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MEP13108A - Targeting of tumor vasculature using radiolabelled antibody l19 against fibronectin ed-b - Google Patents

Targeting of tumor vasculature using radiolabelled antibody l19 against fibronectin ed-b

Info

Publication number
MEP13108A
MEP13108A MEP-131/08A MEP13108A MEP13108A ME P13108 A MEP13108 A ME P13108A ME P13108 A MEP13108 A ME P13108A ME P13108 A MEP13108 A ME P13108A
Authority
ME
Montenegro
Prior art keywords
domain
antibody
cdr1
cdr2
seq
Prior art date
Application number
MEP-131/08A
Other languages
Bosnian (bs)
English (en)
Croatian (hr)
Inventor
Laura Borsi
Barbara Carnemolla
Enrica Balza
Patrizia Castellani
Luciano Zardi
Matthias Friebe
Christoph-Stephan Hilger
Original Assignee
Bayer Schering Pharma Ag
Philogen Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Schering Pharma Ag, Philogen Spa filed Critical Bayer Schering Pharma Ag
Publication of MEP13108A publication Critical patent/MEP13108A/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
MEP-131/08A 2003-09-10 2004-09-01 Targeting of tumor vasculature using radiolabelled antibody l19 against fibronectin ed-b MEP13108A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US50188103P 2003-09-10 2003-09-10
EP03255633A EP1514561A1 (en) 2003-09-10 2003-09-10 Targeting of tumor vasculature using radiolabelled antibody L19 against fibronectin ED-B
PCT/EP2004/009733 WO2005023318A1 (en) 2003-09-10 2004-09-01 Targeting of tumor vasculature using radiolabelled antibody l19 against fibronectin ed-b

Publications (1)

Publication Number Publication Date
MEP13108A true MEP13108A (en) 2011-05-10

Family

ID=34130349

Family Applications (1)

Application Number Title Priority Date Filing Date
MEP-131/08A MEP13108A (en) 2003-09-10 2004-09-01 Targeting of tumor vasculature using radiolabelled antibody l19 against fibronectin ed-b

Country Status (28)

Country Link
US (2) US20050074401A1 (ja)
EP (3) EP1514561A1 (ja)
JP (1) JP2007505065A (ja)
KR (1) KR101129161B1 (ja)
CN (1) CN100482285C (ja)
AT (1) ATE499949T1 (ja)
AU (2) AU2004269897B2 (ja)
BR (1) BRPI0414272A (ja)
CA (1) CA2536256C (ja)
CR (2) CR8331A (ja)
DE (1) DE602004031635D1 (ja)
DK (1) DK1663320T3 (ja)
EA (1) EA010653B1 (ja)
EC (1) ECSP066499A (ja)
ES (1) ES2361743T3 (ja)
HK (1) HK1092375A1 (ja)
IL (1) IL173560A0 (ja)
ME (1) MEP13108A (ja)
NO (1) NO20061619L (ja)
NZ (1) NZ545640A (ja)
PL (1) PL1663320T3 (ja)
PT (1) PT1663320E (ja)
RS (1) RS20060176A (ja)
SG (1) SG162760A1 (ja)
SI (1) SI1663320T1 (ja)
UA (1) UA89759C2 (ja)
WO (1) WO2005023318A1 (ja)
ZA (1) ZA200602014B (ja)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1259548A1 (en) * 2000-02-24 2002-11-27 Eidgenössische Technische Hochschule Zürich Antibody specific for the ed-b domain of fibronectin, conjugates comprising said antibody, and their use for the detection and treatment of angiogenesis
DK1483297T3 (da) * 2002-03-11 2010-05-03 Philogen Spa Antistoffer afledt fra anti-ED-B L19 og rettet mod tumorblodkar
US7785591B2 (en) 2004-10-14 2010-08-31 Morphosys Ag Identification and characterization of function-blocking anti-ED-B-fibronectin antibodies
ATE548052T1 (de) * 2008-01-17 2012-03-15 Philogen Spa Kombination aus einem anti-edb-fibronectin- antikörper-il-2-fusionsprotein und einem b-zellen bindenden molekül, b-zellen-vorläufern und/oder deren krebserregendem gegenspieler
ES2648122T3 (es) * 2008-04-30 2017-12-28 Immunogen, Inc. Reticulantes y sus usos
AU2015202204A1 (en) * 2008-04-30 2015-05-14 Immunogen, Inc. Cross-linkers and their uses
WO2011147762A2 (en) * 2010-05-25 2011-12-01 Bayer Pharma Aktiengesellschaft Stabilized radiopharmaceutical composition
CN104395342B (zh) * 2013-06-06 2017-07-04 合肥立方制药股份有限公司 人源抗纤连蛋白ed‑b结构域的抗体及其用途
GB201621806D0 (en) 2016-12-21 2017-02-01 Philogen Spa Immunocytokines with progressive activation mechanism
US10517238B2 (en) 2017-09-18 2019-12-31 Deere & Company Implement optimization by automated adjustments
WO2020249757A1 (en) 2019-06-14 2020-12-17 Philogen S.P.A Immunoconjugates comprising a single chain diabody and interleukin-15 or interleukin-15 and a sushi domain of interleukin-15 receptor alpha
JP7352040B2 (ja) 2020-05-22 2023-09-27 フィロジェン エッセ．ピー．アー． 脳腫瘍の治療のためのＴＮＦα免疫コンジュゲート療法
CN111808161A (zh) * 2020-06-01 2020-10-23 北京大学 一种对生物化合物进行放射性标记的方法
WO2023131611A1 (en) 2022-01-04 2023-07-13 Philogen S.P.A. Combination of an immunocytokine comprising il-12 and a kinase inhibitor

