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ME01527B - Emulzijski cjepivni pripravci koji sadrže antigen i adjuvans u vodenoj fazi - Google Patents

Emulzijski cjepivni pripravci koji sadrže antigen i adjuvans u vodenoj fazi

Info

Publication number
ME01527B
ME01527B MEP-2013-101A MEP10113A ME01527B ME 01527 B ME01527 B ME 01527B ME P10113 A MEP10113 A ME P10113A ME 01527 B ME01527 B ME 01527B
Authority
ME
Montenegro
Prior art keywords
adjuvant
antigen
aqueous phase
vaccine compositions
emulsion vaccine
Prior art date
Application number
MEP-2013-101A
Other languages
English (en)
Inventor
David Leon Lutz
Jeffrey Harold Rodenberg
Evan James Diehl
Mahesh Kumar
Original Assignee
Zoetis Services Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zoetis Services Llc filed Critical Zoetis Services Llc
Publication of ME01527B publication Critical patent/ME01527B/me

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • A61K39/145Orthomyxoviridae, e.g. influenza virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/107Emulsions ; Emulsion preconcentrates; Micelles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/16Antivirals for RNA viruses for influenza or rhinoviruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/55Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552Veterinary vaccine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505Inorganic adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55555Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55561CpG containing adjuvants; Oligonucleotide containing adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55566Emulsions, e.g. Freund's adjuvant, MF59
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55572Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/39Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011Details
    • C12N2760/16011Orthomyxoviridae
    • C12N2760/16111Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011Details
    • C12N2760/16011Orthomyxoviridae
    • C12N2760/16111Influenzavirus A, i.e. influenza A virus
    • C12N2760/16171Demonstrated in vivo effect

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Dispersion Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
MEP-2013-101A 2007-06-20 2008-06-19 Emulzijski cjepivni pripravci koji sadrže antigen i adjuvans u vodenoj fazi ME01527B (me)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US93657107P 2007-06-20 2007-06-20
PCT/US2008/067433 WO2008157659A1 (en) 2007-06-20 2008-06-19 Emulsion vaccine compositions comprising antigen and adjuvant in the aqueous phase
EP08771428.3A EP2164510B1 (en) 2007-06-20 2008-06-19 Emulsion vaccine compositions comprising antigen and adjuvant in the aqueous phase

Publications (1)

Publication Number Publication Date
ME01527B true ME01527B (me) 2014-04-20

Family

ID=39720537

Family Applications (1)

Application Number Title Priority Date Filing Date
MEP-2013-101A ME01527B (me) 2007-06-20 2008-06-19 Emulzijski cjepivni pripravci koji sadrže antigen i adjuvans u vodenoj fazi

Country Status (26)

