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MX2015015665A - (ciano-dimetil-metil)-isoxazoles y -[1,3,4]tiadiazoles novedosos. - Google Patents

(ciano-dimetil-metil)-isoxazoles y -[1,3,4]tiadiazoles novedosos.

Info

Publication number
MX2015015665A
MX2015015665A MX2015015665A MX2015015665A MX2015015665A MX 2015015665 A MX2015015665 A MX 2015015665A MX 2015015665 A MX2015015665 A MX 2015015665A MX 2015015665 A MX2015015665 A MX 2015015665A MX 2015015665 A MX2015015665 A MX 2015015665A
Authority
MX
Mexico
Prior art keywords
thiadiazoles
cyano
dimethyl
methyl
novel
Prior art date
Application number
MX2015015665A
Other languages
English (en)
Other versions
MX350885B (es
Inventor
Stephan Georg Mueller
Doris Riether
Achim Sauer
Henri Doods
Florian Binder
Janet Rachel Nicholson
Original Assignee
Ct Xion Therapeutics Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ct Xion Therapeutics Corp filed Critical Ct Xion Therapeutics Corp
Publication of MX2015015665A publication Critical patent/MX2015015665A/es
Publication of MX350885B publication Critical patent/MX350885B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/04—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/14—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Este invento se refiere a (ciano-dimetil-metil)isoxazoles y -[1,3,4] tiadiazoles novedosos y sus usos como agonistas del receptor cannabinoide CB2, a composiciones farmacéuticas que los contienen y a su uso para el tratamiento de trastornos o afecciones mediadas por el receptor CB2.
MX2015015665A 2013-05-17 2014-05-16 (ciano-dimetil-metil)-isoxazoles y -[1,3,4]tiadiazoles novedosos. MX350885B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13168165.2A EP2803668A1 (en) 2013-05-17 2013-05-17 Novel (cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles
PCT/EP2014/060033 WO2014184327A1 (en) 2013-05-17 2014-05-16 Novel (cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles

Publications (2)

Publication Number Publication Date
MX2015015665A true MX2015015665A (es) 2016-03-17
MX350885B MX350885B (es) 2017-09-25

Family

ID=48428381

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015015665A MX350885B (es) 2013-05-17 2014-05-16 (ciano-dimetil-metil)-isoxazoles y -[1,3,4]tiadiazoles novedosos.

Country Status (25)

Country Link
US (7) US8865744B1 (es)
EP (2) EP2803668A1 (es)
JP (1) JP6309616B2 (es)
KR (1) KR102293386B1 (es)
CN (1) CN105229000B (es)
AR (1) AR096338A1 (es)
AU (1) AU2014267197B2 (es)
BR (1) BR112015028235A2 (es)
CA (1) CA2912463C (es)
CL (1) CL2015003286A1 (es)
DK (1) DK2997027T3 (es)
EA (1) EA031021B1 (es)
ES (1) ES2626396T3 (es)
HK (1) HK1222851A1 (es)
IL (1) IL242309B (es)
MX (1) MX350885B (es)
NZ (1) NZ713614A (es)
PH (1) PH12015502523A1 (es)
PL (1) PL2997027T3 (es)
PT (1) PT2997027T (es)
TW (1) TW201536762A (es)
UA (1) UA118031C2 (es)
UY (1) UY35571A (es)
WO (1) WO2014184327A1 (es)
ZA (1) ZA201507957B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202432140A (zh) 2013-05-17 2024-08-16 美商英塞特控股公司 作為jak抑制劑之聯吡唑衍生物
EP2803668A1 (en) * 2013-05-17 2014-11-19 Boehringer Ingelheim International Gmbh Novel (cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles
CN110114059A (zh) * 2017-01-06 2019-08-09 克雷西奥生物科技有限公司 地托咪定局部制剂
CN111936135A (zh) 2018-02-16 2020-11-13 因赛特公司 用于治疗细胞因子相关的病症的jak1通路抑制剂
IL277538B2 (en) 2018-03-30 2024-09-01 Incyte Corp Use of JAK inhibitors to treat hidradenitis suppurativa
JP2023528868A (ja) 2020-06-02 2023-07-06 インサイト・コーポレイション Ｊａｋ１阻害剤の調製プロセス
EP4259131A1 (en) 2020-12-08 2023-10-18 Incyte Corporation Jak1 pathway inhibitors for the treatment of vitiligo

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