[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

MX2015011446A - Partículas de transducción no replicativas y sistemas indicadores a base de partículas de transducción. - Google Patents

Partículas de transducción no replicativas y sistemas indicadores a base de partículas de transducción.

Info

Publication number
MX2015011446A
MX2015011446A MX2015011446A MX2015011446A MX2015011446A MX 2015011446 A MX2015011446 A MX 2015011446A MX 2015011446 A MX2015011446 A MX 2015011446A MX 2015011446 A MX2015011446 A MX 2015011446A MX 2015011446 A MX2015011446 A MX 2015011446A
Authority
MX
Mexico
Prior art keywords
reporter
transduction
replicative
particles
systems
Prior art date
Application number
MX2015011446A
Other languages
English (en)
Other versions
MX360560B (es
Inventor
Diego Ariel Rey
Nikol Deforest
Heather Cox
Soni Shukla
Original Assignee
Geneweave Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Geneweave Biosciences Inc filed Critical Geneweave Biosciences Inc
Publication of MX2015011446A publication Critical patent/MX2015011446A/es
Publication of MX360560B publication Critical patent/MX360560B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • C12Q1/14—Streptococcus; Staphylococcus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/18—Testing for antimicrobial activity of a material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/66—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving luciferase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y113/00—Oxidoreductases acting on single donors with incorporation of molecular oxygen (oxygenases) (1.13)
    • C12Y113/12—Oxidoreductases acting on single donors with incorporation of molecular oxygen (oxygenases) (1.13) with incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)(1.13.12)
    • C12Y113/12007—Photinus-luciferin 4-monooxygenase (ATP-hydrolysing) (1.13.12.7), i.e. firefly-luciferase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/10011—Details dsDNA Bacteriophages
    • C12N2795/10111—Myoviridae
    • C12N2795/10141—Use of virus, viral particle or viral elements as a vector
    • C12N2795/10143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/10011—Details dsDNA Bacteriophages
    • C12N2795/10111—Myoviridae
    • C12N2795/10151—Methods of production or purification of viral material
    • C12N2795/10152—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/10011—Details dsDNA Bacteriophages
    • C12N2795/10311—Siphoviridae
    • C12N2795/10341—Use of virus, viral particle or viral elements as a vector
    • C12N2795/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/10011—Details dsDNA Bacteriophages
    • C12N2795/10311—Siphoviridae
    • C12N2795/10351—Methods of production or purification of viral material
    • C12N2795/10352—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
    • G01N2333/305—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Micrococcaceae (F)
    • G01N2333/31—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Micrococcaceae (F) from Staphylococcus (G)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/902—Oxidoreductases (1.)
    • G01N2333/90241—Oxidoreductases (1.) acting on single donors with incorporation of molecular oxygen, i.e. oxygenases (1.13)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Plant Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Se proporcionan métodos y sistemas para envasar moléculas indicadoras de ácido nucleico en partículas de transducción no replicativas. Las partículas de transducción no replicativas se pueden construir de virus y usar en sistemas de transducción y replicación. Las moléculas indicadoras de ácido nucleico incluyen un gen indicador, tal como una molécula indicadora o marcador seleccionable, para detectar células o genes diana. Se proporcionan métodos y sistemas para la detección de células y moléculas diana de ácidos nucleicos usando las partículas de transducción no replicativas como moléculas indicadoras.
MX2015011446A 2013-03-13 2014-03-13 Partículas de transducción no replicativas y sistemas indicadores a base de partículas de transducción. MX360560B (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201361779177P 2013-03-13 2013-03-13
US201361897040P 2013-10-29 2013-10-29
US201461939126P 2014-02-12 2014-02-12
PCT/US2014/026536 WO2014160418A2 (en) 2013-03-13 2014-03-13 Non-replicative transduction particles and transduction particle-based reporter systems

Publications (2)

Publication Number Publication Date
MX2015011446A true MX2015011446A (es) 2016-03-15
MX360560B MX360560B (es) 2018-11-07

Family

ID=51625644

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015011446A MX360560B (es) 2013-03-13 2014-03-13 Partículas de transducción no replicativas y sistemas indicadores a base de partículas de transducción.

