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MX2017007303A - Metodos y composiciones que utilizan polipeptidos variantes klotho. - Google Patents

Metodos y composiciones que utilizan polipeptidos variantes klotho.

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Publication number
MX2017007303A
MX2017007303A MX2017007303A MX2017007303A MX2017007303A MX 2017007303 A MX2017007303 A MX 2017007303A MX 2017007303 A MX2017007303 A MX 2017007303A MX 2017007303 A MX2017007303 A MX 2017007303A MX 2017007303 A MX2017007303 A MX 2017007303A
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MX
Mexico
Prior art keywords
optionally
compositions
methods
mutations
terminus
Prior art date
Application number
MX2017007303A
Other languages
English (en)
Inventor
Guo Donglin
Ibebunjo Chikwendu
Original Assignee
Novartis Ag
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Publication of MX2017007303A publication Critical patent/MX2017007303A/es

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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
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    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01031—Beta-glucuronidase (3.2.1.31)

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
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  • Medicinal Chemistry (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Biophysics (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Obesity (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)

Abstract

La presente descripción se dirige a composiciones y métodos relacionados con una variante alfa sKlotho o fragmento, en el cual 1 hasta a aproximadamente 20 aminoácidos se han suprimido del C-terminal, que tiene opcionalmente también mutaciones en V563 y/o K795. La presente descripción también se refiere a un variante o fragmento de polipéptido alfa sKlotho que tiene las mutaciones en V563 y/o K795, en donde la variante o fragmento de polipéptido es de longitud completa, u opcionalmente 1 hasta a aproximadamente 20 aminoácidos se han suprimido del C-terminal. La presente descripción también se refiere a polipéptidos de fusión que comprenden: (a) un alfa sKlotho, en el cual 1 hasta a aproximadamente 20 aminoácidos se han suprimido del C-terminal, que tiene opcionalmente también mutaciones en V563 y/o K795; (b) un ligamiento; y (c) FGF23, que tiene opcionalmente una mutación en R179, C206 y/o C244, o (c) albúmina de suero.
MX2017007303A 2014-12-04 2015-12-02 Metodos y composiciones que utilizan polipeptidos variantes klotho. MX2017007303A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462087516P 2014-12-04 2014-12-04
PCT/IB2015/059294 WO2016088059A1 (en) 2014-12-04 2015-12-02 Methods and compositions using klotho variant polypeptides

Publications (1)

Publication Number Publication Date
MX2017007303A true MX2017007303A (es) 2017-08-25

Family

ID=55024183

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MX2017007303A MX2017007303A (es) 2014-12-04 2015-12-02 Metodos y composiciones que utilizan polipeptidos variantes klotho.
MX2021000030A MX2021000030A (es) 2014-12-04 2017-06-05 Metodos y composiciones que utilizan polipeptidos variantes klotho.

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MX2021000030A MX2021000030A (es) 2014-12-04 2017-06-05 Metodos y composiciones que utilizan polipeptidos variantes klotho.

Country Status (12)

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US (2) US10654909B2 (es)
EP (1) EP3227319B1 (es)
JP (1) JP2017537926A (es)
KR (1) KR20170084332A (es)
CN (1) CN107810201A (es)
AU (1) AU2015356643B2 (es)
BR (1) BR112017011398A2 (es)
CA (1) CA2969307A1 (es)
EA (1) EA201791238A1 (es)
MX (2) MX2017007303A (es)
TW (1) TW201628641A (es)
WO (1) WO2016088059A1 (es)

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CN112915193B (zh) * 2021-03-05 2022-09-13 南方医科大学南方医院 Kp-1在制备治疗慢性肺病的药物中的用途
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US20180037623A1 (en) 2018-02-08
US20200362015A1 (en) 2020-11-19
MX2021000030A (es) 2021-03-25
EA201791238A1 (ru) 2018-02-28
TW201628641A (zh) 2016-08-16
EP3227319B1 (en) 2019-11-27
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