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MX2010006446A - Nuevos derivados de diazeniodiolato, procedimiento para la preparacion de los mismos y composiciones farmaceuticas que los contienen. - Google Patents

Nuevos derivados de diazeniodiolato, procedimiento para la preparacion de los mismos y composiciones farmaceuticas que los contienen.

Info

Publication number
MX2010006446A
MX2010006446A MX2010006446A MX2010006446A MX2010006446A MX 2010006446 A MX2010006446 A MX 2010006446A MX 2010006446 A MX2010006446 A MX 2010006446A MX 2010006446 A MX2010006446 A MX 2010006446A MX 2010006446 A MX2010006446 A MX 2010006446A
Authority
MX
Mexico
Prior art keywords
preparation
same
pharmaceutical compositions
compositions containing
group
Prior art date
Application number
MX2010006446A
Other languages
English (en)
Inventor
Tony Verbeuren
Christine Courchay
Serge Simonet
Alexis Cordi
Laure Haberkorn
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of MX2010006446A publication Critical patent/MX2010006446A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Psychiatry (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Compuestos de la fórmula (I), en los cuales: R1 representa un átomo de hidrógeno o un grupo -COOR, R2 representa un grupo G o un grupo alquilo de (C1-C6) lineal o ramificado sustituido por un grupo G, donde G representa un grupo -(CH2)n-A(CH2)m-B-(CR4R5)p-(C H2)o-R6 como se definió en la descripción, y R3 representa un átomo de hidrógeno, un grupo alquilo o un grupo NO2.
MX2010006446A 2007-12-11 2008-12-10 Nuevos derivados de diazeniodiolato, procedimiento para la preparacion de los mismos y composiciones farmaceuticas que los contienen. MX2010006446A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0708604A FR2924713B1 (fr) 2007-12-11 2007-12-11 Nouveaux derives diazeniumdiolates, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
PCT/FR2008/001716 WO2009103875A1 (fr) 2007-12-11 2008-12-10 Nouveaux derives diazeniumdiolates, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
MX2010006446A true MX2010006446A (es) 2010-07-05

Family

ID=39158541

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010006446A MX2010006446A (es) 2007-12-11 2008-12-10 Nuevos derivados de diazeniodiolato, procedimiento para la preparacion de los mismos y composiciones farmaceuticas que los contienen.

Country Status (26)