Country Status (15)

Country Link
US (5) US9388453B2 (es)
EP (2) EP2968424B1 (es)
JP (2) JP6431035B2 (es)
KR (1) KR102127358B1 (es)
CN (2) CN105378060B (es)
AU (1) AU2014243796B2 (es)
BR (1) BR112015023108A8 (es)
CA (1) CA2905341C (es)
DK (1) DK2968424T3 (es)
ES (1) ES2780827T3 (es)
HK (1) HK1218429A1 (es)
MX (1) MX360560B (es)
RU (1) RU2661101C2 (es)
SG (1) SG11201507463WA (es)
WO (1) WO2014160418A2 (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6431035B2 (ja) 2013-03-13 2018-11-28 ジーンウィーブ バイオサイエンシズ，インコーポレイティド 非複製的形質導入粒子及び形質導入粒子に基づくレポーターシステム
US9481903B2 (en) 2013-03-13 2016-11-01 Roche Molecular Systems, Inc. Systems and methods for detection of cells using engineered transduction particles
US9540675B2 (en) 2013-10-29 2017-01-10 GeneWeave Biosciences, Inc. Reagent cartridge and methods for detection of cells
US9676641B2 (en) 2014-01-29 2017-06-13 Synphagen Llc Therapeutic phages and methods for delivery of nucleic acids for therapeutic uses
EP3155133B1 (en) * 2014-06-13 2021-04-07 Geneweave Biosciences, Inc. Growth-independent detection of cells
TW201614073A (en) * 2014-08-25 2016-04-16 Geneweave Biosciences Inc Non-replicative transduction particles and transduction particle-based reporter systems
US9879328B2 (en) 2014-11-21 2018-01-30 GeneWeave Biosciences, Inc. Mechanisms of antimicrobial susceptibility
US10227661B2 (en) 2014-11-21 2019-03-12 GeneWeave Biosciences, Inc. Sequence-specific detection and phenotype determination
US10351893B2 (en) * 2015-10-05 2019-07-16 GeneWeave Biosciences, Inc. Reagent cartridge for detection of cells
US10718003B2 (en) 2015-12-31 2020-07-21 Roche Molecular Systems, Inc. Detecting an analyte in a flash and glow reaction
JP2019509746A (ja) 2016-03-28 2019-04-11 ザ・チャールズ・スターク・ドレイパ・ラボラトリー・インコーポレイテッド バクテリオファージ改変法
US11149319B2 (en) * 2016-12-20 2021-10-19 Roche Molecular Systems, Inc. Systems and methods for detecting cells using engineered transduction particles
CN111601897A (zh) 2016-12-30 2020-08-28 奎多公司 用于确定细菌对抗生素或益菌剂的易感性的噬菌体介导的免疫分析和方法
WO2018213301A1 (en) * 2017-05-15 2018-11-22 New York University Compositions and methods for non-antibiotic treating of bacterial infections by blocking or disrupting bacterial genes involved in virulence or viability
US11077444B2 (en) 2017-05-23 2021-08-03 Roche Molecular Systems, Inc. Packaging for a molecular diagnostic cartridge
US11008602B2 (en) * 2017-12-20 2021-05-18 Roche Molecular Systems, Inc. Non-replicative transduction particles and transduction particle-based reporter systems
CA3096281A1 (en) * 2018-04-24 2019-10-31 Laboratory Corporation Of America Holdings Indicator bacteriophage for selecting and monitoring for efficacy of therapeutics and methods for using same
US11541105B2 (en) 2018-06-01 2023-01-03 The Research Foundation For The State University Of New York Compositions and methods for disrupting biofilm formation and maintenance
US10968491B2 (en) 2018-12-05 2021-04-06 GeneWeave Biosciences, Inc. Growth-independent detection of cells
CN113227404A (zh) 2018-12-27 2021-08-06 豪夫迈·罗氏有限公司 用于检测鲍氏不动杆菌的非复制型转导颗粒和基于转导颗粒的报告系统
WO2020136153A1 (en) * 2018-12-29 2020-07-02 F. Hoffmann-La Roche Ag Use of sideromycins to limit cross-reactivity and improve bacterial identification in antibiotic susceptibility assays
US11572595B2 (en) * 2018-12-31 2023-02-07 Roche Molecular Systems, Inc. Non-replicative transduction particles with one or more non-native tail fibers and transduction particle-based reporter systems
WO2020245123A1 (en) 2019-06-06 2020-12-10 F. Hoffmann-La Roche Ag Use of peptidomimetic antimicrobial peptides to limit cross-reactivity and improve bacterial identification in antibiotic susceptibility assays
US11739363B2 (en) * 2019-08-26 2023-08-29 Laboratory Corporation Of America Holdings Devices and methods for detecting microorganisms using recombinant reproduction-deficient indicator bacteriophage
WO2021136752A1 (en) 2019-12-31 2021-07-08 F. Hoffmann-La Roche Ag Quantitative pcr screening of inducible prophage from bacterial isolates
EP4388121A1 (en) * 2021-08-20 2024-06-26 University of Pittsburgh - Of the Commonwealth System of Higher Education Discrimination of antibiotic resistant and sensitive samples

