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MX2017014752A - Nuevos etinos de amidoheteroaril aroil hidrazida. - Google Patents

Nuevos etinos de amidoheteroaril aroil hidrazida.

Info

Publication number
MX2017014752A
MX2017014752A MX2017014752A MX2017014752A MX2017014752A MX 2017014752 A MX2017014752 A MX 2017014752A MX 2017014752 A MX2017014752 A MX 2017014752A MX 2017014752 A MX2017014752 A MX 2017014752A MX 2017014752 A MX2017014752 A MX 2017014752A
Authority
MX
Mexico
Prior art keywords
amidoheteroaryl
ethynes
novel
aroyl
hydrazide
Prior art date
Application number
MX2017014752A
Other languages
English (en)
Inventor
Ashvinbhai Chokshi Hemant
Sengupta Prabal
Trinadha Rao Chitturi
Yusufbhai CHIMANWALA Sabbirhusen
Anilkumar Mehta Varun
Original Assignee
Sun Pharma Advanced Res Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sun Pharma Advanced Res Co Ltd filed Critical Sun Pharma Advanced Res Co Ltd
Publication of MX2017014752A publication Critical patent/MX2017014752A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B43/00—Formation or introduction of functional groups containing nitrogen
    • C07B43/06—Formation or introduction of functional groups containing nitrogen of amide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

La presente invención se refiere a nuevos etinos de amidoheteroaril aroil hidrazida como inhibidores de la tirosina quinasa, el proceso de preparación de los mismos, y el uso de los compuestos para la preparación de composiciones farmacéuticas en el tratamiento terapéutico de trastornos relacionados con tirosina quinasas en humanos.
MX2017014752A 2015-05-18 2016-05-18 Nuevos etinos de amidoheteroaril aroil hidrazida. MX2017014752A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1953MU2015 2015-05-18
PCT/IN2016/050142 WO2016185490A1 (en) 2015-05-18 2016-05-18 Novel amidoheteroaryl aroyl hydrazide ethynes

Publications (1)

Publication Number Publication Date
MX2017014752A true MX2017014752A (es) 2018-03-23

Family

ID=57319598

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017014752A MX2017014752A (es) 2015-05-18 2016-05-18 Nuevos etinos de amidoheteroaril aroil hidrazida.

Country Status (13)

Country Link
US (1) US10150733B2 (es)
EP (1) EP3297991B1 (es)
JP (1) JP6689887B2 (es)
KR (1) KR20180011772A (es)
CN (1) CN107709300A (es)
AU (1) AU2016263311A1 (es)
BR (1) BR112017024633A2 (es)
CA (1) CA2985161A1 (es)
EA (1) EA032697B1 (es)
ES (1) ES2774501T3 (es)
MX (1) MX2017014752A (es)
WO (1) WO2016185490A1 (es)
ZA (1) ZA201707664B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA037697B1 (ru) * 2016-06-02 2021-05-12 Сан Фарма Адвансед Ресёрч Компани Лимитед Лечение болезни паркинсона
EP3463351B1 (en) 2016-06-02 2022-04-27 Sun Pharma Advanced Research Company Limited Treatment for parkinson's disease
EP3596049A4 (en) * 2017-03-15 2021-01-13 Sun Pharma Advanced Research Company Limited NEW AMORPHIC DISPERSION OF CYCLOPROPANECARBOXYLIC ACID (5- {5- [N '- (2-CHLORO-6-METHYLBENZOYL) HYDRAZINOCARBONYL] -2-METHYL-PHENYLETHYNYL} -PYRIDIN-2-AMIDE
CN115192540A (zh) 2018-06-15 2022-10-18 汉达癌症医药责任有限公司 激酶抑制剂的盐类及其组合物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2007249924B2 (en) * 2006-05-08 2013-07-04 Ariad Pharmaceuticals, Inc. Acetylenic heteroaryl compounds
CN103370324B (zh) * 2010-12-27 2016-05-18 孙树萍 作为蛋白激酶抑制剂的芳炔类衍生物及其医疗用途
CA2825367C (en) * 2011-01-21 2018-09-25 Sun Pharma Advanced Research Company Ltd. Diarylacetylene hydrazide containing tyrosine kinase inhibitors
US8859541B2 (en) * 2012-02-27 2014-10-14 Boehringer Ingelheim International Gmbh 6-alkynylpyridines

Also Published As

Publication number Publication date
US10150733B2 (en) 2018-12-11
JP2018515550A (ja) 2018-06-14
US20180127372A1 (en) 2018-05-10
ES2774501T3 (es) 2020-07-21
EP3297991A1 (en) 2018-03-28
EP3297991B1 (en) 2020-01-29
KR20180011772A (ko) 2018-02-02
CN107709300A (zh) 2018-02-16
WO2016185490A1 (en) 2016-11-24
BR112017024633A2 (pt) 2018-07-31
CA2985161A1 (en) 2016-11-24
JP6689887B2 (ja) 2020-04-28
EP3297991A4 (en) 2018-11-21
AU2016263311A1 (en) 2017-11-30
EA032697B1 (ru) 2019-07-31
ZA201707664B (en) 2019-08-28
EA201792445A1 (ru) 2018-04-30

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