Country Link
US (1) US8288433B2 (es)
EP (1) EP2231598B1 (es)
JP (1) JP5247814B2 (es)
KR (1) KR20100083195A (es)
CN (1) CN101910128B (es)
AR (1) AR069643A1 (es)
AT (1) ATE520658T1 (es)
AU (1) AU2008351147B2 (es)
BR (1) BRPI0822066A2 (es)
CA (1) CA2707853C (es)
DK (1) DK2231598T3 (es)
EA (1) EA201000885A1 (es)
ES (1) ES2371699T3 (es)
FR (1) FR2924713B1 (es)
GE (1) GEP20135733B (es)
HR (1) HRP20110755T1 (es)
MA (1) MA31901B1 (es)
MX (1) MX2010006446A (es)
MY (1) MY147973A (es)
NZ (1) NZ586070A (es)
PL (1) PL2231598T3 (es)
PT (1) PT2231598E (es)
RS (1) RS52001B (es)
SI (1) SI2231598T1 (es)
UA (1) UA97035C2 (es)
WO (1) WO2009103875A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2498605B1 (en) * 2009-10-29 2014-08-27 Merck Sharp & Dohme Corp. Diuretics
US8648058B2 (en) 2010-02-12 2014-02-11 Merck Sharp & Dohme Corp. Diazeniumdiolate cyclopentyl derivatives
US8623846B2 (en) 2010-05-21 2014-01-07 Merck Sharp & Dohme Corp. Diazeniumdiolate cyclohexyl derivatives
US9108920B2 (en) 2010-10-29 2015-08-18 Merck Sharp & Dohme Corp. Diazeniumdiolate heterocyclic derivatives
JO3350B1 (ar) * 2011-03-07 2019-03-13 Merck Sharp & Dohme مشتقات حلقية غير متجانسة محتوية على مجموعات أمينو أولية ومركبات داي أزينيومديولات
EP2704568B1 (en) 2011-05-02 2018-01-24 Merck Sharp & Dohme Corp. Diazeniumdiolate cyclohexyl derivatives
CN109608371B (zh) * 2019-01-16 2020-12-29 泰州学院 O2-4-(3-(4-胺磺酰基苯基)脲)苯基偶氮鎓二醇盐衍生物、制备方法及用途
CN114805183B (zh) * 2022-05-07 2022-12-27 武汉科技大学 一类no供体型荜茇酰胺衍生物、制备方法及用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1203691A (en) * 1968-03-06 1970-09-03 Science Union & Cie New disubstituted n-amino indoline derivatives and process for preparing them
JPH0233030B2 (ja) * 1982-01-18 1990-07-25 Mitsui Toatsu Chemicals Surufuamoiruansokukosanjudotaioyobisoreojukoseibuntoshitefukumuchiryoyososeibutsu
JPH07118231A (ja) * 1993-10-22 1995-05-09 Nippon Oil & Fats Co Ltd スルファモイル安息香酸誘導体
US5958427A (en) * 1996-11-08 1999-09-28 Salzman; Andrew L. Nitric oxide donor compounds and pharmaceutical compositions for pulmonary hypertension and other indications
AUPS236902A0 (en) * 2002-05-16 2002-06-13 Northern Sydney Area Health Service Composition and method for treating hypertension
US20080275093A1 (en) * 2004-11-15 2008-11-06 Nitromed, Inc. Diuretic Compounds Comprising Heterocyclic Nitric Oxide Donor Groups, Compositions and Methods of Use
AU2006216665A1 (en) * 2005-02-24 2006-08-31 Nicox S.A. Nitric oxide enhancing diuretic compounds, compositions and methods of use
JP2011510082A (ja) * 2008-01-24 2011-03-31 メルク・シャープ・エンド・ドーム・コーポレイション アンジオテンシンｉｉ受容体拮抗薬
WO2009099853A2 (en) * 2008-02-08 2009-08-13 Merck & Co., Inc. Angiotensin ii receptor antagonists

Also Published As

Publication number Publication date
EA201000885A1 (ru) 2011-02-28
FR2924713A1 (fr) 2009-06-12
WO2009103875A1 (fr) 2009-08-27
GEP20135733B (en) 2013-01-25
MY147973A (en) 2013-02-28
PL2231598T3 (pl) 2011-12-30
US8288433B2 (en) 2012-10-16
RS52001B (en) 2012-04-30
KR20100083195A (ko) 2010-07-21
AU2008351147B2 (en) 2012-04-12
CN101910128B (zh) 2013-01-16
EP2231598B1 (fr) 2011-08-17
ATE520658T1 (de) 2011-09-15
FR2924713B1 (fr) 2010-01-29
JP5247814B2 (ja) 2013-07-24
CA2707853C (fr) 2013-02-05
SI2231598T1 (sl) 2011-11-30
CN101910128A (zh) 2010-12-08
HRP20110755T1 (hr) 2011-11-30
PT2231598E (pt) 2011-10-11
DK2231598T3 (da) 2011-12-05
NZ586070A (en) 2012-06-29
EP2231598A1 (fr) 2010-09-29
UA97035C2 (ru) 2011-12-26
ES2371699T3 (es) 2012-01-09
MA31901B1 (fr) 2010-12-01
BRPI0822066A2 (pt) 2015-09-22
US20100286225A1 (en) 2010-11-11
JP2011506408A (ja) 2011-03-03
AR069643A1 (es) 2010-02-10
CA2707853A1 (fr) 2009-08-27
AU2008351147A1 (en) 2009-08-27

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