Family Cites Families (128)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL289281A (es) 1962-02-28
US3826574A (en) 1973-02-12 1974-07-30 Continental Distributors Nephelometer
US4057148A (en) 1974-06-25 1977-11-08 G. D. Searle & Co. Multiple sample support assembly and apparatus for facilitating radioimmunoassays and the like
CA1277931C (en) 1984-06-05 1990-12-18 Shimon Ulitzur Detection and/or identification of microorganisms in a test sample usingbioluminescence or other exogenous genetically-introduced marker
US4861709A (en) 1985-05-31 1989-08-29 Technicon Research A.G. Detection and/or identification of microorganisms in a test sample using bioluminescence or other exogenous genetically-introduced marker
AU6131086A (en) 1985-07-05 1987-01-30 Whitehead Institute For Biomedical Research Epithelial cells expressing foreign genetic material
US4980286A (en) 1985-07-05 1990-12-25 Whitehead Institute For Biomedical Research In vivo introduction and expression of foreign genetic material in epithelial cells
US5139941A (en) 1985-10-31 1992-08-18 University Of Florida Research Foundation, Inc. AAV transduction vectors
DE3540823C1 (de) 1985-11-16 1986-10-02 Laboratorium Prof. Dr. Rudolf Berthold, 7547 Wildbad Fotometrische Messstation
CA1339465C (en) 1986-04-30 1997-09-16 Richard J. Massey Electrochemiluminescent assays
AU7751687A (en) 1986-07-22 1988-02-10 Boyce Thompson Institute For Plant Research Inc. Use of bacterial luciferase structural genes for cloning and monitoring gene expression in microorganisms and for tagging and identification of genetically engineered organisms
US5221623A (en) 1986-07-22 1993-06-22 Boyce Thompson Institute For Plant Research, Inc. Use of bacterial luciferase structural genes for cloning and monitoring gene expression in microorganisms and for tagging and identification of genetically engineered organisms
EP0633318A1 (en) 1987-09-11 1995-01-11 Whitehead Institute For Biomedical Research Transduced fibroblasts and uses therefor
DE3851153T2 (de) 1987-12-11 1995-01-05 Hughes Howard Med Inst Genetische modifizierung von endothelialen zellen.
DE68927996T2 (de) 1988-02-05 1997-12-04 Hughes Howard Med Inst Modifizierte hepatozyten und deren anwendung
FR2641793B1 (fr) 1988-12-26 1993-10-01 Setratech Procede de recombinaison in vivo de sequences d'adn presentant des mesappariements de bases
US5139745A (en) 1990-03-30 1992-08-18 Block Medical, Inc. Luminometer
GB9017443D0 (en) 1990-08-09 1990-09-26 Amersham Int Plc Reporter bacteria for rapid microbial detection
DK0556345T3 (da) 1990-10-31 1997-06-16 Whitehead Biomedical Inst Retrovirale vektorer,som er egnede til genterapi
US5188455A (en) 1990-11-13 1993-02-23 The Pennsylvania Research Corporation Apparatus for remote mixing of fluids
US5086233A (en) 1991-01-22 1992-02-04 Dynatech Corporation Luminometers with sample container displacement controlled by ramped abutment
US5252479A (en) 1991-11-08 1993-10-12 Research Corporation Technologies, Inc. Safe vector for gene therapy
US6300061B1 (en) 1992-02-07 2001-10-09 Albert Einstein College Of Medicine Of Yeshiva University Mycobacterial species-specific reporter mycobacteriophages
US5242660A (en) 1992-02-28 1993-09-07 Paul Hsei Sample preparation device