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
JPS61134325A (ja) 1984-12-04 1986-06-21 Teijin Ltd ハイブリツド抗体遺伝子の発現方法
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US20030045681A1 (en) * 1998-05-11 2003-03-06 Anthony J. Zelano Specific binding molecules for scintigraphy, conjugates containing them and therapeutic method for treatment of angiogenesis
DE60121733T2 (de) 2000-02-24 2007-08-09 Philogen S.P.A. Zusamensetzungen und Verfahren zur Behandlung von Angiogenese in pathologischen Schädigungen
EP1259548A1 (en) * 2000-02-24 2002-11-27 Eidgenössische Technische Hochschule Zürich Antibody specific for the ed-b domain of fibronectin, conjugates comprising said antibody, and their use for the detection and treatment of angiogenesis
WO2001096599A2 (en) * 2000-06-15 2001-12-20 Philogen S.R.L. Methods for quantitative determination of b-fibronectin in biological fluids and tissues
AU2003210149B2 (en) * 2002-01-03 2008-10-09 Bayer Schering Pharma Aktiengesellschaft Conjugates comprising an antibody specific for the ED-B domain of fibronectin and their use for the detection and treatment of tumours
DK1483297T3 (da) * 2002-03-11 2010-05-03 Philogen Spa Antistoffer afledt fra anti-ED-B L19 og rettet mod tumorblodkar

Also Published As

Publication number Publication date
SI1663320T1 (sl) 2011-06-30
EP1514561A1 (en) 2005-03-16
ATE499949T1 (de) 2011-03-15
KR20060118430A (ko) 2006-11-23
US20090214423A1 (en) 2009-08-27
AU2010200271A1 (en) 2010-02-18
EP1663320A1 (en) 2006-06-07
CA2536256C (en) 2013-02-26
DK1663320T3 (da) 2011-06-06
RS20060176A (en) 2008-08-07
UA89759C2 (ru) 2010-03-10
JP2007505065A (ja) 2007-03-08
EA010653B1 (ru) 2008-10-30
NZ545640A (en) 2009-05-31
NO20061619L (no) 2006-04-10
CN100482285C (zh) 2009-04-29
PL1663320T3 (pl) 2011-07-29
PT1663320E (pt) 2011-06-07
DE602004031635D1 (de) 2011-04-14
EP1663320B1 (en) 2011-03-02
BRPI0414272A (pt) 2006-11-07
IL173560A0 (en) 2006-07-05
CR8331A (es) 2006-10-04
EP2246070A2 (en) 2010-11-03
ECSP066499A (es) 2006-10-10
CN1849144A (zh) 2006-10-18
ES2361743T3 (es) 2011-06-21
EA200600494A1 (ru) 2006-08-25
KR101129161B1 (ko) 2012-03-28
AU2004269897B2 (en) 2009-11-05
CA2536256A1 (en) 2005-03-17
WO2005023318A1 (en) 2005-03-17
ZA200602014B (en) 2007-05-30
US20050074401A1 (en) 2005-04-07
CR20110168A (es) 2011-06-03
HK1092375A1 (en) 2007-02-09
SG162760A1 (en) 2010-07-29
AU2004269897A1 (en) 2005-03-17

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