818B2 (es)
EP (1) EP3319955B1 (es)
JP (1) JP6525362B2 (es)
KR (2) KR102082331B1 (es)
CN (1) CN108026067B (es)
AU (1) AU2016289817B2 (es)
BR (1) BR112018000187A2 (es)
CA (1) CA2991572A1 (es)
EA (1) EA201792612A1 (es)
ES (1) ES2849953T3 (es)
HK (1) HK1252613A1 (es)
IL (1) IL256432A (es)
MX (1) MX2017017124A (es)
NZ (1) NZ738538A (es)
PL (1) PL3319955T3 (es)
PT (1) PT3319955T (es)
SI (1) SI3319955T1 (es)
TW (1) TWI711611B (es)
WO (1) WO2017007694A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016057931A1 (en) 2014-10-10 2016-04-14 The Research Foundation For The State University Of New York Trifluoromethoxylation of arenes via intramolecular trifluoromethoxy group migration
KR102443575B1 (ko) * 2015-07-06 2022-09-16 길리애드 사이언시즈, 인코포레이티드 Cot 조정제 및 그의 사용 방법
PL3319955T3 (pl) 2015-07-06 2021-05-04 Gilead Sciences, Inc. 6-aminochinolino-3-karbonitryle jako modulatory cot
ES2800339T3 (es) * 2016-06-30 2020-12-29 Gilead Sciences Inc 4,6-diaminoquinazolinas como moduladores de cuna y métodos de uso de los mismos
CN107089977B (zh) * 2017-07-09 2018-07-31 王善梅 一种用于治疗艾滋病的药物及其制备方法
JPWO2019065516A1 (ja) * 2017-09-26 2020-09-10 日本曹達株式会社 キノリン化合物および農園芸用殺菌剤
TWI770527B (zh) 2019-06-14 2022-07-11 美商基利科學股份有限公司 Cot 調節劑及其使用方法
CA3175541A1 (en) 2020-03-30 2021-10-07 Gilead Sciences, Inc. Solid forms of (s)-6-(((1-(bicyclo[1.1.1]pentan-1-yl)-1h-1,2,3-triazol-4-yl)2-methyl-1-oxo-1,2- dihydroisoquinolin-5-yl)methyl)))amino)8-chloro-(neopentylamino)quinoline-3-carb onitrile a cot inhibitor compound
WO2021202688A1 (en) 2020-04-02 2021-10-07 Gilead Sciences, Inc. Process for preparing a cot inhibitor compound
TW202304435A (zh) 2021-06-04 2023-02-01 美商基利科學股份有限公司 治療ｎａｓｈ之方法
CN115433096B (zh) * 2022-09-16 2024-02-06 浙江省农业科学院 一种抗臭氧剂的制备方法

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UA73073C2 (uk) 1997-04-03 2005-06-15 Уайт Холдінгз Корпорейшн Заміщені 3-ціанохіноліни, спосіб їх одержання та фармацевтична композиція
CN1835923A (zh) * 2003-08-19 2006-09-20 惠氏控股公司 制备4－氨基－3－喹啉腈的方法
AU2006247520A1 (en) * 2005-05-18 2006-11-23 Wyeth 3-cyanoquinoline inhibitors of TPL2 kinase and methods of making and using the same
CN101223170A (zh) 2005-05-18 2008-07-16 惠氏公司 Tpl2激酶的4,6-二氨基-[1,7]萘啶-3-甲腈抑制剂以及其制备和使用方法
JP5255559B2 (ja) 2006-03-31 2013-08-07 アボット・ラボラトリーズ インダゾール化合物
EP2086960B1 (en) 2006-11-09 2014-03-05 Probiodrug AG Novel inhibitors of glutaminyl cyclase
KR20120139767A (ko) 2010-03-09 2012-12-27 더 브로드 인스티튜트, 인코퍼레이티드 1차 암 요법에 대한 저항성을 갖는 또는 발달시키는 환자에서 암을 진단 및 치료하는 방법
US20150297573A1 (en) 2012-10-24 2015-10-22 INSERM (Institut National de la Santé et de la Recherche Médicale) TPL2 KINASE INHIBITORS FOR PREVENTING OR TREATING DIABETES AND FOR PROMOTING Beta-CELL SURVIVAL
KR102443575B1 (ko) 2015-07-06 2022-09-16 길리애드 사이언시즈, 인코포레이티드 Cot 조정제 및 그의 사용 방법
PL3319955T3 (pl) 2015-07-06 2021-05-04 Gilead Sciences, Inc. 6-aminochinolino-3-karbonitryle jako modulatory cot
ES2800339T3 (es) 2016-06-30 2020-12-29 Gilead Sciences Inc 4,6-diaminoquinazolinas como moduladores de cuna y métodos de uso de los mismos

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IL256432A (en) 2018-02-28
EP3319955A1 (en) 2018-05-16
US9815818B2 (en) 2017-11-14
EP3319955B1 (en) 2020-11-25
KR20200022527A (ko) 2020-03-03
AU2016289817A1 (en) 2018-01-18
PL3319955T3 (pl) 2021-05-04
EA201792612A1 (ru) 2018-07-31
CN108026067A (zh) 2018-05-11
TWI711611B (zh) 2020-12-01
CN108026067B (zh) 2021-01-12
AU2016289817B2 (en) 2019-01-31
HK1252613A1 (zh) 2019-05-31
CA2991572A1 (en) 2017-01-12
JP2018520160A (ja) 2018-07-26
SI3319955T1 (sl) 2021-01-29
US10316017B2 (en) 2019-06-11
KR20180022981A (ko) 2018-03-06
US20170362201A1 (en) 2017-12-21
US20170008873A1 (en) 2017-01-12
KR102082331B1 (ko) 2020-02-27
PT3319955T (pt) 2021-01-05
TW201713643A (zh) 2017-04-16
BR112018000187A2 (pt) 2018-09-04
WO2017007694A1 (en) 2017-01-12
JP6525362B2 (ja) 2019-06-05
NZ738538A (en) 2019-06-28
ES2849953T3 (es) 2021-08-24

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