US5587308A (en) 1992-06-02 1996-12-24 The United States Of America As Represented By The Department Of Health & Human Services Modified adeno-associated virus vector capable of expression from a novel promoter
JPH0634546A (ja) 1992-07-17 1994-02-08 Tosoh Corp 蛍光検出器
US5478745A (en) 1992-12-04 1995-12-26 University Of Pittsburgh Recombinant viral vector system
AU687363B2 (en) 1993-03-19 1998-02-26 Ciba Corning Diagnostics Corp. Luminometer
US5494646A (en) 1993-04-14 1996-02-27 Seymour; Eugene H. Sampling device and sample adequacy system
AU6905294A (en) * 1993-04-29 1994-11-21 Albert Einstein College Of Medicine Of Yeshiva University Mycobacterial species-specific reporter mycobacteriophages
US5645801A (en) 1993-10-21 1997-07-08 Abbott Laboratories Device and method for amplifying and detecting target nucleic acids
US6054299A (en) 1994-04-29 2000-04-25 Conrad; Charles A. Stem-loop cloning vector and method
US5736388A (en) * 1994-12-30 1998-04-07 Chada; Sunil Bacteriophage-mediated gene transfer systems capable of transfecting eukaryotic cells
US5656424A (en) 1995-02-15 1997-08-12 Albert Einstein College Of Medicine, A Division Of Yeshiva University Identification of mycobacterium tuberculosis complex species
US5476768A (en) 1995-03-10 1995-12-19 Becton, Dickinson And Company Mycobacteriophage DSGA specific for the mycobacterium tuberculosis complex
DE19517940A1 (de) 1995-05-18 1996-11-21 Merck Patent Gmbh Nachweis von Listerien mittels rekombinanter Bakteriophagen
CA2196793A1 (en) 1995-06-07 1996-12-19 Hugh V. Cottingham Device and method for phage-based antibiotic susceptibility testing
US5814022A (en) 1996-02-06 1998-09-29 Plasmaseal Llc Method and apparatus for applying tissue sealant
US5939262A (en) 1996-07-03 1999-08-17 Ambion, Inc. Ribonuclease resistant RNA preparation and utilization
US5677124A (en) 1996-07-03 1997-10-14 Ambion, Inc. Ribonuclease resistant viral RNA standards
US5905029A (en) 1997-02-19 1999-05-18 Fritz Berthold Method for rapid hygiene testing
US5989499A (en) 1997-05-02 1999-11-23 Biomerieux, Inc. Dual chamber disposable reaction vessel for amplification reactions
SE9702005D0 (sv) 1997-05-28 1997-05-28 Alphahelix Ab New reaction vessel and method for its use
WO1999004258A1 (en) 1997-07-17 1999-01-28 Synermed International Inc. Assay for total and direct bilirubin
US6054312A (en) * 1997-08-29 2000-04-25 Selective Genetics, Inc. Receptor-mediated gene delivery using bacteriophage vectors
US6506559B1 (en) 1997-12-23 2003-01-14 Carnegie Institute Of Washington Genetic inhibition by double-stranded RNA
US6003566A (en) 1998-02-26 1999-12-21 Becton Dickinson And Company Vial transferset and method
WO1999053050A1 (en) 1998-04-08 1999-10-21 Commonwealth Scientific And Industrial Research Organisation Methods and means for obtaining modified phenotypes
AR020078A1 (es) 1998-05-26 2002-04-10 Syngenta Participations Ag Metodo para alterar la expresion de un gen objetivo en una celula de planta
CA2345936A1 (en) 1998-10-09 2000-04-20 Ingene, Inc. Production of ssdna in a cell
CA2346155A1 (en) 1998-10-09 2000-04-20 Ingene, Inc. Enzymatic synthesis of ssdna
DE19956568A1 (de) 1999-01-30 2000-08-17 Roland Kreutzer Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens
DE60014987T2 (de) 1999-02-22 2005-11-10 Matsushita Electric Industrial Co., Ltd., Kadoma Verfahren zum Nachweis von Bakterien
