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MX2017014550A - Inhibidores del antigeno nuclear epstein-barr 1 (ebna1) y metodos que los utilizan. - Google Patents

Inhibidores del antigeno nuclear epstein-barr 1 (ebna1) y metodos que los utilizan.

Info

Publication number
MX2017014550A
MX2017014550A MX2017014550A MX2017014550A MX2017014550A MX 2017014550 A MX2017014550 A MX 2017014550A MX 2017014550 A MX2017014550 A MX 2017014550A MX 2017014550 A MX2017014550 A MX 2017014550A MX 2017014550 A MX2017014550 A MX 2017014550A
Authority
MX
Mexico
Prior art keywords
same
ebna1
inhibitors
methods
useful
Prior art date
Application number
MX2017014550A
Other languages
English (en)
Inventor
Allen B Reitz
Carlsen Marianne
Zhang Yan
Shuai Chen
E Messick Troy
R Smith Garry
m lieberman Paul
E Mcdonnell Mark
Original Assignee
Wistar Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wistar Inst filed Critical Wistar Inst
Publication of MX2017014550A publication Critical patent/MX2017014550A/es

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
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    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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Abstract

La presente invención proporciona inhibidores de EBNA1, y/o composiciones farmacéuticas que los comprenden, que son útiles para el tratamiento de enfermedades causadas por actividad de EBNA1, tales como, entre otros, cáncer, mononucleosis infecciosa, síndrome de fatiga crónica, esclerosis múltiple, lupus eritematoso sistémico y/o artritis reumatoide; la presente invención proporciona además inhibidores de EBNA1, y/o composiciones farmacéuticas que los comprenden, que son útiles para el tratamiento de enfermedades causadas por infección latente por el virus de Epstein-Barr (EBV) e/o infección por EBV lítico.
MX2017014550A 2015-05-14 2016-05-14 Inhibidores del antigeno nuclear epstein-barr 1 (ebna1) y metodos que los utilizan. MX2017014550A (es)

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