Country Link
US (2) US8980288B2 (me)
EP (1) EP2164510B1 (me)
JP (2) JP5457340B2 (me)
KR (1) KR101569218B1 (me)
CN (2) CN105148268A (me)
AR (1) AR067087A1 (me)
AU (1) AU2008265745B2 (me)
BR (1) BRPI0812856A2 (me)
CA (1) CA2692098C (me)
CL (1) CL2008001806A1 (me)
CO (1) CO6251273A2 (me)
CY (1) CY1114451T1 (me)
DK (1) DK2164510T3 (me)
ES (1) ES2429296T3 (me)
HK (1) HK1218717A1 (me)
HR (1) HRP20130939T1 (me)
ME (1) ME01527B (me)
MX (1) MX2009014070A (me)
NZ (1) NZ582132A (me)
PL (1) PL2164510T3 (me)
PT (1) PT2164510E (me)
RS (1) RS52947B (me)
SI (1) SI2164510T1 (me)
TW (1) TWI507214B (me)
WO (1) WO2008157659A1 (me)
ZA (1) ZA200909173B (me)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CL2008001806A1 (es) * 2007-06-20 2008-09-05 Wyeth Corp Composicion de vacuna en emulsion agua en aceite que comprende un antigeno y un adyuvante en la fase acuosa; y metodo de elaboracion.
KR101333852B1 (ko) 2008-06-27 2013-11-27 조에티스 엘엘씨 신규한 면역증강 조성물
WO2010114169A1 (en) * 2009-03-31 2010-10-07 Japan As Represented By The Director-General Of National Institute Of Infectious Diseases Method for prophylaxis of influenza using vaccine for intranasal administration
CN102741537B (zh) 2010-01-29 2016-01-06 唐纳森公司 用于空气滤清器的水分离器组件及发动机空气流入口结构
CN101829323A (zh) * 2010-04-28 2010-09-15 洛阳普莱柯生物工程有限公司 一种禽用油乳剂疫苗及其制备方法
RU2013150203A (ru) 2011-04-12 2015-05-20 Оро Фину Партисипасойнс Э Эмпреендиментус С/А Пептиды с противомикробной активностью, лекарственные композиции для лечения и профилактики животных, композиции для лечения и профилактики растений, применения указанных пептидов и применения экстракта из paenibacillus elgii ourofinensis
CN109675029A (zh) * 2013-09-19 2019-04-26 硕腾服务有限责任公司 油基佐剂
WO2015084594A1 (en) * 2013-12-06 2015-06-11 Advanced Bionutrition Corporation Composition for oral delivery of bioactive agents
LT3244920T (lt) 2015-01-16 2023-08-25 Zoetis Services Llc Snukio ir nagų ligos vakcina
GB201506948D0 (en) * 2015-04-23 2015-06-10 Croda Int Plc Emulsions for injectable formulations
CN106177939B (zh) * 2015-06-01 2021-01-19 普莱柯生物工程股份有限公司 一种疫苗用佐剂及其应用
CN106344920B (zh) * 2015-07-16 2020-11-27 普莱柯生物工程股份有限公司 一种疫苗用佐剂及其应用
CN107281482B (zh) * 2016-04-05 2021-06-11 普莱柯生物工程股份有限公司 一种免疫佐剂组合物及其制备方法
CN112243373B (zh) * 2018-03-13 2023-09-22 胶囊技术私人有限公司 疫苗组合物
CN110404065B (zh) * 2018-04-27 2023-06-16 洛阳赛威生物科技有限公司 一种猪用佐剂组合物及其制备方法
US11813321B2 (en) 2018-07-13 2023-11-14 Biomune Company Vaccines against avian reoviruses
BR112021001420A2 (pt) 2018-07-27 2021-05-04 Research Development Foundation polipeptídeos imunogênicos quiméricos
CN114306585A (zh) * 2021-12-30 2022-04-12 广西壮族自治区水产科学研究院 一种鱼类高纯度抗原乳剂的制备方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3639577A (en) * 1968-02-23 1972-02-01 Haver Lockhart Lab Inc Injectable adjuvant,method of preparing same and compositions including such adjuvant
NZ221306A (en) 1986-08-15 1990-02-26 Commw Scient Ind Res Org 2-component immunoadjuvant comprising a mycobacterial free immunoadjuvant oil and a polycationic polyelectrolyte immunoadjuvant and vaccines thereof
DE3768232D1 (de) * 1986-12-19 1991-04-04 Duphar Int Res Dimethyldioctadecylammoniumbromid enthaltende stabilisierte adjuvanssuspension.
US5951988A (en) * 1993-03-30 1999-09-14 University Of Saskatchewan Adjuvant formulation with enhanced immunogenic activity, and related compositions and methods
BE1008977A5 (fr) 1994-12-27 1996-10-01 Solvay Adjuvants pour vaccins.
US5744137A (en) 1995-02-06 1998-04-28 The United States Of America As Represented By The Secretary Of The Agriculture Oil emulsion vaccines prepared with animal, vegetable, and synthetic oils using a mixture of nonionic surfactants
CA2314934C (en) * 1997-12-16 2006-08-29 Chiron Corporation Use of microparticles combined with submicron oil-in-water emulsions
FR2775601B1 (fr) * 1998-03-03 2001-09-21 Merial Sas Vaccins vivants recombines et adjuves
FR2776928B1 (fr) 1998-04-03 2000-06-23 Merial Sas Vaccins adn adjuves
MXPA02011545A (es) * 2000-05-24 2003-06-06 Merial Sas Virus del sindrome respiratorio y reproductor porcino (peesv), vacuna recombinante para el virus de la viruela.
FR2810888B1 (fr) * 2000-06-29 2004-07-30 Merial Sas Vaccin contre la fievre aphteuse
US6585978B1 (en) * 2000-09-09 2003-07-01 Akzo Nobel EIA vaccine and diagnostic
US7018638B2 (en) 2000-12-19 2006-03-28 Wyeth Mycoplasma hyopneumoniae bacterin vaccine
US6676958B2 (en) 2001-06-19 2004-01-13 Advanced Bioadjuvants, Llc Adjuvant composition for mucosal and injection delivered vaccines
US20030129161A1 (en) 2001-09-17 2003-07-10 Hsien-Jue Chu Interleukin-12 as a veterinary vaccine adjuvant
JP3812814B2 (ja) * 2001-10-19 2006-08-23 株式会社微生物化学研究所 動物用多価オイルアジュバントワクチン
US7862821B2 (en) 2006-06-01 2011-01-04 Merial Limited Recombinant vaccine against bluetongue virus
CL2008001806A1 (es) * 2007-06-20 2008-09-05 Wyeth Corp Composicion de vacuna en emulsion agua en aceite que comprende un antigeno y un adyuvante en la fase acuosa; y metodo de elaboracion.

Also Published As

Publication number Publication date
AU2008265745B2 (en) 2013-05-30
DK2164510T3 (da) 2013-09-23
TWI507214B (zh) 2015-11-11
CN101790378A (zh) 2010-07-28
JP5802285B2 (ja) 2015-10-28
US8980288B2 (en) 2015-03-17
US9545439B2 (en) 2017-01-17
CN105148268A (zh) 2015-12-16
CA2692098C (en) 2016-06-14
MX2009014070A (es) 2010-05-19
KR101569218B1 (ko) 2015-11-13
US20150297710A1 (en) 2015-10-22
SI2164510T1 (sl) 2013-11-29
CO6251273A2 (es) 2011-02-21
CY1114451T1 (el) 2016-10-05
AU2008265745A1 (en) 2008-12-24
AR067087A1 (es) 2009-09-30
RS52947B (en) 2014-02-28
WO2008157659A1 (en) 2008-12-24
EP2164510B1 (en) 2013-07-17
CA2692098A1 (en) 2008-12-24
JP2010530877A (ja) 2010-09-16
NZ582132A (en) 2012-04-27
ZA200909173B (en) 2010-08-25
PT2164510E (pt) 2013-10-07
CL2008001806A1 (es) 2008-09-05
KR20100022115A (ko) 2010-02-26
HRP20130939T1 (hr) 2013-11-22
US20090017067A1 (en) 2009-01-15
BRPI0812856A2 (pt) 2014-12-09
PL2164510T3 (pl) 2014-03-31
EP2164510A1 (en) 2010-03-24
HK1218717A1 (zh) 2017-03-10
TW200906448A (en) 2009-02-16
JP5457340B2 (ja) 2014-04-02
JP2014088423A (ja) 2014-05-15
ES2429296T3 (es) 2013-11-14

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