CA2365901A1 (en) 1999-04-14 2000-10-19 Musc Foundation For Research Development Tissue-specific and pathogen-specific toxic agents and ribozymes
US6818185B1 (en) 1999-05-28 2004-11-16 Cepheid Cartridge for conducting a chemical reaction
US6271034B1 (en) 1999-07-08 2001-08-07 Albert Einstein College Of Medicine Of Yeshiva University One step allelic exchange in mycobacteria using in vitro generated conditional transducing phages
US6737266B1 (en) 1999-10-01 2004-05-18 3M Innovative Properties Company Devices and methods for microorganism detection
DE10100586C1 (de) 2001-01-09 2002-04-11 Ribopharma Ag Verfahren zur Hemmung der Expression eines Ziegens
US7160511B2 (en) 2000-02-18 2007-01-09 Olympus Corporation Liquid pipetting apparatus and micro array manufacturing apparatus
US8216797B2 (en) 2001-02-07 2012-07-10 Massachusetts Institute Of Technology Pathogen detection biosensor
GB0108830D0 (en) 2001-04-09 2001-05-30 Univ Nottingham Controlling DNA packaging
US6544729B2 (en) 2001-07-20 2003-04-08 University Of Tennessee Bioluminescent biosensor device
EP1435788B1 (en) 2001-09-27 2015-10-21 Gangagen, Inc. Lysin-deficient bacteriophages having reduced immunogenicity
AU2002360272A1 (en) 2001-10-10 2003-04-22 Superarray Bioscience Corporation Detecting targets by unique identifier nucleotide tags
CN1605023A (zh) 2001-10-19 2005-04-06 蒙诺根有限公司 用于获得细胞层的搅拌系统和方法
AU2002365188A1 (en) 2001-11-07 2003-07-30 Musc Foundation For Research Development Nucleic acid delivery and expression
NZ533051A (en) 2001-12-06 2006-10-27 Biocontrol Systems Inc Sample collection and testing system
US8216780B2 (en) 2002-04-12 2012-07-10 Microphage (Tm) Incorporated Method for enhanced sensitivity in bacteriophage-based diagnostic assays
US20050003346A1 (en) 2002-04-12 2005-01-06 Colorado School Of Mines Apparatus and method for detecting microscopic living organisms using bacteriophage
ES2346424T3 (es) 2002-04-12 2010-10-15 Colorado School Of Mines Procedimiento de deteccion de bajas concentraciones de una bacteria diana que utiliza fagos para infectar celulas bacterianas diana.
US20040126783A1 (en) 2002-07-10 2004-07-01 Massachusetts Institute Of Technology Apparatus and method for isolating a nucleic acid from a sample
SE0203366L (sv) 2002-11-14 2003-11-04 Magnetic Biosolutions Sweden A Pipetteringsapparat
US9534224B2 (en) 2002-11-15 2017-01-03 Trustees Of Boston University Cis/trans riboregulators
US7291482B2 (en) * 2002-12-20 2007-11-06 E.I. Du Pont De Nemours And Company Mutations affecting plasmid copy number
US7125727B2 (en) 2003-01-29 2006-10-24 Protedyne Corporation Sample handling tool with piezoelectric actuator
FI20030867A (fi) 2003-06-10 2004-12-11 Wallac Oy Optinen mittausmenetelmä ja laboratoriomittauslaite
EP1654066B1 (en) 2003-07-31 2014-11-12 Handylab, Inc. Processing particle-containing samples
CA2541941C (en) 2003-10-06 2015-05-26 Gangagen, Inc. Anti-bacterial phage tail compositions and uses thereof
FR2860731B1 (fr) 2003-10-14 2006-01-21 Maxmat S A Appareil de mixage d'un analyseur chimique ou biochimique avec entrainement pendulaire d'une pipette
DE102004003434B4 (de) 2004-01-21 2006-06-08 Eppendorf Ag Pipettiervorrichtung mit einer Verdrängungseinrichtung und einer damit lösbar verbundenen Antriebseinrichtung
