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MX2015012922A - Tratamiento del cancer usando anticuerpos que se unen a grp78 en la superficie celular. - Google Patents

Tratamiento del cancer usando anticuerpos que se unen a grp78 en la superficie celular.

Info

Publication number
MX2015012922A
MX2015012922A MX2015012922A MX2015012922A MX2015012922A MX 2015012922 A MX2015012922 A MX 2015012922A MX 2015012922 A MX2015012922 A MX 2015012922A MX 2015012922 A MX2015012922 A MX 2015012922A MX 2015012922 A MX2015012922 A MX 2015012922A
Authority
MX
Mexico
Prior art keywords
antibodies
grp78
antigen
binding fragments
cells
Prior art date
Application number
MX2015012922A
Other languages
English (en)
Inventor
Parkash Gill
Ren Liu
Original Assignee
Ren Liu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51581763&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2015012922(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ren Liu filed Critical Ren Liu
Publication of MX2015012922A publication Critical patent/MX2015012922A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
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    • C07K16/303—Liver or Pancreas
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    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
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Abstract

La presente solicitud proporciona, entre otros, anticuerpos o fragmentos de unión a antígeno de los mismos, dirigidos al GRP78 de superficie celular expresado en células tumorales, células tumorales endoteliales y células cancerosas en estadío inicial. Estos anticuerpos anti-GRP78 y fragmentos de unión a antígeno de los mismos, tienen una alta afinidad por GRP78 y son menos inmunogénicos en comparación a sus anticuerpos precursores no modificados en una especie determinada, por ejemplo la humana, y funcionan para inhibir GRP78. De forma relevante, estos nuevos anticuerpos aislados y fragmentos de unión a antígeno de los mismos, atenúan la señalización PI3K y promueven la apoptosis en células tumorales, mientras que al mismo tiempo no afectan a las células normales. Estos anticuerpos y fragmentos de unión a antígeno de los mismos son útiles para tratamientos terapéuticos para el cáncer dirigidos a UPR.
MX2015012922A 2013-03-14 2014-03-14 Tratamiento del cancer usando anticuerpos que se unen a grp78 en la superficie celular. MX2015012922A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361781395P 2013-03-14 2013-03-14
PCT/US2014/028868 WO2014153056A2 (en) 2013-03-14 2014-03-14 Cancer treatment using antibodies that bing cell surface grp78

Publications (1)

Publication Number Publication Date
MX2015012922A true MX2015012922A (es) 2016-04-04

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MX2015012922A MX2015012922A (es) 2013-03-14 2014-03-14 Tratamiento del cancer usando anticuerpos que se unen a grp78 en la superficie celular.

Country Status (14)

Country Link
US (4) US20160185853A1 (es)
EP (1) EP2970443A4 (es)
JP (1) JP2016520527A (es)
KR (1) KR20160043927A (es)
CN (1) CN105452292A (es)
AU (1) AU2014236309A1 (es)
BR (1) BR112015023212A2 (es)
CA (1) CA2906688A1 (es)
MX (1) MX2015012922A (es)
PE (1) PE20151893A1 (es)
PH (1) PH12015502112A1 (es)
RU (1) RU2015142815A (es)
SG (1) SG11201507563SA (es)
WO (1) WO2014153056A2 (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2015012922A (es) 2013-03-14 2016-04-04 Ren Liu Tratamiento del cancer usando anticuerpos que se unen a grp78 en la superficie celular.
AU2016261223A1 (en) * 2015-05-08 2018-01-04 Oklahoma Medical Research Foundation Nitrofuran derivatives that induce apoptosis in breast cancer cells by activating protein expression
EP3502701A3 (en) * 2015-12-11 2019-07-10 Sanford Health Reagents and methods for monitoring breast cancer therapy
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