US20080241819A1 (en) 2006-10-31 2008-10-02 Microphage (Tm) Incorporated Method and apparatus for enhanced bacteriophage-based diagnostic assays by selective inhibition of potential cross-reactive organisms
US8101431B2 (en) 2004-02-27 2012-01-24 Board Of Regents, The University Of Texas System Integration of fluids and reagents into self-contained cartridges containing sensor elements and reagent delivery systems
US20060257991A1 (en) 2004-02-27 2006-11-16 Mcdevitt John T Integration of fluids and reagents into self-contained cartridges containing particle-based sensor elements and membrane-based sensor elements
CA2562457A1 (en) 2004-04-07 2006-07-20 The Government Of The United States Of America, As Represented By The Se Cretary, Department Of Health And Human Services Reporter plasmid phage packaging system for detection of bacteria
US7674621B2 (en) 2004-05-21 2010-03-09 The United States Of America As Represented By The Department Of Health And Human Services Plasmids and phages for homologous recombination and methods of use
WO2006003001A1 (en) 2004-07-06 2006-01-12 Mixis France S.A. Generation of recombinant genes in bacteriophages
WO2006137847A2 (en) 2004-09-13 2006-12-28 Trustees Of Boston University Engineered enzymatically active bacteriophages and methods of uses thereof
US20060068398A1 (en) 2004-09-24 2006-03-30 Cepheid Universal and target specific reagent beads for nucleic acid amplification
US7244612B2 (en) 2004-10-07 2007-07-17 University Of Wyoming Template reporter bacteriophage platform and multiple bacterial detection assays based thereon
KR100668310B1 (ko) 2004-11-01 2007-01-12 삼성전자주식회사 표적 세포 특이적 바이러스를 이용하여 표적 세포의존재를 검출하는 방법
WO2006083695A2 (en) 2005-01-28 2006-08-10 Parker-Hannifin Corporation Sampling probe, gripper and interface for laboratory sample management systems
WO2006105414A2 (en) 2005-03-31 2006-10-05 Colorado School Of Mines Apparatus and method for detecting microscopic organisms using microphage
US20110097702A1 (en) 2005-03-31 2011-04-28 Voorhees Kent J Methods and compositions for in situ detection of microorganisms on a surface
CA2610793A1 (en) 2005-05-31 2007-05-10 Labnow, Inc. Methods and compositions related to determination and use of white blood cell counts
US20080286757A1 (en) 2005-09-15 2008-11-20 Microphage Incorporated Method and Apparatus for Identification of Microorganisms Using Bacteriophage
US20070072174A1 (en) 2005-09-28 2007-03-29 Sayler Gary S Bioreporter for detection of microbes
US7727473B2 (en) 2005-10-19 2010-06-01 Progentech Limited Cassette for sample preparation
US20070178450A1 (en) 2006-01-27 2007-08-02 Microphage (Tm) Incorporation Method and apparatus for determining level of microorganisms using bacteriophage
US20080003564A1 (en) 2006-02-14 2008-01-03 Iquum, Inc. Sample processing
WO2007115378A1 (en) 2006-04-11 2007-10-18 Minifab (Australia) Pty Ltd Microfluidic package housing
US20070292397A1 (en) 2006-06-19 2007-12-20 Mcnulty Amy K Method for the detection and neutralization of bacteria
US8530178B2 (en) 2006-10-17 2013-09-10 Zymera, Inc. Hydrolase detection system with caged substrates
WO2008055257A2 (en) 2006-11-02 2008-05-08 Vectrant Technologies Inc. Cartridge for conducting diagnostic assays
ITPD20060419A1 (it) 2006-11-13 2008-05-14 Federico Nalesso Dispositivo per il trattamento manutentivo di cateteri venosi centrali
US8355132B2 (en) 2007-04-06 2013-01-15 Qiagen Gaithersburg, Inc. Sample adequacy measurement system having a plurality of sample tubes and using turbidity light scattering techniques
CA2684311A1 (en) 2007-04-18 2008-10-30 Cornell University Microorganism detection method and apparatus
US8483174B2 (en) 2007-04-20 2013-07-09 Qualcomm Incorporated Method and apparatus for providing gateway relocation
WO2008136769A1 (en) 2007-05-03 2008-11-13 Nanyang Technological University Online contaminant detection and removal system
CA2690809A1 (en) 2007-06-15 2008-12-24 Microphage Incorporated Method of detection of microorganisms with enhanced bacteriophage amplification
GB0712844D0 (en) 2007-07-02 2007-08-08 Univ Leuven Kath Colorimetric assay for the visual detection of primary and secondary amines
US8314222B2 (en) * 2007-10-05 2012-11-20 Sapphire Energy, Inc. System for capturing and modifying large pieces of genomic DNA and constructing organisms with chloroplasts
AU2008331866A1 (en) 2007-11-28 2009-06-11 Smart Tube, Inc. Devices, systems and methods for the collection, stimulation, stabilization, and analysis of a biological sample
US8619257B2 (en) 2007-12-13 2013-12-31 Kimberley-Clark Worldwide, Inc. Recombinant bacteriophage for detection of nosocomial infection
US8153119B2 (en) 2007-12-18 2012-04-10 Trustees Of Boston University Engineered enzymatically active bacteriophage and methods for dispersing biofilms
US8329889B2 (en) 2008-02-15 2012-12-11 Trustees Of Boston University In vivo gene sensors
EP2276852B1 (en) 2008-05-14 2015-11-04 Guild Associates, Inc. Phage-mediated bioluminescent detection of yersinia pestis
CA2891990C (en) 2008-05-20 2022-07-26 Ralph Sebastian Dacosta Device and method for fluorescence-based imaging and monitoring
US20120134975A1 (en) 2008-08-13 2012-05-31 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Biological targeting compositions and methods of using the same
US8748122B2 (en) 2008-12-16 2014-06-10 BIO MéRIEUX, INC. Methods for the characterization of microorganisms on solid or semi-solid media
US8645115B2 (en) 2008-12-22 2014-02-04 Trustees Of Boston University Modular nucleic acid-based circuits for counters, binary operations, memory and logic
WO2010096584A1 (en) 2009-02-18 2010-08-26 Cornell University Coupled recognition/detection system for in vivo and in vitro use
US8586347B2 (en) 2010-09-15 2013-11-19 Mbio Diagnostics, Inc. System and method for detecting multiple molecules in one assay
US20110183314A1 (en) 2010-01-26 2011-07-28 Microphage Incorporated Bacteriophage-based microorganism diagnostic assay using speed or acceleration of bacteriophage reproduction
WO2012151473A2 (en) 2011-05-04 2012-11-08 Luminex Corporation Apparatus and methods for integrated sample preparation, reaction and detection
JP6101257B2 (ja) 2011-06-22 2017-03-22 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル サンプル中のカルバペネマーゼ産生菌の存在を検出するための方法
WO2013049121A2 (en) 2011-09-26 2013-04-04 Sample6 Technologies, Inc. Recombinant phage and methods
US9481903B2 (en) 2013-03-13 2016-11-01 Roche Molecular Systems, Inc. Systems and methods for detection of cells using engineered transduction particles
JP6431035B2 (ja) 2013-03-13 2018-11-28 ジーンウィーブ バイオサイエンシズ，インコーポレイティド 非複製的形質導入粒子及び形質導入粒子に基づくレポーターシステム

Also Published As

Publication number Publication date
US20170327910A1 (en) 2017-11-16
JP6708721B2 (ja) 2020-06-10
US9771622B2 (en) 2017-09-26
DK2968424T3 (da) 2020-03-30
RU2015143713A (ru) 2017-04-20
RU2661101C2 (ru) 2018-07-11
SG11201507463WA (en) 2015-10-29
US9388453B2 (en) 2016-07-12
US20170321289A1 (en) 2017-11-09
CN105378060A (zh) 2016-03-02
EP2968424B1 (en) 2020-01-22
NZ712344A (en) 2021-03-26
ES2780827T3 (es) 2020-08-27
HK1218429A1 (zh) 2017-02-17
WO2014160418A3 (en) 2015-03-19
US10227663B2 (en) 2019-03-12
AU2014243796A1 (en) 2015-10-08
EP3699592A1 (en) 2020-08-26
JP2019030328A (ja) 2019-02-28
CA2905341A1 (en) 2014-10-02
MX360560B (es) 2018-11-07
JP2016520290A (ja) 2016-07-14
KR20150131199A (ko) 2015-11-24
BR112015023108A2 (pt) 2017-11-21
US20160281179A1 (en) 2016-09-29
US10227662B2 (en) 2019-03-12
CN110938671A (zh) 2020-03-31
KR102127358B1 (ko) 2020-06-29
WO2014160418A2 (en) 2014-10-02
AU2014243796B2 (en) 2018-07-19
US20160281180A1 (en) 2016-09-29
JP6431035B2 (ja) 2018-11-28
US9752200B2 (en) 2017-09-05
US20150104787A1 (en) 2015-04-16
EP2968424A4 (en) 2017-01-25
CA2905341C (en) 2021-08-24
BR112015023108A8 (pt) 2018-01-23
CN105378060B (zh) 2019-12-10
EP2968424A2 (en) 2016-01-20

Similar Documents

Publication Publication Date Title
MX360560B (es) Partículas de transducción no replicativas y sistemas indicadores a base de partículas de transducción.
TW201614073A (en) Non-replicative transduction particles and transduction particle-based reporter systems
EP3529357A4 (en) METHODS AND SYSTEMS FOR ENCODING NUCLEIC ACID MOLECULES FROM INDIVIDUAL CELLS OR CELL POPULATIONS
MX2017005159A (es) Composiciones y metodos para detectar un virus de rna.
EP3161160A4 (en) Methods of analyzing nucleic acids from individual cells or cell populations
MX2016016713A (es) Procesos y sistemas para el montaje de secuencias de acido nucleico.
EP3041948A4 (en) Alternative nucleic acid molecules containing reduced uracil content and uses thereof
EP3542296A4 (en) TOTAL CANCER GENOME DNA ACCESSIBILITY PREDICTION METHODS AND SYSTEMS
WO2015196128A3 (en) Alternative nucleic acid molecules and uses thereof
WO2015196130A3 (en) Alternative nucleic acid molecules and uses thereof
EP3368178A4 (en) METHODS AND SYSTEMS FOR REGULATING DNA, RNA AND OTHER BIOLOGICAL MOLECULES CROSSING NANOPORES
EP3504347A4 (en) METHODS FOR DETECTING GENOMIC COPY CHANGES IN DNA SAMPLES
MX2017007930A (es) Sistemas de modificación de genoma fúngico y métodos de uso.
UA116205C2 (uk) Спосіб кількісного визначення послідовності нуклеїнової кислоти в зразку
MX2015011575A (es) Sistemas y metodos para la deteccion de celulas usando particulas manejadas de transduccion.
WO2015200717A3 (en) Pcr-activated sorting (pas)
EP3115457A4 (en) Genomic sequence modification method for specifically converting nucleic acid bases of targeted dna sequence, and molecular complex for use in same
GB2550745A (en) Crispr hybrid DNA/RNA Polynucleotides and methods of use
WO2015058008A3 (en) Enhanced nucleic acid identification and detection
EP2746395A4 (en) PRIMER SET, METHOD FOR AMPLIFYING TARGET NUCLEIC ACID SEQUENCE USING THE SAME, AND METHOD FOR DETECTING NUCLEIC ACID MUTRED USING THE SAME
GB2516666B (en) Fluidic cartridge for nucleic acid amplification and detection
MX2016007541A (es) Moléculas modificadas de ácido nucleico y usos de las mismas.
EP3105326A4 (en) Composite liquid cell (clc) mediated nucleic acid library preparation device, and methods for using the same
EP3222718A4 (en) Method for knock-in of dna into target region of mammalian genome, and cell
EP3129505A4 (en) Systems and methods for clonal replication and amplification of nucleic acid molecules for genomic and therapeutic applications

Legal Events

Date Code Title Description
FG Grant or registration